AR058559A1 - Preparacion de gamma -aminoacidos que tienen afinidad por la proteina alfa-2-delta - Google Patents
Preparacion de gamma -aminoacidos que tienen afinidad por la proteina alfa-2-deltaInfo
- Publication number
- AR058559A1 AR058559A1 ARP060105615A ARP060105615A AR058559A1 AR 058559 A1 AR058559 A1 AR 058559A1 AR P060105615 A ARP060105615 A AR P060105615A AR P060105615 A ARP060105615 A AR P060105615A AR 058559 A1 AR058559 A1 AR 058559A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- formula
- arylalkyl
- compound
- cycloalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/32—Preparation of optical isomers by stereospecific synthesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/002—Nitriles (-CN)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/005—Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Reivindicacion 1: Un procedimiento para preparar un compuesto de formula (1) o una sal del mismo en la que R1 y R2 se seleccionan independientemente cada uno de H y alquilo C1-3, con la condicion de que R1 y R2 no sean ambos H; R3 se selecciona de alquilo C1-6, alquenilo C2-6, cicloalquilo C3-6, cicloalquilC3-6-alquilo C1-6, alcoxi C1-6, arilo, y arilalquilo C1-3, en los que cada resto arilo está opcionalmente sustituido con 1 a 3 sustituyentes independientemente seleccionados de alquilo C1- 3, alcoxi C1-3, amino, alquil C1-3-amino y halogeno, y en los que cada uno de los restos alquilo, alquenilo, cicloalquilo y alcoxi anteriormente citados está opcionalmente sustituido con uno a tres átomos de ; y R8 se selecciona de alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-7, cicloalquenilo C3-7, haloalquilo C1-6, haloalquenilo C2-6, haloalquinilo C2-6, arilalquilo C1-6, arilalquenilo C2-6, y arilalquinilo C2-6, y en los que cada uno de los restos arilo anteriormente citados puede estar opcionalmente sustituido con uno a tres sustituyentes independientemente seleccionados de alquilo C1-3, alcoxi C1-3, amino, alquil C1-3-amino y halogeno; y en el que dicho procedimiento comprende: (a) poner en contacto un compuesto de formula (2) on un enzima, en el que la enzima hidroliza diastereoselectivamente el compuesto de formula (2) al compuesto de formula (3) en las que R1, R2 y R3 son como se definen para el compuesto de formula (1); y R6 en la formula (2) se selecciona de alquilo C1-6, alquenilo C2-6, alquinilo C2-6 cicloalquilo C3-7, cicloalquenilo C3-7, haloalquilo C1-6, haloalquenilo C2-6, haloalquinilo C2-6, arilalquilo C1-6, arilalquenilo C2-6 y arilalquinilo C2-6, y en los que cada uno de los restos arilo anteriormente citados puede estar opcionalmente sustituidos con uno a tres sustituyentes independientemente seleccionados de alquilo C1-3, alcoxi C1-3, amino, alquil C1-3-amino y halogeno; y b) aislar el compuesto de formula (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75283905P | 2005-12-21 | 2005-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR058559A1 true AR058559A1 (es) | 2008-02-13 |
Family
ID=37903526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060105615A AR058559A1 (es) | 2005-12-21 | 2006-12-19 | Preparacion de gamma -aminoacidos que tienen afinidad por la proteina alfa-2-delta |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US20070141684A1 (es) |
| EP (2) | EP2017259A3 (es) |
| JP (1) | JP2009520492A (es) |
| KR (1) | KR20080068932A (es) |
| CN (1) | CN101341117A (es) |
| AP (1) | AP2008004485A0 (es) |
| AR (1) | AR058559A1 (es) |
| AU (1) | AU2006327872A1 (es) |
| BR (1) | BRPI0620467A2 (es) |
| CA (1) | CA2633358A1 (es) |
| CR (1) | CR10080A (es) |
| DO (1) | DOP2006000286A (es) |
| EA (1) | EA200801393A1 (es) |
| EC (1) | ECSP088551A (es) |
| GT (1) | GT200600524A (es) |
| IL (1) | IL191840A0 (es) |
| MA (1) | MA30139B1 (es) |
| ME (1) | ME00005B (es) |
| NL (1) | NL2000374C2 (es) |
| NO (1) | NO20082989L (es) |
| NZ (1) | NZ568971A (es) |
| PE (1) | PE20071169A1 (es) |
| RS (1) | RS20080279A (es) |
| TN (1) | TNSN08272A1 (es) |
| TW (1) | TW200736201A (es) |
| UY (1) | UY30031A1 (es) |
| WO (1) | WO2007072159A1 (es) |
| ZA (1) | ZA200804780B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2724828C (en) * | 2008-05-21 | 2016-01-12 | Sandoz Ag | Process for the stereoselective enzymatic hydrolysis of 5-methyl-3-nitromethyl-hexanoic acid ester |
| CN103003264B (zh) | 2010-05-21 | 2014-08-06 | 切米利亚股份公司 | 嘧啶衍生物 |
| FR2966734B1 (fr) * | 2010-10-29 | 2014-07-18 | Max Rombi | Composition comprenant au moins une enzyme proteolytique pour son utilisation pour empecher la synthese des triglycerides |
| EP2688883B1 (en) | 2011-03-24 | 2016-05-18 | Noviga Research AB | Pyrimidine derivatives |
| CN102249833B (zh) * | 2011-05-27 | 2013-12-11 | 中国科学院化学研究所 | 一种制备手性γ-氨基酸及其衍生物的方法 |
| WO2017155025A1 (ja) * | 2016-03-10 | 2017-09-14 | 第一三共株式会社 | 酵素による光学分割を用いた光学活性吉草酸誘導体の製造方法 |
| CN108192932B (zh) * | 2017-12-26 | 2020-09-29 | 上海皓元生物医药科技有限公司 | 一种手性醇的酶催化制备方法 |
| CN112877219A (zh) * | 2021-01-29 | 2021-06-01 | 江西科技师范大学 | 一种高浓度胆固醇培养基及其制备方法和应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| US5618710A (en) | 1990-08-03 | 1997-04-08 | Vertex Pharmaceuticals, Inc. | Crosslinked enzyme crystals |
| GB9518953D0 (en) | 1995-09-15 | 1995-11-15 | Pfizer Ltd | Pharmaceutical formulations |
| WO2000035296A1 (en) | 1996-11-27 | 2000-06-22 | Wm. Wrigley Jr. Company | Improved release of medicament active agents from a chewing gum coating |
| GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
| GEP20074142B (en) | 1999-06-10 | 2007-07-10 | Warner Lambert Co | Mono- and Disubstituted 3-Propyl Gamma-Aminobutyric Acids |
| US6642398B2 (en) * | 1999-06-10 | 2003-11-04 | Warner-Lambert Company | Mono-and disubstituted 3-propyl gamma-aminobutyric acids |
| JP2006513257A (ja) | 2002-12-13 | 2006-04-20 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 線維筋痛症および他の障害を処置するためのプレガバリン誘導体 |
| UA82292C2 (uk) * | 2004-04-14 | 2008-03-25 | Пфайзер Продактс Инк. | Спосіб стереоселективного біоперетворення аліфатичних динітрилів в ціанокарбонові кислоти (варіанти) |
-
2006
- 2006-12-08 US US11/636,304 patent/US20070141684A1/en not_active Abandoned
- 2006-12-11 AU AU2006327872A patent/AU2006327872A1/en not_active Abandoned
- 2006-12-11 CA CA002633358A patent/CA2633358A1/en not_active Abandoned
- 2006-12-11 EP EP08168440A patent/EP2017259A3/en not_active Withdrawn
- 2006-12-11 ME MEP-2008-7A patent/ME00005B/me unknown
- 2006-12-11 JP JP2008546670A patent/JP2009520492A/ja not_active Withdrawn
- 2006-12-11 BR BRPI0620467-8A patent/BRPI0620467A2/pt not_active IP Right Cessation
- 2006-12-11 NZ NZ568971A patent/NZ568971A/en unknown
- 2006-12-11 CN CNA200680048461XA patent/CN101341117A/zh active Pending
- 2006-12-11 EA EA200801393A patent/EA200801393A1/ru unknown
- 2006-12-11 KR KR1020087014805A patent/KR20080068932A/ko not_active Application Discontinuation
- 2006-12-11 WO PCT/IB2006/003656 patent/WO2007072159A1/en active Application Filing
- 2006-12-11 AP AP2008004485A patent/AP2008004485A0/xx unknown
- 2006-12-11 EP EP06831738A patent/EP1973867A1/en not_active Withdrawn
- 2006-12-11 RS RSP-2008/0279A patent/RS20080279A/sr unknown
- 2006-12-13 NL NL2000374A patent/NL2000374C2/nl not_active IP Right Cessation
- 2006-12-18 DO DO2006000286A patent/DOP2006000286A/es unknown
- 2006-12-19 AR ARP060105615A patent/AR058559A1/es not_active Application Discontinuation
- 2006-12-19 UY UY30031A patent/UY30031A1/es not_active Application Discontinuation
- 2006-12-20 GT GT200600524A patent/GT200600524A/es unknown
- 2006-12-20 TW TW095147978A patent/TW200736201A/zh unknown
- 2006-12-20 PE PE2006001658A patent/PE20071169A1/es not_active Application Discontinuation
-
2008
- 2008-05-29 IL IL191840A patent/IL191840A0/en unknown
- 2008-06-02 ZA ZA200804780A patent/ZA200804780B/xx unknown
- 2008-06-17 EC EC2008008551A patent/ECSP088551A/es unknown
- 2008-06-18 CR CR10080A patent/CR10080A/es not_active Application Discontinuation
- 2008-06-20 TN TNP2008000272A patent/TNSN08272A1/fr unknown
- 2008-06-20 MA MA31065A patent/MA30139B1/fr unknown
- 2008-07-02 NO NO20082989A patent/NO20082989L/no not_active Application Discontinuation
-
2009
- 2009-07-31 US US12/533,193 patent/US20090299093A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| RS20080279A (en) | 2009-07-15 |
| NO20082989L (no) | 2008-09-19 |
| MEP0708A (xx) | 2010-02-10 |
| NL2000374A1 (nl) | 2007-06-25 |
| CN101341117A (zh) | 2009-01-07 |
| EP2017259A2 (en) | 2009-01-21 |
| BRPI0620467A2 (pt) | 2011-11-16 |
| US20070141684A1 (en) | 2007-06-21 |
| TW200736201A (en) | 2007-10-01 |
| AU2006327872A1 (en) | 2007-06-28 |
| NL2000374C2 (nl) | 2010-02-09 |
| WO2007072159A1 (en) | 2007-06-28 |
| MA30139B1 (fr) | 2009-01-02 |
| IL191840A0 (en) | 2008-12-29 |
| CA2633358A1 (en) | 2007-06-28 |
| GT200600524A (es) | 2007-12-03 |
| KR20080068932A (ko) | 2008-07-24 |
| PE20071169A1 (es) | 2007-11-30 |
| AP2008004485A0 (en) | 2008-06-30 |
| EP2017259A3 (en) | 2011-04-13 |
| EA200801393A1 (ru) | 2009-12-30 |
| ME00005B (me) | 2010-06-10 |
| TNSN08272A1 (fr) | 2009-10-30 |
| UY30031A1 (es) | 2007-07-31 |
| CR10080A (es) | 2008-07-10 |
| WO2007072159B1 (en) | 2008-08-21 |
| DOP2006000286A (es) | 2007-07-31 |
| JP2009520492A (ja) | 2009-05-28 |
| ECSP088551A (es) | 2008-07-30 |
| ZA200804780B (en) | 2009-05-27 |
| EP1973867A1 (en) | 2008-10-01 |
| NZ568971A (en) | 2010-04-30 |
| US20090299093A1 (en) | 2009-12-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |