AR052149A1 - Composicion dispersable oralmente y procedimiento para prepararla - Google Patents
Composicion dispersable oralmente y procedimiento para prepararlaInfo
- Publication number
- AR052149A1 AR052149A1 ARP050105143A ARP050105143A AR052149A1 AR 052149 A1 AR052149 A1 AR 052149A1 AR P050105143 A ARP050105143 A AR P050105143A AR P050105143 A ARP050105143 A AR P050105143A AR 052149 A1 AR052149 A1 AR 052149A1
- Authority
- AR
- Argentina
- Prior art keywords
- derivatives
- active ingredient
- group
- hydrophilic
- acid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Zoology (AREA)
- Physiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un procedimiento para la preparacion de una forma farmacéutica solida dispersable oralmente que comprende las siguientes etapas: a) revestimiento del principio activo con por lo menos un polímero hidrofilo carboxilato; b) granulacion del principio activo revestido obtenido en la etapa (a) con por lo menos una sustancia lipídica que tiene un punto de fusion inferior al del principio activo; c) mezcla del granulado en la etapa b) con por lo menos un polímero natural hidrofilo de alto peso molecular; y d) mezcla del granulado obtenido en la etapa c) con ingredientes adecuados para la obtencion de una forma farmacéuticamente solida dispersable oralmente; y también a la forma farmacéutica solida dispersable oralmente que comprende un principio activo revestido con por lo menos un polímero hidrofilo carboxilato y por lo menos una sustancia lipídica, en la que dicho principio activo revestido está sumergido (embebido) en una matriz que comprende por lo menos un polímero natural hidrofilo de alto peso molecular. Reivindicacion 6: Procedimiento segun la reivindicacion 5, caracterizado porque dicho principio activo se elige del grupo que comprende derivados del ácido salicílico, derivados de la pirazolona, derivados del paraaminofenol, derivados del ácido N-fenilantranílico, y derivados del ácido propionico. Reivindicacion 7: Procedimiento segun la reivindicacion 5, caracterizado porque dicho principio se elige en el grupo que comprende ibuprofeno, naxopreno, flurbiprofeno, fenoprofeno, quetoprofeno, fenbufeno, pirprofeno, oxaprozina, indoprofeno y ácido tiaprofénico. Reivindicacion 9: Procedimiento segun cualquiera de las anteriores reivindicaciones 1 a 8, caracterizado porque dicho polímero hidrofilo carboxilato se elige en el grupo que comprende polímeros de carboxialquilcelulosa, hemiésteres de ácidos bicarboxílicos de alquilcelulosa, y copolímeros de un alquenilcarboxiácido con alquilésteres de un alquenilcarboxiácido. Reivindicacion 11: Procedimiento segun cualquiera de las anteriores reivindicaciones 1 a 10, caracterizado porque dicha sustancia lipídica se elige del grupo que comprende ácidos grasos, ésteres de los ácidos grasos con alcoholes alifáticos, alcoholes grasos, y triglicéridos de ácidos grasos. Reivindicacion 13: Procedimiento segun cualquiera de las anteriores reivindicaciones 1 a 12, caracterizado porque dicho polímero natural hidrofilo de alto peso molecular se elige del grupo que comprende goma aguar, goma arábiga, goma karaya, goma gellano, carragenano, quitosano, galactano, PolglumytTM y sus mezclas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT002356A ITMI20042356A1 (it) | 2004-12-10 | 2004-12-10 | Composizione farmaceutica orodisperdibile e procedimento per prepararla |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR052149A1 true AR052149A1 (es) | 2007-03-07 |
Family
ID=34956709
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050105143A AR052149A1 (es) | 2004-12-10 | 2005-12-09 | Composicion dispersable oralmente y procedimiento para prepararla |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20090074867A1 (es) |
| EP (1) | EP1819320B1 (es) |
| JP (1) | JP4980926B2 (es) |
| KR (1) | KR101249855B1 (es) |
| CN (1) | CN101065113B (es) |
| AR (1) | AR052149A1 (es) |
| AT (1) | ATE409463T1 (es) |
| AU (1) | AU2005313588B2 (es) |
| BR (1) | BRPI0518847A2 (es) |
| CA (1) | CA2585940C (es) |
| DE (1) | DE602005010115D1 (es) |
| DK (1) | DK1819320T3 (es) |
| EA (1) | EA010587B1 (es) |
| ES (1) | ES2314742T3 (es) |
| GE (1) | GEP20094589B (es) |
| HK (1) | HK1105872A1 (es) |
| IL (1) | IL182865A (es) |
| IT (1) | ITMI20042356A1 (es) |
| MX (1) | MX2007006705A (es) |
| PL (1) | PL1819320T3 (es) |
| PT (1) | PT1819320E (es) |
| SI (1) | SI1819320T1 (es) |
| UA (1) | UA89656C2 (es) |
| WO (1) | WO2006061142A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20061883A1 (it) * | 2006-09-29 | 2008-03-30 | Monteres S R L | Formulazioni orodispersibili, gastroprotettive e taste- masking contenenti almeno un principio attivo gastrolesivo |
| US20100273736A1 (en) * | 2008-02-01 | 2010-10-28 | Aziende Chim. Riun. Ang. Franc. A.C.R.A.F. S.P.A. | Cosmetic composition comprising glycogen for skin application with velvet effect |
| EA026651B1 (ru) | 2009-01-23 | 2017-05-31 | Ацьенде Кимике Рьюните Анджелини Франческо А.К.Р.А.Ф. С.П.А. | Фармацевтический или пищевой состав с контролируемым высвобождением и способ его получения |
| US8889654B2 (en) * | 2009-08-03 | 2014-11-18 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. | Food formulation comprising glycogen |
| EP2316433A1 (en) * | 2009-10-22 | 2011-05-04 | Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi | Orally disintegrating tablets of flurbiprofen |
| WO2013151754A1 (en) * | 2012-04-02 | 2013-10-10 | Teikoku Pharma Usa, Inc. | Ibuprofen solid oral dosage composition comprising a methacrylic acid copolymer |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1214629B (it) * | 1985-08-29 | 1990-01-18 | Formenti Farmaceutici Spa | Procedimento di microincapsulazione di un medicamento,medicamento cosi'preparato,e composizioni farmaceutiche che lo comprendono |
| DE3730533A1 (de) * | 1987-09-11 | 1989-03-30 | Biotest Pharma Gmbh | Verfahren zur sterilisation von plasma oder plasmafraktionen |
| US4916161A (en) * | 1988-10-25 | 1990-04-10 | Bristol-Myers Squibb | Taste-masking pharmaceutical agents |
| JPH02282323A (ja) * | 1989-04-21 | 1990-11-19 | Shin Etsu Chem Co Ltd | 徐放性錠剤の製造方法 |
| US5084278A (en) * | 1989-06-02 | 1992-01-28 | Nortec Development Associates, Inc. | Taste-masked pharmaceutical compositions |
| NZ234587A (en) * | 1989-08-04 | 1991-11-26 | Mcneil Ppc Inc | A chewable pharmaceutical tablet of compressed coated granules |
| CA2063141C (en) * | 1989-08-04 | 1997-03-04 | Edward J. Roche | Rotogranulations and taste masking coatings for preparation of chewable pharmaceutical tablets |
| US5460825A (en) * | 1990-05-23 | 1995-10-24 | Mcneil-Ppc, Inc. | Taste mask coatings for preparing chewable pharmaceutical tablets |
| CA2068402C (en) * | 1991-06-14 | 1998-09-22 | Michael R. Hoy | Taste mask coatings for preparation of chewable pharmaceutical tablets |
| US5464632C1 (en) * | 1991-07-22 | 2001-02-20 | Prographarm Lab | Rapidly disintegratable multiparticular tablet |
| US5405617A (en) * | 1991-11-07 | 1995-04-11 | Mcneil-Ppc, Inc. | Aliphatic or fatty acid esters as a solventless carrier for pharmaceuticals |
| AU666509B2 (en) * | 1991-12-24 | 1996-02-15 | Yamanouchi Pharmaceutical Co., Ltd. | Intrabuccally disintegrating preparation and production thereof |
| JP3069458B2 (ja) * | 1992-01-29 | 2000-07-24 | 武田薬品工業株式会社 | 口腔内崩壊型錠剤およびその製造法 |
| US5298261A (en) * | 1992-04-20 | 1994-03-29 | Oregon Freeze Dry, Inc. | Rapidly distintegrating tablet |
| US5837277A (en) * | 1992-06-04 | 1998-11-17 | Smithkline Beecham Corporation | Palatable pharmaceutical compositions |
| CA2128820A1 (en) * | 1993-07-27 | 1995-01-28 | Walter G. Gowan, Jr. | Rapidly disintegrating pharmaceutical dosage form and process for preparation thereof |
| US5622719A (en) * | 1993-09-10 | 1997-04-22 | Fuisz Technologies Ltd. | Process and apparatus for making rapidly dissolving dosage units and product therefrom |
| US5576014A (en) * | 1994-01-31 | 1996-11-19 | Yamanouchi Pharmaceutical Co., Ltd | Intrabuccally dissolving compressed moldings and production process thereof |
| US5728403A (en) * | 1994-10-05 | 1998-03-17 | The Board Of Regents Of The University Of Nebraska | Coating technology for taste masking orally administered bitter drugs |
| US5738875A (en) * | 1994-10-28 | 1998-04-14 | R.P. Scherer Corporation | Process for preparing solid pharmaceutical dosage forms |
| US5762961A (en) * | 1996-02-09 | 1998-06-09 | Quadrant Holdings Cambridge Ltd. | Rapidly soluble oral solid dosage forms, methods of making same, and compositions thereof |
| BR9711585A (pt) * | 1996-10-01 | 2000-01-18 | Cima Labs Inc | Composição de microcápsula, com sabor mascarado, de um remédio solúvel em água, formulação farmacêutica para administrar um remédio, e, processo para disfarçar o sabor de um remédio. |
| US6024981A (en) * | 1997-04-16 | 2000-02-15 | Cima Labs Inc. | Rapidly dissolving robust dosage form |
| FR2766089B1 (fr) * | 1997-07-21 | 2000-06-02 | Prographarm Lab | Comprime multiparticulaire perfectionne a delitement rapide |
| US5869098A (en) * | 1997-08-20 | 1999-02-09 | Fuisz Technologies Ltd. | Fast-dissolving comestible units formed under high-speed/high-pressure conditions |
| PL197989B1 (pl) * | 1997-12-19 | 2008-05-30 | Smithkline Beecham Corp | Sposób wytwarzania szybko rozpraszających się tabletek do podawania doustnego, szybko rozpraszający się preparat farmaceutyczny w postaci tabletek i szybko rozpraszająca się, farmaceutycznie dopuszczalna, tabletka do podawania doustnego |
| JP2002505269A (ja) * | 1998-03-06 | 2002-02-19 | エウランド インターナショナル ソシエタ ペル アチオニ | 急速崩壊錠剤 |
| US6465009B1 (en) * | 1998-03-18 | 2002-10-15 | Yamanouchi Pharmaceutical Co., Ltd. | Water soluble polymer-based rapidly dissolving tablets and production processes thereof |
