AR051940A1 - Compuestos y metodos para modular la actividad de la trombopoyetina - Google Patents

Compuestos y metodos para modular la actividad de la trombopoyetina

Info

Publication number
AR051940A1
AR051940A1 ARP050104466A ARP050104466A AR051940A1 AR 051940 A1 AR051940 A1 AR 051940A1 AR P050104466 A ARP050104466 A AR P050104466A AR P050104466 A ARP050104466 A AR P050104466A AR 051940 A1 AR051940 A1 AR 051940A1
Authority
AR
Argentina
Prior art keywords
optionally substituted
ring
aliphatic
hydrogen
haloaliphatic
Prior art date
Application number
ARP050104466A
Other languages
English (en)
Inventor
Chen
Dalgard
Kallel
Lau
Inc Mcneil-Ppc
Miller
Nguyen
Phillips
Ruppar
Zhi
Penuliar
Original Assignee
Ligand Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ligand Pharm Inc filed Critical Ligand Pharm Inc
Publication of AR051940A1 publication Critical patent/AR051940A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/04—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/54—Nitrogen and either oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Compuestos arilhidrazino sustituidos, composiciones farmacéuticas que los comprenden, métodos que los utilizan para modular la actividad de un receptor de trombopoyetina, métodos para identificar compuestos como moduladores del receptor de trombopoyetina, y métodos para tratar una enfermedad administrando un compuesto de la presente a un paciente que necesite dicho tratamiento. Reivindicacion 1: Un compuesto caracterizado porque responde a la formula (1), o una sal, un éster, una amida o una prodroga aceptables para uso farmacéutico del mismo, donde: R1 se selecciona entre CO2R10, CONR10R11, SO3R10, y un bioisostero de ácido carboxílico; R2 y R3 se seleccionan en forma independiente entre sí entre ausente, hidrogeno, OR12, NR12R13, alifático C1-4 opcionalmente sustituido, haloalifático C1-4, opcionalmente sustituido, heteroalifático C1-4 opcionalmente sustituido, anillo opcionalmente sustituido, y (CH2)mR14; o R2 y R3 tomados juntos forman una olefina opcionalmente sustituida; o R2 y R3 se unen para formar un anillo C3-6 opcionalmente sustituido; R4 se selecciona entre hidrogeno, F, Cl, Br, alifático C1-4, haloalifático C1-4, heteroalifático C1-4, y un anillo; R5 se selecciona entre hidrogeno, OR10, SR10, NHR11, y CO2H; R6 se selecciona entre hidrogeno, OR12, NR12R13, F, Cl, Br, alquilo C1-4, haloalquilo C1-4, heteroalquilo C1-4, y un anillo; R7 se selecciona entre hidrogeno, alifático C1-8 opcionalmente sustituido, haloalifático C1-8 opcionalmente sustituido, heteroalifático C1-6 opcionalmente sustituido, heterohaloalifático C1-8 opcionalmente sustituido, anillo opcionalmente sustituido, y (CH2)mR14; R10 se selecciona entre hidrogeno, alifático C1-4 opcionalmente sustituido, haloalifático C1- 4, heteroalifático C1-4, y un anillo; R11 se selecciona entre hidrogeno, SO2R15, alifático C1-4, haloalifático C1-4, heteroalifático C1-4, y un anillo; R112 y R13 se seleccionan en forma independiente entre sí entre hidrogeno, alifático C1-4 opcionalmente sustituido, haloalifático C1-4 opcionalmente sustituido, heteroalifático C1-4 opcionalmente sustituido, un anillo opcionalmente sustituido, y (CH2)mR14; o uno de R12 y R13 es alifático C2-6 opcionalmente sustituido o un anillo opcionalmente sustituido y el otro de R12 y R13 está ausente; o R12 y R13 se unen para formar un anillo C3-8 opcionalmente sustituido; R14 se selecciona entre un arilo opcionalmente sustituido y un heteroarilo opcionalmente sustituido; R15 se selecciona entre hidrogeno, alifático C1-3, haloalifático C1-3, y un anillo; Y es un separador de 1-4 átomos que comprende uno o más grupos seleccionados entre un alifático C1-6 opcionalmente sustituido, heteroalifático C1-6 opcionalmente sustituido, un fenilo opcionalmente sustituido, un heteroarilo opcionalmente sustituido, heterociclo C3-5 opcionalmente sustituido, y un alicíclico opcionalmente sustituido; con la condicion de que Y no sea -N=CR6- orientado para formar un dihidropirazol; Z se selecciona entre: un separador de 2-5 átomos seleccionados entre un arilo C6-10 opcionalmente sustituido y heteroarilo C1-6 opcionalmente sustituido; y un separador de 1-5 átomos seleccionado entre alifático C1-6 opcionalmente sustituido, heteroalifático C1-6 opcionalmente sustituido, y haloalifático C1-6 opcionalmente sustituido; m es 0, 1, o 2; y n es 0 o 1.
ARP050104466A 2004-10-25 2005-10-25 Compuestos y metodos para modular la actividad de la trombopoyetina AR051940A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62187904P 2004-10-25 2004-10-25
US67500105P 2005-04-25 2005-04-25

Publications (1)

Publication Number Publication Date
AR051940A1 true AR051940A1 (es) 2007-02-21

Family

ID=35610075

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050104466A AR051940A1 (es) 2004-10-25 2005-10-25 Compuestos y metodos para modular la actividad de la trombopoyetina

Country Status (15)

Country Link
US (3) US7314887B2 (es)
EP (1) EP1805155B1 (es)
JP (1) JP4728340B2 (es)
KR (1) KR100958337B1 (es)
AR (1) AR051940A1 (es)
AT (1) ATE486859T1 (es)
AU (1) AU2005299720B2 (es)
BR (1) BRPI0516883A (es)
CA (1) CA2583764C (es)
DE (1) DE602005024599D1 (es)
IL (2) IL182763A (es)
MX (1) MX2007004765A (es)
NO (1) NO20072199L (es)
NZ (1) NZ554662A (es)
WO (1) WO2006047344A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CY2010012I2 (el) * 2000-05-25 2020-05-29 Novartis Ag Μιμητικα θρομβοποιητινης
WO2005118551A2 (en) * 2004-05-28 2005-12-15 Ligand Pharmaceuticals Inc. Thrombopoietin activity modulating compounds and methods
CA2583764C (en) * 2004-10-25 2009-06-09 Ligand Pharmaceuticals, Inc. Thrombopoietin activity modulating compounds and methods
WO2007062078A2 (en) * 2005-11-23 2007-05-31 Ligand Pharmaceuticals Inc. Thrombopoietin activity modulating compounds and methods
AU2007329464A1 (en) * 2006-12-01 2008-06-12 Stategics, Inc. Thrombopoietin mimetics
US20090304634A1 (en) * 2006-12-12 2009-12-10 Smithkline Beecham Corporation Novel Combinations
WO2008074078A1 (en) * 2006-12-19 2008-06-26 University Of Wollongong Selectively deliverable isatin-based cytotoxic agents
US20110129550A1 (en) * 2007-02-16 2011-06-02 Connie Erickson-Miller Cancer treatment method
US20110160130A1 (en) * 2007-02-16 2011-06-30 Connie Erickson-Miller Cancer treatment method
UY30915A1 (es) * 2007-02-16 2008-09-02 Smithkline Beecham Corp Método de tratamiento de canceres
CA2709224C (en) * 2007-10-09 2015-06-23 The Trustees Of The University Of Pennsylvania Thrombopoietin receptor agonist (tpora) kills acute human myeloid leukemia cells
WO2009140464A1 (en) * 2008-05-16 2009-11-19 Ligand Pharmaceuticals, Inc. Methods of administration of thrombopoietin mimetic compounds
US8476249B2 (en) 2009-05-07 2013-07-02 Glaxosmithkline Llc Method of treating thrombocytopenia
US8680150B2 (en) * 2009-05-28 2014-03-25 Ligand Pharmaceuticals, Inc. Small molecule hematopoietic growth factor mimetic compounds that activate hematopoietic growth factor receptors
JP6072058B2 (ja) * 2011-11-14 2017-02-01 リガンド・ファーマシューティカルズ・インコーポレイテッド 顆粒球コロニー刺激因子受容体と結合する方法および組成物
US9962370B2 (en) 2013-03-15 2018-05-08 Ligand Pharmaceuticals Incorporated Methods of treatment associated with the granulocyte colony-stimulating factor receptor
AU2014354643B2 (en) 2013-11-27 2020-03-05 Redwood Bioscience, Inc. Hydrazinyl-pyrrolo compounds and methods for producing a conjugate
CN106632407A (zh) * 2016-09-30 2017-05-10 陕西科技大学 一种具抗肿瘤活性的不对称双7‑n杂靛红席夫碱类化合物的合成方法
AU2020257272A1 (en) * 2019-04-17 2021-11-11 Colorado Research Partners LLC Novel compounds and methods of use treating fructose-related disorders or diseases

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE193633C (es)
US3148192A (en) * 1961-06-27 1964-09-08 Roussel Uclaf Halogenated 20alpha-yohimbane compounds
BE653800A (es)
DE450819C (de) 1924-12-24 1927-10-20 Chemische Ind Ges Verfahren zur Herstellung von chromhaltigen Azofarbstoffen
GB252957A (en) * 1926-02-19 1926-06-10 Chem Fab Vormals Sandoz Manufacture of diazotizable azo-dyestuffs and intermediate products therefor
GB898706A (en) * 1957-09-20 1962-06-14 Polaroid Corp Azo dyes derived from dihydroxyphenyl ketones and their use in photography
BE594503A (es) * 1959-08-29
GB1080864A (en) 1963-02-26 1967-08-23 Ici Ltd Five membered heterocyclic systems and their use as fungicides
GB1269781A (en) * 1968-11-12 1972-04-06 Ici Ltd Alkanolamine derivatives
US3966900A (en) * 1969-03-12 1976-06-29 Airwick Industries, Inc. Evaporator system comprising a stabilized pesticidal phosphoric acid ester and method for stabilizing such ester enclosed in an evaporator
US3754857A (en) * 1969-08-27 1973-08-28 American Cyanamid Co Polyethylene terephthalate,nylon and organic esters of cellulose dyedwith 5-(2-nitro-pranisylazo) barbituric acid
EP0034725B1 (de) * 1980-02-18 1984-07-25 BASF Aktiengesellschaft Imidazolylmethylgruppen enthaltende Farbstoffe und deren Verwendung
US4322533A (en) * 1980-03-17 1982-03-30 Lesher George Y 1H-Indole-2,3-dione derivatives
DE3329340A1 (de) 1983-08-13 1985-03-07 Basf Ag, 6700 Ludwigshafen Verlackungsmittel enthaltende farbstoffzubereitungen basischer farbstoffe
DE3434379A1 (de) * 1984-09-19 1986-03-20 Basf Farben + Fasern Ag, 2000 Hamburg Pigmentzubereitungen
GB8431426D0 (en) 1984-12-13 1985-01-23 Glaxo Group Ltd Chemical compounds
DE3743235A1 (de) * 1987-12-19 1989-06-29 Bayer Ag Basische farbstoffe
DE3810958A1 (de) 1988-03-31 1989-10-12 Basf Ag Tinten fuer ink-jet-aufzeichnungsverfahren
GB8816944D0 (en) * 1988-07-15 1988-08-17 Sobio Lab Compounds
JP2683097B2 (ja) 1989-04-28 1997-11-26 キヤノン株式会社 電子写真感光体
US5164404A (en) * 1991-03-15 1992-11-17 Neurosearch A/S Hydrazone derivatives and their use
JP2709750B2 (ja) * 1991-03-27 1998-02-04 富士写真フイルム株式会社 ハロゲン化銀写真感光材料
US5298658A (en) * 1991-12-20 1994-03-29 E. I. Du Pont De Nemours And Company Photographic elements with reduced print-through
DE4335623A1 (de) 1993-10-19 1995-04-20 Henkel Kgaa Indolinon-Derivate zum Färben keratinhaltiger Fasern
US5482546A (en) * 1994-03-30 1996-01-09 Canon Kabushiki Kaisha Dye, ink containing the same, and ink-jet recording method and instrument using the ink
GEP20002180B (en) 1994-03-31 2000-07-25 Amgen Inc Composition and Methods for Stimulating Megakaryocyte Growth and Differentiation
US6184363B1 (en) * 1997-06-13 2001-02-06 Northwestern University Inhibitors of β-lactamases and uses therefor
US6075044A (en) * 1997-07-21 2000-06-13 The Regents Of The University Of California Heterocyclic derivatives as inhibitors of purine salvage phosphoribosyltransferases
GB9718913D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
US6649631B1 (en) * 1997-10-23 2003-11-18 The Board Of Regents Of The University Of Texas System Compositions and methods for treating bone deficit conditions
GC0000177A (en) * 1998-12-17 2006-03-29 Smithkline Beecham Thrombopoietin mimetics
JP2000206645A (ja) 1999-01-18 2000-07-28 Fuji Photo Film Co Ltd 画像形成材料および画像形成方法
GB9904933D0 (en) * 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds
WO2001007423A1 (fr) * 1999-07-26 2001-02-01 Shionogi & Co., Ltd. Compositions medicamenteuses possedant une activite agoniste de la thrombopoietine
EP1213965B1 (en) 1999-09-10 2006-01-18 Smithkline Beecham Corporation Thrombopoietin mimetics
ATE350044T1 (de) 1999-09-24 2007-01-15 Smithkline Beecham Corp Thrombopoietinmimetika
US6720345B1 (en) * 1999-11-05 2004-04-13 Smithkline Beecham Corporation Semicarbazone derivatives and their use as thrombopoietin mimetics
JP2001152055A (ja) 1999-11-26 2001-06-05 Fuji Photo Film Co Ltd インクジェット記録用インクおよびそれを用いた画像記録方法
CY2010012I2 (el) * 2000-05-25 2020-05-29 Novartis Ag Μιμητικα θρομβοποιητινης
JP4359382B2 (ja) 2000-07-11 2009-11-04 富士フイルム株式会社 新規なヒドラゾン色素
EP1317446A1 (en) * 2000-09-01 2003-06-11 Glaxo Group Limited Oxindole derivatives
WO2002020479A1 (en) * 2000-09-01 2002-03-14 Glaxo Group Limited Substituted oxindole derivatives as tyrosine kinase inhibitors
US6642265B1 (en) * 2000-09-08 2003-11-04 Smithkline Beecham Corporation Thrombopoietin mimetics
JP2002129073A (ja) 2000-10-20 2002-05-09 Fuji Photo Film Co Ltd 油性インク組成物
JP2002129072A (ja) 2000-10-20 2002-05-09 Fuji Photo Film Co Ltd インクジェット記録用インク及びそれを用いた画像記録方法
CA2436288A1 (en) * 2000-12-19 2002-06-27 Smithkline Beecham Corporation Thrombopoietin mimetics
CA2432800A1 (en) * 2000-12-21 2002-07-25 Smithkline Beecham Corporation Regulated activation of cell-membrane receptors by metal-chelating agonists
EP1361220A4 (en) * 2001-01-26 2005-09-07 Shionogi & Co CYCLIC COMPOUNDS WITH THROMBOPOIETIN RECEPTAGONISM
JP2004527541A (ja) * 2001-03-01 2004-09-09 スミスクライン・ビーチャム・コーポレイション トロンボポエチン模倣物
EP1975620A3 (en) * 2001-03-02 2008-12-24 GPC Biotech AG Three hybrid assay system
GB0106343D0 (en) * 2001-03-14 2001-05-02 Avecia Ltd Compounds compositions and processes
CA2454656A1 (en) * 2001-07-23 2003-02-06 Ramot At Tel Aviv University Ltd. Methods and compositions for treating fungal infections
WO2003011287A1 (en) * 2001-08-03 2003-02-13 Vertex Pharmaceuticals Incorporated Pyrazolon derivatives as inhibitors of gsk-3
JP2003128946A (ja) 2001-10-26 2003-05-08 Fuji Photo Film Co Ltd 新規なアゾ色素、及び該アゾ色素の互変異性体
GB0126036D0 (en) 2001-10-30 2001-12-19 Amedis Pharm Ltd Silicon compounds
WO2003062233A1 (fr) * 2002-01-18 2003-07-31 Yamanouchi Pharmaceutical Co., Ltd. Derive de 2-acylaminothiazole et son sel
US20050049267A1 (en) * 2002-03-01 2005-03-03 Pintex Pharmaceuticals, Inc. Pin1-modulating compounds and methods of use thereof
CA2480634A1 (en) 2002-03-29 2003-10-09 The Board Of Trustees Of The Leland Stanford Junior University Use of statins and other immunomodulatory agents in the treatment of autoimmune disease
US20030229453A1 (en) * 2002-04-09 2003-12-11 Antonysamy Stephen Suresh Crystals and structures of PAK4KD kinase PAK4KD
JP2003313450A (ja) 2002-04-22 2003-11-06 Fuji Photo Film Co Ltd アゾ色素及びその互変異性体
JP2003335972A (ja) 2002-05-21 2003-11-28 Fuji Photo Film Co Ltd アゾ化合物及びその製造方法
MY142390A (en) * 2002-05-22 2010-11-30 Glaxosmithkline Llc 3' - [(2z)-[1-(3,4-dimethylphenyl)-1,5- dihydro-3- methyl-5-0xo-4h-pyrazol-4- ylidene]hydrazino]-2' -hydroxy -[1,1' -biphenyl]-3-carboxylic acid bis-(monoethanolamine)
JP4562523B2 (ja) * 2002-06-06 2010-10-13 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー トロンボポエチン疑似体
TWI324593B (en) * 2002-10-09 2010-05-11 Nissan Chemical Ind Ltd Pyrazolone compounds and thrombopoietin receptor activator
JP2004143118A (ja) 2002-10-28 2004-05-20 Fuji Photo Film Co Ltd アゾ化合物及びその互変異性体、並びに、その製造方法
WO2004054515A2 (en) * 2002-12-13 2004-07-01 Smithkline Beecham Corporation Thrombopoietin mimetics
US20040253178A1 (en) * 2002-12-20 2004-12-16 Shane Atwell Crystals and structures of spleen tyrosine kinase SYKKD
EP1622609A4 (en) * 2003-04-29 2008-09-03 Smithkline Beecham Corp METHODS OF TREATING DEGENERATIVE DISEASES / LESIONS
EP1638487A2 (en) * 2003-05-28 2006-03-29 Medcool, Inc. Methods and apparatus for thermally activating a console of a thermal delivery system
UA82695C2 (uk) * 2003-06-06 2008-05-12 Нисан Кемикал Индастриз, Лтд. Гетероароматичні сполуки як активатори рецептора тромбопоетину
CA2563316A1 (en) 2004-04-06 2005-10-20 Semafore Pharmaceuticals, Inc. Pten inhibitors
BRPI0511057A (pt) 2004-05-12 2007-11-27 Bayer Cropscience Gmbh regulação de crescimento da planta
WO2005118551A2 (en) 2004-05-28 2005-12-15 Ligand Pharmaceuticals Inc. Thrombopoietin activity modulating compounds and methods
SE0401790D0 (sv) 2004-07-07 2004-07-07 Forskarpatent I Syd Ab Tamoxifen response in pre- and postmenopausal breast cancer patients
CA2583764C (en) 2004-10-25 2009-06-09 Ligand Pharmaceuticals, Inc. Thrombopoietin activity modulating compounds and methods
GT200500321A (es) 2004-11-09 2006-09-04 Compuestos y composiciones como inhibidores de proteina kinase.
US7563781B2 (en) 2005-01-14 2009-07-21 Janssen Pharmaceutica Nv Triazolopyrimidine derivatives
WO2007062078A2 (en) 2005-11-23 2007-05-31 Ligand Pharmaceuticals Inc. Thrombopoietin activity modulating compounds and methods
US20070162306A1 (en) 2006-01-11 2007-07-12 Peters James D System and methods for performing distributed payment transactions

Also Published As

Publication number Publication date
AU2005299720B2 (en) 2010-02-04
US20060116417A1 (en) 2006-06-01
EP1805155B1 (en) 2010-11-03
JP2008517932A (ja) 2008-05-29
US7314887B2 (en) 2008-01-01
WO2006047344A1 (en) 2006-05-04
ATE486859T1 (de) 2010-11-15
KR20070084506A (ko) 2007-08-24
IL182763A0 (en) 2007-07-24
CA2583764C (en) 2009-06-09
US7691895B2 (en) 2010-04-06
KR100958337B1 (ko) 2010-05-17
DE602005024599D1 (de) 2010-12-16
US20080103190A1 (en) 2008-05-01
CA2583764A1 (en) 2006-05-04
JP4728340B2 (ja) 2011-07-20
IL182763A (en) 2010-12-30
US20080146594A1 (en) 2008-06-19
BRPI0516883A (pt) 2008-09-23
IL191542A (en) 2013-08-29
MX2007004765A (es) 2007-07-09
IL191542A0 (en) 2008-11-03
NO20072199L (no) 2007-06-05
NZ554662A (en) 2008-11-28
AU2005299720A1 (en) 2006-05-04
EP1805155A1 (en) 2007-07-11

Similar Documents

Publication Publication Date Title
AR051940A1 (es) Compuestos y metodos para modular la actividad de la trombopoyetina
AR119698A2 (es) Compuesto amida n-urea sustituida derivado de aminoácido
AR072227A1 (es) Derivados de triazinona sustituidos
AR083849A1 (es) Antagonistas de mdm2 de espiro-oxindol
RU2014141579A (ru) Гетероциклические соединения в качестве ингибиторов бета-лактамаз
RU2008109908A (ru) Соединения и композиции в качестве ингибиторов протеинкиназы
AR082152A1 (es) Derivados de n-(metilsulfonil)benzamida, composiciones farmaceuticas que los comprenden y su uso en la preparacion de medicamentos para el tratamiento de enfermedades mediadas por la inhibicion de nav1.7
AR086977A1 (es) Derivados heterociclicos nitrogenados utiles para el tratamiento del cancer y composiciones farmaceuticas que los contienen
AR081626A1 (es) Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
PE20090159A1 (es) COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs
AR038881A1 (es) Compuestos que modulan la actividad de ppar, composicion farmaceutica que los contiene y un procedimiento para la preparcion de aquellos
AR086972A1 (es) Procesos para preparar compuestos heterociclicos, que incluyen trans-7-oxo-6-(sulfooxi)-1,6-diazabiciclo[3,2,1]octano-2-carboxamida y sales de la misma
AR045510A1 (es) Derivados de 1,3 diazoles
AR063912A1 (es) Derivados de 1,2,4 oxadiazol. composiciones farmaceuticas.
NZ610312A (en) 6-amino-2-phenylamino-1h-benzimidazole-5-carboxamide- derivatives and their use as microsomal prostaglandin e2 synthase-1 inhibitors
AR066348A1 (es) Inhibidores de las iap
RU2014121090A (ru) Модуляторы рецептора нмда и их применение
RU2008108898A (ru) Соединения и композиции в качестве ингибиторов протеинкиназы
AR058546A1 (es) Derivados de 2- adamantilurea como inhibidores selectivos de 11 beta - hsd1
AR058402A1 (es) 3-aminociclopentanocarboxamidas como moduladores de receptores de quimioquinas.composiciones farmaceuticas.
PE20091444A1 (es) Derivados de isoxazolo-pirazina
AR068466A1 (es) Cianoisoquinolina
AR055554A1 (es) Compuestos piridinicos, composicion farmaceutica y uso de los compuestos para preparar medicamentos
AR054272A1 (es) Derivados de 3- aminopirrilidinas tri, tetra - sustituidos
AR068888A1 (es) Derivados de 1, 3, 4 - tiadiazol, una composicion farmaceutica que los comprende y su uso en la preparacion de medicamentos para el tratamiento de enfermedades mediadas por la inhibicion de la quinesina ksp.

Legal Events

Date Code Title Description
FA Abandonment or withdrawal
FC Refusal
FG Grant, registration
FD Application declared void or lapsed, e.g., due to non-payment of fee