AR056459A1 - Derivados de 3-sulfonililindazol para el tratamiento de trastornos del snc afectados por el receptor 5-ht6 - Google Patents

Derivados de 3-sulfonililindazol para el tratamiento de trastornos del snc afectados por el receptor 5-ht6

Info

Publication number
AR056459A1
AR056459A1 ARP060103550A ARP060103550A AR056459A1 AR 056459 A1 AR056459 A1 AR 056459A1 AR P060103550 A ARP060103550 A AR P060103550A AR P060103550 A ARP060103550 A AR P060103550A AR 056459 A1 AR056459 A1 AR 056459A1
Authority
AR
Argentina
Prior art keywords
optionally substituted
aryl
heteroaryl group
alkyl
cycloalkyl
Prior art date
Application number
ARP060103550A
Other languages
English (en)
Inventor
Kevin Liu
Cristina Grosanu
Hassan Mahmoud Elokdah
Geraldine Ruth Mcfarlane
Jennifer Rebecca Lo
Albert J Robichaud
Alexander Alexei Greenfield
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR056459A1 publication Critical patent/AR056459A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Reivindicacion 1: Un compuesto de formula (1), caracterizado porque: X es O, S, NR, CH2, CO, CH2O, CH2S, CH2NR, CH2CO, CONR o NRCO; n es 0 o un entero entre 1, 2, 3, 4, 5, o 6; R es H o un grupo alquilo opcionalmente sustituido; R1 es H o un grupo alquilo, cicloalquilo, arilo o heteroarilo cada uno sustituido opcionalmente; R2 es un grupo alquilo, cicloalquilo, arilo o heteroarilo opcionalmente sustituido o un sistema de anillo bicíclico o tricíclico de 8- 13- miembros opcionalmente sustituido que tiene un átomo N en un cabezal de puente y opcionalmente contiene 1, 2 o 3 heteroátomos adicionales seleccionados entre N, O o S; R3 y R4 son cada uno independientemente H o un grupo alquilo opcionalmente sustituido; R5 es H, COR12 o un grupo alquilo, alquenilo, alquinilo, cicloalquilo, cicloheteroalquilo, arilo o heteroarilo cada uno opcionalmente sustituido; R6 es H o un grupo alquilo opcionalmente sustituido; p es 0 o un entero ente 1 o 2; R7 es halogeno, CN, OR8, CO2R9, CONR10R11, o un grupo alquilo, alquenilo, alquinilo, cicloalquilo, cicloheteroalquilo, arilo o heteroarilo cada uno opcionalmente sustituido; m es 0 o un entero entre 1, 2 o 3; R8 es H, COR12, o un grupo alquilo, alquenilo, alquinilo, arilo o heteroarilo cada uno opcionalmente sustituido; R9 es H o a un grupo alquilo C1-6, arilo o heteroarilo cada uno opcionalmente sustituido; R10 y R11 son cada uno independientemente cada uno H o un grupo alquilo opcionalmente sustituido; y R12 es un grupo alquilo C1-6, cicloalquilo, cicloheteroalquilo, arilo o heteroarilo opcionalmente sustituido; o un estereoisomero de ellos o una sal farmacéuticamente aceptables de ella.
ARP060103550A 2005-08-15 2006-08-14 Derivados de 3-sulfonililindazol para el tratamiento de trastornos del snc afectados por el receptor 5-ht6 AR056459A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70831705P 2005-08-15 2005-08-15

Publications (1)

Publication Number Publication Date
AR056459A1 true AR056459A1 (es) 2007-10-10

Family

ID=37315656

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060103550A AR056459A1 (es) 2005-08-15 2006-08-14 Derivados de 3-sulfonililindazol para el tratamiento de trastornos del snc afectados por el receptor 5-ht6

Country Status (21)

Country Link
US (1) US7790751B2 (es)
EP (1) EP1915348A1 (es)
JP (1) JP2009504738A (es)
KR (1) KR20080034497A (es)
CN (1) CN101291913A (es)
AR (1) AR056459A1 (es)
AU (1) AU2006291414A1 (es)
BR (1) BRPI0614341A2 (es)
CA (1) CA2619309A1 (es)
CR (1) CR9733A (es)
EC (1) ECSP088176A (es)
GT (1) GT200600374A (es)
IL (1) IL189416A0 (es)
MX (1) MX2008002158A (es)
NO (1) NO20080553L (es)
PE (1) PE20070373A1 (es)
RU (1) RU2008103700A (es)
SV (1) SV2008002653A (es)
TW (1) TW200800913A (es)
WO (1) WO2007032833A1 (es)
ZA (1) ZA200801524B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006280091A1 (en) * 2005-08-15 2007-02-22 Wyeth Substituted-3-sulfonylindazole derivatives as 5-hydroxytryptamine-6 ligands
JP2009543773A (ja) * 2006-07-14 2009-12-10 ランバクシー ラボラトリーズ リミテッド ＨＭＧ−ＣｏＡレダクターゼ阻害剤の多形体及びその使用
DE602007011962D1 (en) * 2006-11-09 2011-02-24 Hoffmann La Roche Arylsulfonylpyrrolidine als 5-ht6-inhibitoren
EP2158195A1 (en) 2007-05-15 2010-03-03 Wyeth LLC 5- (aminoazacyclyl) -3-sulfonyl-lh- indazoles as 5-hydroxytryptamine- 6 ligands for the treatment of cns disorders
US20090012308A1 (en) * 2007-06-13 2009-01-08 Wyeth Process for the manufacture of benzylsulfonylarenes
MX2011011182A (es) * 2009-04-23 2012-02-21 Abbott Lab Moduladores de los receptores 5-ht y metodos de uso de los mismos.
US8518933B2 (en) * 2009-04-23 2013-08-27 Abbvie Inc. Modulators of 5-HT receptors and methods of use thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU754734B2 (en) * 1997-11-04 2002-11-21 Pfizer Products Inc. Indazole bioisostere replacement of catechol in therapeutically active compounds
JP2003505369A (ja) * 1999-07-15 2003-02-12 エヌピーエス アレリックス コーポレーション 偏頭痛を治療するための複素環式化合物
DK1355904T3 (da) * 2000-12-22 2007-10-15 Wyeth Corp Heterocyclindazol- og -azaindazolforbindelser som 5-hydroxytryptamin-6-ligander
AR034588A1 (es) * 2001-04-20 2004-03-03 Wyeth Corp Derivados heterociclilalcoxi-, -alquiltio- y -alquilamino-benzazol como ligandos de 5-hidroxitriptamina-6, un proceso para su preparacion, intermediarios, composiciones farmaceuticas y el uso de dichos derivados para la manufactura de medicamentos
WO2002085892A1 (en) * 2001-04-20 2002-10-31 Wyeth Heterocyclyloxy-, -thioxy- and -aminobenzazole derivatives as 5-hydroxytryptamine-6 ligands
EP1403255A4 (en) 2001-06-12 2005-04-06 Sumitomo Pharma INHIBITORS OF RHO KINASE
US20050113283A1 (en) * 2002-01-18 2005-05-26 David Solow-Cordero Methods of treating conditions associated with an EDG-4 receptor
TW200400177A (en) * 2002-06-04 2004-01-01 Wyeth Corp 1-(Aminoalkyl)-3-sulfonylindole and-indazole derivatives as 5-hydroxytryptamine-6 ligands
JP4754821B2 (ja) * 2002-06-20 2011-08-24 プロキシマゲン・リミテッド 肥満症、ｉｉ型糖尿病およびｃｎｓ障害の治療に有用な新規化合物
TW200401641A (en) * 2002-07-18 2004-02-01 Wyeth Corp 1-Heterocyclylalkyl-3-sulfonylindole or-indazole derivatives as 5-hydroxytryptamine-6 ligands
TW200412945A (en) * 2002-10-25 2004-08-01 Upjohn Co Quaternary ammonium compounds
WO2004074243A2 (en) * 2003-02-14 2004-09-02 Wyeth Heterocyclyl-3-sulfonylindazoles as 5-hydroxytryptamine-6 ligands
EP1747202A1 (en) * 2004-02-27 2007-01-31 F.Hoffmann-La Roche Ag Indazole derivatives and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
TW200800913A (en) 2008-01-01
GT200600374A (es) 2007-03-29
BRPI0614341A2 (pt) 2011-03-29
CA2619309A1 (en) 2007-03-22
AU2006291414A1 (en) 2007-03-22
CN101291913A (zh) 2008-10-22
KR20080034497A (ko) 2008-04-21
JP2009504738A (ja) 2009-02-05
PE20070373A1 (es) 2007-04-04
US7790751B2 (en) 2010-09-07
ECSP088176A (es) 2008-04-28
SV2008002653A (es) 2008-04-11
RU2008103700A (ru) 2009-09-27
ZA200801524B (en) 2010-04-28
CR9733A (es) 2008-04-02
WO2007032833A1 (en) 2007-03-22
NO20080553L (no) 2008-04-23
IL189416A0 (en) 2008-06-05
MX2008002158A (es) 2008-04-19
US20070054896A1 (en) 2007-03-08
EP1915348A1 (en) 2008-04-30

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