TWI465416B - 胺甲酸酯立體異構物 - Google Patents
胺甲酸酯立體異構物 Download PDFInfo
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- TWI465416B TWI465416B TW097132496A TW97132496A TWI465416B TW I465416 B TWI465416 B TW I465416B TW 097132496 A TW097132496 A TW 097132496A TW 97132496 A TW97132496 A TW 97132496A TW I465416 B TWI465416 B TW I465416B
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- 150000004657 carbamic acid derivatives Chemical class 0.000 title description 11
- 150000001875 compounds Chemical class 0.000 claims description 69
- 239000000203 mixture Substances 0.000 claims description 46
- 150000003839 salts Chemical class 0.000 claims description 25
- 239000008194 pharmaceutical composition Substances 0.000 claims description 22
- 125000006239 protecting group Chemical group 0.000 claims description 16
- 239000002253 acid Substances 0.000 claims description 13
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 10
- -1 funnisolide Chemical compound 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 9
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 5
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- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 claims description 4
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- VLARUOGDXDTHEH-UHFFFAOYSA-L disodium cromoglycate Chemical group [Na+].[Na+].O1C(C([O-])=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C([O-])=O)O2 VLARUOGDXDTHEH-UHFFFAOYSA-L 0.000 claims 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
- C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96639107P | 2007-08-28 | 2007-08-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200920725A TW200920725A (en) | 2009-05-16 |
| TWI465416B true TWI465416B (zh) | 2014-12-21 |
Family
ID=39967298
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW097132496A TWI465416B (zh) | 2007-08-28 | 2008-08-26 | 胺甲酸酯立體異構物 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7718822B2 (enExample) |
| EP (1) | EP2190813B1 (enExample) |
| JP (1) | JP5529740B2 (enExample) |
| KR (1) | KR20100065303A (enExample) |
| AR (1) | AR071045A1 (enExample) |
| AU (1) | AU2008293444B2 (enExample) |
| CA (1) | CA2696922C (enExample) |
| ES (1) | ES2430338T3 (enExample) |
| MX (1) | MX2010002039A (enExample) |
| NZ (1) | NZ583202A (enExample) |
| TW (1) | TWI465416B (enExample) |
| WO (1) | WO2009029717A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8501994B2 (en) * | 2007-08-28 | 2013-08-06 | Sunovion Pharmaceuticals Inc. | Acetamide stereoisomer |
| US7718822B2 (en) * | 2007-08-28 | 2010-05-18 | Sepracor Inc. | Carbamate Stereoisomer |
| CN112279776B (zh) * | 2020-11-02 | 2022-09-02 | 扬州中宝药业股份有限公司 | 一种合成阿福特罗游离碱的方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3657319A (en) * | 1970-05-05 | 1972-04-18 | Smith Kline French Lab | Alpha-aminoalkyl-4-hydroxy-3-carboalkoxyaminobenzyl alcohols |
| US3994974A (en) * | 1972-02-05 | 1976-11-30 | Yamanouchi Pharmaceutical Co., Ltd. | α-Aminomethylbenzyl alcohol derivatives |
| US4038314A (en) * | 1971-04-01 | 1977-07-26 | Boehringer Ingelheim Gmbh | 1-Hydroxy-1-[(4'-hydroxy-3'aminosulfonamido)-phenyl]-2-amino-ethanes and salts |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2305092A1 (de) | 1972-02-05 | 1973-08-16 | Yamanouchi Pharma Co Ltd | Alpha-aminomethylbenzylalkoholderivate |
| GB1415256A (en) | 1972-02-05 | 1975-11-26 | Yamanouchi Pharma Co Ltd | Alpha-aminomethylbenzyl alcohol derivatives |
| JPS4880523A (enExample) * | 1972-02-05 | 1973-10-29 | ||
