AR062726A1 - Composiciones que comprenden compuestos marcados con 18f y metodos relacionados - Google Patents
Composiciones que comprenden compuestos marcados con 18f y metodos relacionadosInfo
- Publication number
- AR062726A1 AR062726A1 ARP070103993A ARP070103993A AR062726A1 AR 062726 A1 AR062726 A1 AR 062726A1 AR P070103993 A ARP070103993 A AR P070103993A AR P070103993 A ARP070103993 A AR P070103993A AR 062726 A1 AR062726 A1 AR 062726A1
- Authority
- AR
- Argentina
- Prior art keywords
- anion
- heteroaryl
- aryl
- alkyl
- group
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 6
- 125000001072 heteroaryl group Chemical group 0.000 abstract 6
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000004475 heteroaralkyl group Chemical group 0.000 abstract 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 150000007522 mineralic acids Chemical class 0.000 abstract 2
- 150000007524 organic acids Chemical class 0.000 abstract 2
- -1 perchlorate anion Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 abstract 1
- 229910004679 ONO2 Inorganic materials 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000002059 diagnostic imaging Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 239000012216 imaging agent Substances 0.000 abstract 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-M iodide Chemical compound [I-] XMBWDFGMSWQBCA-UHFFFAOYSA-M 0.000 abstract 1
- KIWSYRHAAPLJFJ-DNZSEPECSA-N n-[(e,2z)-4-ethyl-2-hydroxyimino-5-nitrohex-3-enyl]pyridine-3-carboxamide Chemical compound [O-][N+](=O)C(C)C(/CC)=C/C(=N/O)/CNC(=O)C1=CC=CN=C1 KIWSYRHAAPLJFJ-DNZSEPECSA-N 0.000 abstract 1
- 125000006340 pentafluoro ethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 abstract 1
- VLTRZXGMWDSKGL-UHFFFAOYSA-M perchlorate Inorganic materials [O-]Cl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-M 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000006850 spacer group Chemical group 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57545—Neuropeptide Y
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06090166A EP1897885A1 (en) | 2006-09-08 | 2006-09-08 | Compounds and methods for F labelled agents |
| EP07090079A EP1985624A3 (en) | 2007-04-23 | 2007-04-23 | Single step method of radiofluorination of biologically active compounds or biomolecules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR062726A1 true AR062726A1 (es) | 2008-11-26 |
Family
ID=39031005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070103993A AR062726A1 (es) | 2006-09-08 | 2007-09-10 | Composiciones que comprenden compuestos marcados con 18f y metodos relacionados |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8557776B2 (OSRAM) |
| EP (5) | EP3056509A1 (OSRAM) |
| JP (2) | JP5603074B2 (OSRAM) |
| KR (1) | KR20090058553A (OSRAM) |
| AR (1) | AR062726A1 (OSRAM) |
| AU (1) | AU2007294124A1 (OSRAM) |
| BR (1) | BRPI0716554A2 (OSRAM) |
| CA (2) | CA2858907A1 (OSRAM) |
| CL (1) | CL2007002620A1 (OSRAM) |
| CO (1) | CO6150196A2 (OSRAM) |
| CR (1) | CR10654A (OSRAM) |
| IL (4) | IL197363A0 (OSRAM) |
| MA (1) | MA30780B1 (OSRAM) |
| MX (1) | MX2009002492A (OSRAM) |
| NO (1) | NO20091428L (OSRAM) |
| PE (1) | PE20080850A1 (OSRAM) |
| RU (1) | RU2009112716A (OSRAM) |
| TN (1) | TN2009000063A1 (OSRAM) |
| TW (1) | TW200829277A (OSRAM) |
| WO (1) | WO2008028688A2 (OSRAM) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8557776B2 (en) | 2006-09-08 | 2013-10-15 | Bayer Pharma AG | Compounds and methods for 18F labeled agents |
| US20090317326A1 (en) * | 2007-03-01 | 2009-12-24 | Ananth Srinivasan | Radiofluorination methods |
| GB201013808D0 (en) | 2010-08-18 | 2010-09-29 | Ge Healthcare Ltd | Peptide radiotracer compositions |
| WO2012094334A1 (en) * | 2011-01-04 | 2012-07-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | One-step 18f labeling of biological substrates and uses of 18f labeled biological substrates |
| JP2014526952A (ja) * | 2011-06-09 | 2014-10-09 | ジーイー・ヘルスケア・リミテッド | 蒸留装置及び方法 |
| ES2743433T3 (es) * | 2013-03-15 | 2020-02-19 | Cancer Targeted Tech Llc | Agentes para imágenes de pet dirigidos a psma marcados con 18F |
| GB201314936D0 (en) | 2013-08-21 | 2013-10-02 | Ge Healthcare Ltd | Radiolabelling method |
| GB201322456D0 (en) | 2013-12-18 | 2014-02-05 | Ge Healthcare Ltd | Radiotracer compositions and methods |
| US11518754B2 (en) | 2017-02-17 | 2022-12-06 | Yale University | Radiolabeled pharmaceuticals and methods of making and using same |
| IL271903B2 (en) | 2017-07-11 | 2025-04-01 | Synthorx Inc | Combination of unnatural nucleotides and methods therefor |
| SG11202000939PA (en) | 2017-08-03 | 2020-02-27 | Synthorx Inc | Cytokine conjugates for the treatment of proliferative and infectious diseases |
| US20210238124A1 (en) * | 2018-04-20 | 2021-08-05 | The General Hospital Corporation | Acetylated prodrugs for delivery across the blood-brain barrier |
| EP3923974A4 (en) | 2019-02-06 | 2023-02-08 | Synthorx, Inc. | IL-2 CONJUGATES AND METHODS OF USE THEREOF |
| CN113150065B (zh) * | 2021-03-11 | 2022-07-08 | 武汉英纳氏药业有限公司 | 一种合成肽及其应用 |
| WO2022246118A2 (en) * | 2021-05-20 | 2022-11-24 | The Regents Of The University Of California | Pet imaging tracers |
| KR20250164815A (ko) | 2023-03-31 | 2025-11-25 | 닛산 가가쿠 가부시키가이샤 | 피라졸 화합물 및 유해 생물 방제제 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5084555A (en) | 1989-08-21 | 1992-01-28 | The Administrators Of The Tulane Educational Fund | An octapeptide bombesin analog |
| JP2795449B2 (ja) * | 1987-09-24 | 1998-09-10 | ジ・アドミニストレーターズ・オブ・ザ・ツーレイン・エデュケイショナル・ファンド | 治療用ペプチド |
| US5723578A (en) * | 1987-09-24 | 1998-03-03 | The Administrators Of Tulane Educational Fund | Peptide analogs of bombesin |
| DE68928667T2 (de) * | 1988-10-14 | 1998-10-01 | Univ Tulane | Peptide als arzneimittel |
| JP2846463B2 (ja) * | 1989-06-02 | 1999-01-13 | ジョージタウン・ユニバーシティー | 抗ストレプトキナーゼ抗体の検出方法 |
| US6232071B1 (en) | 1990-06-11 | 2001-05-15 | Gilead Sciences, Inc. | Tenascin-C nucleic acid ligands |
| US5244883A (en) * | 1990-11-29 | 1993-09-14 | The Administrators Of The Tulane Educational Fund | Nonapeptide bombesin antagonists |
| TW432073B (en) * | 1995-12-28 | 2001-05-01 | Pfizer | Pyrazolopyridine compounds |
| AU2010299A (en) | 1997-12-24 | 1999-07-19 | Vertex Pharmaceuticals Incorporated | Prodrugs os aspartyl protease inhibitors |
| WO1999033795A1 (en) | 1997-12-24 | 1999-07-08 | Vertex Pharmaceuticals Incorporated | Prodrugs of aspartyl protease inhibitors |
| ID25551A (id) | 1997-12-24 | 2000-10-12 | Vertex Pharma | Bahan baku obat penghambat protease aspartil |
| US6436989B1 (en) | 1997-12-24 | 2002-08-20 | Vertex Pharmaceuticals, Incorporated | Prodrugs of aspartyl protease inhibitors |
| US6639076B1 (en) | 1998-08-18 | 2003-10-28 | Eli Lilly And Company | Growth hormone secretagogues |
| JP2003502314A (ja) | 1999-06-14 | 2003-01-21 | イーライ・リリー・アンド・カンパニー | 化合物 |
| WO2002044144A2 (en) * | 2000-11-30 | 2002-06-06 | Advanced Research And Technology Institute, Inc. | Nucleophilic approach for preparing radiolabeled imaging agents and associated compounds |
| GB0115927D0 (en) | 2001-06-29 | 2001-08-22 | Nycomed Amersham Plc | Solid-phase nucleophilic fluorination |
| GB0206750D0 (en) | 2002-03-22 | 2002-05-01 | Amersham Plc | Radiofluorination methods |
| ATE332307T1 (de) | 2002-04-09 | 2006-07-15 | Lilly Co Eli | Wachstumhormonsekretionsförderer |
| AU2003250899A1 (en) * | 2002-08-09 | 2004-03-11 | Astellas Pharma Europe B.V. | Compounds binding to p-selectin |
| US20080063599A1 (en) | 2002-11-18 | 2008-03-13 | Jorge Setoain Quinquer | Compounds Which Can Be Used To Diagnose And Monitor Diseases Associated With The Formation Of Amyloid Protein Fibrils |
| EP1597270A2 (en) | 2003-02-20 | 2005-11-23 | University of South Florida | Peptidomimetic inhibitors of stat3 activity and their medical uses |
| GB0305704D0 (en) | 2003-03-13 | 2003-04-16 | Amersham Plc | Radiofluorination methods |
| WO2006083424A2 (en) | 2004-12-28 | 2006-08-10 | The Trustees Of Columbia University In The City Of New York | Radiolabeled compounds and uses thereof |
| CN101583352A (zh) | 2005-07-29 | 2009-11-18 | 拜尔健康护理有限责任公司 | 治疗肥胖症的联苯氨基酸衍生物的制备和用途 |
| US20080029548A1 (en) | 2006-05-05 | 2008-02-07 | Ann De Wree | Fabric treatment dispensing package |
| US8557776B2 (en) | 2006-09-08 | 2013-10-15 | Bayer Pharma AG | Compounds and methods for 18F labeled agents |
-
2007
- 2007-09-07 US US11/851,910 patent/US8557776B2/en active Active
- 2007-09-07 JP JP2009527069A patent/JP5603074B2/ja active Active
- 2007-09-07 AU AU2007294124A patent/AU2007294124A1/en not_active Abandoned
- 2007-09-07 RU RU2009112716/15A patent/RU2009112716A/ru not_active Application Discontinuation
- 2007-09-07 EP EP16153790.7A patent/EP3056509A1/en not_active Ceased
- 2007-09-07 BR BRPI0716554-4A2A patent/BRPI0716554A2/pt not_active IP Right Cessation
- 2007-09-07 KR KR1020097007141A patent/KR20090058553A/ko not_active Ceased
- 2007-09-07 CA CA2858907A patent/CA2858907A1/en not_active Abandoned
- 2007-09-07 CA CA002662449A patent/CA2662449A1/en not_active Abandoned
- 2007-09-07 EP EP11193716.5A patent/EP2455105B1/en active Active
- 2007-09-07 MX MX2009002492A patent/MX2009002492A/es not_active Application Discontinuation
- 2007-09-07 EP EP10183062.8A patent/EP2279759A3/en not_active Withdrawn
- 2007-09-07 WO PCT/EP2007/008042 patent/WO2008028688A2/en not_active Ceased
- 2007-09-07 EP EP20100183074 patent/EP2289564A3/en not_active Withdrawn
- 2007-09-07 EP EP07802326.4A patent/EP2063918B1/en active Active
- 2007-09-10 AR ARP070103993A patent/AR062726A1/es unknown
- 2007-09-10 PE PE2007001212A patent/PE20080850A1/es not_active Application Discontinuation
- 2007-09-10 CL CL200702620A patent/CL2007002620A1/es unknown
- 2007-09-10 TW TW096133780A patent/TW200829277A/zh unknown
-
2009
- 2009-02-27 TN TN2009000063A patent/TN2009000063A1/fr unknown
- 2009-03-03 IL IL197363A patent/IL197363A0/en unknown
- 2009-03-05 CR CR10654A patent/CR10654A/es not_active Application Discontinuation
- 2009-03-06 CO CO09023386A patent/CO6150196A2/es unknown
- 2009-04-06 MA MA31764A patent/MA30780B1/fr unknown
- 2009-04-07 NO NO20091428A patent/NO20091428L/no not_active Application Discontinuation
-
2011
- 2011-02-03 IL IL211033A patent/IL211033A0/en unknown
- 2011-03-03 IL IL211526A patent/IL211526A0/en unknown
- 2011-03-03 IL IL211527A patent/IL211527A0/en unknown
-
2013
- 2013-08-16 JP JP2013169253A patent/JP5722966B2/ja active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR062726A1 (es) | Composiciones que comprenden compuestos marcados con 18f y metodos relacionados | |
| CO6220836A2 (es) | Compuestos activos biologicamnete marcados con fluoro-benzoilo 18f como agentes de diagnostico por imagenes asi como precursores de benzotriazol-1-iloxi-benzoilo2,5-dioxo-pirrolidin-1-iloxi-benzoilo y trimetilamonio benzoilo | |
| Kang et al. | Copper-catalyzed trifluoromethylthiolation of aryl and vinyl boronic acids with a shelf-stable electrophilic trifluoromethylthiolating reagent | |
| Wang et al. | Chloride ion-catalyzed generation of difluorocarbene for efficient preparation of gem-difluorinated cyclopropenes and cyclopropanes | |
| JP2012522873A5 (OSRAM) | ||
| AR073892A1 (es) | Proceso de preparacion de inhibidores de sglt | |
| HRP20191249T1 (hr) | Procesi za pripremu (s)-1-(3-etoksi-4metoksifenil)-2-metansulfoniletilamina | |
| BR102013003576A2 (pt) | Métodos de produzir compostos de sulfilimina | |
| RU2580915C2 (ru) | Пламегасящая композиция, содержащая органическую кислоту | |
| IL264541A (en) | History of sulfamolepyrolamide and their use as drugs for the treatment of jaundice b | |
| IL284528B2 (en) | Liquid concentrate fire retardant compositions containing mixtures of ammonium phosphates | |
| RU2015148006A (ru) | Дейтерированные нуклеозидные пролекарства, применимые для лечения hcv | |
| ME02295B (me) | Inhibitori neprilizina | |
| BR112012015748A2 (pt) | método para preparar uma composição antitranspirante líquida anidra | |
| AR074705A1 (es) | Procedimiento de preparacion de benzociclobutenos funcionalizados, intermediarios y aplicacion en la sintesis de la ivabradina y de sus sales de adicion a un acido farmaceuticamente aceptable | |
| AR049401A1 (es) | Aza-biciclononanos | |
| KR20040078078A (ko) | 강화액소화약제의 조성물 | |
| AR071592A1 (es) | Fenoxibenzamidas sustituidas | |
| AR087470A1 (es) | Derivados imidazolicos bifenilenicos y composiciones farmaceuticas que los contienen | |
| Nurminen et al. | Mechanisms of the substitution reactions of phosphoramidites and their congeners | |
| PE20090956A1 (es) | PROCESO PARA LA OBTENCION DE DERIVADOS DE PIRIDO [2,1-a] - ISOQUINOLINA | |
| RU2008153041A (ru) | Производные фторалкоксикомбретастатина, способы их производства и использования | |
| Liu et al. | Efficient synthesis of unsymmetrical S-(bromodifluoromethyl) diarylsulfonium salts for electrophilic bromodifluoromethylating reagents | |
| CN108478980A (zh) | 一种泡沫灭火剂 | |
| CN104844535A (zh) | 用于制备稠合杂环离子通道调节剂的方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |