AR076703A1 - (dihidro)imidazoiso[5,1-a]quinolina y composiciones farmaceuticas que los contienen - Google Patents
(dihidro)imidazoiso[5,1-a]quinolina y composiciones farmaceuticas que los contienenInfo
- Publication number
- AR076703A1 AR076703A1 ARP100101803A ARP100101803A AR076703A1 AR 076703 A1 AR076703 A1 AR 076703A1 AR P100101803 A ARP100101803 A AR P100101803A AR P100101803 A ARP100101803 A AR P100101803A AR 076703 A1 AR076703 A1 AR 076703A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- amino
- hydroxy
- optionally substituted
- heterocycloalkyl
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 23
- -1 quinoline compound Chemical class 0.000 abstract 9
- 125000003545 alkoxy group Chemical group 0.000 abstract 7
- 229910052736 halogen Inorganic materials 0.000 abstract 7
- 150000002367 halogens Chemical class 0.000 abstract 7
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 7
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 7
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 5
- 125000001424 substituent group Chemical group 0.000 abstract 5
- 125000003342 alkenyl group Chemical group 0.000 abstract 4
- 125000004414 alkyl thio group Chemical group 0.000 abstract 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 4
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 abstract 3
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000006254 cycloalkyl carbonyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 1
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004656 alkyl sulfonylamino group Chemical group 0.000 abstract 1
- 125000006598 aminocarbonylamino group Chemical group 0.000 abstract 1
- SMWDFEZZVXVKRB-UHFFFAOYSA-N anhydrous quinoline Natural products N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 abstract 1
- 150000001540 azides Chemical class 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000005222 heteroarylaminocarbonyl group Chemical group 0.000 abstract 1
- 125000005224 heteroarylcarbonylamino group Chemical group 0.000 abstract 1
- 125000005553 heteroaryloxy group Chemical group 0.000 abstract 1
- 208000000509 infertility Diseases 0.000 abstract 1
- 230000036512 infertility Effects 0.000 abstract 1
- 231100000535 infertility Toxicity 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Reproductive Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gynecology & Obstetrics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pregnancy & Childbirth (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09161274 | 2009-05-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR076703A1 true AR076703A1 (es) | 2011-06-29 |
Family
ID=42315817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100101803A AR076703A1 (es) | 2009-05-27 | 2010-05-26 | (dihidro)imidazoiso[5,1-a]quinolina y composiciones farmaceuticas que los contienen |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP2435433B1 (OSRAM) |
| JP (1) | JP5647675B2 (OSRAM) |
| CN (1) | CN102448961B (OSRAM) |
| AR (1) | AR076703A1 (OSRAM) |
| AU (1) | AU2010252007B2 (OSRAM) |
| CA (1) | CA2763118A1 (OSRAM) |
| TW (1) | TWI461426B (OSRAM) |
| WO (1) | WO2010136438A1 (OSRAM) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2796774T3 (es) | 2011-07-01 | 2020-11-30 | Merck Patent Gmbh | Dihidropirazoles, composiciones farmacéuticas de los mismos y su uso para el tratamiento de trastornos de fertilidad |
| CA2834199C (en) | 2011-07-18 | 2020-01-07 | Merck Patent Gmbh | Benzamides as allosteric modulators of the fsh receptor |
| US9409897B2 (en) | 2012-01-10 | 2016-08-09 | Merck Patent Gmbh | Benzamide derivatives as modulators of the follicle stimulating hormone |
| CN104114544A (zh) | 2012-02-08 | 2014-10-22 | 默克专利有限公司 | 用作卵泡刺激素受体激动剂的氘化噻唑烷酮类似物 |
| EP3013823B1 (en) | 2013-06-24 | 2017-11-01 | Merck Patent GmbH | Imidazole compounds as modulators of fshr and uses thereof |
| SG11201509411VA (en) * | 2013-06-24 | 2015-12-30 | Merck Patent Gmbh | Pyrazole compounds as modulators of fshr and uses thereof |
| TWI720451B (zh) | 2014-02-13 | 2021-03-01 | 美商英塞特控股公司 | 作為lsd1抑制劑之環丙胺 |
| US9493442B2 (en) | 2014-02-13 | 2016-11-15 | Incyte Corporation | Cyclopropylamines as LSD1 inhibitors |
| KR102421235B1 (ko) | 2014-02-13 | 2022-07-15 | 인사이트 코포레이션 | Lsd1 저해제로서 사이클로프로필아민 |
| US9527835B2 (en) | 2014-02-13 | 2016-12-27 | Incyte Corporation | Cyclopropylamines as LSD1 inhibitors |
| WO2015196335A1 (en) | 2014-06-23 | 2015-12-30 | Tocopherx, Inc. | Pyrazole compounds as modulators of fshr and uses thereof |
| TW201613925A (en) | 2014-07-10 | 2016-04-16 | Incyte Corp | Imidazopyrazines as LSD1 inhibitors |
| WO2016007722A1 (en) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Triazolopyridines and triazolopyrazines as lsd1 inhibitors |
| US9758523B2 (en) | 2014-07-10 | 2017-09-12 | Incyte Corporation | Triazolopyridines and triazolopyrazines as LSD1 inhibitors |
| TWI687419B (zh) | 2014-07-10 | 2020-03-11 | 美商英塞特公司 | 作為ｌｓｄ１抑制劑之咪唑并吡啶及咪唑并吡嗪 |
| SG11201708047UA (en) | 2015-04-03 | 2017-10-30 | Incyte Corp | Heterocyclic compounds as lsd1 inhibitors |
| CN110402244B (zh) | 2015-08-12 | 2023-02-03 | 因赛特公司 | Lsd1抑制剂的盐 |
| SG10202010414QA (en) | 2016-04-22 | 2020-11-27 | Incyte Corp | Formulations of an lsd1 inhibitor |
| CN106866692A (zh) * | 2017-03-30 | 2017-06-20 | 毛阿龙 | 具有苯并1,4‑二氧杂环己二烯酮结构的fshr拮抗剂的制备方法 |
| WO2020047198A1 (en) | 2018-08-31 | 2020-03-05 | Incyte Corporation | Salts of an lsd1 inhibitor and processes for preparing the same |
| JP2025535050A (ja) * | 2022-10-05 | 2025-10-22 | ラディオネティクス オンコロジー，インク． | 卵胞刺激ホルモン受容体（ｆｓｈｒ）を標的とした治療薬およびその使用 |
| TW202435866A (zh) | 2023-03-08 | 2024-09-16 | 荷蘭商菲林公司 | 小分子ｆｓｈ受體調節劑 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RO66059A (ro) * | 1973-05-25 | 1981-05-30 | Gruppo Lepetit Spa,It | Procedeu de obtinere a unor derivati de triazolochinoline |
| PH15001A (en) * | 1977-07-25 | 1982-03-22 | Sandoz Ag | Prolactin secretion inhibitors |
| PT1102763E (pt) * | 1998-08-07 | 2005-01-31 | Applied Research Systems | Mimeticos fsh para o tratamento da infertilidade |
| KR100908468B1 (ko) * | 2001-07-02 | 2009-07-21 | 엔.브이.오가논 | 테트라히드로퀴놀린 유도체 |
| EP1624893A2 (en) * | 2003-04-01 | 2006-02-15 | Applied Research Systems ARS Holding N.V. | Inhibitors of phosphodiesterases in infertility |
| TW200510407A (en) * | 2003-06-30 | 2005-03-16 | Altana Pharma Ag | Novel pyrrolodihydroisoquinolines as PDE 10 inhibitors |
| TW200944523A (en) * | 2008-02-08 | 2009-11-01 | Organon Nv | (Dihydro)pyrrolo[2,1-a]isoquinolines |
-
2010
- 2010-05-06 TW TW099114528A patent/TWI461426B/zh not_active IP Right Cessation
- 2010-05-25 JP JP2012512338A patent/JP5647675B2/ja not_active Expired - Fee Related
- 2010-05-25 CN CN201080023361.8A patent/CN102448961B/zh not_active Expired - Fee Related
- 2010-05-25 AU AU2010252007A patent/AU2010252007B2/en not_active Ceased
- 2010-05-25 CA CA2763118A patent/CA2763118A1/en not_active Abandoned
- 2010-05-25 WO PCT/EP2010/057134 patent/WO2010136438A1/en not_active Ceased
- 2010-05-25 EP EP10723991.5A patent/EP2435433B1/en not_active Not-in-force
- 2010-05-26 AR ARP100101803A patent/AR076703A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010136438A1 (en) | 2010-12-02 |
| EP2435433B1 (en) | 2013-08-28 |
| AU2010252007A1 (en) | 2011-12-22 |
| CA2763118A1 (en) | 2010-12-02 |
| TW201107322A (en) | 2011-03-01 |
| JP2012528105A (ja) | 2012-11-12 |
| AU2010252007B2 (en) | 2014-06-05 |
| CN102448961A (zh) | 2012-05-09 |
| CN102448961B (zh) | 2016-01-06 |
| EP2435433A1 (en) | 2012-04-04 |
| JP5647675B2 (ja) | 2015-01-07 |
| TWI461426B (zh) | 2014-11-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR076703A1 (es) | (dihidro)imidazoiso[5,1-a]quinolina y composiciones farmaceuticas que los contienen | |
| PE20080070A1 (es) | Derivados de indolobenzazepina fusionados a ciclopropilo como inhibidores de la polimerasa ns5b del virus de la hepatitis c | |
| AR061083A1 (es) | Derivados de cicloalquilaminoacidos y composiciones farmaceuticas que los contienen | |
| AR070345A1 (es) | (dihidro ) pirrolo (2,1-a) isoquinolinas | |
| PE20090648A1 (es) | Compuestos para el tratamiento de la hepatitis c | |
| AR077130A1 (es) | Inhibidores de la replicacion de los virus de influenza | |
| EA201000775A1 (ru) | Ингибиторы бета-лактамазы | |
| BR112014010420A2 (pt) | inibidores de pak para o tratamento de distúrbios proliferativos celulares | |
| AR110128A2 (es) | Compuesto del grupo de las 3-(imidazoil)-pirazolo[3,4-b]piridinas, composición farmacéutica que lo comprende y método para preparar el mismo | |
| CO5271665A1 (es) | (compuestos de pirrolo [2,3-d] pirimidina | |
| AR067396A1 (es) | Compuesto derivado de imidazo(1,2-a)piridin-2-ilmetil piperidina sustituida sal hidrocloruro del mismo uso del compuesto o de la sal hidrocloruro para la preparacion de un medicamento y composiciones farmaceuticas que los comprende | |
| PE20141557A1 (es) | Derivado de pirazoloquinolina | |
| PT2101740E (pt) | Nova composição farmacêutica não susceptível de abuso que compreende opióides | |
| MY148583A (en) | Pyridine [3,4-b] pyrazinones | |
| AR076228A1 (es) | Piperidinas sustituidas como antagonistas de ccr3 | |
| BR112014006840A2 (pt) | derivados de pirrolopirimidina e purina | |
| WO2006103399A8 (en) | Hiv integrase inhibitors | |
| MX2012002925A (es) | Inhibidores de virus flaviviridae. | |
| SG10201407538WA (en) | Intravenous formulations of neurokinin-1 antagonists | |
| MX2009009238A (es) | Nuevos inhibidores de fosfodiesterasa. | |
| AR049898A1 (es) | Compuestos aminocarbonil fenilo sustituidos, composicion farmaceutica,uso y proceso para prepararlos | |
| AR061015A1 (es) | Compuesto y composicion farmaceutica para el tratamiento de un trastorno del sistema nervioso central relacionado con o afectado por el receptor histamina-3 y para la inhibicion del receptor h3 y proceso para la preparacion del compuesto | |
| AR063805A1 (es) | Derivados de triazol sustituidos como inhibidores de ksp. composiciones farmaceuticas. | |
| CL2008001670A1 (es) | Compuestos derivados de piperidina o piperazina, inhibidores de dgat1; composicion farmaceutica; combinacion farmaceutica; y uso para la prevencion o tratamiento de enfermedades tales como obesidad, hipercolesterolemia, dislipidemia, entre otras. | |
| MY141024A (en) | Niacin receptor agonists, compositions containing such compounds and methods of treatment |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |