AR053683A1 - Derivados de piperidina con actividad antibacteriana - Google Patents
Derivados de piperidina con actividad antibacterianaInfo
- Publication number
- AR053683A1 AR053683A1 ARP060100590A ARP060100590A AR053683A1 AR 053683 A1 AR053683 A1 AR 053683A1 AR P060100590 A ARP060100590 A AR P060100590A AR P060100590 A ARP060100590 A AR P060100590A AR 053683 A1 AR053683 A1 AR 053683A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- carbamoyl
- halo
- alkoxy
- alkanoyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Abstract
Compuestos de formula (1) y sus sales aceptables para uso farmacéutico. Procesos para su preparacion, composiciones farmacéuticas que los contienen, su uso como medicamentos y su uso en el tratamiento de infecciones bacterianas. Reivindicacion 1: Un compuesto caracterizado porque responde a la formula (1), en donde: R1 se selecciona entre hidrogeno, nitro, hidroxi, halo, ciano, alquilo C1-4, alcoxi C1-4, alquenilo C2-4, alquinilo C2-4, alcanoilo C1-4, alquilC1-4S(O)a, en donde a es entre 0 y 2 y cicloalquilo C3-6; en donde R1 puede estar opcionalmente sustituido sobre carbono por uno o más halo o ciclopropilo; R2 se selecciona entre hidrogeno, nitro, hidroxi, halo, ciano, alquilo C1-4, alcoxi C1-4, alquenilo C2-4, alquinilo C2-4, alcanoilo C1-4, alquilC1-4S(O)a, en donde a es entre 0 y 2 y cicloalquilo C3-6; en donde R2 puede estar opcionalmente sustituido sobre carbono por uno o más halo o cicloalquilo C3-6; R3 se selecciona entre hidrogeno, nitro, hidroxi, halo, ciano, - C=N-OR', en donde R' es H o alquilo C1-4, alquilo C1-4, alcoxi C1-4, alquenilo C2-4, alquinilo C2-4, alcanoilo C1-4, alquilC1-4S(O)a, en donde a es entre 0 y 2 y cicloalquilo C3-6; en donde R3 puede estar opcionalmente sustituido sobre carbono por uno o más halo o cicloalquilo C3-6; W es -O-, -N(R6)- o -C(R7)(R8)-; X es un enlace directo, -CH2-, -C(O)- o -S(O)q- (en donde q es 1 o 2); el anillo A es carbociclilo o heterociclilo; en donde si dicho heterociclilo contiene una porcion -NH- dicho nitrogeno puede estar opcionalmente sustituido por un grupo seleccionado entre R9; R4 y R5 son sustituyentes sobre carbono y se seleccionan en forma independiente entre halo, nitro, ciano, hidroxi, trifluorometoxi, amino, carboxi, carbamoilo, mercapto, sulfamoilo, sulfo, formilo, ureido, hidroxiiminometilo, alcoxiiminometilo C1-4, N-hidroxiformanido, hidrazino C1-4, hidrazinocarbonilo, N-hidroxiethanimidoilo, amino(hidroxiimino)metilo, alquilo C1-4, alquenilo C2-4, alquinilo C2-4, alcoxi C1-4, alcanoilo C1-4, alcanoiloxi C1-4, N-(alquilC1-4)amino, N,N-(alquilC1-4)2amino, alcanoilamino C1-4, N-(alquilC1-4)carbamoilo, N,N-(alquilC1-4) 2carbamoilo, N-(alcoxiC1-4)carbamoilo, N'-(alquilC1-4)ureido, N',N'-(alquilC1-4)2ureido, N-(alquilC1- 4)-N-(alcoxiC1-4)carbamoilo, alquilC1-4S(O)a en donde a es entre 0 y 2, alcoxicarbonilo C1-4, alcoxicarbonilamino C1-4, N-(alquilC1-4)sulfamoilo, N,N-(alquilC1-4) 2sulfamoilo, alquilsulfonilamino C1-4, alquilsulfonilaminocarbonilo C1-4, N'-(alquilC1- 4)hidrazinocarbonilo, N',N'-(alquilC1-4) 2hidrazinocarbonilo, carbociclil-R10- o heterociclil-R11-; en donde R4 y R5 en forma independiente entre sí pueden estar opcionalmente sustituidos sobre carbono por uno o más R12; y donde si dicho heterociclilo contiene una porcion -NH- dicho nitrogeno puede estar opcionalmente sustituido por un grupo seleccionado entre R13; R6 R7 y R8 se seleccionan en forma independiente entre hidrogeno o C1-4 alquilo; n es 1-4; en donde los valores de R4 pueden ser iguales o diferentes; m es 0-4; en donde los valores de R5 pueden ser iguales o diferentes; R12 se selecciona entre azido, halo, nitro, ciano, hidroxi, trifluorometoxi, amino, carboxi, carbamoilo, mercapto, sulfamoilo, alquilo C1-4, alquenilo C2-4, alquinilo C2-4, alcoxi C1-4, alcanoilo C1-4, alcanoiloxi C1-4, N-(alquilC1-4)amino, N,N-(alquilC1-4)2amino, alcanoilamino C1-4, N-(alquilC1-4)carbamoilo, N,N-(alquilC1-4)2carbamoilo, alquilC1-4S(O)a, en donde a es entre 0 y 2, alcoxicarboniloC1-4, N-(alquilC1-4)sulfamoilo, N,N-(alquilC1-4)2sulfamoilo, alquilsulfonilamino C1-4, alcoxicarbonilamino C1-4, carbociclil-R14- o heterociclil-R15-; en donde R12 en forma independiente entre sí pueden estar opcionalmente sustituidos sobre carbono por uno o más R16; y en donde si dicho heterociclilo contiene una porcion -NH- dicho nitrogeno puede estar opcionalmente sustituido por un grupo seleccionado entre R17; R9, R13 y R17 se seleccionan en forma independiente entre alquilo C1-4, alcanoilo C1-4, alquilsulfonilo C1-4, alcoxicarbonilo C1-4, carbamoilo, N-(alquilC1-4)carbamoilo, N,N-(alquilC1-4)carbamoilo, bencilo, benciloxicarbonilo, benzoílo y fenilsulfonilo; R10, R11, R14 y R15 se seleccionan en forma independiente entre un enlace directo, -O-, -N(R18)-, -C(O)-, - N(R19)C(O)-, -C(O)N(R20)-, -S(O)p-, -SO2N(R21)- o -N(R22)SO2-; en donde R18, R19, R20, R21 y R22 se seleccionan en forma independiente entre hidrogeno o alquilo C1-4 y p es 0-2; R16 se selecciona entre halo, nitro, ciano, hidroxi, trifluorometoxi, trifluorometilo, amino, carboxi, carbamoilo, mercapto, sulfamoilo, metilo, etilo, etenilo, etinilo, metoxi, etoxi, acetilo, acetoxi, metilamino, etilamino, dimetilamino, dietilamino, N-metil-N- etilamino; acetilamino, N-metilcarbamoilo, N-etilcarbamoilo, N,N-dimetilcarbamoilo, N,N- dietilcarbamoilo, N-metil-N-etilcarbamoilo, metiltio, etiltio, metilsulfinilo, etilsulfinilo, mesilo, etilsulfonilo, metoxicarbonilo, etoxicarbonilo, N- metilsulfamoilo, N-etilsulfamoilo, N,N-dimetilsulfamoilo, N,N-dietilsulfalmoilo o N-metil-N-etilsulfamoilo; o una de sus sales aceptables para uso farmacéutico.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65467005P | 2005-02-18 | 2005-02-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR053683A1 true AR053683A1 (es) | 2007-05-16 |
Family
ID=36218455
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP060100590A AR053683A1 (es) | 2005-02-18 | 2006-02-17 | Derivados de piperidina con actividad antibacteriana |
Country Status (22)
Country | Link |
---|---|
US (2) | US8399489B2 (es) |
EP (1) | EP1853586B1 (es) |
JP (4) | JP4058106B2 (es) |
KR (2) | KR101422432B1 (es) |
CN (1) | CN101163693B (es) |
AR (1) | AR053683A1 (es) |
AU (1) | AU2006215399B2 (es) |
BR (1) | BRPI0607756A2 (es) |
CA (1) | CA2598423C (es) |
ES (1) | ES2430569T3 (es) |
HK (1) | HK1114376A1 (es) |
IL (1) | IL185306A (es) |
MX (1) | MX2007010072A (es) |
NO (1) | NO20074703L (es) |
NZ (1) | NZ561613A (es) |
RU (1) | RU2424240C2 (es) |
SA (1) | SA06270020B1 (es) |
TW (1) | TWI402263B (es) |
UA (1) | UA94901C2 (es) |
UY (1) | UY29384A1 (es) |
WO (1) | WO2006087543A1 (es) |
ZA (1) | ZA200706920B (es) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200526626A (en) | 2003-09-13 | 2005-08-16 | Astrazeneca Ab | Chemical compounds |
US8399489B2 (en) * | 2005-02-18 | 2013-03-19 | Astrazeneca Ab | Antibacterial piperdine derivatives |
EP1861396A1 (en) * | 2005-03-04 | 2007-12-05 | AstraZeneca AB | Tricyclic derivatives of azetidine and pyrrole with antibacterial activity |
MY150958A (en) | 2005-06-16 | 2014-03-31 | Astrazeneca Ab | Compounds for the treatment of multi-drug resistant bacterial infections |
WO2008020229A2 (en) * | 2006-08-17 | 2008-02-21 | Astrazeneca Ab | Antibacterial pyrrolecarboxamides |
WO2008020227A2 (en) * | 2006-08-17 | 2008-02-21 | Astrazeneca Ab | Antibacterial pyrrolecarboxamides |
TW200819437A (en) * | 2006-08-17 | 2008-05-01 | Astrazeneca Ab | Chemical compounds |
WO2008084861A1 (ja) | 2007-01-12 | 2008-07-17 | Astellas Pharma Inc. | 縮合ピリジン化合物 |
TW200906412A (en) * | 2007-06-12 | 2009-02-16 | Astrazeneca Ab | Piperidine compounds and uses thereof |
AU2008341953B2 (en) * | 2007-12-26 | 2013-05-02 | Msd K.K. | Sulfonyl substituted 6-membered ring derivative |
TWI498115B (zh) * | 2007-12-27 | 2015-09-01 | Daiichi Sankyo Co Ltd | 咪唑羰基化合物 |
US20120108565A1 (en) * | 2008-07-30 | 2012-05-03 | Lalima Sharma | Pyrrole carboxylic acid derivatives as antibacterial agents |
US8841305B2 (en) * | 2008-10-09 | 2014-09-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Activators of the human pyruvate kinase M2 receptor |
TW201026694A (en) * | 2008-12-12 | 2010-07-16 | Astrazeneca Ab | Compound 468 |
US8071605B2 (en) | 2008-12-12 | 2011-12-06 | Astrazeneca Ab | Piperidine compounds for use in the treatment of bacterial infections |
WO2010075257A1 (en) * | 2008-12-22 | 2010-07-01 | Chemocentryx, Inc. | C5ar antagonists |
WO2010118063A2 (en) | 2009-04-06 | 2010-10-14 | Agios Pharmaceuticals, Inc. | Therapeutic compositions and related methods of use |
PL2427441T3 (pl) | 2009-05-04 | 2017-06-30 | Agios Pharmaceuticals, Inc. | Aktywatory PKM2 do stosowania w leczeniu raka |
TW201102065A (en) | 2009-05-29 | 2011-01-16 | Astrazeneca Ab | Heterocyclic urea derivatives and methods of use thereof |
PL2448581T3 (pl) | 2009-06-29 | 2017-06-30 | Agios Pharmaceuticals, Inc. | Kompozycje terapeutyczne i odnośne sposoby ich stosowania |
ES2632954T3 (es) | 2009-06-29 | 2017-09-18 | Agios Pharmaceuticals, Inc. | Derivados de quinolina-8-sulfonamida que tienen una actividad anticancerosa |
TW201111380A (en) | 2009-08-26 | 2011-04-01 | Astrazeneca Ab | Heterocyclic urea derivatives and methods of use thereof |
CA2797694A1 (en) | 2010-04-29 | 2011-11-03 | The United States Of America, As Represented By The Secretary, Departmen T Of Health And Human Services | Activators of human pyruvate kinase |
PL2585064T3 (pl) | 2010-06-24 | 2017-09-29 | Chemocentryx, Inc. | Antagoniści C5AR |
US20130296363A1 (en) | 2010-09-01 | 2013-11-07 | Ambit Biosciences Corporation | Quinoline and isoquinoline derivatives for use as jak modulators |
EP2651898B1 (en) | 2010-12-17 | 2015-12-09 | Agios Pharmaceuticals, Inc. | Novel n-(4-(azetidine-1-carbonyl)phenyl)-(hetero-)arylsulfonamide derivatives as pyruvate kinase m2 (pmk2) modulators |
MX336022B (es) | 2010-12-21 | 2016-01-06 | Agios Pharmaceuticals Inc | Activadores de pkm2 bicíclicos. |
TWI549947B (zh) | 2010-12-29 | 2016-09-21 | 阿吉歐斯製藥公司 | 治療化合物及組成物 |
EP2511263A1 (en) | 2011-04-14 | 2012-10-17 | Phenex Pharmaceuticals AG | Pyrrolo sulfonamide compounds for modulation of orphan nuclear receptor RAR-related orphan receptor-gamma (RORgamma, NR1F3) activity and for the treatment of chronic inflammatory and autoimmune diseases |
CN103476823A (zh) | 2011-04-18 | 2013-12-25 | 默克专利股份有限公司 | 共轭聚合物 |
SG194697A1 (en) | 2011-05-03 | 2013-12-30 | Agios Pharmaceuticals Inc | Pyruvate kinase activators for use in therapy |
WO2013084241A1 (en) * | 2011-12-09 | 2013-06-13 | Cadila Healthcare Limited | Compounds as inhibitors of renin |
CN104093715B (zh) * | 2012-02-02 | 2017-04-26 | 埃科特莱茵药品有限公司 | 4‑(苯并咪唑‑2‑基)‑噻唑化合物及相关氮杂衍生物 |
WO2015011099A1 (en) * | 2013-07-22 | 2015-01-29 | Actelion Pharmaceuticals Ltd | 1-(piperazin-1-yl)-2-([1,2,4]triazol-1-yl)-ethanone derivatives |
PL3670522T3 (pl) | 2014-07-24 | 2022-02-21 | W.R. Grace & Co. - Conn. | Krystaliczna postać chlorku rybozydu nikotynamidu |
CN113121415A (zh) | 2014-09-29 | 2021-07-16 | 凯莫森特里克斯股份有限公司 | 制备C5aR拮抗剂的方法和中间体 |
KR102629310B1 (ko) | 2015-03-09 | 2024-01-24 | 더블유.알. 그레이스 앤드 캄파니-콘. | 니코틴아미드 리보사이드의 결정 형태 |
US11234976B2 (en) | 2015-06-11 | 2022-02-01 | Agios Pharmaceuticals, Inc. | Methods of using pyruvate kinase activators |
CN105067814A (zh) * | 2015-07-24 | 2015-11-18 | 中国科学院成都生物研究所 | 解旋酶水解atp活性测定方法 |
MY184406A (en) | 2015-09-30 | 2021-04-01 | Daiichi Sankyo Co Ltd | Hydroxyalkyl thiadiazole derivatives |
BR112018014222A2 (pt) | 2016-01-14 | 2018-12-11 | Chemocentryx, Inc. | método de tratamento da glomerulopatia c3 |
PT3490986T (pt) | 2016-07-28 | 2022-02-01 | Idorsia Pharmaceuticals Ltd | Moduladores do recetor de piperidina cxcr7 |
WO2018169092A1 (en) | 2017-03-14 | 2018-09-20 | Daiichi Sankyo Company, Limited | N-phosphonoxymethyl prodrugs of hydroxyalkyl thiadiazole derivatives |
US20210070747A1 (en) | 2017-03-24 | 2021-03-11 | Taisho Pharmaceutical Co., Ltd. | 2(1h)-quinolinone derivative |
WO2019126482A1 (en) | 2017-12-22 | 2019-06-27 | Elysium Health, Inc. | Crystalline forms of nicotinamide riboside chloride |
CN111683945B (zh) | 2018-01-26 | 2023-11-10 | 爱杜西亚药品有限公司 | Cxcr7受体拮抗剂的结晶型 |
WO2020048949A1 (en) | 2018-09-03 | 2020-03-12 | Univerza V Ljubljani | New class of dna gyrase and/or topoisomerase iv inhibitors with activity against gram-positive and gram-negative bacteria |
EP4263503A1 (en) | 2020-12-17 | 2023-10-25 | Univerza V Ljubljani | New n-phenylpyrrolamide inhibitors of dna gyrase and topoisomerase iv with antibacterial activity |
CN115466246B (zh) * | 2021-06-11 | 2024-02-06 | 中国医学科学院药物研究所 | 吡咯酰哌啶胺类化合物及其用途 |
CN115612309B (zh) * | 2022-10-14 | 2023-07-21 | 浙江博澳新材料股份有限公司 | 一种双杂环双酯基偶氮分散染料及其制备方法 |
Family Cites Families (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL23847A (en) | 1964-08-07 | 1969-02-27 | Merck & Co Inc | Benzimidazoles useful as antifungals |
US3963480A (en) | 1973-04-11 | 1976-06-15 | Sterling Drug Inc. | Herbicidal pyrrole-2-carboxamides |
US4046775A (en) | 1973-04-11 | 1977-09-06 | Sterling Drug Inc. | 4,5-Dihalopyrrole-2-carboxamides |
US4912109A (en) | 1987-02-02 | 1990-03-27 | Boc, Inc. | N-heterocyclic-N-(4-piperidinyl) amides and pharmaceutical compositions and methods employing such compounds |
US4791112A (en) | 1987-02-02 | 1988-12-13 | The Boc Group, Inc. | N-heterocyclic-N-(4-piperidyl)amides and pharmaceutical compositions and methods employing such compounds |
US5739135A (en) | 1993-09-03 | 1998-04-14 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
FR2766488B1 (fr) | 1997-07-23 | 2000-02-18 | Hoechst Marion Roussel Inc | Nouveaux derives aromatiques substitues par un ribose, leur procede de preparation et leur application comme medicaments |
AU2437900A (en) * | 1999-01-20 | 2000-08-07 | Smithkline Beecham Plc | Piperidinylquinolines as protein tyrosine kinase inhibitors |
US7629360B2 (en) * | 1999-05-07 | 2009-12-08 | Celgene Corporation | Methods for the treatment of cachexia and graft v. host disease |
JP2003104971A (ja) | 1999-08-12 | 2003-04-09 | Wakunaga Pharmaceut Co Ltd | 新規アニリド誘導体又はその塩及びこれを含有する医薬 |
EA005680B1 (ru) | 2000-01-18 | 2005-04-28 | Вертекс Фармасьютикалз Инкорпорейтед | Ингибиторы гиразы и их применение для лечения бактериальной инфекции |
EP1251849A1 (en) | 2000-01-18 | 2002-10-30 | Vertex Pharmaceuticals Incorporated | Gyrase inhibitors and uses thereof |
TWI284639B (en) | 2000-01-24 | 2007-08-01 | Shionogi & Co | A compound having thrombopoietin receptor agonistic effect |
PE20020665A1 (es) | 2000-06-15 | 2002-08-14 | Pharmacia Corp | ACIDO CICLOALQUIL FENIL ALCANOICO COMO ANTAGONISTA DE INTEGRINAS OVß3 |
US6964966B2 (en) | 2001-04-25 | 2005-11-15 | Wockhardt Limited | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
DOP2002000386A (es) | 2001-05-30 | 2002-12-15 | Warner Lambert Co | Agentes antibacterianos |
MXPA04001253A (es) | 2001-08-09 | 2004-06-03 | Ono Pharmaceutical Co | Derivados de acidos carboxilicos y agente farmaceutico que comprende los mismos como ingrediente activo. |
MXPA04005343A (es) | 2001-12-05 | 2004-09-27 | Aventis Pharma Gmbh | 4-fenil-tetrahidro-isoquinolinas sustituidas, procedimiento para su preparacion, su uso como medicamento, y medicamento que las contiene. |
AR038536A1 (es) | 2002-02-25 | 2005-01-19 | Upjohn Co | N-aril-2-oxazolidinona-5- carboxamidas y sus derivados |
WO2003072554A1 (en) | 2002-02-28 | 2003-09-04 | Takeda Chemical Industries, Ltd. | Azole compounds |
AR040336A1 (es) | 2002-06-26 | 2005-03-30 | Glaxo Group Ltd | Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto |
JP2006503837A (ja) * | 2002-09-20 | 2006-02-02 | ルピン・リミテッド | 新規の抗マイコバクテリア化合物 |
US7135469B2 (en) | 2003-03-18 | 2006-11-14 | Bristol Myers Squibb, Co. | Linear chain substituted monocyclic and bicyclic derivatives as factor Xa inhibitors |
CA2519794A1 (en) | 2003-04-08 | 2004-10-21 | Sumitomo Pharmaceuticals Co., Ltd. | Novel carbapenem compounds |
DE10316081A1 (de) * | 2003-04-08 | 2004-10-21 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Neue Verbindungen mit antibakterieller Aktivität |
SE0302116D0 (sv) | 2003-07-21 | 2003-07-21 | Astrazeneca Ab | Novel compounds |
US7094791B2 (en) * | 2003-07-31 | 2006-08-22 | Avalon Pharmaceuticals, Inc. | Derivatives of 3-hydroxy-pyrrole-2,4-dicarboxylic acid and uses thereof |
TW200526626A (en) * | 2003-09-13 | 2005-08-16 | Astrazeneca Ab | Chemical compounds |
GB0325956D0 (en) | 2003-11-06 | 2003-12-10 | Addex Pharmaceuticals Sa | Novel compounds |
US20050197336A1 (en) | 2004-03-08 | 2005-09-08 | Miikana Therapeutics Corporation | Inhibitors of histone deacetylase |
US7345043B2 (en) | 2004-04-01 | 2008-03-18 | Miikana Therapeutics | Inhibitors of histone deacetylase |
EP1790636A4 (en) | 2004-09-17 | 2009-07-01 | Takeda Pharmaceutical | PIPERIDINE DERIVATIVES AND THEIR USE |
AU2005299837A1 (en) | 2004-10-22 | 2006-05-04 | Janssen Pharmaceutica, N.V. | Inhibitors of c-fms kinase |
CN101084208A (zh) | 2004-10-22 | 2007-12-05 | 詹森药业有限公司 | 作为c-fms激酶抑制剂的芳族酰胺 |
WO2006087544A2 (en) | 2005-02-18 | 2006-08-24 | Astrazeneca Ab | Pyrrole derivatives as dna gyrase and topoisomerase inhibitors |
US20080161306A1 (en) | 2005-02-18 | 2008-07-03 | Brian Sherer | Pyrrole Derivatives as Dna Gyrase and Topoisomerase Inhibitors |
US8399489B2 (en) | 2005-02-18 | 2013-03-19 | Astrazeneca Ab | Antibacterial piperdine derivatives |
JP2008531671A (ja) | 2005-03-04 | 2008-08-14 | アストラゼネカ アクチボラグ | 化合物 |
EP1861396A1 (en) | 2005-03-04 | 2007-12-05 | AstraZeneca AB | Tricyclic derivatives of azetidine and pyrrole with antibacterial activity |
US8071065B2 (en) * | 2005-03-31 | 2011-12-06 | Touchstone Research Laboratory, Ltd | High density carbon foam composite tooling |
US20080312211A1 (en) | 2005-12-23 | 2008-12-18 | Astrazeneca Ab | Antibacterial Pyrrolopyridines, Pyrrolopyrimidines and Pyrroloazepines-154 |
TW200819437A (en) | 2006-08-17 | 2008-05-01 | Astrazeneca Ab | Chemical compounds |
TW200906412A (en) * | 2007-06-12 | 2009-02-16 | Astrazeneca Ab | Piperidine compounds and uses thereof |
US8071605B2 (en) * | 2008-12-12 | 2011-12-06 | Astrazeneca Ab | Piperidine compounds for use in the treatment of bacterial infections |
-
2006
- 2006-02-16 US US11/816,612 patent/US8399489B2/en not_active Expired - Fee Related
- 2006-02-16 JP JP2007514146A patent/JP4058106B2/ja not_active Expired - Fee Related
- 2006-02-16 MX MX2007010072A patent/MX2007010072A/es active IP Right Grant
- 2006-02-16 RU RU2007134380/04A patent/RU2424240C2/ru not_active IP Right Cessation
- 2006-02-16 EP EP06709766.7A patent/EP1853586B1/en active Active
- 2006-02-16 ES ES06709766T patent/ES2430569T3/es active Active
- 2006-02-16 KR KR1020137019849A patent/KR101422432B1/ko not_active IP Right Cessation
- 2006-02-16 UA UAA200710264A patent/UA94901C2/ru unknown
- 2006-02-16 AU AU2006215399A patent/AU2006215399B2/en not_active Ceased
- 2006-02-16 WO PCT/GB2006/000529 patent/WO2006087543A1/en active Application Filing
- 2006-02-16 CN CN2006800130583A patent/CN101163693B/zh not_active Expired - Fee Related
- 2006-02-16 NZ NZ561613A patent/NZ561613A/en not_active IP Right Cessation
- 2006-02-16 CA CA2598423A patent/CA2598423C/en not_active Expired - Fee Related
- 2006-02-16 KR KR1020077021453A patent/KR20070113233A/ko not_active Application Discontinuation
- 2006-02-16 BR BRPI0607756-0A patent/BRPI0607756A2/pt not_active IP Right Cessation
- 2006-02-17 AR ARP060100590A patent/AR053683A1/es unknown
- 2006-02-17 UY UY29384A patent/UY29384A1/es not_active Application Discontinuation
- 2006-02-17 TW TW095105415A patent/TWI402263B/zh not_active IP Right Cessation
- 2006-02-18 SA SA6270020A patent/SA06270020B1/ar unknown
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2007
- 2007-08-15 IL IL185306A patent/IL185306A/en not_active IP Right Cessation
- 2007-08-17 ZA ZA200706920A patent/ZA200706920B/xx unknown
- 2007-09-14 JP JP2007239467A patent/JP2008024715A/ja active Pending
- 2007-09-14 JP JP2007239383A patent/JP2007326882A/ja active Pending
- 2007-09-14 JP JP2007239427A patent/JP2007326883A/ja active Pending
- 2007-09-14 NO NO20074703A patent/NO20074703L/no not_active Application Discontinuation
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2008
- 2008-03-07 HK HK08102716.1A patent/HK1114376A1/xx not_active IP Right Cessation
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2013
- 2013-02-05 US US13/759,323 patent/US20130150366A1/en not_active Abandoned
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