AR061955A1 - Compuestos quimicos - Google Patents
Compuestos quimicosInfo
- Publication number
- AR061955A1 AR061955A1 ARP070103007A ARP070103007A AR061955A1 AR 061955 A1 AR061955 A1 AR 061955A1 AR P070103007 A ARP070103007 A AR P070103007A AR P070103007 A ARP070103007 A AR P070103007A AR 061955 A1 AR061955 A1 AR 061955A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- alkyl
- optionally
- alkenyl
- aryl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 6
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 229920006395 saturated elastomer Polymers 0.000 abstract 3
- 125000003107 substituted aryl group Chemical group 0.000 abstract 3
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000000027 (C1-C10) alkoxy group Chemical group 0.000 abstract 1
- 206010027654 Allergic conditions Diseases 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 208000029578 Muscle disease Diseases 0.000 abstract 1
- 208000021642 Muscular disease Diseases 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000001118 alkylidene group Chemical group 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 230000009610 hypersensitivity Effects 0.000 abstract 1
- 230000004968 inflammatory condition Effects 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 210000002460 smooth muscle Anatomy 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
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- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
- C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
- C07C217/22—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by carbon atoms having at least two bonds to oxygen atoms
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- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
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- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
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Abstract
Compuestos de la fórmula general (1), en donde R¹ y R² son seleccionados independientemente uno de otro desde hidrógeno, alquilo C₁₋₁₀ opcionalmente sustituido, -CO-(alquil C₁₋₁₀) opcionalmente sustituido, cicloalquil C₃₋₁₀ opcionalmente sustituido, -CO-(cicloalquil C₃₋₁₀) opcionalmente sustituido, alquenilo C₂₋₁₀ opcionalmente sustituido, -CO-(alquenil C₂₋₁₀) opcionalmente sustituido, arilo opcionalmente sustituido, -CO-arilo opcionalmente sustituido o R¹ y R² representando juntos un grupo alquilideno C₁₋₁₀ opcionalmente sustituido, saturado o no saturado o un grupo cicloalquilideno C₃₋₁₀ opcionalmente sustituido, saturado o no saturado o R¹ y R² juntos con el átomo de carbono al cual ellos son ligados representan un anillo orgánico saturado o no saturado que contiene 3, 4, 5, 6, 7 u 8 átomos de carbono y opcionalmente un anillo de 1, 2 ó 3 heteroátomos seleccionado desde O, N y S; R³ el cual puede ser el mismo como, o diferente de, ya sea de R¹ y R², seleccionado desde un alquilo C₁₋₁₀ opcionalmente sustituido, cicloalquilo C₃₋₁₀ opcionalmente sustituido, alquenilo C₂₋₁₀ opcionalmente sustituido y arilo opcionalmente sustituido; R⁴, R⁵ y R⁶ son seleccionados independientemente uno de otro desde hidrógeno, alquilo C₁₋₁₀ opcionalmente sustituido, OH, alcoxi C₁₋₁₀ opcionalmente sustituido, halo, ariloxi opcionalmente sustituido, (alquil C₁₋₁₀) opcionalmente sustituido-S(O)ₙ- donde n = 0, 1 ó 2, aril-S(O)ₙ-opcionalmente sustituido donde n = 0, 1 ó 2, o R⁴ y R⁵ representan juntos una cadena orgánica opcionalmente sustituida que contiene 1, 2, 3, 4, 5, 6 ó 7 átomos de carbono y opcionalmente cadena 1, 2 ó 3 heteroátomos seleccionados desde O, N y S, contemplando que la cadena es de a lo menos tres átomos de largo; con la provisión que cuando R¹ = R² = hidrógeno, luego cualquier alquilo C₁₋₁₀ opcionalmente sustituido o alquenil C₂₋₁₀ opcionalmente sustituido para R³, deben tener un punto de ramificación en una o más de las posiciones a y b contadas desde el grupo carbonilo (o forma tautómera de éstas) a las cuales es ligado R³; o una sal fisiológicamente aceptable, complejo o prodroga de estos; son descriptos per se y para el uso en el tratamiento o profilaxis de la hipersensibilidad, desordenes del músculo liso, condiciones espasmódicas condiciones alérgicas, condiciones inflamatorias y/o dolor.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0613518.0A GB0613518D0 (en) | 2006-07-06 | 2006-07-06 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
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AR061955A1 true AR061955A1 (es) | 2008-08-10 |
Family
ID=36926634
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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ARP070103007A AR061955A1 (es) | 2006-07-06 | 2007-07-05 | Compuestos quimicos |
Country Status (15)
Country | Link |
---|---|
US (1) | US7589123B2 (es) |
EP (1) | EP2046311A2 (es) |
JP (1) | JP5397903B2 (es) |
CN (1) | CN101511350A (es) |
AR (1) | AR061955A1 (es) |
AU (1) | AU2007270951B2 (es) |
CA (1) | CA2660182A1 (es) |
CL (1) | CL2007001976A1 (es) |
GB (2) | GB0613518D0 (es) |
HK (1) | HK1114600A1 (es) |
MX (1) | MX2009000283A (es) |
PE (1) | PE20080274A1 (es) |
TW (1) | TW200819122A (es) |
UY (1) | UY30468A1 (es) |
WO (1) | WO2008003978A2 (es) |
Families Citing this family (20)
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US8063050B2 (en) | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
PL2049500T3 (pl) | 2006-07-06 | 2012-02-29 | Array Biopharma Inc | Cyklopenta[d]pirymidyny jako inhibitory kinaz białkowych AKT |
ATE532789T1 (de) | 2006-07-06 | 2011-11-15 | Array Biopharma Inc | Dihydrothienopyrimidine als akt-proteinkinase- inhibitoren |
DE602007011628D1 (de) | 2006-07-06 | 2011-02-10 | Array Biopharma Inc | Dihydrofuropyrimidine als akt-proteinkinaseinhibitoren |
US9409886B2 (en) | 2007-07-05 | 2016-08-09 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
CN103396409B (zh) | 2007-07-05 | 2015-03-11 | 阵列生物制药公司 | 作为akt蛋白激酶抑制剂的嘧啶基环戊烷 |
US8377937B2 (en) | 2007-07-05 | 2013-02-19 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
US8846683B2 (en) | 2007-07-05 | 2014-09-30 | Array Biopharma, Inc. | Pyrimidyl cyclopentanes as Akt protein kinase inhibitors |
US8853216B2 (en) | 2008-01-09 | 2014-10-07 | Array Biopharma, Inc. | Hydroxylated pyrimidyl cyclopentane as AKT protein kinase inhibitor |
US8835434B2 (en) | 2008-01-09 | 2014-09-16 | Array Biopharma, Inc. | Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors |
CA2749575C (en) * | 2009-01-12 | 2016-05-03 | Versitech Limited | Compounds and uses thereof for treating inflammation and modulating immune responses |
BR112013025353A8 (pt) | 2011-04-01 | 2018-01-02 | Genentech Inc | combinação de a) um composto de fórmula ia, composto de fórmula ia ou um sal farmaceuticamente aceitável do mesmo, método para tratamento de um distúrbio hiperproliferativo em um mamífero, uso de um composto de fórmula ia ou um sal farmaceuticamente aceitável do mesmo, kit e produto |
JP6147246B2 (ja) | 2011-04-01 | 2017-06-14 | ジェネンテック, インコーポレイテッド | Akt及びmek阻害剤化合物の組み合わせ、及び使用方法 |
KR101369882B1 (ko) * | 2012-01-17 | 2014-03-26 | 한국화학연구원 | (4-하이드록시-3-메톡시페닐)부테논 유도체 또는 이의 약학적으로 허용가능한 염을 유효성분으로 함유하는 천식 예방 또는 치료용 약학적 조성물 |
US8754084B2 (en) | 2012-03-27 | 2014-06-17 | The Board Of Trustees Of The University Of Illinois | Therapeutic methods and agents for treating myotonic dystrophy |
WO2014087331A2 (en) * | 2012-12-06 | 2014-06-12 | Mahesh Kandula | Compositions and methods for the treatment of epilepsy and neurologic diseases |
US9376421B2 (en) | 2014-08-08 | 2016-06-28 | The Board Of Trustees Of The University Of Illinois | Compounds and methods for myotonic dystrophy therapy |
WO2018005732A1 (en) * | 2016-06-29 | 2018-01-04 | The General Hospital Corporation | Half-curcuminoids as amyloid-beta pet imaging agents |
WO2019040750A1 (en) | 2017-08-25 | 2019-02-28 | The Board Of Trustees Of The University Of Illinois | MULTIVALENT LIGAND FOR MYOTONIC DYSTROPHY |
CN115894241A (zh) * | 2022-10-17 | 2023-04-04 | 深圳凯联健康生物科技有限公司 | 咖啡活性酚、组合物及其在制备具有促进肠蠕动作用和/或缓解便秘作用的产品中的应用 |
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DE1133385B (de) * | 1960-04-14 | 1962-07-19 | Zyma Blaes A G Chem Fab | Verfahren zur Herstellung von 3-Pyrazyl-pyrazolderivaten |
US4649157A (en) * | 1986-03-28 | 1987-03-10 | G. D. Searle & Co. | Pharmaceutical compositions containing 5-phenyl-1,3-dioxoalkenyl compounds |
US4810716A (en) | 1986-04-11 | 1989-03-07 | Warner-Lambert Company | Diarylalkanoids having activity as lipoxygenase inhibitors |
DE68915750T2 (de) | 1988-03-02 | 1994-11-10 | Terumo Corp | Kathecholverbindungen, verfahren zur herstellung und arzneimittelzubereitung, die diese enthält. |
ZA941088B (en) | 1993-02-19 | 1995-09-27 | Symphar Sa | Substituted ketophosphonates the processes for their preparation and pharmaceutical compositions containing them |
JP3376016B2 (ja) | 1993-05-31 | 2003-02-10 | 塩野義製薬株式会社 | カルバペネムの合成中間体の製造方法 |
US6518315B1 (en) * | 1997-10-21 | 2003-02-11 | The University Of Sydney | Medicinal uses of phenylaikanols and derivatives |
JP2003306438A (ja) | 2002-02-18 | 2003-10-28 | Shiseido Co Ltd | ケモカイン発現阻害剤 |
KR20050034732A (ko) * | 2002-08-02 | 2005-04-14 | 아젠터 디스커버리 리미티드 | 히스톤 디아세틸라제 억제제로서의 치환된티에닐-히드록사믹산 |
EP1553075B1 (en) * | 2002-10-03 | 2013-08-14 | Ono Pharmaceutical Co., Ltd. | Lpa receptor antagonists |
WO2004037793A1 (ja) | 2002-10-24 | 2004-05-06 | Wakamoto Pharmaceutical Co., Ltd. | シクロオキシゲナーゼ及び5−リポキシゲナーゼを阻害するピラゾール−4−アルカン酸誘導体 |
GB0308318D0 (en) * | 2003-04-10 | 2003-05-14 | Merck Sharp & Dohme | Therapeutic agents |
-
2006
- 2006-07-06 GB GBGB0613518.0A patent/GB0613518D0/en not_active Ceased
-
2007
- 2007-07-05 AU AU2007270951A patent/AU2007270951B2/en not_active Expired - Fee Related
- 2007-07-05 AR ARP070103007A patent/AR061955A1/es unknown
- 2007-07-05 JP JP2009517431A patent/JP5397903B2/ja not_active Expired - Fee Related
- 2007-07-05 CN CNA2007800255371A patent/CN101511350A/zh active Pending
- 2007-07-05 EP EP07733478A patent/EP2046311A2/en not_active Withdrawn
- 2007-07-05 CL CL200701976A patent/CL2007001976A1/es unknown
- 2007-07-05 PE PE2007000872A patent/PE20080274A1/es not_active Application Discontinuation
- 2007-07-05 CA CA002660182A patent/CA2660182A1/en not_active Abandoned
- 2007-07-05 GB GB0713117A patent/GB2440034B/en not_active Expired - Fee Related
- 2007-07-05 MX MX2009000283A patent/MX2009000283A/es active IP Right Grant
- 2007-07-05 WO PCT/GB2007/002527 patent/WO2008003978A2/en active Application Filing
- 2007-07-05 TW TW096124462A patent/TW200819122A/zh unknown
- 2007-07-05 US US11/773,952 patent/US7589123B2/en not_active Expired - Fee Related
- 2007-07-06 UY UY30468A patent/UY30468A1/es not_active Application Discontinuation
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2008
- 2008-04-22 HK HK08104461.4A patent/HK1114600A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
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US20080045591A1 (en) | 2008-02-21 |
MX2009000283A (es) | 2009-01-26 |
HK1114600A1 (en) | 2008-11-07 |
WO2008003978A2 (en) | 2008-01-10 |
US7589123B2 (en) | 2009-09-15 |
AU2007270951A1 (en) | 2008-01-10 |
UY30468A1 (es) | 2008-05-31 |
TW200819122A (en) | 2008-05-01 |
CL2007001976A1 (es) | 2008-05-16 |
JP2009544577A (ja) | 2009-12-17 |
GB2440034B (en) | 2011-02-16 |
CN101511350A (zh) | 2009-08-19 |
JP5397903B2 (ja) | 2014-01-22 |
PE20080274A1 (es) | 2008-04-10 |
GB2440034A (en) | 2008-01-16 |
WO2008003978A3 (en) | 2008-12-31 |
EP2046311A2 (en) | 2009-04-15 |
AU2007270951B2 (en) | 2013-04-11 |
GB0713117D0 (en) | 2007-08-15 |
GB0613518D0 (en) | 2006-08-16 |
CA2660182A1 (en) | 2008-01-10 |
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