AR071586A1 - Tienopirimidinas - Google Patents
TienopirimidinasInfo
- Publication number
- AR071586A1 AR071586A1 ARP090101244A ARP090101244A AR071586A1 AR 071586 A1 AR071586 A1 AR 071586A1 AR P090101244 A ARP090101244 A AR P090101244A AR P090101244 A ARP090101244 A AR P090101244A AR 071586 A1 AR071586 A1 AR 071586A1
- Authority
- AR
- Argentina
- Prior art keywords
- hal
- mono
- trisubstituted
- atoms
- alko
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Virology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- AIDS & HIV (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Las tienopirimidinas de la formula 1 en donde R1 es benzofuranilo, benzotiazolilo, benzotiofenilo, imidazo[1,2a)piridina, quinolinilo, isoquinolinilo o furanilo no sustituido o mono-, di- o trisustituido con A y/o Hal, o piridinilo mono-, di- o trisustituido con A y/o Hal, R2 es H, Alk, Het1, Cyc, AlkNH2, AlkNHA, AlkNAA', AlkOH, AlkOA, AlkCyc, AlkHet1, AlkOAlkOH, AlkO(CH2)mNAA', AlkCHOH(CH2)mOH, AlkO(CH2)mHet1, AlkAr o AlkO(CH2)mAr, X es un enlace simple, NH, S o SO2, Alk es alquileno o alquinilo C1-6, en donde 1 a 4 átomos de H pueden estar sustituidos con F, Cl, Br y/o CN, Cyc es cicloalquilo C3-7, en donde 1 a 4 átomos de H pueden estar reemplazados por A, Hal, OH y/u OA; Het1 es un heterociclo saturado, insaturado o aromático mono- o bicíclico con 1 a 4 átomos de N, O y/o S, que puede estar mono-, di- o trisustituido con A, OH, OA, Hal, SO2A y/u =O (oxígeno del carbonilo), Ar es fenilo, que no está sustituido o que está mono-, di- o trisustituido con A, OH, OA, Hal, SO2NH2, SO2NA y/o SO2NAA', A, A' son en cada caso, de modo independiente entre sí, alquilo no ramificado o ramificado C1-10, en donde uno, dos o tres grupos CH2 que pueden estar reemplazados, de modo independiente entre sí, por grupos -CH=CH- y/o -C:::C- y/o 1-5 átomos de H pueden estar reemplazados por F, Cl y/o Br, Hal es F, Cl, Br o I, m es 1,2, 3 o 4, así como sus derivados, sales, solvatos, tautomeros y estereoisomeros farmacéuticamente aceptables, incluyendo sus mezclas en todas las proporciones, procedimiento de preparacion, composicion farmacéutica y uso como inhibidores de la quinasa del receptor TGF-beta, y se pueden emplear, por ejemplo, para el tratamiento de tumores.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102008017853A DE102008017853A1 (de) | 2008-04-09 | 2008-04-09 | Thienopyrimidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR071586A1 true AR071586A1 (es) | 2010-06-30 |
Family
ID=40765631
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090101244A AR071586A1 (es) | 2008-04-09 | 2009-04-08 | Tienopirimidinas |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20110028472A1 (es) |
| EP (1) | EP2260044A2 (es) |
| JP (1) | JP2011518132A (es) |
| KR (1) | KR20110010721A (es) |
| CN (1) | CN102015724A (es) |
| AR (1) | AR071586A1 (es) |
| AU (1) | AU2009235729A1 (es) |
| BR (1) | BRPI0911364A2 (es) |
| CA (1) | CA2720878A1 (es) |
| DE (1) | DE102008017853A1 (es) |
| EA (1) | EA201001576A1 (es) |
| IL (1) | IL208066A0 (es) |
| MX (1) | MX2010011015A (es) |
| WO (1) | WO2009124653A2 (es) |
| ZA (1) | ZA201007979B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2445916A1 (en) * | 2009-06-22 | 2012-05-02 | Merck Patent GmbH | Alkoxy-thienopyrimidines as tgf-beta receptor kinase modulators |
| CN102596961B (zh) | 2009-10-30 | 2015-12-02 | 詹森药业有限公司 | 咪唑并[1，2-b]哒嗪衍生物及其作为PDE10抑制剂的用途 |
| CA2789021C (en) | 2010-02-05 | 2018-02-06 | Merck Patent Gmbh | Hetaryl-[1,8]naphthyridine derivatives |
| ES2528441T3 (es) | 2010-02-22 | 2015-02-10 | Merck Patent Gmbh | Hetarilaminonaftiridinas |
