AR056042A1 - Inhibidores de la map quinasa p38 y metodos para utilizarla - Google Patents

Inhibidores de la map quinasa p38 y metodos para utilizarla

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Publication number
AR056042A1
AR056042A1 ARP060103657A ARP060103657A AR056042A1 AR 056042 A1 AR056042 A1 AR 056042A1 AR P060103657 A ARP060103657 A AR P060103657A AR P060103657 A ARP060103657 A AR P060103657A AR 056042 A1 AR056042 A1 AR 056042A1
Authority
AR
Argentina
Prior art keywords
alkyl
hydrogen
heteroalkyl
heterocyclyl
aryl
Prior art date
Application number
ARP060103657A
Other languages
English (en)
Inventor
Nidhi Arora
Humberto Bartolome Arzeno
Roland Joseph Billedeau
Nolan James Dewdney
Kieran Durkin
Kurt D Gabrielson
Kristen Lynn Mccaleb
Michael Soth
Dennis Mitsugu Yasuda
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37651018&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR056042(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR056042A1 publication Critical patent/AR056042A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
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    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
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    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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Abstract

Reivindicacion 1: Un compuesto con las formulas (1) o (2), o una sal farmacéuticamente aceptable del mismo, en el que: R1 es arilo or heteroarilo; R2 es -NRiRa, -NRiSO2Ra, -NRiC(=O)Ra, alquilsulfonamidilC1-6-alquiloC1-6, alcoxicarbonilaminoC1-6- alquiloC1-6, alquilo C3-6 lineal, alquenilo Cl 6, cicloalquilC3-7-alquiloC1-4, cicloalquenilo C3-7, cicloalquenilC3-7-alquiloC1-4, halo-alquiloC1-6, halocicloalquilo C3-7, hidroxialquilo C1-6, alquilsulfonilC1-6-alquiloC1-6, alquilsulfanilC1-6- alquiloC1-6, arilalquilo C1-6 o heteroarilalquilo C1-6; en el que: Ra es hidrogeno, alquilo C1-6, cicloalquilo C3-7, cicloalquilC3-7-alquiloC1-4, cicloalquenilo C3-7, cicloalquenilC3-7-alquiloC1-4, haloalquilo C1-6, halocicloalquilo C3-7, hidroxialquilo C1-6, alquilosulfonilC1-6-alquiloC1-6, alquilsulfanilC1-6-alquiloC1-6, arilsulfonilalquilo C1-6, arilo, arilalquilo C1-6, arilalquiloxi C1-6, heteroarilo, heteroarilalquilo C1-6, alquilsulfonamidilC1-6-alquiloC1-6, alcoxicarbonilaminoC1-6-alquiloC1-6, alcoxicarbonilC1-6-alquiloC1-6, alcoxiaminocarbonilC1-6-alquiloC1-6, aminocarbonilalquilo C1-6, alquilaminocarnonilC1-6-alquiloC1-6, carboxialquilo C1-6, heterociclilo, heterociclilalquilo, alquilcarbonilC1-6- alquiloC1-6, heterociclilalquilo C1-6, aminoalquilo C1-6, N-alquilaminoC1-6-alquiloC1-6, N,N-dialquilaminoC1-6-alquiloC1-6, alcoxiC1-6-alquiloC1-6, o heteroarilalquilo C1-6, y Ri es hidrogeno, hidroxi, o alquilo; R3 es hidrogeno o alquilo C1-6; R4 es hidrogeno, alquilo C1-6, hidroxi, amino, heteroalquilo C1-6, heteroalcoxi C1-6, heteroalquilamino C1-6, heterociclilo, heterociclilalquilo C1-6, hidroxicicloalquilo C3-6, cicloalquilC3-6-alquiloC1-6, alquilsulfonilo C1-6, alquilsulfonamido C1-6, arilo, heteroarilo, ariloalquilo C1-6, heteroarilalquilo C1-6, alcoxi C1-6, heteroarilalcoxi C1-6, -(CHRb)r-C(=O)-Rc, -(CHRb)r-O-C(=O)Rc, -(CHRb)r-NH-C(=O)Rc o -SO2-Rc; en el que: Rb es hidrogeno, alquilo C1-6 o heteroalquilo C1-6; Rc es alquilo C1- 6, hidroxi, amino, heteroalquilo C1-6, arilo, arilalquilo C1-6, heteroarilo, o heterociclilo; r es de 0 a 4; X y Y son nitrogeno, o uno de X y Y es nitrogeno y el es CRd; en el que: Rd es hidrogeno, alquilo C1-6, hidroxi, alcoxi C1-6, amino, haloalquilo C1-6, ciano, halo, heteroalquilo C1-6, C(=O)Re o -SO2-Re; en el que Re es hidrogeno o alquilo; W es un enlace, O, S(O)m, CH2 o NRf; en el que: m es de 0 a 2, y Rf es hidrogeno, alquilo C1-6, heteroalquilo C1-6, heterociclilo, hidroxicicloalquilo C3-6, -C(=O)-Rg o -SO2-Rg, en el que Rg es alquilo C1-6, arilo, arilalquilo C1-6, heteroarilo, heteroalquilo C1-6 o heterociclilo; o R4 y Rf junto con los átomos a los que están unidos pueden formar un anillo heterocíclico; A es O, CH2, S(O)n, C(=O), NRh, o CH(ORh), en el que: n es de 0 a 2; y Rh es hidrogeno o alquilo C1-6.
ARP060103657A 2005-08-25 2006-08-23 Inhibidores de la map quinasa p38 y metodos para utilizarla AR056042A1 (es)

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US71200905P 2005-08-25 2005-08-25

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US (1) US7601726B2 (es)
EP (1) EP1919913A2 (es)
JP (1) JP2009506006A (es)
KR (1) KR101011957B1 (es)
CN (1) CN101243090A (es)
AR (1) AR056042A1 (es)
AU (1) AU2006283940A1 (es)
BR (1) BRPI0614884A2 (es)
CA (1) CA2620254A1 (es)
IL (1) IL189264A0 (es)
MX (1) MX2008002385A (es)
NO (1) NO20080675L (es)
RU (1) RU2008110941A (es)
TW (1) TW200740815A (es)
WO (1) WO2007023110A2 (es)
ZA (1) ZA200801441B (es)

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US7601726B2 (en) 2009-10-13
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