AR052864A1 - Preparacion de cetoamidas - Google Patents
Preparacion de cetoamidasInfo
- Publication number
- AR052864A1 AR052864A1 ARP060100037A ARP060100037A AR052864A1 AR 052864 A1 AR052864 A1 AR 052864A1 AR P060100037 A ARP060100037 A AR P060100037A AR P060100037 A ARP060100037 A AR P060100037A AR 052864 A1 AR052864 A1 AR 052864A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- ketoamide
- piperidone
- carbonyl
- aprotic solvent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Las cetoamidas son intermediarios utiles para la preparacion de antagonista del receptor CCR5. Específicamente revela un proceso para sintetizar 1-(2,4-dimetilpirimidin-5-carbonil)-4-piperidona, 1-[(2,4-dimetil-3-piridinil)carbonil]-4-piperidona y compuestos relacionados de reaccion. Reivindicacion 1: Un proceso de preparacion de una cetoamida de formula (1), donde R1 es un sustituyente seleccionado de los sustituyentes alquilo, arilo, cicloalquilo, heteroarilo y heterociclilo, con la condicion de que R1 no contenga una amina primaria o secundaria, comprendiendo dicho proceso: i) hacer reaccionar un ácido carboxílico de formula (2), con un reactivo clorante para sustituir un radical hidroxi por un átomo de cloro en el ácido carboxílico, utilizando un catalizador y un solvente aprotico para producir una solucion del cloruro de ácido de formula (3), ii) preparar en forma separada un medio de reaccion multifásico con una fase salina concentrada acuosa y una fase orgánica que comprende un solvente aprotico apropiado y el compuesto de formula (3), y agregar dicha solucion de cloruro de ácido al medio de reaccion para dar la cetoamida de formula (1).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64189905P | 2005-01-06 | 2005-01-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR052864A1 true AR052864A1 (es) | 2007-04-11 |
Family
ID=36283752
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP060100037A AR052864A1 (es) | 2005-01-06 | 2006-01-05 | Preparacion de cetoamidas |
Country Status (10)
Country | Link |
---|---|
US (3) | US7759487B2 (es) |
EP (1) | EP1838695A2 (es) |
JP (2) | JP4728350B2 (es) |
CN (1) | CN101133046B (es) |
AR (1) | AR052864A1 (es) |
CA (1) | CA2594106A1 (es) |
MX (1) | MX2007008214A (es) |
SG (1) | SG158857A1 (es) |
WO (1) | WO2006074264A2 (es) |
ZA (1) | ZA200705515B (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100396676C (zh) * | 2002-03-29 | 2008-06-25 | 先灵公司 | 作为ccr5拮抗药的哌啶和哌嗪化合物的合成 |
US7759487B2 (en) * | 2005-01-06 | 2010-07-20 | Schering Corporation | Preparation of ketone amides |
US8367674B2 (en) | 2008-04-17 | 2013-02-05 | Concert Pharmaceuticals, Inc. | Piperazine derivatives |
JP2021534270A (ja) * | 2018-08-21 | 2021-12-09 | ハンツマン・インターナショナル・エルエルシー | Pir/purフォーム製造用触媒 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5466687A (en) * | 1992-10-22 | 1995-11-14 | Dr. Karl Thomae Gmbh | Arylidene-1-azacycloalkanes and arylalkyl-1-azacyclo-alkanes, their salts, medicaments containing these compounds and their use, and processes for their preparation |
US5376666A (en) * | 1992-11-30 | 1994-12-27 | The Du Pont Merck Pharmaceutical Company | Angiotension-II receptor blocking, azacycloalkyl or azacycloalkenyl |
DE4426671A1 (de) * | 1994-07-28 | 1996-02-01 | Hoechst Ag | Verfahren zur Kreuzkupplung von aromatischen Borverbindungen mit aromatischen Halogenverbindungen oder Perfluoralkylsulfonaten |
US5889006A (en) * | 1995-02-23 | 1999-03-30 | Schering Corporation | Muscarinic antagonists |
US6387930B1 (en) * | 1999-05-04 | 2002-05-14 | Schering Corporation | Piperidine derivatives useful as CCR5 antagonists |
US6689765B2 (en) * | 1999-05-04 | 2004-02-10 | Schering Corporation | Piperazine derivatives useful as CCR5 antagonists |
US6410750B1 (en) * | 1999-06-18 | 2002-06-25 | Pfizer Inc. | Processes and intermediates for preparing 3(S)-[(5-chloro-1H-indole-2-carbonyl)-amino]-2(R)-hydroxy-4-phenyl-butyric acid |
ATE330961T1 (de) * | 2001-10-19 | 2006-07-15 | Ortho Mcneil Pharm Inc | Phosphonsäureverbindungen als inhibitoren von serinproteasen |
CN100396676C (zh) * | 2002-03-29 | 2008-06-25 | 先灵公司 | 作为ccr5拮抗药的哌啶和哌嗪化合物的合成 |
US7759487B2 (en) * | 2005-01-06 | 2010-07-20 | Schering Corporation | Preparation of ketone amides |
-
2006
- 2006-01-05 US US11/326,156 patent/US7759487B2/en not_active Expired - Fee Related
- 2006-01-05 WO PCT/US2006/000251 patent/WO2006074264A2/en active Application Filing
- 2006-01-05 JP JP2007550444A patent/JP4728350B2/ja not_active Expired - Fee Related
- 2006-01-05 CA CA002594106A patent/CA2594106A1/en not_active Abandoned
- 2006-01-05 SG SG201000064-4A patent/SG158857A1/en unknown
- 2006-01-05 AR ARP060100037A patent/AR052864A1/es unknown
- 2006-01-05 MX MX2007008214A patent/MX2007008214A/es active IP Right Grant
- 2006-01-05 EP EP06717452A patent/EP1838695A2/en not_active Withdrawn
- 2006-01-05 CN CN2006800065103A patent/CN101133046B/zh not_active Expired - Fee Related
-
2007
- 2007-07-05 ZA ZA200705515A patent/ZA200705515B/en unknown
-
2009
- 2009-09-22 US US12/564,504 patent/US20100029939A1/en not_active Abandoned
-
2011
- 2011-02-16 JP JP2011031434A patent/JP2011102328A/ja not_active Withdrawn
- 2011-11-23 US US13/303,272 patent/US20120065397A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ZA200705515B (en) | 2008-05-28 |
JP4728350B2 (ja) | 2011-07-20 |
US20120065397A1 (en) | 2012-03-15 |
JP2008526860A (ja) | 2008-07-24 |
WO2006074264A2 (en) | 2006-07-13 |
EP1838695A2 (en) | 2007-10-03 |
CN101133046A (zh) | 2008-02-27 |
US20100029939A1 (en) | 2010-02-04 |
MX2007008214A (es) | 2007-08-17 |
US7759487B2 (en) | 2010-07-20 |
JP2011102328A (ja) | 2011-05-26 |
CN101133046B (zh) | 2011-08-03 |
WO2006074264A3 (en) | 2006-11-02 |
CA2594106A1 (en) | 2006-07-13 |
US20060247437A1 (en) | 2006-11-02 |
SG158857A1 (en) | 2010-02-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2524045T3 (es) | Nuevas amidas y tioamidas heteroaromáticas como plaguicidas | |
ES2587903T3 (es) | Compuestos de imidazolidinadiona y sus usos | |
AR116300A1 (es) | Proceso para la preparación de 6-(2,4-diclorofenil)-5-[4-[(3s)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7h-benzo[7]anuleno-2-carboxilato de metilo | |
CO6220910A2 (es) | Proceso para la producir compuestos pesticidas de benzamidas | |
DK1678119T3 (da) | Fremgangsmåde til fremstilling af 2-dihalogenacyl-3-amino-acrylsyreestere og 3-dihalogenmethyl-pyrazol-4-carboxylsyreestere | |
CY1112914T1 (el) | Υποκατεστημενα παραγωγα ινδολυλ αλκυλ αμινης ως νεοι αναστολεις των αποακετυλασων ιστονης | |
BRPI0516911A (pt) | método para a preparação de um composto e composto de anilina | |
RU2009105669A (ru) | Способ получения 3-замещенных 2-амино-5-галогенбензамидов | |
UA101036C2 (en) | Substituted 1-(diazinyl) pyrazole-4-yl-acetic acids | |
AR083399A1 (es) | Proceso para la preparacion de cicloheptapiridina como antagonista del receptor de cgrp | |
UA92733C2 (ru) | Способ получения производных 4-(фенокси-5-метилпиримидин-4-илокси)пиперидин-1-карбоновой кислоты и родственных соединений | |
AR074511A1 (es) | Proceso para la fabricacion de derivados del acido 5-metoximetilpiridin-2,3-dicarboxilico sustituido | |
NZ614088A (en) | Process for preparing pyridinamines and novel polymorphs thereof | |
MX347564B (es) | Proceso para la preparacion de n-metoxi-[1-metil-2-feniletil]amida s del acido 3-difluorometil-1-metil-1h-pirazol-4-carboxilico sustituidas con fenilo. | |
WO2009154754A3 (en) | Synthesis of deuterated morpholine derivatives | |
ES2655265T3 (es) | Procedimiento de preparación de bifenilanilidas sustituidas | |
AR052864A1 (es) | Preparacion de cetoamidas | |
AR075915A1 (es) | Proceso para la obtencion de derivados de acido propionico | |
AR114134A2 (es) | Sal de maleato de 11-(2-pirrolidin-1-il-etoxi)-14,19-dioxa-5,7,26-triaza-tetraciclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaeno | |
ES2535033T3 (es) | Derivados de 5,6 dihidroxi isoindol como conectores para la síntesis de oligómeros en fase sólida | |
DE602006005349D1 (de) | Verfahren zur herstellung von hydrazon-derivaten | |
EA200800149A1 (ru) | 4,5-диарилпиррольные производные, способ их получения и применение в терапии | |
AR052276A1 (es) | Proceso para preparar compuestos aromaticos biciclicos | |
ATE532516T1 (de) | Verfahren zur synthese von glyt-1-hemmern | |
AR069053A1 (es) | Sintesis de compuestos de sales cuaternarias |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |