AR069461A1 - Uso de melanocortinas para tratar la sensibilidad a insulina - Google Patents
Uso de melanocortinas para tratar la sensibilidad a insulinaInfo
- Publication number
- AR069461A1 AR069461A1 ARP080104846A ARP080104846A AR069461A1 AR 069461 A1 AR069461 A1 AR 069461A1 AR P080104846 A ARP080104846 A AR P080104846A AR P080104846 A ARP080104846 A AR P080104846A AR 069461 A1 AR069461 A1 AR 069461A1
- Authority
- AR
- Argentina
- Prior art keywords
- cys
- arg
- phe
- seq
- trp
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Se refiere a ligandos péptidos de los receptores de melanocortina, en particular, el receptor de melanocortina 4, y como tales, son utiles en el tratamiento de trastornos sensibles a la activacion de este receptor, tales como la resistencia a la insulina. Reivindicacion 1: Uso de un agonista del receptor de melanocortina 4 caracterizado porque es para la manufactura de un medicamento util para el tratamiento de la resistencia a la insulina en un sujeto que lo necesita. Reivindicacion 2: El uso de acuerdo con la reivindicacion 1, donde dicho agonista de receptor de melanocortina 4 util para el tratamiento de la resistencia a la insulina se selecciona del grupo que consiste en: Ac-Nle-c(Asp-His-D-Phe-Arg-Trp-b-Ala-Lys)-NH2, SEQ. ID. Ns 1; Ac-Nle-c(Asp-His-D-Phe-Arg-Trp-A6c-Lys)-NH2, SEQ. ID. NRO,: 1; Ac-Nle-c(Cys-His-D-Phe-Arg-Trp-Ahx-Cys)-NH2, SEQ. ID. Ns 2; D-Phe-c(Cys-His-D-Phe-Arg-Trp-Ala-D-Cys)-Thr-NH2, SEQ. ID. Ns 3; D-Phe-c(Cys-His-D-Phe-Arg-Trp-b-AIa-D-Cys)-Thr-NH2, SEQ. ID. Ns 3; D-Phe-c(Cys-His-D-Phe-Arg-Trp-Gaba-D-Cys)-Thr-NH2, SEQ. ID. Ns 3; Ac-Nle-c(Cys-His-D-Phe-Arg-Trp-Apn-Cys)-NH2, SEQ. ID. Ns 2; Ac-Nle-c(Asp-His-D-Phe-Arg-Trp-Apn-Lys)-NH2, SEQ. ID. Ns 4; Ac-A6c-c(Asp-His-D-Phe-Arg-Trp-Gaba-Lys)-NH2, SEQ. ID. Ns 5; Ac-D-2-Nal-c(Asp-His-D-Phe-Arg-Trp-Gaba-Lys)-NH2, SEQ. ID. Ns 6; Ac-Cha-c(Asp-His-D-Phe-Arg-Trp-Gaba-Lys)-NH2, SEQ. ID. Ns 6; Ac-Nle-c(Asp-His-D-Phe-Arg-Trp-Gaba-Lys)-NH2, SEQ. ID. Ns 6; Ac-Nle-c(Cys-D-Ala-His-D-Phe-Arg-Trp-Cys)-NH2, SEQ. ID. Ns 7; Ac-Nle-c(Cys-b-Ala-His-D-Phe-Arg-Trp-Cys)-NH2, SEQ. ID. Ns 7; Ac-NIe-c(Cys-Gaba-His-D-Phe-Arg-Trp-Cys)-NH2, SEQ. ID. Ns 7; Ac-Nle-c(Cys-Aib-His-D-Phe-Arg-Trp-Cys)-NH2, SEQ. ID. Ns 7; Ac-NIe-c(Cys-GIy-His-D-Phe-Arg-Trp-Cys)-NH2, SEQ. ID. Ns 7; Ac-NIe-c(D-Cys-AIa-His-D-Phe-Arg-Trp-Cys)-NH2, SEQ. ID. Ns 8; Ac-NIe-c(D-Cys-D-AIa-His-D-Phe-Arg-Trp-Cys)-NH2, SEQ. ID. Ns 8; Ac-NIe-c(D-Cys-b-AIa-His-D-Phe-Arg-Trp-Cys)-NH2, SEQ. ID. Ns 8; Ac-NIe-c(D-Cys-Gaba-His-D-Phe-Arg-Trp-Cys)-NH2, SEQ. ID. Ns 8; Ac-NIe-c(D-Cys-Aib-His-D-Phe-Arg-Trp-Cys)-NH2, SEQ. ID. Ns 8; Ac-NIe-c(D-Cys-GIy-His-D-Phe-Arg-Trp-Cys)-NH2, SEQ. ID. Ns 8; Ac-NIe-c(Cys-D-AIa-His-D-Phe-Arg-Trp-D-Cys)-NH2, SEQ. ID. Ns 9; Ac-NIe-c(Cys-b-AIa-His-D-Phe-Arg-Trp-D-Cys)-NH2, SEQ. ID. Ns 9; Ac-NIe-c(Cys-Gaba-His-D-Phe-Arg-Trp-D-Cys)-NH2, SEQ. ID. Ns 9; Ac-NIe-c(Cys-Aib-His-D-Phe-Arg-Trp-D-Cys)-NH2, SEQ. ID. Ns 9; Ac-NIe-c(Cys-GIy-His-D-Phe-Arg-Trp-D-Cys)-NH2, SEQ. ID. Ns 9; Ac-NIe-c(D-Cys-AIa-His-D-Phe-Arg-Trp-D-Cys)-NH2, SEQ. ID. Ns 10; Ac-NIe-c(D-Cys-D-AIa-His-D-Phe-Arg-Trp-D-Cys)-NH2, SEQ. ID. Ns 10; Ac-NIe-c(D-Cys-b-AIa-His-D-Phe-Arg-Trp-D-Cys)-NH2, SEQ. ID. Ns 10; Ac-NIe-c(D-Cys-Gaba-His-D-Phe-Arg-Trp-D-Cys)-NH2, SEQ. ID. Ns 10; Ac-NIe-c(D-Cys-Aib-His-D-Phe-Arg-Trp-D-Cys)-NH2, SEQ. ID. Ns 10; Ac-Oic-c(Asp-His-D-Phe-Arg-Trp-Gaba-Lys)-NH2, SEQ. ID. Ns 11; Ac-Chg-c(Asp-His-D-Phe-Arg-Trp-Gaba-Lys)-NH2, SEQ. ID. Ns 11; Ac-hCha-c(Asp-His-D-Phe-Arg-Trp-Gaba-Lys)-NH2, SEQ. ID. Ns 11; Ac-D-Cha-c(Asp-His-D-Phe-Arg-Trp-Gaba-Lys)-NH2, SEC. ID. Ns 11; Ac-Nip-c(Asp-His-D-Phe-Arg-Trp-Gaba-Lys)-NH2, SEQ. ID. Ns 11; Ac-hPro-c(Asp-His-D-Phe-Arg-Trp-Gaba-Lys)-NH2, SEQ. ID. Ns 11; Ac-hLeu-c(Asp-His-D-Phe-Arg-Trp-Gaba-Lys)-NH2, SEQ. ID. Ns 11; Ac-Phe-c(Asp-His-D-Phe-Arg-Trp-Gaba-Lys)-NH2, SEQ. ID. Ns 11; Ac-D-Phe-c(Asp-His-D-Phe-Arg-Trp-Gaba-Lys)-NH2, SEQ. ID. Ns 11; Ac-D-Chg-c(Asp-His-D-Phe-Arg-Trp-Gaba-Lys)-NH2, SEQ. ID. Ns 11; n-butanoiI-Cha-c(Asp-His-D-Phe-Arg-Trp-Gaba-Lys)-NH2 SEQ. ID. Ns 12; Ac-hPhe-c(Asp-His-D-Phe-Arg-Trp-Gaba-Lys)-NH2, SEQ. ID. Ns 11; Ac-b-hMet-c(Asp-His-D-Phe-Arg-Trp-Gaba-Lys)-NH2, SEQ. ID. Ns 11; Ac-Gaba-c(Asp-His-D-Phe-Arg-Trp-Gaba-Lys)-NH2, SEQ. ID. Ns 11; Ac-Cha-c(Asp-His-D-Phe-Arg-D-Trp-AIa-Lys)-NH2, SEQ. ID. Ns 