AR072202A1 - 7-sulfanilmetil-, 7-sulfinilmetil-, y 7-sulfonilmetilindoles sustituidos y el uso de los mismos - Google Patents
7-sulfanilmetil-, 7-sulfinilmetil-, y 7-sulfonilmetilindoles sustituidos y el uso de los mismosInfo
- Publication number
- AR072202A1 AR072202A1 ARP090102242A ARP090102242A AR072202A1 AR 072202 A1 AR072202 A1 AR 072202A1 AR P090102242 A ARP090102242 A AR P090102242A AR P090102242 A ARP090102242 A AR P090102242A AR 072202 A1 AR072202 A1 AR 072202A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- group
- trifluoromethyl
- cyano
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente se refiere a derivados de 7-sulfanilmetil-, 7-sulfinilmetil- y 7-sulfonilmetilindol, a procedimientos para la preparacion de los mismos, al uso de los mismos solos o en combinaciones para el tratamiento y/o la prevencion de enfermedades, y al uso de los mismos para la preparacion de medicamentos para el tratamiento y/o la prevencion de enfermedades, especialmente para el tratamiento y/o la prevencion de enfermedades cardiovasculares. Reivindicacion 1: Un compuesto de formula (1) en la que A es -S-, -S(=O)- o -S(=O)2-, R1 es alquilo C1-4 o ciclopropilo, R2 es hidrogeno, fluor o cloro, R3 es hidrogeno, fluor, cloro o metilo, R4 es hidrogeno o fluor, R5 es un grupo de formula (2) o (3) en la que es el punto de union a indol y D es -CH2-, -O-, -CH2CH2- o -CH2-O-, R6 es alquilo C1-4 o cicloalquilo C3-6, en el que alquilo C1-4 puede estar sustituido con 1 a 3 sustituyentes seleccionados independientemente uno de otro del grupo de fluor, trifluorometilo, hidroxi y ciano y en el que cicloalquilo C3-6 puede estar sustituido con 1 a 3 sustituyentes seleccionados independientemente uno de otro del grupo de fluor, hidroxi y ciano, R7 es hidrogeno, halogeno, alquilo C1-4, trifluorometilo o alcoxi C1-4, R8 es hidrogeno, halogeno, metilo o trifluorometilo, R9 es fenilo, naftilo o heteroarilo de 5 a 10 miembros, en el que fenilo, naftilo y heteroarilo de 5 a 10 miembros pueden estar sustituidos con 1 a 3 sustituyentes seleccionados independientemente uno de otro del grupo de halogeno, ciano, alquilo C1-4, fluorometilo, difluorometilo, trifluorometilo, alcoxi C1-4, fluorometoxi, difluorometoxi, trifluorometoxi y trifluorometiltio, o en el que dos sustituyentes unidos a tomos de carbono adyacentes de un anillo de fenilo forman juntos un grupo de formula -O-CH2-O-, -O-CHF-O-, -O-CF2-O-, -O-CH2-CH2-O- o -O-CF2-CF2-O-, R10 es alquilo C1-6, cicloalquilo C3-7 o fenilo, en el que alquilo C1-6 puede estar sustituido con 1 a 3 sustituyentes seleccionados independientemente uno del otro del grupo F, fluorometilo, difluorometilo, trifluorometilo, hidroxi y ciano, y en el que cicloalquilo C3-7 puede estar sustituido con 1 a 3 sustituyentes seleccionados independientemente uno de otro del grupo F, hidroxi y ciano, y en el que fenilo puede estar sustituido con 1 a 3 sustituyentes seleccionados independientemente uno de otro del grupo de halogeno, ciano, alquilo C1-4, fluorometilo, difluorometilo, trifluorometilo, alcoxi C1-4, fluorometoxi, difluorometoxi, trifluorometoxi y trifluorometiltio, R11 es hidrogeno, metilo, etilo, trifluorometilo o ciclopropilo, y sus sales, solvatos y solvatos de las sales.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102008030207A DE102008030207A1 (de) | 2008-06-25 | 2008-06-25 | Substituierte 7-Sulfanylmethyl-, 7-Sulfinylmethyl- und 7-Sulfonylmethyl-Indole und ihre Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR072202A1 true AR072202A1 (es) | 2010-08-11 |
Family
ID=41017186
