AR059905A1 - Pirrolidina-3-ilaminas n-substituidas como antagonistas del receptor histamina-3, composicion farmaceutica y proceso para preparar el compuesto - Google Patents
Pirrolidina-3-ilaminas n-substituidas como antagonistas del receptor histamina-3, composicion farmaceutica y proceso para preparar el compuestoInfo
- Publication number
- AR059905A1 AR059905A1 ARP070101063A ARP070101063A AR059905A1 AR 059905 A1 AR059905 A1 AR 059905A1 AR P070101063 A ARP070101063 A AR P070101063A AR P070101063 A ARP070101063 A AR P070101063A AR 059905 A1 AR059905 A1 AR 059905A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- group
- histamine
- compound
- independently
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000005557 antagonist Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 3
- 125000004429 atom Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- -1 cycloheteroalkyl Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78251306P | 2006-03-15 | 2006-03-15 | |
| US85907906P | 2006-11-15 | 2006-11-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR059905A1 true AR059905A1 (es) | 2008-05-07 |
Family
ID=38353957
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070101063A AR059905A1 (es) | 2006-03-15 | 2007-03-15 | Pirrolidina-3-ilaminas n-substituidas como antagonistas del receptor histamina-3, composicion farmaceutica y proceso para preparar el compuesto |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7820825B2 (enExample) |
| EP (1) | EP1994022A2 (enExample) |
| JP (1) | JP2009530274A (enExample) |
| AR (1) | AR059905A1 (enExample) |
| AU (1) | AU2007227681A1 (enExample) |
| BR (1) | BRPI0709612A2 (enExample) |
| CA (1) | CA2645731A1 (enExample) |
| MX (1) | MX2008011791A (enExample) |
| PE (1) | PE20071023A1 (enExample) |
| TW (1) | TW200800958A (enExample) |
| WO (1) | WO2007108936A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1972914A (zh) * | 2004-03-31 | 2007-05-30 | 詹森药业有限公司 | 作为组胺h3受体配合体的非咪唑杂环化合物 |
| AU2007227681A1 (en) | 2006-03-15 | 2007-09-27 | Wyeth | N-substituted-azacyclylamines as histamine-3 antagonists |
| JP2009537542A (ja) | 2006-05-19 | 2009-10-29 | ワイス | ヒスタミン−３アンタゴニストとしてのｎ−ベンゾイルピロリジン−３−イルアミンおよびｎ−ベンジルピロリジン−３−イルアミン |
| NZ573028A (en) * | 2006-05-30 | 2011-11-25 | Janssen Pharmaceutica Nv | Substituted pyridyl amide compounds as modulators of the histamine h3 receptor |
| WO2008002816A1 (en) * | 2006-06-29 | 2008-01-03 | Janssen Pharmaceutica N.V. | Substituted benzamide modulators of the histamine h3 receptor |
| PE20081152A1 (es) | 2006-10-06 | 2008-08-10 | Wyeth Corp | Azaciclilaminas n-sustituidas como antagonistas de histamina-3 |
| TW200823204A (en) * | 2006-10-17 | 2008-06-01 | Arena Pharm Inc | Biphenyl sulfonyl and phenyl-heteroaryl sulfonyl modulators of the histamine H3-receptor useful for the treatment of disorders related thereto |
| WO2008147945A1 (en) * | 2007-05-24 | 2008-12-04 | Wyeth | Azacyclylbenzamide derivatives as histamine-3 antagonists |
| CA2693138A1 (en) | 2007-07-16 | 2009-01-22 | Wyeth Llc | Aminoalkylazole derivatives as histamine-3 antagonists |
| WO2009067401A1 (en) * | 2007-11-20 | 2009-05-28 | Janssen Pharmaceutica N.V. | Cycloalkyloxy-and hetξrocycloalky- loxypyridine compounds as modulators of the histamine h3 receptor |
| WO2009067406A1 (en) * | 2007-11-20 | 2009-05-28 | Janssen Pharmaceutica N.V. | Substituted pyridyl amide compounds as modulators of the histamine h3 receptor |
| AR077223A1 (es) * | 2009-06-26 | 2011-08-10 | Sanofi Aventis | Sales de fumarato de un antagonista del receptor de histamina h3 |
| US8796247B2 (en) | 2011-01-25 | 2014-08-05 | Kissei Pharmaceutical Co., Ltd. | Indole derivative, and pharmacologically acceptable salt thereof |
| PE20150371A1 (es) | 2012-07-17 | 2015-03-27 | Glaxosmithkline Ip No 2 Ltd | Indolcarbonitrilos como moduladores selectivos del receptor de androgeno |
| CN107820494B (zh) | 2015-06-09 | 2020-10-16 | 艾伯维公司 | 核受体调节剂 |
| AU2019387370A1 (en) | 2018-11-30 | 2021-06-10 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1416872A (en) | 1972-03-10 | 1975-12-10 | Wyeth John & Brother Ltd | 4-aminoquinoline derivatives |
| US3933829A (en) * | 1974-08-22 | 1976-01-20 | John Wyeth & Brother Limited | 4-Aminoquinoline derivatives |
| US4159331A (en) * | 1978-05-05 | 1979-06-26 | The Upjohn Company | Antihypertensive 4-aminoquinolines |
| US4166853A (en) * | 1978-05-05 | 1979-09-04 | The Upjohn Company | Antihypertensive 7-trifluoromethyl-4-aminoquinolones |
| US5294631A (en) * | 1990-04-13 | 1994-03-15 | Smithkline Beecham Corporation | Substituted benzimidazoles useful as angiotension II receptor antagonists |
| ES2179071T3 (es) | 1993-04-07 | 2003-01-16 | Otsuka Pharma Co Ltd | Agentes vasodilatadores perifericos que comprenden como principio activo derivados de la piperidina 4-amino n-acilada. |
| IL117149A0 (en) * | 1995-02-23 | 1996-06-18 | Schering Corp | Muscarinic antagonists |
| US6034093A (en) * | 1995-06-07 | 2000-03-07 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Substituted sulfonic acid N-[(aminoiminomethyl)phenylalkyl]-azaheterocyclylamide compounds |
| JP2001523256A (ja) * | 1997-05-01 | 2001-11-20 | イーライ・リリー・アンド・カンパニー | 抗血栓物質 |
| US7375125B2 (en) * | 1999-08-04 | 2008-05-20 | Ore Pharmaceuticals, Inc. | Melanocortin-4 receptor binding compounds and methods of use thereof |
| US6699873B1 (en) * | 1999-08-04 | 2004-03-02 | Millennium Pharmaceuticals, Inc. | Melanocortin-4 receptor binding compounds and methods of use thereof |
| AU1734401A (en) | 1999-12-09 | 2001-06-18 | Mitsubishi Pharma Corporation | Carboxyamido derivatives |
| DE60138605D1 (de) | 2000-03-31 | 2009-06-18 | Ortho Mcneil Pharm Inc | Phenyl-substituierte indole als h3 histaminrezeptorantagonisten |
| EP1341768A1 (en) * | 2000-12-07 | 2003-09-10 | AstraZeneca AB | Therapeutic benzimidazole compounds |
| HN2002000156A (es) | 2001-07-06 | 2003-11-27 | Inc Agouron Pharmaceuticals | Derivados de benzamida tiazol y composiciones farmaceuticas para inhibir la proliferacion de celulas y metodos para su utilización. |
| ES2336094T3 (es) | 2002-03-29 | 2010-04-08 | Novartis Vaccines And Diagnostics, Inc. | Benzazoles sustituidos y uso de los mismos como inhibidores de quinasa raf. |
| PL383655A1 (pl) | 2003-03-14 | 2008-04-14 | Medigene Limited | Związki heterocykliczne regulujące układ odpornościowy |
| ATE454372T1 (de) * | 2004-04-01 | 2010-01-15 | Lilly Co Eli | Am histamin-h3-rezeptor wirksame mittel, herstellung und therapeutische anwendungen |
| RS52436B (sr) * | 2004-05-14 | 2013-02-28 | Millennium Pharmaceuticals Inc. | Jedinjenja i postupci za inhibiciju napredovanja mitoze putem inhibicije aurora kinaze |
| TW200602314A (en) | 2004-05-28 | 2006-01-16 | Tanabe Seiyaku Co | A novel pyrrolidine compound and a process for preparing the same |
| US20060014733A1 (en) * | 2004-07-19 | 2006-01-19 | Pfizer Inc | Histamine-3 agonists and antagonists |
| EP1786790B1 (en) | 2004-07-26 | 2009-06-03 | Eli Lilly And Company | Oxazole derivatives as histamine h3 receptor agents, preparation and therapeutic uses |
| ES2534605T3 (es) | 2004-08-23 | 2015-04-24 | Eli Lilly And Company | Agentes receptores de la histamina H3, preparación y usos terapéuticos |
| JP2008512346A (ja) * | 2004-09-09 | 2008-04-24 | アステラス製薬株式会社 | Ｖａｐ−１阻害活性を有するチアゾール誘導体 |
| UY29149A1 (es) | 2004-10-07 | 2006-05-31 | Boehringer Ingelheim Int | Tiazolil-dihidro-indazoles |
| US7381732B2 (en) * | 2004-10-26 | 2008-06-03 | Bristol-Myers Squibb Company | Pyrazolobenzamides and derivatives as factor Xa inhibitors |
| CA2595157A1 (en) * | 2005-01-21 | 2006-07-27 | Schering Corporation | Imidazole and benzimidazole derivatives useful as histamine h3 antagonists |
| US20070032475A1 (en) * | 2005-04-15 | 2007-02-08 | Ye Xiaocong M | Novel compounds useful for bradykinin B1 receptor antagonism |
| AU2007227681A1 (en) | 2006-03-15 | 2007-09-27 | Wyeth | N-substituted-azacyclylamines as histamine-3 antagonists |
| KR20090005003A (ko) | 2006-03-20 | 2009-01-12 | 글락소 그룹 리미티드 | Ａｍｐａ 수용체를 강화시키는 화합물 및 의약에서의 이의 용도 |
| US20070238718A1 (en) | 2006-04-06 | 2007-10-11 | Matthias Grauert | Thiazolyl-dihydro-indazole |
| JP2009537542A (ja) * | 2006-05-19 | 2009-10-29 | ワイス | ヒスタミン−３アンタゴニストとしてのｎ−ベンゾイルピロリジン−３−イルアミンおよびｎ−ベンジルピロリジン−３−イルアミン |
| PE20081152A1 (es) * | 2006-10-06 | 2008-08-10 | Wyeth Corp | Azaciclilaminas n-sustituidas como antagonistas de histamina-3 |
-
2007
- 2007-03-08 AU AU2007227681A patent/AU2007227681A1/en not_active Abandoned
- 2007-03-08 WO PCT/US2007/005776 patent/WO2007108936A2/en not_active Ceased
- 2007-03-08 EP EP07752471A patent/EP1994022A2/en not_active Withdrawn
- 2007-03-08 BR BRPI0709612-7A patent/BRPI0709612A2/pt not_active Application Discontinuation
- 2007-03-08 MX MX2008011791A patent/MX2008011791A/es unknown
- 2007-03-08 JP JP2009500385A patent/JP2009530274A/ja not_active Withdrawn
- 2007-03-08 CA CA002645731A patent/CA2645731A1/en not_active Abandoned
- 2007-03-13 PE PE2007000268A patent/PE20071023A1/es not_active Application Discontinuation
- 2007-03-13 TW TW096108558A patent/TW200800958A/zh unknown
- 2007-03-14 US US11/724,078 patent/US7820825B2/en not_active Expired - Fee Related
- 2007-03-15 AR ARP070101063A patent/AR059905A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2645731A1 (en) | 2007-09-27 |
| WO2007108936A3 (en) | 2007-11-01 |
| EP1994022A2 (en) | 2008-11-26 |
| MX2008011791A (es) | 2008-09-25 |
| US7820825B2 (en) | 2010-10-26 |
| JP2009530274A (ja) | 2009-08-27 |
| PE20071023A1 (es) | 2007-10-03 |
| WO2007108936A2 (en) | 2007-09-27 |
| AU2007227681A1 (en) | 2007-09-27 |
| TW200800958A (en) | 2008-01-01 |
| BRPI0709612A2 (pt) | 2011-07-19 |
| US20070219240A1 (en) | 2007-09-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |