ES2723098T3 - Agonistas del péptido CRHR2 y usos de los mismos - Google Patents
Agonistas del péptido CRHR2 y usos de los mismos Download PDFInfo
- Publication number
- ES2723098T3 ES2723098T3 ES09748922T ES09748922T ES2723098T3 ES 2723098 T3 ES2723098 T3 ES 2723098T3 ES 09748922 T ES09748922 T ES 09748922T ES 09748922 T ES09748922 T ES 09748922T ES 2723098 T3 ES2723098 T3 ES 2723098T3
- Authority
- ES
- Spain
- Prior art keywords
- peptide agonists
- peptide
- crhr2 peptide
- crhr2
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57509—Corticotropin releasing factor [CRF] (Urotensin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
Abstract
Un péptido que tiene actividad agonista hacia el receptor de la hormona liberadora de corticotropina tipo 2, dicho péptido tiene una secuencia de aminoácidos seleccionada del grupo que consiste de las SEQ ID NO 2, 3, 4, 5, 6, 7, 9, 10, 11, 12 , 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 35, 36, 37, 39 , 40, y 41; o una sal o amida farmacéuticamente aceptable del mismo.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11123308P | 2008-11-04 | 2008-11-04 | |
US17889009P | 2009-05-15 | 2009-05-15 | |
PCT/US2009/063276 WO2010053990A2 (en) | 2008-11-04 | 2009-11-04 | Crhr2 peptide agonists and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2723098T3 true ES2723098T3 (es) | 2019-08-21 |
Family
ID=41509080
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09748922T Active ES2723098T3 (es) | 2008-11-04 | 2009-11-04 | Agonistas del péptido CRHR2 y usos de los mismos |
Country Status (20)
Country | Link |
---|---|
US (1) | US10040838B2 (es) |
EP (1) | EP2362881B1 (es) |
JP (1) | JP2012508014A (es) |
KR (1) | KR20110091720A (es) |
CN (1) | CN102272151B (es) |
AU (1) | AU2009313619A1 (es) |
BR (1) | BRPI0921640A2 (es) |
CA (1) | CA2742710A1 (es) |
CO (1) | CO6341479A2 (es) |
CR (1) | CR20110305A (es) |
EA (1) | EA201170647A1 (es) |
EC (1) | ECSP11011099A (es) |
ES (1) | ES2723098T3 (es) |
IL (1) | IL212685A0 (es) |
MX (1) | MX2011004718A (es) |
NI (1) | NI201100087A (es) |
NZ (1) | NZ592670A (es) |
SG (1) | SG171957A1 (es) |
WO (1) | WO2010053990A2 (es) |
ZA (1) | ZA201104160B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA201170647A1 (ru) | 2008-11-04 | 2011-12-30 | Янссен Фармацевтика Нв | Пептиды-агонисты crhr2 и их использование |
MX2012005262A (es) * | 2009-11-04 | 2012-09-28 | Janssen Pharmaceutica Nv | Metodo para tratar la insuficiencia cardiaca con petidos tipo estrescopina. |
CN104220098B (zh) | 2012-02-14 | 2018-04-10 | 加利福尼亚大学董事会 | 用于心血管疾病和其它病况的旁分泌基因的全身性递送和受调节的表达 |
JOP20170153A1 (ar) | 2016-07-15 | 2019-01-30 | Lilly Co Eli | نظائر urocortin-2 جديدة معدلة بحمض دهني لعلاج داء السكري وأمراض الكلى المزمنة |
JOP20190095A1 (ar) | 2016-10-27 | 2019-04-28 | Janssen Pharmaceutica Nv | مركبات ببتيد تيروسين-تيروسين الحلقية كمعدلات لمستقبلات الببتيد العصبي y |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2045175C (en) | 1989-11-06 | 2003-03-18 | Arthur I. Skoultchi | Production of proteins using homologous recombination |
US5272071A (en) * | 1989-12-22 | 1993-12-21 | Applied Research Systems Ars Holding N.V. | Method for the modification of the expression characteristics of an endogenous gene of a given cell line |
US6552170B1 (en) * | 1990-04-06 | 2003-04-22 | Amgen Inc. | PEGylation reagents and compounds formed therewith |
US5766897A (en) * | 1990-06-21 | 1998-06-16 | Incyte Pharmaceuticals, Inc. | Cysteine-pegylated proteins |
JP3693671B2 (ja) * | 1991-03-15 | 2005-09-07 | アムゲン インコーポレーテッド | ポリペプチドのpeg化 |
US5554728A (en) * | 1991-07-23 | 1996-09-10 | Nexstar Pharmaceuticals, Inc. | Lipid conjugates of therapeutic peptides and protease inhibitors |
EP0922446A1 (en) * | 1997-12-03 | 1999-06-16 | Applied Research Systems Ars Holding N.V. | Solution-phase site-specific preparation of GRF-PEG conjugates |
US6420339B1 (en) * | 1998-10-14 | 2002-07-16 | Amgen Inc. | Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility |
US20020082409A1 (en) * | 2000-10-26 | 2002-06-27 | Hsu Sheau Yu | Stresscopins and their uses |
US6673580B2 (en) * | 2000-10-27 | 2004-01-06 | Genentech, Inc. | Identification and modification of immunodominant epitopes in polypeptides |
CA2425902C (en) | 2001-03-15 | 2017-01-03 | Research Development Foundation | Urocortin-iii and uses thereof |
DK1389137T3 (da) | 2001-05-21 | 2006-10-30 | Injet Digital Aerosols Ltd | Sammensætninger til lungelægemiddellevering af protein |
US7144985B2 (en) * | 2001-12-03 | 2006-12-05 | Metabolex, Inc. | Methods and reagents for diagnosis and treatment of diabetes |
CN100480267C (zh) * | 2002-01-16 | 2009-04-22 | 宝洁公司 | 促肾上腺皮质激素释放因子2受体激动剂 |
US7192924B2 (en) * | 2002-01-16 | 2007-03-20 | The Procter & Gamble Company | Corticotropin releasing factor 2 receptor agonists |
KR100512483B1 (ko) * | 2003-05-07 | 2005-09-05 | 선바이오(주) | 신규한 폴리에틸렌글리콜-말레이미드 유도체의 합성방법 |
GB0316294D0 (en) * | 2003-07-11 | 2003-08-13 | Polytherics Ltd | Conjugated biological molecules and their preparation |
ES2737837T3 (es) * | 2003-10-09 | 2020-01-16 | Ambrx Inc | Derivados poliméricos |
US20080261863A1 (en) * | 2004-06-12 | 2008-10-23 | Bayer Pharmaceuticals Corp | Pegylation of Vasoactive Intestinal Peptide (Vip) / Pituitary Adenylate Cyclase Activating Peptide (Pacap) Receptor 2 (Vpac2) Agonists and Methods of Use |
PA8660701A1 (es) | 2005-02-04 | 2006-09-22 | Pfizer Prod Inc | Agonistas de pyy y sus usos |
GB2427360A (en) | 2005-06-22 | 2006-12-27 | Complex Biosystems Gmbh | Aliphatic prodrug linker |
WO2007090087A2 (en) * | 2006-01-27 | 2007-08-09 | Research Development Foundation | Use of corticotropin releasing factor receptor-2 inhibitors for treating insulin-related diseases |
WO2008047241A2 (en) | 2006-10-16 | 2008-04-24 | Conjuchem Biotechnologies Inc. | Modified corticotropin releasing factor peptides and uses thereof |
WO2009027844A2 (en) | 2007-05-25 | 2009-03-05 | Celtic Pharma Management L.P. | Crf conjugates with extended half-lives |
KR20100061478A (ko) | 2007-09-11 | 2010-06-07 | 몬도바이오테크 래보래토리즈 아게 | 치료제로서의 세크레틴 및 임의의 유로딜라틴의 용도 |
EP2205748A1 (en) | 2007-09-14 | 2010-07-14 | BASF Plant Science GmbH | Plants having increased yield-related traits and a method for making the same |
EA201170647A1 (ru) | 2008-11-04 | 2011-12-30 | Янссен Фармацевтика Нв | Пептиды-агонисты crhr2 и их использование |
US20120277158A1 (en) | 2009-10-06 | 2012-11-01 | Angiochem Inc. | Compositions and methods for the transport of therapeutic agents |
MX2012005262A (es) * | 2009-11-04 | 2012-09-28 | Janssen Pharmaceutica Nv | Metodo para tratar la insuficiencia cardiaca con petidos tipo estrescopina. |
PL2734544T3 (pl) | 2011-07-18 | 2021-05-31 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Sposoby i kompozycje do hamowania patologii związanej z poliomawirusem |
-
2009
- 2009-11-04 EA EA201170647A patent/EA201170647A1/ru unknown
- 2009-11-04 JP JP2011535643A patent/JP2012508014A/ja active Pending
- 2009-11-04 NZ NZ592670A patent/NZ592670A/xx not_active IP Right Cessation
- 2009-11-04 SG SG2011040755A patent/SG171957A1/en unknown
- 2009-11-04 CA CA2742710A patent/CA2742710A1/en not_active Abandoned
- 2009-11-04 BR BRPI0921640A patent/BRPI0921640A2/pt not_active IP Right Cessation
- 2009-11-04 KR KR1020117012435A patent/KR20110091720A/ko not_active Application Discontinuation
- 2009-11-04 US US12/612,548 patent/US10040838B2/en active Active
- 2009-11-04 CN CN200980154228.3A patent/CN102272151B/zh not_active Expired - Fee Related
- 2009-11-04 WO PCT/US2009/063276 patent/WO2010053990A2/en active Application Filing
- 2009-11-04 EP EP09748922.3A patent/EP2362881B1/en active Active
- 2009-11-04 MX MX2011004718A patent/MX2011004718A/es not_active Application Discontinuation
- 2009-11-04 ES ES09748922T patent/ES2723098T3/es active Active
- 2009-11-04 AU AU2009313619A patent/AU2009313619A1/en not_active Abandoned
-
2011
- 2011-05-04 NI NI201100087A patent/NI201100087A/es unknown
- 2011-05-04 IL IL212685A patent/IL212685A0/en unknown
- 2011-05-18 CO CO11061124A patent/CO6341479A2/es active IP Right Grant
- 2011-06-02 EC EC2011011099A patent/ECSP11011099A/es unknown
- 2011-06-03 ZA ZA2011/04160A patent/ZA201104160B/en unknown
- 2011-06-06 CR CR20110305A patent/CR20110305A/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CR20110305A (es) | 2011-11-10 |
NZ592670A (en) | 2013-01-25 |
CA2742710A1 (en) | 2010-05-14 |
ZA201104160B (en) | 2012-11-28 |
KR20110091720A (ko) | 2011-08-12 |
EP2362881A2 (en) | 2011-09-07 |
CN102272151A (zh) | 2011-12-07 |
MX2011004718A (es) | 2011-07-28 |
CN102272151B (zh) | 2014-08-20 |
NI201100087A (es) | 2011-10-25 |
WO2010053990A2 (en) | 2010-05-14 |
WO2010053990A3 (en) | 2010-07-01 |
IL212685A0 (en) | 2011-07-31 |
JP2012508014A (ja) | 2012-04-05 |
EP2362881B1 (en) | 2019-03-13 |
BRPI0921640A2 (pt) | 2019-09-24 |
AU2009313619A1 (en) | 2010-05-14 |
CO6341479A2 (es) | 2011-11-21 |
US20100130424A1 (en) | 2010-05-27 |
ECSP11011099A (es) | 2011-07-29 |
EA201170647A1 (ru) | 2011-12-30 |
SG171957A1 (en) | 2011-07-28 |
US10040838B2 (en) | 2018-08-07 |
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