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090102242A AR072202A1 (es) | 2008-06-25 | 2009-06-19 | 7-sulfanilmetil-, 7-sulfinilmetil-, y 7-sulfonilmetilindoles sustituidos y el uso de los mismos |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US20110201564A1 (es) |
| EP (1) | EP2300423A1 (es) |
| JP (1) | JP2011525504A (es) |
| KR (1) | KR20110023895A (es) |
| CN (1) | CN102131776A (es) |
| AR (1) | AR072202A1 (es) |
| AU (1) | AU2009262582A1 (es) |
| BR (1) | BRPI0915405A2 (es) |
| CA (1) | CA2729048A1 (es) |
| CL (1) | CL2010001508A1 (es) |
| CO (1) | CO6321237A2 (es) |
| CR (1) | CR11869A (es) |
| DE (1) | DE102008030207A1 (es) |
| DO (1) | DOP2010000400A (es) |
| EC (1) | ECSP10010711A (es) |
| IL (1) | IL209718A0 (es) |
| MA (1) | MA32416B1 (es) |
| MX (1) | MX2010014447A (es) |
| PE (1) | PE20110331A1 (es) |
| RU (1) | RU2011102472A (es) |
| SV (1) | SV2010003773A (es) |
| TW (1) | TW201012800A (es) |
| UY (1) | UY31903A (es) |
| WO (1) | WO2009156072A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011137220A1 (en) * | 2010-04-28 | 2011-11-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Small molecule neuropeptide s antagonists for the treatment of addictive disorders, mood, anxiety and sleep disorders |
| CN103384661B (zh) | 2011-01-20 | 2016-08-10 | 默沙东公司 | 盐皮质激素受体拮抗剂 |
| DE102011015126B4 (de) * | 2011-03-25 | 2014-09-25 | Airbus Operations Gmbh | Flugzeugheckbereich mit einem in dem Flugzeugheckbereich installierten Kühlsystem |
| KR20170016754A (ko) * | 2015-08-04 | 2017-02-14 | 씨제이헬스케어 주식회사 | 크로마논 유도체의 신규한 제조방법 |
| KR101894091B1 (ko) | 2018-01-23 | 2018-08-31 | 씨제이헬스케어 주식회사 | 크로마논 유도체의 신규한 제조방법 |
| CN111039873B (zh) * | 2019-12-20 | 2022-03-15 | 河北美荷药业有限公司 | 一种芬苯达唑亚砜的制备方法 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2778819A (en) | 1950-08-21 | 1957-01-22 | Bayer Ag | 1-alkoxy-3 imino-isoindolenine derivatives |
| NL82464C (es) | 1952-01-05 | |||
| US2765320A (en) | 1954-09-03 | 1956-10-02 | Pittsburgh Plate Glass Co | Preparation of 2, 3-dimethylindole |
| AU4649189A (en) | 1988-11-14 | 1990-06-12 | Upjohn Company, The | Alpha-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents |
| GB9609641D0 (en) | 1996-05-09 | 1996-07-10 | Pfizer Ltd | Compounds useful in therapy |
| US5808064A (en) | 1996-08-13 | 1998-09-15 | Merck & Co., Inc. | Palladium catalyzed indolization |
| CN1084751C (zh) | 1996-08-13 | 2002-05-15 | 麦克公司 | 钯催化的吲哚化反应 |
| DE19834047A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Substituierte Pyrazolderivate |
| DE19834044A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Neue substituierte Pyrazolderivate |
| DE19943639A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Dicarbonsäurederivate mit neuartigen pharmazeutischen Eigenschaften |
| DE19943634A1 (de) | 1999-09-13 | 2001-04-12 | Bayer Ag | Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE19943635A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE19943636A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| AR031176A1 (es) | 2000-11-22 | 2003-09-10 | Bayer Ag | Nuevos derivados de pirazolpiridina sustituidos con piridina |
| DE10110749A1 (de) | 2001-03-07 | 2002-09-12 | Bayer Ag | Substituierte Aminodicarbonsäurederivate |
| DE10110750A1 (de) | 2001-03-07 | 2002-09-12 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE10220570A1 (de) | 2002-05-08 | 2003-11-20 | Bayer Ag | Carbamat-substituierte Pyrazolopyridine |
| US20060235222A1 (en) | 2003-01-22 | 2006-10-19 | Eli Lilly And Company | Indole-derivative modulators of steroid hormone nuclear receptors |
| EP1723105B1 (en) | 2004-03-03 | 2013-05-15 | Eli Lilly And Company | Bicyclic substituted indole-derivative steroid hormone nuclear receptor modulators |
| CA2569238A1 (en) | 2004-06-01 | 2005-12-15 | F. Hoffmann-La Roche Ag | Monoamine reuptake inhibitor |
| KR20080063288A (ko) | 2005-09-30 | 2008-07-03 | 다이닛본 스미토모 세이야꾸 가부시끼가이샤 | 신규 융합 피롤 유도체 |
| ES2368416T3 (es) | 2005-11-30 | 2011-11-17 | F. Hoffmann-La Roche Ag | Procedimiento para la síntesis de 3-amino-1-arilpropil-indoles. |
| WO2007070892A2 (en) | 2005-12-16 | 2007-06-21 | Ironwood Pharmaceuticals, Inc. | Useful indole compounds |
| CA2660704A1 (en) | 2006-08-07 | 2008-02-14 | Ironwood Pharmaceuticals, Inc. | Indole compounds |
| US20090118503A1 (en) | 2007-06-20 | 2009-05-07 | Kevin Sprott | Faah inhibitors |
-
2008
- 2008-06-25 DE DE102008030207A patent/DE102008030207A1/de not_active Withdrawn
-
2009
- 2009-06-16 WO PCT/EP2009/004305 patent/WO2009156072A1/de active Application Filing
- 2009-06-16 KR KR1020117001788A patent/KR20110023895A/ko not_active Application Discontinuation
- 2009-06-16 JP JP2011515162A patent/JP2011525504A/ja active Pending
- 2009-06-16 US US13/001,133 patent/US20110201564A1/en not_active Abandoned
- 2009-06-16 CN CN2009801336549A patent/CN102131776A/zh active Pending
- 2009-06-16 AU AU2009262582A patent/AU2009262582A1/en not_active Abandoned
- 2009-06-16 RU RU2011102472/04A patent/RU2011102472A/ru unknown
- 2009-06-16 MX MX2010014447A patent/MX2010014447A/es not_active Application Discontinuation
- 2009-06-16 UY UY0001031903A patent/UY31903A/es not_active Application Discontinuation
- 2009-06-16 CA CA2729048A patent/CA2729048A1/en not_active Abandoned
- 2009-06-16 EP EP09768921A patent/EP2300423A1/de not_active Withdrawn
- 2009-06-16 BR BRPI0915405A patent/BRPI0915405A2/pt not_active Application Discontinuation
- 2009-06-16 PE PE2010001181A patent/PE20110331A1/es not_active Application Discontinuation
- 2009-06-19 AR ARP090102242A patent/AR072202A1/es unknown
- 2009-06-24 TW TW098121092A patent/TW201012800A/zh unknown
- 2009-06-24 US US12/490,333 patent/US8063234B2/en not_active Expired - Fee Related
-
2010
- 2010-12-02 IL IL209718A patent/IL209718A0/en unknown
- 2010-12-21 SV SV2010003773A patent/SV2010003773A/es not_active Application Discontinuation
- 2010-12-22 CL CL2010001508A patent/CL2010001508A1/es unknown
- 2010-12-22 CO CO10161163A patent/CO6321237A2/es not_active Application Discontinuation
- 2010-12-22 DO DO2010000400A patent/DOP2010000400A/es unknown
- 2010-12-23 MA MA33457A patent/MA32416B1/fr unknown
- 2010-12-23 CR CR11869A patent/CR11869A/es not_active Application Discontinuation
- 2010-12-23 EC EC2010010711A patent/ECSP10010711A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CO6321237A2 (es) | 2011-09-20 |
| DE102008030207A1 (de) | 2009-12-31 |
| CA2729048A1 (en) | 2009-12-30 |
| ECSP10010711A (es) | 2011-01-31 |
| CL2010001508A1 (es) | 2011-05-06 |
| KR20110023895A (ko) | 2011-03-08 |
| EP2300423A1 (de) | 2011-03-30 |
| JP2011525504A (ja) | 2011-09-22 |
| US8063234B2 (en) | 2011-11-22 |
| SV2010003773A (es) | 2011-08-29 |
| BRPI0915405A2 (pt) | 2015-11-03 |
| RU2011102472A (ru) | 2012-07-27 |
| CN102131776A (zh) | 2011-07-20 |
| AU2009262582A1 (en) | 2009-12-30 |
| WO2009156072A1 (de) | 2009-12-30 |
| CR11869A (es) | 2011-05-10 |
| MX2010014447A (es) | 2011-01-21 |
| US20110201564A1 (en) | 2011-08-18 |
| US20100105744A1 (en) | 2010-04-29 |
| UY31903A (es) | 2010-01-29 |
| IL209718A0 (en) | 2011-02-28 |
| PE20110331A1 (es) | 2011-06-22 |
| MA32416B1 (fr) | 2011-06-01 |
| TW201012800A (en) | 2010-04-01 |
| DOP2010000400A (es) | 2011-01-31 |
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