| US20030180352A1 (en) * | 1999-11-23 | 2003-09-25 | Patel Mahesh V. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| US7223421B2 (en) * | 2000-06-30 | 2007-05-29 | Mcneil-Ppc, Inc. | Teste masked pharmaceutical particles |
-
2004
- 2004-12-10 IT IT002356A patent/ITMI20042356A1/it unknown
-
2005
- 2005-11-25 PT PT05817592T patent/PT1819320E/pt unknown
- 2005-11-25 WO PCT/EP2005/012859 patent/WO2006061142A1/en active IP Right Grant
- 2005-11-25 BR BRPI0518847-4A patent/BRPI0518847A2/pt not_active Application Discontinuation
- 2005-11-25 SI SI200530528T patent/SI1819320T1/sl unknown
- 2005-11-25 JP JP2007544783A patent/JP4980926B2/ja not_active Expired - Fee Related
- 2005-11-25 DE DE602005010115T patent/DE602005010115D1/de active Active
- 2005-11-25 US US11/577,762 patent/US20090074867A1/en not_active Abandoned
- 2005-11-25 GE GEAP200510172A patent/GEP20094589B/en unknown
- 2005-11-25 DK DK05817592T patent/DK1819320T3/da active
- 2005-11-25 UA UAA200707792A patent/UA89656C2/ru unknown
- 2005-11-25 AT AT05817592T patent/ATE409463T1/de active
- 2005-11-25 EA EA200700877A patent/EA010587B1/ru not_active IP Right Cessation
- 2005-11-25 EP EP05817592A patent/EP1819320B1/en active Active
- 2005-11-25 PL PL05817592T patent/PL1819320T3/pl unknown
- 2005-11-25 MX MX2007006705A patent/MX2007006705A/es active IP Right Grant
- 2005-11-25 ES ES05817592T patent/ES2314742T3/es active Active
- 2005-11-25 AU AU2005313588A patent/AU2005313588B2/en not_active Ceased
- 2005-11-25 KR KR1020077012985A patent/KR101249855B1/ko not_active IP Right Cessation
- 2005-11-25 CA CA2585940A patent/CA2585940C/en not_active Expired - Fee Related
- 2005-11-25 CN CN2005800403707A patent/CN101065113B/zh not_active Expired - Fee Related
- 2005-12-09 AR ARP050105143A patent/AR052149A1/es not_active Application Discontinuation
-
2007
- 2007-04-30 IL IL182865A patent/IL182865A/en not_active IP Right Cessation
- 2007-10-18 HK HK07111295.2A patent/HK1105872A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HK1105872A1 (en) | 2008-02-29 |
| WO2006061142A1 (en) | 2006-06-15 |
| CN101065113B (zh) | 2012-04-11 |
| EA200700877A1 (ru) | 2007-10-26 |
| IL182865A0 (en) | 2007-08-19 |
| KR101249855B1 (ko) | 2013-04-05 |
| EP1819320B1 (en) | 2008-10-01 |
| DE602005010115D1 (de) | 2008-11-13 |
| PT1819320E (pt) | 2008-11-20 |
| CA2585940C (en) | 2012-09-25 |
| BRPI0518847A2 (pt) | 2008-12-09 |
| US20090074867A1 (en) | 2009-03-19 |
| DK1819320T3 (da) | 2009-01-12 |
| CA2585940A1 (en) | 2006-06-15 |
| EP1819320A1 (en) | 2007-08-22 |
| IL182865A (en) | 2010-06-30 |
| PL1819320T3 (pl) | 2009-03-31 |
| GEP20094589B (en) | 2009-01-12 |
| AU2005313588A1 (en) | 2006-06-15 |
| SI1819320T1 (sl) | 2009-02-28 |
| ES2314742T3 (es) | 2009-03-16 |
| UA89656C2 (ru) | 2010-02-25 |
| CN101065113A (zh) | 2007-10-31 |
| EA010587B1 (ru) | 2008-10-30 |
| JP2008522995A (ja) | 2008-07-03 |
| JP4980926B2 (ja) | 2012-07-18 |
| MX2007006705A (es) | 2007-10-08 |
| ATE409463T1 (de) | 2008-10-15 |
| ITMI20042356A1 (it) | 2005-03-10 |
| AU2005313588B2 (en) | 2012-05-24 |
| KR20070085941A (ko) | 2007-08-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |