AR070527A1 - Bloqueadores poliaromaticos del canal de sodio - Google Patents

Bloqueadores poliaromaticos del canal de sodio

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Publication number
AR070527A1
AR070527A1 ARP090100664A ARP090100664A AR070527A1 AR 070527 A1 AR070527 A1 AR 070527A1 AR P090100664 A ARP090100664 A AR P090100664A AR P090100664 A ARP090100664 A AR P090100664A AR 070527 A1 AR070527 A1 AR 070527A1
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AR
Argentina
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chor8
het
nr13r13
conr13r13
ch2ch2o
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ARP090100664A
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English (en)
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Johnson Michael R
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • C07D241/28—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms
    • C07D241/30—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms in which said hetero-bound carbon atoms are part of a substructure —C(=X)—X—C(=X)—X— in which X is an oxygen or sulphur atom or an imino radical, e.g. imidoylguanidines
    • C07D241/32—(Amino-pyrazinoyl) guanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Se proporcionan bloqueadores del canal de sodio poliaromáticos, así como también una variedad de composiciones, combinaciones y métodos de tratamiento que emplean estos bloqueadores del canal de sodio de la presente. Reivindicacion 1: Un compuesto representado por la formula (1) y racematos, enantiomeros, diastereomeros, tautomeros, polimorfos, pseudopolimorfos y sales farmacéuticamente aceptables de dicho compuesto, en donde X es hidrogeno, halogeno, trifluorometilo, alquilo inferior, fenilo sustituido o no sustituido, alquilo inferior-tio, fenil-alquilo inferior-tio, alquilo inferior-sulfonilo o fenil-alquilo inferior-sulfonilo; Y es hidrogeno, hidroxilo, mercapto, alcoxi inferior, alquilo inferior-tio, halogeno, alquilo inferior, arilo mononuclear sustituido o no sustituido, o -N(R2)2; R1 es hidrogeno o alquilo inferior; cada R2 es, independientemente, -R7, -(CH2)m-OR8, (CH2)m-NR7R10, -(CH2)n(CHOR8)(CHOR8)n-CH2OR8, -(CH2CH2O)m-R8, (CH2CH2O)m-CH2CH2NR7R10, -(CH2)n-C(=O)NR7R10, -(CH2)n-(Z)g-R7, (CH2)m-NR10-CH2(CHOR8)(CHOR8)n-CH2OR8, -(CH2)n-CO2R7, o un resto de formula (2a); R3 y R4 son cada uno, independientemente, hidrogeno, alquilo inferior, hidroxil-alquilo inferior, fenilo, (fenil)-alquilo inferior, (halofenil)-alquilo inferior, ((alquilo inferior)fenil)-alquilo inferior, ((alcoxi inferior)fenil)-alquilo inferior, (naftil)-alquilo inferior o (piridil)-alquilo inferior, o un grupo representado por la formula A o formula B, con la condicion de que al menos uno de R3 y R4 sea un grupo representado por la formula A o formula B; formula A: -(C(RL)2)o-x-(C(RL)2)pA1 formula B: -(C(RL)2)o-x-(C(RL)2)pA2 A1 es un carbociclo aromático de C7-15 miembros sustituido con al menos un R5, y los sustituyentes restantes son R6; A2 es un heterociclo aromático de siete a quince miembros sustituido con al menos un R5, y los sustituyentes restantes son R6, en donde dicho heterociclo aromático comprende 1-4 heteroátomos seleccionados del grupo que consiste en O, N y S; cada RL es, independientemente, -R7, -(CH2)n-OR8, O-(CH2)m-OR8, -(CH2)n-NR7R10, -O-(CH2)m-NR7R10, -(CH2)n(CHOR8)(CHOR8)n-CH2OR8, -O-(CH2)m(CHOR8)(CHOR8)n-CH2OR8, -(CH2CH2O)m-R8, -O-(CH2CH2O)m-R8, -(CH2CH2O)m-CH2CH2NR7R10, -O-(CH2CH2O)m-CH2CH2NR7R10, -(CH2)n-C(=O)NR7R10, -O-(CH2)m-C(=O)NR7R10, -(CH2)n-(Z)g-R7, O-(CH2)m-(Z)g-R7, -(CH2)n-NR10-CH2(CHOR8)(CHOR8)n-CH2OR8, -O-(CH2)m-NR10-CH2(CHOR8)(CHOR8)n-CH2OR8, -(CH2)n-CO2R7, -O-(CH2)m-CO2R7, OSO3H, -O-glucuronida, -O-glucosa, o los restos de formulas (2) y (3); cada o es, independientemente, un numero entero de 0 a 10; cada p es, independientemente, un numero entero de 0 a 10; con la condicion de que la suma de o y p en cada cadena contigua sea de 1 a 10; cada x es, independientemente, O, NR10, C(=O), CHOH, C(=N-R10), CHNR7R10 o un enlace simple; cada R5 es, independientemente, OH, -(CH2)m-OR8, -O-(CH2)m-OR8, -(CH2)n-NR7R10, -O-(CH2)m-NR7R10, -(CH2)n-(CHOR8)(CHOR8)n-CH2OR8, -O-(CH2)m-(CHOR8)(CHOR8)n-CH2OR8, -(CH2CH2O)m-R8, -O-(CH2CH2O)m-R8, -(CH2CH2O)m-CH2CH2NR7R10, -O-(CH2CH2O)m-CH2CH2NR7R10, -(CH2)n-C(=O)NR7R10, -O-(CH2)m-C(=O)NR7R10, -(CH2)n-(Z)g-R7, -O-0(CH2)m-(Z)g-R7, -(CH2)n-NR10-CH2(CHOR8)(CHOR8)n-CH2OR8, -O-(CH2)m-NR10-CH2(CHOR8)(CHOR8)n-CH2OR8, -(CH2)n-CO2R7, -O-(CH2)m-CO2R7, -OSO3H, -O-glucuronida, -O-glucosa, los restos de formulas (2), (3) y (4), -(CH2)n-CO2R13, -Het-(CH2)m-CO2R13, -(CH2)n-(Z)g-CO2R13, -Het-(CH2)m-(Z)g-CO2R13, -(CH2)n-NR10-(CH2)m(CHOR8)n-CO2R13, -Het-(CH2)m-NR10-(CH2)m-(CHOR8)n-CO2R13, -(CH2)n-(CHOR8)m-CO2R13, -Het-(CH2)m-(CHOR8)m-CO2R13, -(CH2)n-(CHOR8)m(Z)g-CO2R13, -Het-(CH2)n-(CHOR8)m-(Z)g-CO2R13, -(CH2)n-(Z)g-(CH2)m-CO2R13, -(CH2)n-(Z)g(CHOR8)m-(Z)g-CO2R13, -Het-(CH2)n-(Z)g-(CHOR8)m-(Z)g-CO2R13, -(CH2)n-CONH-C(=NR13)-NR13R13, -Het-(CH2)n-CO-NH-C(=NR13)-NR13R13, -(CH2)n-(Z)g-CONH-C(=NR13)-NR13R13, -Het-(CH2)n-(Z)g-CONH-C(=NR13)-NR13R13, -(CH2)n-NR10-(CH2)m(CHOR8)n-CONH-C(=NR13)-NR13R13, -Het-(CH2)n-NR10-(CH2)m(CHOR8)n-CONH-C(=NR13)-NR13R13, -(CH2)n-(CHOR8)m-CONH-C(=NR13)-NR13R13, -Het-(CH2)n-(CHOR8)mCONH-C(=NR13)-NR13R13, -(CH2)n-(CHOR8)m-(Z)g-CONH-C(=NR13)-NR13R13, -Het-(CH2)n-(CHOR8)m-(Z)g-CONH-C(=NR13)-NR13R13, -(CH2)n-(Z)g-(CH2)m-CONH-C(=NR13)-NR13R13, -Het-(CH2)n-(Z)g-(CH2)m-CONH-C(=NR13)-NR13R13, -(CH2)n-(Z)g-(CHOR8)m-(Z)g-CONH-C(=NR13)-NR13R13, -Het-(CH2)n-(Z)g-(CHOR8)m-(Z)g-CONH-C(=NR13)-NR13R13, -(CH2)n-CONR7-CONR13R13, -Het-(CH2)n-CONR7-CONR13R13, -(CH2)n-(Z)g-CONR7-CONR13R13, -(CH2)n-NR10-(CH2)m(CHOR8)m-CONR7-CONR13R13, -Het-(CH2)n-NR10, -(CH2)m(CHOR8)n-CONR7-CONR13R13, -(CH2)n-(CHOR8)m-CONR7-CONR13R13, Het-(CH2)n-(CHOR8)m-CONR7-CONR13R13, -(CH2)n-(CHOR8)m-(Z)g-CONR7-CONR13R13, -Het-(CH2)n-(CHOR8)m-(Z)g-CNR7-CONR13R13, -(CH2)n-(Z)g-(CH2)m-CONR7-CONR13R13, -Het-(CH2)n-(Z)g-(CH2)m-CONR7-CONR13R13, -(CH2)n-(Z)g-(CHOR8)m-(Z)g-CONR7-CONR13R13, -Het-(CH2)n-(Z)g(CHOR8)m-(Z)g-CONR7-CONR13R13, -(CH2)n-CONR7SO2NR13R13, -Het-(CH2)m-(Z)g-CONR7SO2NR13R13, -(CH2)n-(Z)g-CONR7SO2NR13R13, -Het-(CH2)m-(Z)g-CONR7SO2NR13R13, -(CH2)n-NR10-(CH2)m(CHOR8)n-CONR7SO2NR13R13, -Het-(CH2)m-NR10-(CH2)m(CHOR8)n-CONR7SO2NR13R13, -(CH2)n-(CHOR8)m-CONR7SO2NR13R13, -Het-(CH2)m-(CHOR8)m-CONR7SO2NR13R13, -(CH2)n-(CHOR8)m-(Z)g-CONR7SO2NR13R13, -Het-(CH2)n-(CHOR8)m-(Z)g-CONR7SO2NR13R13, -(CH2)n-(Z)g-(CH2)m-CONR7SO2NR13R13, -Het-(CH2)n-(Z)g-(CH2)m-CONR7SO2NR13R13, -(CH2)n-(Z)g-(CHOR8)m-(Z)g-CONR7SO2NR13R13, -Het-(CH2)n-(Z)g-(CHOR8)m-(Z)g-CONR7SO2NR13R13, -(CH2)n-SO2NR13R13, -Het-(CH2)m-SO2NR13R13, -(CH2)-(Z)g-SO2NR13R13, -Het-(CH2)m-(Z)g-SO2NR13R13, -(CH2)n-NR10-(CH2)m(CHOR8)n-SO2NR13R13, -Het-(CH2)m-NR10-(CH2)m(CHOR8)n-SO2NR13R13, -(CH2)n-(CHOR8)m-SO2NR13R13, -Het-(CH2)m-(CHOR8)m-SO2NR13R13, -(CH2)n-(CHOR8)m-(Z)g-SO2NR13R13, -Het-(CH2)n-(CHOR8)m-(Z)g-SO2NR13R13, -(CH2)n-(Z)g-(CH2)m-SO2NR13R13, -Het-(CH2)n-(Z)g-(CH2)m-SO2NR13R13, -(CH2)n-(Z)g-(CHOR8)m-(Z)g-SO2NR13R13, -Het-(CH2)n-(Z)g-(CHOR8)m-(Z)g-SO2NR13R13, -(CH2)n-CONR13R13, -Het-(CH2)m-CONR13R13, -(CH2)n-(Z)g-CONR13R13, -Het-(CH2)m-(Z)g-CONR13R13, -(CH2)n-NR10-(CH2)m(CHOR8)n-CONR13R13, -Het-(CH2)m-NR10-(CH2)m(CHOR8)n-CONR13R13, -(CH2)n-(CHOR8)m-CONR13R13, -Het-(CH2)n-(CHOR8)m-CONR13R13, -(CH2)n-(CHOR8)m-(Z)g-CONR13R13, -Het-(CH2)n-(CHOR8)m-(Z)g-CONR13R13, -(CH2)n-(Z)g-(CH2)m-CONR13R13, -Het-(CH2)n-(Z)g-CONR13R13, -(CH2)n-(Z)g-(CHOR8)m-(Z)g-CONR13R13, -Het-(CH2)n-(Z)g-(CHOR8)m-(Z)g-CONR13R13, -(CH2)n-CONR7COR13, -Het-(CH2)m-CONR7COR13, -(CH2)n-(Z)g-CONR7COR13, -Het-(CH2)m-(Z)g-CONR7COR13, -(CH2)n-NR10-(CH2)m(CHOR8)n-CONR7COR13, -Het-(CH2)m-NR10-(CH2)m(CHOR8)n-CONR7COR13, -(CH2)n-(CHOR8)m-CONR7COR13, -Het-(CH2)m-(CHOR8)m-CONR7COR13, -(CH2)n-(CHOR8)m-(Z)g-CONR7COR13, -Het-(CH2)n-(CHOR8)m-CONR7COR13, (CH2)n-(Z)g-(CH2)mCONR7COR13, -Het-(CH2)n-(Z)g-(CHOR8)m-(Z)g-CONR7COR13, -(CH2)n-CONR7CO2R13, -(CH2)n-(Z)g-CONR7CO2R13, -Het-(CH2)m-(Z)g-CONR7CO2R13, -(CH2)n-NR10-(CH2)m(CHOR8)n-CONR7CO2R13, -Het-(CH2)m-NR10-(CH2)m(CHOR8)n-CONR7CO2R13, -(CH2)n-(CHOR8)m-CONR7CO2R13, -Het-(CH2)m-(CHOR8)m-CONR7CO2R13, -(CH2)n-(CHOR8)m-(Z)g-CONR7CO2R13, -Het-(CH2)n-(CHOR8)m-(Z)g-CONR7CO2R13, -(CH2)n-(Z)g-(CH2)m-CONR7CO2R13, -Het-(CH2)n-(Z)g-(CH2)m-CONR7CO2R13, -(CH2)n-(Z)g-(CHOR8)m-(Z)g-CONR7CO2R13, -Het-(CH2)n-(Z)g-(CHOR8)m-(Z)g-CONR7CO2R13, -(CH2)n-NH-C(=NR13)-NR13R13, -Het-(CH2)m-NH-C(=NR13)-NR13R13, (CH2)n-(Z)g-NH-C(=NR13)-NR13R13, -Het-(CH2)m-(Z)g-NH-C(=NR13)-NR13R13, (CH2)n-NR10-(CH2)m(CHOR8)n-NH-C(=NR13)NR13R13, -Het-(CH2)m-NR10-(CH2)m(CHOR8)n-NH-C(=NR13)-NR13R13, -(CH2)n-(CHOR8)m-NH-C(=NR13)-NR13R13, -Het-(CH2)m-(CHOR8)m-NH-C(=NR13)-NR13R13, -(CH2)n-(CHOR8)m-(Z)g-NH-C(=NR13)-NR13R13, -Het-(CH2)n-(CHOR8)m-(Z)g-NH-C(=NR13)-NR13R13, -(CH2)n-(Z)g-(CH2)mNH-C(=NR13)-NR13R13, -Het-(CH2)n-(Z)g-(CH2)mNH-C(=NR13)-NR13R13, -(CH2)n-(Z)g-(CHOR8)m-(Z)g-NH-C(=NR13)-NR13R13, -Het-(CH2)n-(Z)g-(CHOR8)m-(Z)g-NH-C(=NR13)-NR13R13, -(CH2)n-C(=NR13)-NR13R13, Het-(CH2)m-C(=NH)-NR13R13, -(CH2)n-(Z)g-C(=NH)-NR13R13, -Het-(CH2)m-(Z)g-C(=NH)-NR13R13, -(CH2)n-NR10-(CH2)m-(CHOR8)n-C(=NR13)-NR13R13, -Het-(CH2)m-NR10-(CH2)m(CHOR8)n-C(=NR13)-NR13R13, -(CH2)n-(CHOR8)m-C(=NR13)-NR13R13, -Het-(CH2)m-(CHOR8)m-C(=NR13)-NR13R13, -(CH2)n-(CHOR8)m-(Z)g-C(=NR13)-NR13R13, -Het-(CH2)n-(CHOR8)m-(Z)g-C(=NR13)-NR13R13, -(CH2)n-(Z)g-(CH2)m-C(=NH)C(=NR13)-NR13R13, Het-(CH2)n-(Z)g-(CH2)m-C(=NR13)-NR13R13, -(CH2)n-(Z)g-(CHOR8)m-(Z)g-C(=NR13)-NR13R13, -Het-(CH2)n-(Z)g-(CHOR8)m-(Z)g-C(NR13)-NR13R13, -(CH2)n-NR12R12, -O-(CH2)m-NR12R12, -O-(CH2)n-NR12R12, -O-(CH2)m-(Z)g-R12, -(CH2)n-NR11R11, -O-(CH2)m-NR11R11, -(CH2)n-N+(R11)3, -O-(CH2)m-N+(R11)3, -(CH2)n-(Z)g-(CH2)m-NR10R10, -O-(CH2)m-(Z)g-(CH2)m-NR10R10, -(CH2CH2O)m-CH2CH2NR12R12, -O-(CH2CH2O)m-CH2CH2NR12R12, -(CH2)n-(C=O)NR12R12, -O-(CH2)m-(C=O)NR12R12, -O-(CH2)m-(CHOR8)mCH2NR10-(Z)g-R10, -(CH2)n-(CHOR8)mCH2-NR10-(Z)g-R10, -(CH2)nNR10-O(CH2)m(CHOR8)nCH2NR10-(Z)g-R10, -O(CH2)m-NR10-(CH2)m(CHOR8)nCH2NR10-(Z)g-R10, -(Het)-(CH2)m-OR8, -(Het)-(CH2)m-NR7R10, -(Het)-(CH2)m(CHOR8)(CHOR8)n-CH2OR8, -(Het)-(CH2CH2O)m-R8, -(Het)-(CH2CH2O)m-CH2CH2NR7R10, -(Het)-(CH2)m-C(=O)NR7R10, (Het)-(CH2)m-(Z)g-R7, -(Het)-(CH2)m-NR10-CH2(CHOR8)(CHOR8)n-CH2OR8, -(Het)-(CH2)m-CO2R7, -(Het)-(CH2)m-NR12R12, -(Het)-(CH2)n-NR12R12, -(Het)-(CH2)m-(Z)gR12, -(Het)-(CH2)mNR11R11, -(Het)-(CH2)mN+(R11)3, -(Het)-(CH2)m-(Z)g-(CH2)m-NR10R10, -(Het)-(CH2CH2O)m-CH2CH2NR12R12, -(Het)-(CH2)m-(C=O)NR12R12, -(Het)-(CH2)m-(CHOR8)mCH2NR10-(Z)g-R10, -(Het)-(CH2)m-NR10-(CH2)m-(CHOR8)nCH2NR10-(Z)g-R10, -(CH2)n(CHOR8)(CHOR8)n-CH2OR8, -O-(CH2)m(CHOR8)(CHOR8)n-CH2OR8, -(CH2)n-NR10-CH2(CHOR8)(CHOR8)n-CH2OR8, -O-(CH2)m-NR10-CH2(CHOR8)(CHOR8)n-CH2OR8, Enlace-(CH2)n-CAP, Enlace-(CH2)(CHOR8)(CHOR8)n-CAP, Enlace-(CH2CH2O)m-CH2-CAP, Enlace-(CH2CH2O)m-CH2CH2-CAP, Enlace-(CH2)-(Z)g-CAP, Enlace-(CH2)n-(Z)g-(CH2)m-CAP, Enlace-(CH2)-NR13-CH2(CHOR8)(CHOR8)n-CAP, Enlace-(CH2)n-(CHOR8)m-CH2-NR13-(Z)g-CAP, Enlace-(CH2)NR13-(CH2)m(CHOR8)nCH2NR13-(Z)g-CAP, Enlace-(CH2)m-(Z)g-(CH2)m-CAP, Enlace-NHC(=O)-NH(CH2)m-CAP, Enlace-(CH2)m-C(=O)NR13-(CH2)m-C(=O)NR10R10, Enlace-(CH2)m-C(=O)NR13-(CH2)m-CAP, EnIace-(CH2)m-C(=O)NR11R11, Enlace-(CH2)m-C(=O)NR12R12, Enlace-(CH2)n-(Z)g-(CH2)m-(Z)g-CAP, Enlace-(Z)g-(CH2)m-Het-(CH2)m-CAP, Enlace-(CH2)n-CR11R11-CAP, Enla
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