CA2763118A1 - (dihydro) imidazoiso (5, 1-a)quinolines as fsh receptor agonists for the treatment of fertility disorders - Google Patents

(dihydro) imidazoiso (5, 1-a)quinolines as fsh receptor agonists for the treatment of fertility disorders Download PDF

Info

Publication number
CA2763118A1
CA2763118A1 CA2763118A CA2763118A CA2763118A1 CA 2763118 A1 CA2763118 A1 CA 2763118A1 CA 2763118 A CA2763118 A CA 2763118A CA 2763118 A CA2763118 A CA 2763118A CA 2763118 A1 CA2763118 A1 CA 2763118A1
Authority
CA
Canada
Prior art keywords
alkyl
amino
vacuo
optionally substituted
butyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2763118A
Other languages
English (en)
French (fr)
Inventor
Hubert Jan Jozef Loozen
Cornelis Marius Timmers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme BV
Original Assignee
Organon NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon NV filed Critical Organon NV
Publication of CA2763118A1 publication Critical patent/CA2763118A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pregnancy & Childbirth (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gynecology & Obstetrics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CA2763118A 2009-05-27 2010-05-25 (dihydro) imidazoiso (5, 1-a)quinolines as fsh receptor agonists for the treatment of fertility disorders Abandoned CA2763118A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09161274 2009-05-27
EP09161274.7 2009-05-27
PCT/EP2010/057134 WO2010136438A1 (en) 2009-05-27 2010-05-25 (dihydro) imidazoiso (5, 1-a) quinolines as fsh receptor agonists for the treatment of fertility disorders

Publications (1)

Publication Number Publication Date
CA2763118A1 true CA2763118A1 (en) 2010-12-02

Family

ID=42315817

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2763118A Abandoned CA2763118A1 (en) 2009-05-27 2010-05-25 (dihydro) imidazoiso (5, 1-a)quinolines as fsh receptor agonists for the treatment of fertility disorders

Country Status (8)

Country Link
EP (1) EP2435433B1 (OSRAM)
JP (1) JP5647675B2 (OSRAM)
CN (1) CN102448961B (OSRAM)
AR (1) AR076703A1 (OSRAM)
AU (1) AU2010252007B2 (OSRAM)
CA (1) CA2763118A1 (OSRAM)
TW (1) TWI461426B (OSRAM)
WO (1) WO2010136438A1 (OSRAM)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2796774T3 (es) 2011-07-01 2020-11-30 Merck Patent Gmbh Dihidropirazoles, composiciones farmacéuticas de los mismos y su uso para el tratamiento de trastornos de fertilidad
CA2834199C (en) 2011-07-18 2020-01-07 Merck Patent Gmbh Benzamides as allosteric modulators of the fsh receptor
CN104080784B (zh) 2012-01-10 2017-07-18 默克专利有限公司 用作卵泡刺激素调节剂的苯甲酰胺衍生物
BR112014019351A8 (pt) * 2012-02-08 2017-07-11 Merck Patent Gmbh Análogos de tiazolidinona deuterados como agonistas para o receptor do hormônio folículo estimulante
CA2912921C (en) * 2013-06-24 2021-05-18 Merck Patent Gmbh Pyrazole compounds as modulators of fshr and uses thereof
EP3013823B1 (en) 2013-06-24 2017-11-01 Merck Patent GmbH Imidazole compounds as modulators of fshr and uses thereof
ME03654B (me) 2014-02-13 2020-07-20 Incyte Corp Ciklopropilamini kao lsd1 inhibitori
WO2015123437A1 (en) 2014-02-13 2015-08-20 Incyte Corporation Cyclopropylamines as lsd1 inhibitors
TW201613860A (en) 2014-02-13 2016-04-16 Incyte Corp Cyclopropylamines as LSD1 inhibitors
PT3105226T (pt) 2014-02-13 2019-11-06 Incyte Corp Ciclopropilaminas como inibidores de lsd1
WO2015196335A1 (en) 2014-06-23 2015-12-30 Tocopherx, Inc. Pyrazole compounds as modulators of fshr and uses thereof
TW201613925A (en) 2014-07-10 2016-04-16 Incyte Corp Imidazopyrazines as LSD1 inhibitors
WO2016007722A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines and triazolopyrazines as lsd1 inhibitors
WO2016007727A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines and triazolopyrazines as lsd1 inhibitors
WO2016007731A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Imidazopyridines and imidazopyrazines as lsd1 inhibitors
AU2016243939B2 (en) 2015-04-03 2020-09-03 Incyte Holdings Corporation Heterocyclic compounds as LSD1 inhibitors
KR102710120B1 (ko) 2015-08-12 2024-09-27 인사이트 홀딩스 코포레이션 Lsd1 저해제의 염
AR109452A1 (es) 2016-04-22 2018-12-12 Incyte Corp Formulación farmacéutica de un inhibidor de lsd1 y método de tratamiento
CN106866692A (zh) * 2017-03-30 2017-06-20 毛阿龙 具有苯并1,4‑二氧杂环己二烯酮结构的fshr拮抗剂的制备方法
WO2020047198A1 (en) 2018-08-31 2020-03-05 Incyte Corporation Salts of an lsd1 inhibitor and processes for preparing the same
EP4598928A1 (en) * 2022-10-05 2025-08-13 Radionetics Oncology, Inc. Follicle-stimulating hormone receptor (fshr) targeted therapeutics and uses thereof
KR20250157379A (ko) 2023-03-08 2025-11-04 훼링 비.브이. 소분자 fsh 수용체 조절제

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RO66059A (ro) * 1973-05-25 1981-05-30 Gruppo Lepetit Spa,It Procedeu de obtinere a unor derivati de triazolochinoline
PH15001A (en) * 1977-07-25 1982-03-22 Sandoz Ag Prolactin secretion inhibitors
CA2339018A1 (en) * 1998-08-07 2000-02-17 Applied Research Systems Ars Holding N.V. Fsh mimetics for the treatment of infertility
JP4523273B2 (ja) * 2001-07-02 2010-08-11 ナームローゼ・フエンノートチヤツプ・オルガノン テトラヒドロキノリン誘導体
WO2004087211A2 (en) * 2003-04-01 2004-10-14 Applied Research Systems Ars Holding N.V. Inhibitors of phosphodiesterases in infertility
CA2530316A1 (en) * 2003-06-30 2005-01-13 Altana Pharma Ag Pyrrolodihydroisoquinolines as pde10 inhibitors
TW200944523A (en) * 2008-02-08 2009-11-01 Organon Nv (Dihydro)pyrrolo[2,1-a]isoquinolines

Also Published As

Publication number Publication date
CN102448961A (zh) 2012-05-09
WO2010136438A1 (en) 2010-12-02
TW201107322A (en) 2011-03-01
EP2435433A1 (en) 2012-04-04
JP2012528105A (ja) 2012-11-12
AU2010252007A1 (en) 2011-12-22
JP5647675B2 (ja) 2015-01-07
AU2010252007B2 (en) 2014-06-05
EP2435433B1 (en) 2013-08-28
CN102448961B (zh) 2016-01-06
TWI461426B (zh) 2014-11-21
AR076703A1 (es) 2011-06-29

Similar Documents

Publication Publication Date Title
CA2763118A1 (en) (dihydro) imidazoiso (5, 1-a)quinolines as fsh receptor agonists for the treatment of fertility disorders
KR102394518B1 (ko) 브로모도메인 억제제로서의 비사이클릭 헤테로사이클릭 유도체
RS60136B1 (sr) Inhibitori bromodomena
KR20180012853A (ko) 피페리딘 유도체 및 이의 제조 방법 및 약학적 용도
EP2079738A2 (en) 7-azaindole derivatives as c-met kinase inhibitors
IL186831A (en) History 4 - Phenyl - 5 - Oxo - 8,7,6,5,4,1 - Hexahydroquinoline as a drug for the treatment of infertility
JP2007519720A (ja) チアゾール化合物
US8431564B2 (en) Ring-annulated dihydropyrrolo[2,1-α]isoquinolines
KR20090074179A (ko) Ｐｐａｒ 조절제로서 유용한 １ｈ­인돌­２­카르복실산 유도체
EP2459560B1 (en) Ring-annulated dihydropyrrolo[2,l-a]isoquinolines
CA2849111C (en) Fsh receptor antagonists
RU2530775C2 (ru) ПРОИЗВОДНЫЕ 1Н-ПИРАЗОЛО[4,3-c]ИЗОХИНОЛИНОВ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЕ В ТЕРАПИИ
KR20170132278A (ko) 암 치료에 유용한 1-(사이클로) 알킬 피리딘-2-온의 트리사이클릭 융합 유도체
EP2459551B1 (en) Dihydrobenzoindazoles
US8071587B2 (en) (Dihydro)imidazoiso[5,1-A]quinolines
US8071589B2 (en) Dihydrobenzoindazoles
EP2125807B1 (en) Imidazo[1,2-a]pyrrolo[3,2-c]pyridine compounds useful as pestivirus inhibitors
WO2013050341A1 (en) Azabenzoxazine derivatives as crac modulators

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20150521

FZDE Dead

Effective date: 20190320