AR071045A1 - Estereo isomero de metil-( 2-hidroxi-5- (((2-(4-hidroxifenil)-1-metiletil) amino)etil)fenil)- carbamato, mezcla de sus isomeros, proceso de preparacion del mismo, una composicion farmaceutica que contiene a dicho carbamato y uso del mismo - Google Patents
Estereo isomero de metil-( 2-hidroxi-5- (((2-(4-hidroxifenil)-1-metiletil) amino)etil)fenil)- carbamato, mezcla de sus isomeros, proceso de preparacion del mismo, una composicion farmaceutica que contiene a dicho carbamato y uso del mismoInfo
- Publication number
- AR071045A1 AR071045A1 ARP080103725A ARP080103725A AR071045A1 AR 071045 A1 AR071045 A1 AR 071045A1 AR P080103725 A ARP080103725 A AR P080103725A AR P080103725 A ARP080103725 A AR P080103725A AR 071045 A1 AR071045 A1 AR 071045A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- carbamate
- same
- pharmaceutical composition
- mixture
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- -1 AMINO Chemical class 0.000 title 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 8
- 206010006482 Bronchospasm Diseases 0.000 abstract 2
- 230000007885 bronchoconstriction Effects 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000000414 obstructive effect Effects 0.000 abstract 2
- 230000002441 reversible effect Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000004203 4-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- WGQKYBSKWIADBV-UHFFFAOYSA-N benzylamine Chemical group NCC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 abstract 1
- 102000014974 beta2-adrenergic receptor activity proteins Human genes 0.000 abstract 1
- 108040006828 beta2-adrenergic receptor activity proteins Proteins 0.000 abstract 1
- 229940124630 bronchodilator Drugs 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000002496 methyl group Chemical class [H]C([H])([H])* 0.000 abstract 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 210000002345 respiratory system Anatomy 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
- C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96639107P | 2007-08-28 | 2007-08-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR071045A1 true AR071045A1 (es) | 2010-05-26 |
Family
ID=39967298
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080103725A AR071045A1 (es) | 2007-08-28 | 2008-08-27 | Estereo isomero de metil-( 2-hidroxi-5- (((2-(4-hidroxifenil)-1-metiletil) amino)etil)fenil)- carbamato, mezcla de sus isomeros, proceso de preparacion del mismo, una composicion farmaceutica que contiene a dicho carbamato y uso del mismo |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7718822B2 (enExample) |
| EP (1) | EP2190813B1 (enExample) |
| JP (1) | JP5529740B2 (enExample) |
| KR (1) | KR20100065303A (enExample) |
| AR (1) | AR071045A1 (enExample) |
| AU (1) | AU2008293444B2 (enExample) |
| CA (1) | CA2696922C (enExample) |
| ES (1) | ES2430338T3 (enExample) |
| MX (1) | MX2010002039A (enExample) |
| NZ (1) | NZ583202A (enExample) |
| TW (1) | TWI465416B (enExample) |
| WO (1) | WO2009029717A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8501994B2 (en) * | 2007-08-28 | 2013-08-06 | Sunovion Pharmaceuticals Inc. | Acetamide stereoisomer |
| US7718822B2 (en) * | 2007-08-28 | 2010-05-18 | Sepracor Inc. | Carbamate Stereoisomer |
| CN112279776B (zh) * | 2020-11-02 | 2022-09-02 | 扬州中宝药业股份有限公司 | 一种合成阿福特罗游离碱的方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3657319A (en) * | 1970-05-05 | 1972-04-18 | Smith Kline French Lab | Alpha-aminoalkyl-4-hydroxy-3-carboalkoxyaminobenzyl alcohols |
| DE2115926C3 (de) | 1971-04-01 | 1978-05-03 | C.H. Boehringer Sohn, 6507 Ingelheim | 1 -(4-Hydroxy-3-dimethylaminosuIfamidophenyI)-2-aminoäthanderivate, Verfahren zu ihrer Herstellung und diese enthaltende Mittel |
| DE2305092A1 (de) | 1972-02-05 | 1973-08-16 | Yamanouchi Pharma Co Ltd | Alpha-aminomethylbenzylalkoholderivate |
| GB1415256A (en) | 1972-02-05 | 1975-11-26 | Yamanouchi Pharma Co Ltd | Alpha-aminomethylbenzyl alcohol derivatives |
| JPS4880523A (enExample) * | 1972-02-05 | 1973-10-29 | ||
| US3994974A (en) * | 1972-02-05 | 1976-11-30 | Yamanouchi Pharmaceutical Co., Ltd. | α-Aminomethylbenzyl alcohol derivatives |
| JPS599542B2 (ja) * | 1980-06-11 | 1984-03-03 | 山之内製薬株式会社 | 新規な３−アシルアミノ−４−ヒドロキシ−α−（アラルキルアミノメチル）ベンジルアルコ−ルの製法 |
| ES2005492A6 (es) | 1987-12-23 | 1989-03-01 | Lasa Lab | Procedimiento de obtencion de n-(2-hidroxi-5-(1-hidroxi-2((2- (4-metoxifenil)-1metiletil)amino)etil)fenil)foramida (i). |
| ES2031407A6 (es) | 1988-10-05 | 1992-12-01 | Lasa Lab | Mejoras introducidas en el objeto de la patente principal n{ 8703715 por: procedimiento de obtencion de n-(2-hidroxi-5-(1-hidroxi-2-((2-(4-metoxifenil)-1-metiletil)amino)etil)fenil)formamida". |
| DE69630319T2 (de) | 1996-01-10 | 2004-07-29 | Asahi Kasei Kabushiki Kaisha | Neue trizyklische verbindungen und arzneimittelzusammensetzungen die diese enthalten |
| US6040344A (en) * | 1996-11-11 | 2000-03-21 | Sepracor Inc. | Formoterol process |
| EP0938467B1 (en) | 1996-11-11 | 2002-06-12 | Sepracor, Inc. | Process for the preparation of optically pure isomers of formoterol |
| US6303145B2 (en) * | 1999-05-10 | 2001-10-16 | Sepracor Inc. | (S,R) formoterol methods and compositions |
| AU4831801A (en) * | 2000-03-01 | 2001-09-12 | Glaxo Group Limited | Metered dose inhaler |
| US6472563B1 (en) * | 2001-11-09 | 2002-10-29 | Sepracor Inc. | Formoterol tartrate process and polymorph |
| US7718822B2 (en) * | 2007-08-28 | 2010-05-18 | Sepracor Inc. | Carbamate Stereoisomer |
-
2008
- 2008-08-21 US US12/196,071 patent/US7718822B2/en active Active
- 2008-08-26 TW TW097132496A patent/TWI465416B/zh not_active IP Right Cessation
- 2008-08-27 AR ARP080103725A patent/AR071045A1/es unknown
- 2008-08-28 AU AU2008293444A patent/AU2008293444B2/en not_active Ceased
- 2008-08-28 NZ NZ583202A patent/NZ583202A/en not_active IP Right Cessation
- 2008-08-28 ES ES08828303T patent/ES2430338T3/es active Active
- 2008-08-28 EP EP08828303.1A patent/EP2190813B1/en not_active Not-in-force
- 2008-08-28 MX MX2010002039A patent/MX2010002039A/es active IP Right Grant
- 2008-08-28 KR KR1020107004336A patent/KR20100065303A/ko not_active Ceased
- 2008-08-28 JP JP2010523135A patent/JP5529740B2/ja not_active Expired - Fee Related
- 2008-08-28 WO PCT/US2008/074643 patent/WO2009029717A1/en not_active Ceased
- 2008-08-28 CA CA2696922A patent/CA2696922C/en active Active
-
2010
- 2010-03-31 US US12/751,563 patent/US8173829B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US8173829B2 (en) | 2012-05-08 |
| AU2008293444B2 (en) | 2013-11-21 |
| US20090060917A1 (en) | 2009-03-05 |
| TWI465416B (zh) | 2014-12-21 |
| NZ583202A (en) | 2012-03-30 |
| ES2430338T3 (es) | 2013-11-20 |
| US7718822B2 (en) | 2010-05-18 |
| KR20100065303A (ko) | 2010-06-16 |
| CA2696922C (en) | 2015-10-06 |
| JP5529740B2 (ja) | 2014-06-25 |
| JP2010538009A (ja) | 2010-12-09 |
| CA2696922A1 (en) | 2009-03-05 |
| EP2190813B1 (en) | 2013-07-31 |
| US20100215589A1 (en) | 2010-08-26 |
| TW200920725A (en) | 2009-05-16 |
| WO2009029717A1 (en) | 2009-03-05 |
| AU2008293444A1 (en) | 2009-03-05 |
| MX2010002039A (es) | 2010-03-25 |
| EP2190813A1 (en) | 2010-06-02 |
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| Date | Code | Title | Description |
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| FB | Suspension of granting procedure |