| JPS599542B2 (ja) * | 1980-06-11 | 1984-03-03 | 山之内製薬株式会社 | 新規な３−アシルアミノ−４−ヒドロキシ−α−（アラルキルアミノメチル）ベンジルアルコ−ルの製法 |
| ES2005492A6 (es) | 1987-12-23 | 1989-03-01 | Lasa Lab | Procedimiento de obtencion de n-(2-hidroxi-5-(1-hidroxi-2((2- (4-metoxifenil)-1metiletil)amino)etil)fenil)foramida (i). |
| ES2031407A6 (es) | 1988-10-05 | 1992-12-01 | Lasa Lab | Mejoras introducidas en el objeto de la patente principal n{ 8703715 por: procedimiento de obtencion de n-(2-hidroxi-5-(1-hidroxi-2-((2-(4-metoxifenil)-1-metiletil)amino)etil)fenil)formamida". |
| DE69630319T2 (de) | 1996-01-10 | 2004-07-29 | Asahi Kasei Kabushiki Kaisha | Neue trizyklische verbindungen und arzneimittelzusammensetzungen die diese enthalten |
| US6040344A (en) * | 1996-11-11 | 2000-03-21 | Sepracor Inc. | Formoterol process |
| EP0938467B1 (en) | 1996-11-11 | 2002-06-12 | Sepracor, Inc. | Process for the preparation of optically pure isomers of formoterol |
| US6303145B2 (en) * | 1999-05-10 | 2001-10-16 | Sepracor Inc. | (S,R) formoterol methods and compositions |
| AU4831801A (en) * | 2000-03-01 | 2001-09-12 | Glaxo Group Limited | Metered dose inhaler |
| US6472563B1 (en) * | 2001-11-09 | 2002-10-29 | Sepracor Inc. | Formoterol tartrate process and polymorph |
| US7718822B2 (en) * | 2007-08-28 | 2010-05-18 | Sepracor Inc. | Carbamate Stereoisomer |
-
2008
- 2008-08-21 US US12/196,071 patent/US7718822B2/en active Active
- 2008-08-26 TW TW097132496A patent/TWI465416B/zh not_active IP Right Cessation
- 2008-08-27 AR ARP080103725A patent/AR071045A1/es unknown
- 2008-08-28 AU AU2008293444A patent/AU2008293444B2/en not_active Ceased
- 2008-08-28 NZ NZ583202A patent/NZ583202A/en not_active IP Right Cessation
- 2008-08-28 ES ES08828303T patent/ES2430338T3/es active Active
- 2008-08-28 EP EP08828303.1A patent/EP2190813B1/en not_active Not-in-force
- 2008-08-28 MX MX2010002039A patent/MX2010002039A/es active IP Right Grant
- 2008-08-28 KR KR1020107004336A patent/KR20100065303A/ko not_active Ceased
- 2008-08-28 JP JP2010523135A patent/JP5529740B2/ja not_active Expired - Fee Related
- 2008-08-28 WO PCT/US2008/074643 patent/WO2009029717A1/en not_active Ceased
- 2008-08-28 CA CA2696922A patent/CA2696922C/en active Active
-
2010
- 2010-03-31 US US12/751,563 patent/US8173829B2/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3657319A (en) * | 1970-05-05 | 1972-04-18 | Smith Kline French Lab | Alpha-aminoalkyl-4-hydroxy-3-carboalkoxyaminobenzyl alcohols |
| US4038314A (en) * | 1971-04-01 | 1977-07-26 | Boehringer Ingelheim Gmbh | 1-Hydroxy-1-[(4'-hydroxy-3'aminosulfonamido)-phenyl]-2-amino-ethanes and salts |
| US3994974A (en) * | 1972-02-05 | 1976-11-30 | Yamanouchi Pharmaceutical Co., Ltd. | α-Aminomethylbenzyl alcohol derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| US8173829B2 (en) | 2012-05-08 |
| AU2008293444B2 (en) | 2013-11-21 |
| US20090060917A1 (en) | 2009-03-05 |
| NZ583202A (en) | 2012-03-30 |
| ES2430338T3 (es) | 2013-11-20 |
| US7718822B2 (en) | 2010-05-18 |
| KR20100065303A (ko) | 2010-06-16 |
| CA2696922C (en) | 2015-10-06 |
| JP5529740B2 (ja) | 2014-06-25 |
| JP2010538009A (ja) | 2010-12-09 |
| CA2696922A1 (en) | 2009-03-05 |
| EP2190813B1 (en) | 2013-07-31 |
| US20100215589A1 (en) | 2010-08-26 |
| TW200920725A (en) | 2009-05-16 |
| WO2009029717A1 (en) | 2009-03-05 |
| AU2008293444A1 (en) | 2009-03-05 |
| MX2010002039A (es) | 2010-03-25 |
| EP2190813A1 (en) | 2010-06-02 |
| AR071045A1 (es) | 2010-05-26 |
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| MM4A | Annulment or lapse of patent due to non-payment of fees |