AR073112A1 - Produccion de aminoacidos azufrados n- acilados con actividad enzimatica n- aciltransferasa potenciada en microorganismos - Google Patents

Produccion de aminoacidos azufrados n- acilados con actividad enzimatica n- aciltransferasa potenciada en microorganismos

Info

Publication number
AR073112A1
AR073112A1 ARP090103229A ARP090103229A AR073112A1 AR 073112 A1 AR073112 A1 AR 073112A1 AR P090103229 A ARP090103229 A AR P090103229A AR P090103229 A ARP090103229 A AR P090103229A AR 073112 A1 AR073112 A1 AR 073112A1
Authority
AR
Argentina
Prior art keywords
amino acids
production
microorganisms
aciltranspherase
acilated
Prior art date
Application number
ARP090103229A
Other languages
English (en)
Original Assignee
Metabolic Explorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolic Explorer Sa filed Critical Metabolic Explorer Sa
Publication of AR073112A1 publication Critical patent/AR073112A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Polipéptido aislado con actividad L-aminoácido-N-acil transferasa y un microorganismo modificado en el que esta enzima se sobreexpresa. Los sustratos de dicha enzima incluyen principalmente metionina y sus derivados o análogos. La sobreexpresion en microorganismos productores de aminoácidos azufrados permite la produccion de mayores cantidades de aminoácidos azufrados n-acilados. También se reivindica el asilamiento de aminoácidos azufrados n-acilados a partir del medio de fermentacion.
ARP090103229A 2008-08-22 2009-08-21 Produccion de aminoacidos azufrados n- acilados con actividad enzimatica n- aciltransferasa potenciada en microorganismos AR073112A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2008/060999 WO2010020289A1 (en) 2008-08-22 2008-08-22 Production of n-acetylated sulphur-containing amino acids with microorganisms having enhanced n-acetyltransferase enzymatic activity
US12/370,434 US8143031B2 (en) 2008-08-22 2009-02-12 Production of N-acylated sulphur-containing amino acids with microorganisms having enhanced N-acyltransferase enzymatic activity

Publications (1)

Publication Number Publication Date
AR073112A1 true AR073112A1 (es) 2010-10-13

Family

ID=40364448

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090103229A AR073112A1 (es) 2008-08-22 2009-08-21 Produccion de aminoacidos azufrados n- acilados con actividad enzimatica n- aciltransferasa potenciada en microorganismos

Country Status (8)

Country Link
US (1) US8143031B2 (es)
JP (1) JP2012500623A (es)
KR (1) KR20110042383A (es)
CN (1) CN102131923A (es)
AR (1) AR073112A1 (es)
MX (1) MX2011001961A (es)
RU (1) RU2011108706A (es)
WO (2) WO2010020289A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010020290A1 (en) * 2008-08-22 2010-02-25 Metabolic Explorer Producing methionine without n-acetyl methionine
BR112016027518A2 (pt) * 2014-05-23 2018-01-30 Evonik Degussa Gmbh produção biossintética de acil-aminoácidos".
KR101821050B1 (ko) * 2015-10-14 2018-03-09 씨제이제일제당 (주) 바이오-기반 n-아세틸-l-메티오닌 및 이의 용도
WO2017065567A1 (en) * 2015-10-14 2017-04-20 Cj Cheiljedang Corporation Bio-based n-acetyl-l-methionine and use thereof
KR101941745B1 (ko) * 2016-07-20 2019-01-24 씨제이제일제당 (주) 아실전이효소의 활성을 갖는 미생물 및 이의 용도

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2402285A1 (en) * 2000-03-10 2001-09-27 Trustees Of Tufts College Nimr compositions and their methods of use
JP4682454B2 (ja) 2000-06-28 2011-05-11 味の素株式会社 新規変異型ｎ−アセチルグルタミン酸合成酵素及びｌ−アルギニンの製造法
DE10144493A1 (de) 2001-09-11 2003-07-03 Degussa Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coyneformer Bakterien
DE102004013503A1 (de) 2004-03-18 2005-10-06 Degussa Ag Verfahren zur Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien
DE102004055414A1 (de) 2004-11-17 2006-05-24 Degussa Ag Allele des metK-Gens aus coryneformen Bakterien
US8389250B2 (en) 2006-01-04 2013-03-05 Metabolic Explorer Methods for producing methionine by culturing a microorganism modified to enhance production of cysteine
WO2009043372A1 (en) 2007-10-02 2009-04-09 Metabolic Explorer Increasing methionine yield

Also Published As

Publication number Publication date
RU2011108706A (ru) 2012-09-27
WO2010020289A1 (en) 2010-02-25
CN102131923A (zh) 2011-07-20
WO2010020682A1 (en) 2010-02-25
KR20110042383A (ko) 2011-04-26
US8143031B2 (en) 2012-03-27
JP2012500623A (ja) 2012-01-12
US20100047880A1 (en) 2010-02-25
MX2011001961A (es) 2011-03-21

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