AR071027A1 - Derivados de aminopiperidinilo y usos de los mismos - Google Patents
Derivados de aminopiperidinilo y usos de los mismosInfo
- Publication number
- AR071027A1 AR071027A1 ARP090101025A ARP090101025A AR071027A1 AR 071027 A1 AR071027 A1 AR 071027A1 AR P090101025 A ARP090101025 A AR P090101025A AR P090101025 A ARP090101025 A AR P090101025A AR 071027 A1 AR071027 A1 AR 071027A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- independently
- cycloalkyl
- hydroxy
- haloalkyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Addiction (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
En esta solicitud se describen compuestos de amino-piperidinilo, o sales farmacéuticamente aceptables de los mismos, que son utiles para el tratamiento de enfermedades asociadas con inhibidores de reabsorcion de monoaminas. Se proporcionan también composiciones farmacéuticas, métodos de uso y métodos para la obtencion de los compuestos. Reivindicacion 1: Un compuesto de la formula 1 o un enantiomero, diastereomero o una sal farmacéuticamente aceptable del mismo, en la que: m es el numero 0 o 1; R es hidroxi, halogeno, alquilo inferior o alcoxi inferior; Q1 es N(Ra') o S; Q2 es CH, C(Rb) o N; Q3 es CH, C(Rb) o N; Ra es H o alquilo inferior; Ra' es H, alquilo inferior o -S(=O)2Rc; cada Rb es con independencia Rb' o Rbö; cada R' es con independencia hidroxi, halogeno, -CN, alquilo inferior, alquenilo inferior, alquinilo inferior, alcoxi inferior, haloalquilo inferior, fenilo, cicloalquilo o cicloalquil-alquilo, opcionalmente sustituido por uno o más Rc; cada Rbö es con independencia -C(=O)(Rc), -C(=O)O(Rc), -OC(=O)(Rc), -N(Rc)2, -S(=O)2Rc, -C(=O)N(Rc)2, S(=O)2N(Rc)2 o -NHC(=O)(Rc); cada Rc es con independencia Rd o Re; Rd es H; Re es alquilo inferior, haloalquilo inferior, cicloalquilo o fenilo, opcionalmente sustituido por uno o más Re'; cada Re' es con independencia hidroxi, halogeno, amino, alquilo inferior, alcoxi inferior, haloalquilo inferior o -CN; R2a y R2b son con independencia entre sí H, hidroxi, alquilo inferior, haloalquilo inferior o alcoxi inferior; r es el numero 0, 1, 2 o 3; y R3 es halogeno, hidroxi, alquilo inferior, alcoxi inferior, haloalquilo inferior, haloalcoxi inferior, hidroxi-alquilo inferior, cicloalquilo, cicloalquil-alquilo, -CN, -C(=O)N(Rc)2, -S(=O)2Rc, -C(=O)(Rc), -C(=O)O(Rc), -OC(=O)(Rc), -N(Rc)2, S(=O)2N(Rc)2 o -NHC(=O)(Rc). Reivindicacion 18: Un compuesto de la formula (2) o un enantiomero, diastereomero o una sal farmacéuticamente aceptable del mismo, en la que: m es el numero 0 o 1; R es hidroxi, halogeno, alquilo interior o alcoxi inferior; Q1 es N(Ra') o S; Q2 es CH, C(Rb) o N; Q3 es CH, C(Rb) o N; Ra es H o alquilo inferior; Ra' es H, alquilo interior o -S(=O)2Rc; cada Rb es con independencia Rb' o Rbö; cada Rb' es con independencia hidroxi, halogeno, -CN, alquilo interior, alquenilo inferior, alquinilo inferior, alcoxi inferior, haloalquilo inferior, fenilo, cicloalquilo o cicloalquil-alquilo, opcionalmente sustituido por uno o más Rc; cada Rö es con independencia -C(=O)(Rc), -C(=O)O(Rc), -OC(=O)(Rc), -N(Rc)2, -S(=O)2Rc, -C(=O)N(Rc)2, S(=O)2N(Rc)2 o -NHC(=O)(Rc); cada Rc es con independencia Rd o Re; Rd es H; Re es alquilo inferior, haloalquilo inferior, cicloalquilo o fenilo, opcionalmente sustituido por uno o más Re'; cada Re' es con independencia hidroxi, halogeno, amino, alquilo inferior, alcoxi inferior, haloalquilo inferior o -CN; R1 es R1a o R1b, R1a es H; R1b es alquilo inferior, alquenilo inferior, alquinilo inferior, alcoxi inferior, haloalquilo inferior, cicloalquilo, cicloalquil-alquilo, bencilo, heterocicloalquilo, heterocicloalquil-alquilo, heteroarilo, naftalenilo, opcionalmente sustituido por uno o más Rb1'; cada Rb1' es con independencia hidroxi, halogeno, amino, fenilo, alquilo inferior, alcoxi inferior, haloalquilo, inferior, o -CN; R2a y R2b son con independencia entre sí H, hidroxi, alquilo inferior, haloalquilo inferior o alcoxi inferior; r es el numero 0, 1, 2 o 3; y R3 es halogeno, hidroxi, alquilo inferior, alcoxi inferior, haloalcoxi inferior, hidroxialquilo inferior, cicloalquilo, cicloalquil-alquilo, -CN, -C(=O)N(Rc)2, -S(=O)2Rc, -C(=O)(Rc), -C(=O)O(Rc), -OC(=O)(Rc), -N(Rc)2, S(=O)2N(Rc)2 o -NHC(=O)(Rc).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3928608P | 2008-03-25 | 2008-03-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR071027A1 true AR071027A1 (es) | 2010-05-19 |
Family
ID=40613046
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090101025A AR071027A1 (es) | 2008-03-25 | 2009-03-23 | Derivados de aminopiperidinilo y usos de los mismos |
Country Status (15)
Country | Link |
---|---|
US (1) | US8093285B2 (es) |
EP (1) | EP2268631A1 (es) |
JP (1) | JP2011515435A (es) |
KR (1) | KR20100115808A (es) |
CN (1) | CN101977904A (es) |
AR (1) | AR071027A1 (es) |
AU (1) | AU2009228727A1 (es) |
BR (1) | BRPI0910113A2 (es) |
CA (1) | CA2712468A1 (es) |
CL (1) | CL2009000704A1 (es) |
IL (1) | IL206950A0 (es) |
MX (1) | MX2010009877A (es) |
PE (1) | PE20091716A1 (es) |
TW (1) | TW200942526A (es) |
WO (1) | WO2009118254A1 (es) |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1403255A4 (en) * | 2001-06-12 | 2005-04-06 | Sumitomo Pharma | INHIBITORS OF RHO KINASE |
US20070021404A1 (en) * | 2003-06-24 | 2007-01-25 | Dan Peters | Novel aza-ring derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
WO2005030754A1 (en) * | 2003-09-24 | 2005-04-07 | Janssen Pharmaceutica, N.V. | Indole or quinoline derivatives as non-pepticid npy y2 receptor inhibitors useful for the treatment of anxiolytic and depressive disorders and obesity |
EP1708703A4 (en) * | 2003-12-11 | 2008-04-09 | Anormed Inc | CHEMOKIN RECEPTOR BINDING COMPOUNDS |
WO2009034581A1 (en) * | 2007-09-11 | 2009-03-19 | Suven Life Sciences Limited | Substituted indolyl compounds and their use as 5-ht6 ligands |
-
2009
- 2009-03-16 AU AU2009228727A patent/AU2009228727A1/en not_active Abandoned
- 2009-03-16 CN CN2009801096530A patent/CN101977904A/zh active Pending
- 2009-03-16 JP JP2011501174A patent/JP2011515435A/ja active Pending
- 2009-03-16 EP EP09726213A patent/EP2268631A1/en not_active Withdrawn
- 2009-03-16 MX MX2010009877A patent/MX2010009877A/es active IP Right Grant
- 2009-03-16 BR BRPI0910113A patent/BRPI0910113A2/pt not_active IP Right Cessation
- 2009-03-16 KR KR1020107020845A patent/KR20100115808A/ko not_active Application Discontinuation
- 2009-03-16 WO PCT/EP2009/053055 patent/WO2009118254A1/en active Application Filing
- 2009-03-16 CA CA2712468A patent/CA2712468A1/en not_active Abandoned
- 2009-03-23 TW TW098109409A patent/TW200942526A/zh unknown
- 2009-03-23 AR ARP090101025A patent/AR071027A1/es unknown
- 2009-03-23 CL CL2009000704A patent/CL2009000704A1/es unknown
- 2009-03-24 PE PE2009000438A patent/PE20091716A1/es not_active Application Discontinuation
- 2009-03-25 US US12/383,538 patent/US8093285B2/en not_active Expired - Fee Related
-
2010
- 2010-07-12 IL IL206950A patent/IL206950A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
CL2009000704A1 (es) | 2010-02-26 |
WO2009118254A1 (en) | 2009-10-01 |
CN101977904A (zh) | 2011-02-16 |
PE20091716A1 (es) | 2009-11-13 |
JP2011515435A (ja) | 2011-05-19 |
AU2009228727A1 (en) | 2009-10-01 |
MX2010009877A (es) | 2010-11-25 |
EP2268631A1 (en) | 2011-01-05 |
IL206950A0 (en) | 2010-12-30 |
BRPI0910113A2 (pt) | 2019-03-06 |
US20090247568A1 (en) | 2009-10-01 |
TW200942526A (en) | 2009-10-16 |
CA2712468A1 (en) | 2009-10-01 |
KR20100115808A (ko) | 2010-10-28 |
US8093285B2 (en) | 2012-01-10 |
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