13; Ac-hCha-c(Asp-His-D-Phe-Arg-D-Trp-AIa-Lys)-NH2, SEQ. ID. Ns 13; Ac-Leu-c(Asp-His-D-Phe-Arg-D-Trp-AIa-Lys)-NH2, SEC. ID. Ns 13; Ac-hLeu-c(Asp-His-D-Phe-Arg-D-Trp-AIa-Lys)-NH2, SEQ. ID. Ns 13; Ac-Phe-c(Asp-His-D-Phe-Arg-D-Trp-AIa-Lys)-NH2, SEQ. ID. Ns 13; Ac-NIe-c(Asp-His-D-Phe-Arg-D-Trp-D-AIa-Lys)-NH2, SEQ. ID. Ns 14; Ac-NIe-c(Asp-His-D-Phe-Arg-D-Trp-b-AIa-Lys)-NH2, SEQ. ID. Ns 14; Ac-NIe-c(Asp-His-D-Phe-Arg-D-Trp-Gaba-Lys)-NH2, SEQ. ID. Ns 14; Ac-NIe-c(Asp-His-D-Phe-Arg-D-Trp-Aha-Lys)-NH2, SEQ. ID. Ns 14; Ac-NIe-c(Asp-His-D-Phe-Arg-D-Trp-Apn-Lys)-NH2, SEQ. ID. Ns 14; Ac-NIe-c(Cys-His-D-Phe-Arg-D-Trp-Apn-Cys)-NH2, SEQ. ID. Ns 15; Ac-NIe-c(Cys-His-D-Phe-Arg-D-Trp-Gaba-Cys)-NH2, SEQ. ID. Ns 15; Ac-NIe-c(Cys-His-D-Phe-Arg-D-Trp-Ahx-Cys)-NH2, SEQ. ID. Ns 15; Ac-NIe-c(Cys-His-D-Phe-Arg-D-Trp-b-AIa-Cys)-NH2, SEQ. ID. Ns 15; Ac-NIe-c(Cys-His-D-Phe-Arg-D-Trp-D-AIa-Cys)-NH2, SEQ. ID. Ns 15; Ac-NIe-c(Cys-D-AIa-His-D-2-NaI-Arg-Trp-Cys)-NH2, SEQ. ID. Ns 16; Ac-NIe-c(Cys-D-AIa-His-D-2-NaI-Arg-2-NaI-Cys)-NH2, SEQ. ID. Ns 16; Ac-NIe-c(Cys-D-AIa-His-D-2-NaI-Arg-1-NaI-Cys)-NH2, SEQ. ID. Ns 16; n-butanoil-NIe-c(Cys-D-AIa-His-D-Phe-Arg-2-NaI-Cys)-NH2, SEQ. ID. Ns 17; n-butanoil-NIe-c(Cys-D-AIa-His-D-Phe-Arg-Trp-Cys)-NH2, SEQ. ID. Ns 17; Ac-NIe-c(Cys-D-AIa-His-D-Phe-Arg-2-NaI-Cys)-NH2, SEQ. ID. Ns 18; Ac-Nle-c(Cys-D-Ala-His-D-Phe-Arg-1-NaI-Cys)-NH2, SEQ. ID. Ns 18; Ac-NIe-c(Cys-D-AIa-His-D-Phe-Arg-BaI-Cys)-NH2, SEQ. ID. Ns 18; Ac-NIe-c(Cys-D-GIu-His-D-Phe-Arg-Trp-Cys)-NH2, SEQ. ID. Ns 59; Ac-NIe-c(Asp-His-D-Phe-Arg-Trp-D-AIa-LYS)-NH2, SEQ. ID. Ns 19; Ac-NIe-c(Cys-D-AIa-Hs-D-2-NaI-Arg-BaI-Cys)-NH2, SEQ. ID. Ns 20; Ac-NIe-c(Pen-D-AIa-His-D-Phe-Arg-Trp-Cys)-NH2, SEQ. ID. Ns 21; Ac-NIe-c(Cys-D-AIa-His-D-Phe-Arg-Trp-Pen)-NH2, SEQ. ID. Ns 22; Ac-NIe-c(Pen-D-AIa-His-D-Phe-Arg-Trp-Pen)-NH2, SEQ. ID. Ns 22; D-Phe-c(Cys-His-D-Phe-hArg-Trp-b-AIa-D-Cys)-Thr-NH2, SEQ. ID. Ns 23; D-Phe-c(Cys-His-D-(Et)Tyr-Arg-Trp-b-AIa-D-Cys)-Thr-NH2, SEQ. ID. Ns 24; D-Phe-c(Cys-His-D-Phe-Arg-Bip-b-AIa-D-Cys)-Thr-NH2, SEQ. ID. Ns 25; D-Phe-c(Cys-His-D-(Et)Tyr-hArg-Trp-b-AIa-D-Cys)-Thr-NH2, SEQ. ID. Ns 24; D-Phe-c(Cys-His-D-Phe-hArg-Bip-b-AIa-D-Cys)-Thr-NH2, SEQ. ID. Ns 26; D-Phe-c(Cys-His-D-(Et)Tyr-hArg-Bip-b-AIa-D-Cys)-Thr-NH2, SEQ. ID. Ns 26; NIe-c(Cys-His-D-Phe-Arg-Trp-Apn-Cys)-NH2, SEQ. ID. Ns 27; Ac-NIe-c(Asp-D-AIa-His-D-Phe-Arg-Trp-Lys)-NH2, SEQ. ID. Ns 28; Ac-NIe-c(Asp-D-AIa-His-D-Phe-Arg-BaI-Lys)-NH2, SEQ. ID. Ns 28; Ac-NIe-c(Cys-D-AIa-His-D-Phe-Arg-Trp-Pen)-OH, SEQ. ID. Ns 29; Ac-NIe-c(Cys-D-Abu-His-D-Phe-Arg-Trp-Cys)-NH2, SEQ. ID. Ns 30; Ac-NIe-c(Cys-D-VaI-His-D-Phe-Arg-Trp-Cys)-NH2, SEQ. ID, Ns 30; Ac-NIe-c(Cys-D-IIe-His-D-Phe-Arg-Trp-Cys)-NH2, SEQ. ID. Ns 30; Ac-NIe-c(Cys-D-Leu-His-D-Phe-Arg-Trp-Cys)-NH2, SEQ. ID. Ns 30; Ac-NIe-c(Cys-D-TIe-His-D-Phe-Arg-Trp-Cys)-NH2, SEQ. ID. Ns 30; Ac-NIe-c(Cys-D-Cha-His-D-Phe-Arg-Trp-Cys)-NH2, SEQ. ID. Ns 30; Ac-NIe-c(Pen-His-D-Phe-Arg-Trp-Gaba-Cys)-NH2, SEQ. ID. Ns 31; Ac-NIe-c(Cys-His-D-Phe-Arg-Trp-Gaba-Pen)-NH2, SEQ. ID. Ns 32; Ac-NIe-c(Pen-His-D-Phe-Arg-Trp-Gaba-Pen)-NH2, SEQ. ID. Ns 32; Ac-Leu-c(Cys-His-D-Phe-Arg-Trp-Gaba-Cys)-NH2, SEQ. ID. Ns 33; Ac-Cha-c(Cys-His-D-Phe-Arg-Trp-Gaba-Cys)-NH2, SEQ. ID. Ns 33; Ac-IIe-c(Cys-His-D-Phe-Arg-Trp-Gaba-Cys)-NH2, SEC. ID. Ns 33; Ac-Phe-c(Cys-His-D-Phe-Arg-Trp-Gaba-Cys)-NH2, SEQ. ID. Ns 33; Ac-VaI-c(Cys-His-D-Phe-Arg-Trp-Gaba-Cys)-NH2, SEQ. ID. Ns 33; Ac-2-NaI-c(Cys-His-D-Phe-Arg-Trp-Gaba-Cys)-NH2, SEQ. ID. Ns 33; NIe-c(Cys-His-D-Phe-Arg-Trp-Gaba-Cys)-NH2, SEQ. ID. Ns 34; Phe-c(Cys-His-D-Phe-Arg-Trp-Gaba-Cys)-NH2, SEQ. ID. Ns 34; Ac-NIe-c(Cys-3-PaI-D-Phe-Arg-Trp-Gaba-Cys)-NH2, SEQ. ID. Ns 35; Ac-NIe-c(Cys-D-AIa-His-D-Phe-Arg-Trp-Cys)-OH SEQ. ID. Ns 36; Ac-NIe-c(Cys-His-Phe-Arg-D-Trp-Gaba-Cys)-NH2, SEQ. ID. Ns 37; Ac-NIe-c(Asp-His-D-2-NaI-Arg-Trp-AIa-Lys)-NH2, SEQ. ID. Ns 38; Ac-Nle-c(Asp-Hs-D-2-NaI-Arg-Trp-b-AIa-Lys)-NH2, SEQ, ID. Ns 38; Ac-NIe-c(Cys-His-D-2-NaI-Arg-Trp-Gaba-Cys)-NH2, SEQ. ID. Ns 39; Ac-NIe-c(Cys-His-D-2-NaI-Arg-Trp-Ahx-Cys)-NH2, SEQ. ID. Ns 39; Ac-hPhe-c(Asp-His-D-2-NaI-Arg-Trp-Gaba-Lys)-NH2, SEQ. ID. Ns 40; Ac-Cha-c(Asp-His-D-2-NaI-Arg-Trp-Gaba-Lys)-NH2, SEQ. ID. Ns 40; Ac-NIe-c(Asp-Hs-D-Phe-Arg-Trp-b-AIa-Lys)-OH SEQ. ID. Ns 41; Ac-NIe-c(Cys-His-D-Phe-Arg-Trp-Ahx-Cys)-OH SEQ. ID. Ns 42; D-Phe-c(Cys-His-D-Phe-Arg-Trp-AIa-D-Cys)-Thr-OH SEQ. ID. Ns 43; D-Phe-c(Cys-His-D-Phe-Arg-Trp-b-AIa-D-Cys)-Thr-OH SEQ. ID. Ns 43; D-Phe-c(Cys-His-D-Phe-Arg-Trp-Gaba-D-Cys)-thr-OH SEQ. ID. Ns 43; Ac-NIe-c(Cys-His-D-Phe-Arg-Trp-Apn-Cys)-OH SEQ. ID. Ns 42; Ac-NIe-c(Asp-His-D-Phe-Arg-Trp-Apn-Lys)-OH SEQ. ID. Ns 41; Ac-Cha-c(Asp-His-D-Phe-Arg-Trp-Gaba-Lys)-OH SEQ. ID. Ns 44; Ac-Nle-c(Asp-His-D-Phe-Arg-Trp-Gaba-Lys)-OH SEQ. ID. Ns 44; Ac-Chg-c(Asp-His-D-Phe-Arg-Trp-Gaba-Lys)-OH SEQ. ID. Ns 44; Ac-D-Cha-c(Asp-His-D-Phe-Arg-Trp-Gaba-Lys)-OH SEQ. ID. Ns 44; Ac-hCha-c(Asp-His-D-Phe-Arg-Trp-Gaba-Lys)-OH SEQ. ID. Ns 44; Ac-D-Chg-c(Asp-His-D-Phe-Arg-Trp-Gaba-Lys)-OH SEQ. ID. Ns 44; Ac-hPhe-c(Asp-His-D-Phe-Arg-Trp-Gaba-Lys)-OH SEQ. ID. Ns 44; Ac-NIe-c(Cys-His-D-Phe-Arg-D-Trp-Gaba-Cys)-OH SEQ. ID. Ns 45; Ac-NIe-c(Cys-His-D-Phe-Arg-D-Trp-Ahx-Cys)-OH SEQ. ID. Ns 45; Ac-NIe-c(Cys-His-D-Phe-Arg-D-Trp-b-AIa-Cys)-OH SEQ. ID. Ns 45; Ac-NIe-c(Cys-His-D-Phe-Arg-D-Trp-D-AIa-Cys)-OH SEQ. ID. Ns 45; Ac-NIe-c(Cys-D-Ala-His-D-2-NaI-Arg-Trp-Cys)-OH SEQ. ID. Ns 46; Ac-NIe-c(Cys-D-AIa-His-D-2-NaI-Arg-2-NaI-Cys)-OH SEC. ID. Ns 46; Ac-NIe-c(Cys-D-AIa-His-D-2-NaI-Arg-1-NaI-Cys)-OH SEQ. ID. Ns 46; Ac-NIe-c(Cys-D-AIa-His-D-2-NaI-Arg-BaI-Cys)-OH SEQ. ID. Ns 46; Ac-NIe-c(Pen-D-AIa-His-D-Phe-Arg-Trp-Cys)-OH SEQ. ID. Ns 47; Ac-NIe-c(Cys-His-D-Phe-Arg-Trp-Gaba-Pen)-OH SEQ. ID. Ns 48; Ac-Arg-c(Cys-D-AIa-His-D-2-NaI-Arg-Trp-Cys)-NH2, SEQ. ID. Ns 49; Ac-Arg-c(Cys-D-AIa-His-D-Phe-Arg-Trp-Cys)-NH2, SEQ. ID. Ns 50; Ac-D-Arg-c(Cys-D-AIa-His-D-Phe-Arg-Trp-Cys)-NH2, SEQ. ID. Ns 50; Ac-D-Arg-c(Cys-D-AIa-His-D-Phe-Arg-Trp-Pen)-NH2, SEQ. ID. Ns 51; Ac-D-Arg-c(Cys-His-D-Phe-Arg-Trp-Gaba-Pen)-NH2, SEQ. ID. Ns 52; Ac-Arg-c(Cys-His-D-Phe-Arg-Trp-Gaba-Pen)-NH2, SEQ. ID. Ns 52; Ac-Arg-c(Cys-D-AIa-His-D-Phe-Arg-Trp-Pen)-NH2, SEQ. ID. Ns 51; Ac-D-Arg-c(Asp-His-D-Phe-Arg-Trp-AIa-Lys)-NH2, SEQ. ID. Ns 53; Ac-Arg-c(Asp-His-D-Phe-Arg-Trp-AIa-Lys)-NH2, SEQ. ID. Ns 53; Ac-NIe-c(Cys-3-PaI-D-Phe-Arg-Trp-Gaba-Cys)-NH2, SEQ. ID. Ns 35; Ac-NIe-c(Cys-D-AIa-His-D-Phe-Arg-Trp-GIy-Cys)-NH2, SEQ. ID. N
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US193307P | 2007-11-05 | 2007-11-05 |
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AR069461A1 true AR069461A1 (es) | 2010-01-27 |
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ARP080104846A AR069461A1 (es) | 2007-11-05 | 2008-11-05 | Uso de melanocortinas para tratar la sensibilidad a insulina |
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JP (3) | JP2011502987A (es) |
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AR (1) | AR069461A1 (es) |
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TR (1) | TR201815292T4 (es) |
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CA2689016C (en) * | 2007-05-25 | 2014-08-12 | Ipsen Pharma S.A.S. | Melanocortin receptor ligands modified with hydantoin |
RU2453328C2 (ru) | 2007-11-05 | 2012-06-20 | Ипсен Фарма С.А.С. | Применение меланокортинов для лечения чувствительности к инсулину |
WO2010144341A2 (en) | 2009-06-08 | 2010-12-16 | Palatin Technologies, Inc. | Lactam-bridged melanocortin receptor-specific peptides |
KR101726893B1 (ko) | 2009-06-08 | 2017-04-13 | 팔라틴 테크놀로지스 인코포레이티드 | 멜라노코르틴 수용체-특이적 펩티드 |
RU2012108110A (ru) * | 2009-08-05 | 2013-09-10 | Ипсен Фарма С.А.С. | Применение меланокортинов для лечения дислипидемии |
HUE031856T2 (en) * | 2009-08-31 | 2017-08-28 | Tensive Controls Inc | Stabilized melanocortin ligands |
RU2548753C2 (ru) | 2009-11-16 | 2015-04-20 | Ипсен Фарма С.А.С. | Фармацевтические композиции лигандов рецепторов меланокортинов |
EP2504351A4 (en) | 2009-11-23 | 2013-10-30 | Palatin Technologies Inc | MELANOCORTIN-1 RECEPTOR-SPECIFIC LINEAR PEPTIDE |
MX2012005862A (es) | 2009-11-23 | 2012-09-07 | Palatin Technologies Inc | Peptidos ciclicos especificos del receptor de melanocortina-1. |
WO2012172433A2 (en) * | 2011-06-14 | 2012-12-20 | Ipsen Pharma S.A.S. | A sustained-release composition containing peptides as active ingredient |
HRP20211950T1 (hr) | 2011-12-29 | 2022-03-18 | Rhythm Pharmaceuticals, Inc. | Postupak liječenja poremećaja u vezi sa melanokortin-4 receptorom u heterozigotnim nosiocima |
US9534018B2 (en) | 2012-03-13 | 2017-01-03 | Tensive Controls Inc. | Melanocortin analogs having enhanced activity and transport |
RU2019116003A (ru) | 2013-03-15 | 2019-07-17 | Ритм Фармасьютикалз, Инк. | Фармацевтические композиции |
CN118240012A (zh) | 2013-03-15 | 2024-06-25 | 节奏制药公司 | 肽组合物 |
US10314883B2 (en) | 2015-02-13 | 2019-06-11 | University Of Virginia Patent Foundation | Compositions and methods for regulating blood pressure |
WO2017019952A1 (en) | 2015-07-29 | 2017-02-02 | University Of Virginia Patent Foundation | Compositions and methods for regulating leukocyte adhesion |
WO2017049140A2 (en) | 2015-09-18 | 2017-03-23 | Wake Forest University Health Sciences | Angiotensin (1-7) analogs and methods relating thereto |
US11124541B2 (en) * | 2016-10-18 | 2021-09-21 | Regents Of The University Of Minnesota | Chimeric melanocortin ligands and methods of use thereof |
CA3102603A1 (en) | 2018-06-05 | 2019-12-12 | The Research Foundation For The State University Of New York | Method for passive wireless channel estimation in radio frequency network and apparatus for same |
US11332499B2 (en) | 2018-08-16 | 2022-05-17 | Regents Of The University Of Minnesota | Cyclic peptides and methods of use thereof |
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US5672659A (en) | 1993-01-06 | 1997-09-30 | Kinerton Limited | Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides |
US5595760A (en) | 1994-09-02 | 1997-01-21 | Delab | Sustained release of peptides from pharmaceutical compositions |
US5665702A (en) | 1995-06-06 | 1997-09-09 | Biomeasure Incorporated | Ionic molecular conjugates of N-acylated derivatives of poly(2-amino-2-deoxy-D-glucose) and polypeptides |
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CA2689016C (en) * | 2007-05-25 | 2014-08-12 | Ipsen Pharma S.A.S. | Melanocortin receptor ligands modified with hydantoin |
EP2167112A4 (en) * | 2007-06-15 | 2012-01-25 | Ipsen Pharma Sas | CYCLIC PEPTIDE MELANOCORTIN RECEPTOR LIGANDS |
RU2453328C2 (ru) * | 2007-11-05 | 2012-06-20 | Ипсен Фарма С.А.С. | Применение меланокортинов для лечения чувствительности к инсулину |
RU2012108110A (ru) | 2009-08-05 | 2013-09-10 | Ипсен Фарма С.А.С. | Применение меланокортинов для лечения дислипидемии |
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