| AR080754A1 (es) | 2010-03-09 | 2012-05-09 | Janssen Pharmaceutica Nv | Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10 |
| ES2575092T3 (es) | 2011-06-27 | 2016-06-24 | Janssen Pharmaceutica, N.V. | Derivados de 1-aril-4-metil-[1,2,4]triazolo[4,3-a]quinoxalina |
| FR2988722B1 (fr) | 2012-04-03 | 2014-05-09 | Sanofi Sa | Nouveaux derives de thienopyrimidines, leurs procedes de preparation et leurs utilisations therapeutiques |
| EP2863909B1 (en) | 2012-06-26 | 2020-11-04 | Janssen Pharmaceutica N.V. | Combinations comprising 4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline compounds as pde 2 inhibitors and pde 10 inhibitors for use in the treatment of neurological or metabolic disorders |
| EP2869822B1 (en) | 2012-07-09 | 2016-09-14 | Janssen Pharmaceutica, N.V. | Inhibitors of phosphodiesterase 10 enzyme |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5747469A (en) | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
| GB9904387D0 (en) | 1999-02-25 | 1999-04-21 | Pharmacia & Upjohn Spa | Antitumour synergistic composition |
| AU4972900A (en) | 1999-04-08 | 2000-11-14 | Arch Development Corporation | Use of anti-vegf antibody to enhance radiation in cancer therapy |
| JPWO2005080377A1 (ja) * | 2004-02-20 | 2007-10-25 | キリンホールディングス株式会社 | ＴＧＦβ阻害活性を有する化合物およびそれを含んでなる医薬組成物 |
| WO2006090094A1 (en) * | 2005-02-28 | 2006-08-31 | Vernalis R & D Ltd | Pyrimidothiophene compounds for use as hsp90 inhibitors |
| DE102005013621A1 (de) * | 2005-03-24 | 2006-09-28 | Curacyte Discovery Gmbh | Substituierte 2-Aryl(Hetaryl)-5-aminothieno[2,3-d]pyrimidin-6-carbonsäureamide, Verfahren zu ihrer Herstellung und Verwendung als Pharmazeutika |
| JP2009523805A (ja) * | 2006-01-17 | 2009-06-25 | シグナル ファーマシューティカルズ，エルエルシー | ＴＮＦα、ＰＤＥ４及びＢ−ＲＡＦの阻害剤、それらの組成物及びそれらの使用法 |
| WO2008020622A1 (fr) * | 2006-08-17 | 2008-02-21 | Kyorin Pharmaceutical Co., Ltd. | NOUVEAU COMPOSÉ DE THIÉNO[2,3-d]PYRIMIDINE |
-
2008
- 2008-04-09 DE DE102008017853A patent/DE102008017853A1/de not_active Withdrawn
-
2009
- 2009-03-23 JP JP2011503357A patent/JP2011518132A/ja active Pending
- 2009-03-23 EP EP09731280A patent/EP2260044A2/de not_active Withdrawn
- 2009-03-23 BR BRPI0911364A patent/BRPI0911364A2/pt not_active Application Discontinuation
- 2009-03-23 CN CN2009801122450A patent/CN102015724A/zh active Pending
- 2009-03-23 US US12/937,031 patent/US20110028472A1/en not_active Abandoned
- 2009-03-23 MX MX2010011015A patent/MX2010011015A/es not_active Application Discontinuation
- 2009-03-23 CA CA2720878A patent/CA2720878A1/en not_active Abandoned
- 2009-03-23 KR KR1020107025024A patent/KR20110010721A/ko not_active Application Discontinuation
- 2009-03-23 WO PCT/EP2009/002112 patent/WO2009124653A2/de active Application Filing
- 2009-03-23 EA EA201001576A patent/EA201001576A1/ru unknown
- 2009-03-23 AU AU2009235729A patent/AU2009235729A1/en not_active Abandoned
- 2009-04-08 AR ARP090101244A patent/AR071586A1/es unknown
-
2010
- 2010-09-07 IL IL208066A patent/IL208066A0/en unknown
- 2010-11-08 ZA ZA2010/07979A patent/ZA201007979B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE102008017853A1 (de) | 2009-10-15 |
| AU2009235729A1 (en) | 2009-10-15 |
| ZA201007979B (en) | 2011-07-27 |
| US20110028472A1 (en) | 2011-02-03 |
| KR20110010721A (ko) | 2011-02-07 |
| EP2260044A2 (de) | 2010-12-15 |
| WO2009124653A2 (de) | 2009-10-15 |
| CN102015724A (zh) | 2011-04-13 |
| JP2011518132A (ja) | 2011-06-23 |
| EA201001576A1 (ru) | 2011-04-29 |
| BRPI0911364A2 (pt) | 2015-12-29 |
| MX2010011015A (es) | 2010-11-22 |
| IL208066A0 (en) | 2010-12-30 |
| WO2009124653A3 (de) | 2009-12-03 |
| CA2720878A1 (en) | 2009-10-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |