AR064765A1 - Compuestos con una combinacion de antagonismo de cb1 cannabinoide e inhibicion de recaptacion de serotonina - Google Patents
Compuestos con una combinacion de antagonismo de cb1 cannabinoide e inhibicion de recaptacion de serotoninaInfo
- Publication number
- AR064765A1 AR064765A1 ARP080100048A ARP080100048A AR064765A1 AR 064765 A1 AR064765 A1 AR 064765A1 AR P080100048 A ARP080100048 A AR P080100048A AR P080100048 A ARP080100048 A AR P080100048A AR 064765 A1 AR064765 A1 AR 064765A1
- Authority
- AR
- Argentina
- Prior art keywords
- atom
- cannabinoid
- group
- compounds
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Reivindicacion 1: Compuestos con una combinacion de antagonismo de CB1 cannabinoide e inhibicion de la recaptacion de serotonina. Reivindicacion 3:Compuestos segun lo reivindicado en la reivindicacion 1 de la formula (1) o un tautomero, estereoisomero, N-oxido, análogo isotopicamente marcado o una sal, hidrato o solvato farmacologicamente aceptable de cualquiera de los anteriores, en donde: A representa un elemento estructural esencial de cualquier antagonista conocido de CB1 cannabinoide que contiene al menos dos anillos fenilo que están independientemente opcionalmente sustituidos con uno o más sustituyentes seleccionados de halogeno, metoxi y trifluorometilo, estando dicho elemento estructural esencial unido a un aceptor de enlace hidrogeno en dicho antagonista de CB1 cannabinoide, en donde el grupo molecular aceptor de enlace H es un grupo carbonilo, sulfonilo, o un átomo de N u O incorporado en una estructura de anillo heteroaromático; N representa un átomo de nitrogeno no básico; T representa una cadena de carbonos saturada o insaturada de 0-8 átomos, en donde un átomo de C puede estar reemplazado con un átomo de N, opcionalmente sustituido con un grupo alquilo C1-3 o CH2CF3, o reemplazado con un átomo de O o un átomo de S, y la cual cadena está opcionalmente sustituida con uno o más sustituyentes seleccionados de F, amino, ciano, alquilo C1-3, alcoxi C1-3 y trifluorometilo; R representa un átomo de H, o un grupo alquilo C1-3, o R junto con el átomo de N al cual está unido, y junto con una parte de T, forma un grupo heterocicloalquilo C4-7 o un grupo heteroarilo, B representa un elemento estructural esencial de cualquier inhibidor de la recaptacion de serotonina conocido.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07100323 | 2007-01-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR064765A1 true AR064765A1 (es) | 2009-04-22 |
Family
ID=38069361
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080100048A AR064765A1 (es) | 2007-01-10 | 2008-01-07 | Compuestos con una combinacion de antagonismo de cb1 cannabinoide e inhibicion de recaptacion de serotonina |
Country Status (6)
Country | Link |
---|---|
CN (1) | CN101809000A (es) |
AR (1) | AR064765A1 (es) |
BR (1) | BRPI0806452A2 (es) |
MX (1) | MX2009007405A (es) |
SA (1) | SA08280759B1 (es) |
TW (1) | TW200845963A (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103547263B (zh) * | 2010-11-18 | 2015-12-09 | 詹里恩探索公司 | 对于治疗代谢性疾病,包括肥胖症和糖尿病有用的大麻素受体拮抗剂/反相激动剂 |
CN104666291A (zh) * | 2013-11-26 | 2015-06-03 | 山东绿叶制药有限公司 | 去甲基文拉法辛苯甲酸酯类化合物在制备改善性功能障碍药物中的应用 |
ES2964790T3 (es) * | 2016-05-25 | 2024-04-09 | Minerva Neurosciences Inc | (2S)-1-[4-(3,4-Diclorofenil)piperidin-1-il]-3-[2-(5-metil-l,3,4-oxadiazol-2-il)benzo[b]furano-4-iloxi]propan-2-ol o su metabolito para tratar trastornos de ansiedad |
KR102036909B1 (ko) * | 2017-11-28 | 2019-10-25 | 한국과학기술원 | 신규 디스토니아 치료용 약학적 조성물 |
CA3110652A1 (en) | 2018-09-04 | 2020-05-22 | Minerva Neurosciences, Inc. | Methods of using a phenoxypropylamine compound to treat pain |
CN115052868A (zh) * | 2020-02-06 | 2022-09-13 | 伦敦制药与研究公司 | 大麻素硫酸酯、及其盐和用途 |
-
2008
- 2008-01-06 SA SA8280759A patent/SA08280759B1/ar unknown
- 2008-01-07 AR ARP080100048A patent/AR064765A1/es not_active Application Discontinuation
- 2008-01-07 TW TW097100554A patent/TW200845963A/zh unknown
- 2008-01-09 MX MX2009007405A patent/MX2009007405A/es unknown
- 2008-01-09 CN CN200880001916A patent/CN101809000A/zh active Pending
- 2008-01-09 BR BRPI0806452-0A patent/BRPI0806452A2/pt not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
SA08280759B1 (ar) | 2011-05-04 |
CN101809000A (zh) | 2010-08-18 |
BRPI0806452A2 (pt) | 2011-09-06 |
MX2009007405A (es) | 2009-07-17 |
TW200845963A (en) | 2008-12-01 |
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