AR077140A1 - Derivados de pirazina como inhibidores de dgat-1, un proceso para prepararlos y una composicion farmaceutica que los comprende - Google Patents

Derivados de pirazina como inhibidores de dgat-1, un proceso para prepararlos y una composicion farmaceutica que los comprende

Info

Publication number
AR077140A1
AR077140A1 ARP100102161A ARP100102161A AR077140A1 AR 077140 A1 AR077140 A1 AR 077140A1 AR P100102161 A ARP100102161 A AR P100102161A AR P100102161 A ARP100102161 A AR P100102161A AR 077140 A1 AR077140 A1 AR 077140A1
Authority
AR
Argentina
Prior art keywords
alkyl
alkoxy
group
cyano
independently
Prior art date
Application number
ARP100102161A
Other languages
English (en)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR077140A1 publication Critical patent/AR077140A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Abstract

Se describen compuestos inhibidores de DGAT-1 de la formula (1), sales farmacéuticamente aceptables de los mismos, junto con composiciones farmacéuticas, procesos para prepararlos y sus usos en tratar, por ejemplo la obesidad Reivindicacion 1: Un compuesto de la formula (1), o una sal farmacéuticamente aceptable del mismo, donde cada r es de manera independiente 0 o 1 y cada X1 se selecciona de manera independiente de alquilo (C1-3) lineal, alquenilo (C2-3), alquinilo (C2-3), alcoxi (C1-2), metoximetilo, amino y ciano; cada q es de manera independiente 0 o 1 y cada X2 se selecciona de manera independiente de fluor, cloro, bromo, amino, ciano, alquilo (C1-3), alquenilo (C2-3), alquinilo (C2-3) y alcoxi (C1-2); Y1 se selecciona de fluor, cloro, bromo, ciano, alquilo (C1-3) y alcoxi (C1-2); n es 0, 1 o 2 y cada Y2 se selecciona de manera independiente de fluor, cloro, bromo, ciano, hidroxi, alquilo (C1-3) y alcoxi (C1-2); p es 0, 1 o 2 y cada Y3 es de manera independiente alquilo (C1-3) o cuando p es 2 cada Y3 también se puede ligar para formar un anillo cicloalquilo (C3-5); Z es carboxi o un grupo Q seleccionado de -CONHSO2Me o uno de los anillos del grupo (2), o Z es -CONRbRc donde Rb y Rc se seleccionan de manera independiente de hidrogeno, alquilo (C1-4) y alcoxietilo (C1-4)o Rb y Rc se ligan de manera de formar un anillo morfolino o un anillo heterocíclico (C4-6), y cuando Z es -CONRbRc el grupo alquilo (C1-4) y anillos morfolino o heterocíclico (C4-6) que se pueden formar pueden estar opcionalmente sustituidos en un átomo de carbono disponible con carboxi o un grupo Q; y donde cualquier átomo de carbono en un grupo que contiene alquilo (C1-3) lineal, alquilo (C1-3) o alcoxi (C1-2) que se definio con anterioridad puede estar opcionalmente sustituido con hasta 3 átomos de fluor.
ARP100102161A 2009-06-19 2010-06-18 Derivados de pirazina como inhibidores de dgat-1, un proceso para prepararlos y una composicion farmaceutica que los comprende AR077140A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21853909P 2009-06-19 2009-06-19

Publications (1)

Publication Number Publication Date
AR077140A1 true AR077140A1 (es) 2011-08-03

Family

ID=42357808

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100102161A AR077140A1 (es) 2009-06-19 2010-06-18 Derivados de pirazina como inhibidores de dgat-1, un proceso para prepararlos y una composicion farmaceutica que los comprende

Country Status (14)

Country Link
US (2) US8188092B2 (es)
EP (1) EP2443096A1 (es)
JP (1) JP2012530122A (es)
KR (1) KR20120037939A (es)
CN (1) CN102498103A (es)
AR (1) AR077140A1 (es)
AU (1) AU2010261499A1 (es)
BR (1) BRPI1016109A2 (es)
CA (1) CA2764013A1 (es)
MX (1) MX2011014018A (es)
RU (1) RU2011152517A (es)
TW (1) TW201103895A (es)
UY (1) UY32716A (es)
WO (1) WO2010146395A1 (es)

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Also Published As

Publication number Publication date
US20120289520A1 (en) 2012-11-15
JP2012530122A (ja) 2012-11-29
US20100324068A1 (en) 2010-12-23
AU2010261499A1 (en) 2012-01-12
RU2011152517A (ru) 2013-07-27
CN102498103A (zh) 2012-06-13
MX2011014018A (es) 2012-02-22
CA2764013A1 (en) 2010-12-23
BRPI1016109A2 (pt) 2016-05-17
WO2010146395A1 (en) 2010-12-23
EP2443096A1 (en) 2012-04-25
US8188092B2 (en) 2012-05-29
KR20120037939A (ko) 2012-04-20
UY32716A (es) 2011-01-31
TW201103895A (en) 2011-02-01

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