AR049773A1 - Derivados de tiadiazolurea. metodos de obtencion y composiciones farmaceuticas - Google Patents
Derivados de tiadiazolurea. metodos de obtencion y composiciones farmaceuticasInfo
- Publication number
- AR049773A1 AR049773A1 ARP050100704A ARP050100704A AR049773A1 AR 049773 A1 AR049773 A1 AR 049773A1 AR P050100704 A ARP050100704 A AR P050100704A AR P050100704 A ARP050100704 A AR P050100704A AR 049773 A1 AR049773 A1 AR 049773A1
- Authority
- AR
- Argentina
- Prior art keywords
- mono
- hal
- unsubstituted
- cha
- atoms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Reproductive Health (AREA)
- Pregnancy & Childbirth (AREA)
- Pain & Pain Management (AREA)
- Gynecology & Obstetrics (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Uso de compuestos de la formula (1), en donde: Ar1 es fenilo, naftilo, bifenilo, o Het insustituido o mono, di, tri, tetra o pentasustituido con R1; Ar2 es fenilo, naftilo, bifenilo, o Het insustituido o mono, di, tri, tetra o pentasustituido con R2; Y es O, S, CH-NO2, C(CN)2 o N-R4; Z es -O-, -S-, -CH2-(CH2)n-, -(CH2)n-CHA-, -CHA-(CH2)n-, -C(=O)-, ,-CH(OH)-, -(CHA)nO-, -(CH2)nO-, -O(CHA)n-, -O(CH2)n-, -(CH2)nS-, -S(CH2)n-, -(CH2)nNH-, -NH(CH2)n-, -(CH2)nNA-, -NA(CH2)n-, -CHHal- o -C(Hal)2-; Het es un heterociclo aromático mono o bicíclico con 1 a 4 átomos de N, O y/o S; R1, R2 son, de modo independiente entre sí, A, Ar', OR3, SR3, OAr', SAr', N(R3)2, NHAr', Hal, NO2, CN, (CH2)nCOOR3, (CH2)nCON(R3)n, COR3, S(O)mA, S(O)mAr', NHCOA, NHCOAr', NHSOmA, NHSOmAr', SOmN(R3)2, -O-(CH2)n-N(R3)2, O(CH2)nNHR3, O(CH2)nNA2,-O(CH2)nC(H3)2(CH2)nN(R3)2, NH(CH2)n(CH3)2(CH2)nN(R3)2, O(CH2)nN(R3)SOmA, O(CH2)nN(R3)SOmN(R3)A, O(CH2)nN(R3)SOmAr', (CH2)nN(R3)SOmA, (CH2)nN(R3)SOmN(R3)A, (CH2)nN(R3)SOmA, O(CH2)nSOmA, O(CH2)nSOmN(R3)A, O(CH2)nSOmAr', (CH2)nSOmA, (CH2)nN(R3)A, (CH2)nSOmAr', -NH-(CH2)n-NH2, -NH(CH2)n-NHA, -NH-(CH2)n-NA2, -NA-(CH2)n-NH2, -NA-(CH2)nNHA, -NA-(CH2)n-NA2, -O-(CH2)n-Het1 o Het1; R3 es H, A o -(CH2)nAr'; R4 es H, CN, OH, A, (CH2)mAr', COR3, COAr', S(O)mA o S(O)mAr'; Ar' es fenilo insustituido o mono, di, tri, tetra o pentasustituido con A, Ph, OH, OA, SH, SA, OPh, NH2, NHA, NA2, NHPh, Hal, NO2, CN, (CH2)nCOOH, (CH2)nCOOA, (CH2)nCONH2, (CH2)nCONHA, CHO, COA, S(O)mA, S(O)mPh, NHCOA, NHCOPh, NHSO2A, NHSO2Ph o SO2NH2; Ph es fenilo insustituido o mono, di o trisustituido con A, Hal, CN, COOR, COOH, NH2, NO2, OH u OA; Het1 es un heterociclo saturado monocíclico con 1 a 4 átomos de N, o y/o S, que puede estar insustituido, o mono, di o trisustituido con Hal, A, OA, CN, (CH2)nOH, (CH2)nHal, NH2, =NH, =N-OH, =N-OA y/o el oxígeno del carbonilo (=O); A es alquilo C1-10, en donde también 1-7 átomos de H pueden estar reemplazados por F y/o cloro; Hal es F, Cl, Br o I; n es 0, 1, 2, 3, 4 o 5; m es 0, 1 o 2; así como sus derivados, solvatos, sales y estereoisomeros de utilidad farmacéutica, incluyendo sus mezclas en todas las proporciones para preparar un medicamento para la prevencion en y/o el tratamiento de enfermedades en las cuales la inhibicion, la regulacion y/o la modulacion de la transduccion de senales de quinasas, en especial de las RAF-quinasas, desempena un papel importante. Método de obtencion de dichos compuestos y composiciones farmacéuticas que los contienen. Reivindicacion 11: Compuestos de acuerdo con la formula general (2), en donde: Ar1 es fenilo insustituido o mono, di, tri, tetra o pentasustituido con R1; Ar2 es fenilo o Het insustituido o mono, di, tri, tetra o pentasustituido con R2; Y es O; Z es -O-, -CH2-(CH2)n-, -(CH2)n-CHA-, -CHA-(CH2)n-, -C(=O)-, ,-CH(OH)-, --CH(OA)-, (CH2)nO-, -O(CH2)n-, -(CH2)nNH- o -NH(CH2)n-; Het es un heterociclo aromático mono o bicíclico con 1 a 4 átomos de N, O y/o S; R1, R2 son, de modo independiente entre sí, A, OR3, Hal, NO2, CN, S(O)mA, O(CH2)nNA2 o Het1; R3 es H o A; Het1 es un heterociclo saturado monocíclico con 1 a 4 átomos de N, O y/o S, que puede estar insustituido o mono, di o trisustituido con Hal, A, OA, CN, (CH2)nOH, (CH2)nHal, NH2, =NH, =N-OH, =N-OA y/o el oxígeno del carbonilo (=O); A es alquilo C1-10, en donde también 1-7 átomos de H pueden estar reemplazados por F y/o cloro; Hal es F, Cl, Br o I; n es 0, 1 o 2; m es 0, 1 o 2; así como sus derivados, solvatos, sales y estereoisomeros de utilidad farmacéutica, incluyendo sus mezclas en todas las proporciones.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102004009933A DE102004009933A1 (de) | 2004-02-26 | 2004-02-26 | Verwendung von Thiadiazolharnstoffderivaten |
Publications (1)
Publication Number | Publication Date |
---|---|
AR049773A1 true AR049773A1 (es) | 2006-09-06 |
Family
ID=34853867
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP050100704A AR049773A1 (es) | 2004-02-26 | 2005-02-25 | Derivados de tiadiazolurea. metodos de obtencion y composiciones farmaceuticas |
Country Status (8)
Country | Link |
---|---|
US (1) | US20070191353A1 (es) |
EP (1) | EP1720846A1 (es) |
JP (1) | JP2007523922A (es) |
AR (1) | AR049773A1 (es) |
AU (1) | AU2005219499A1 (es) |
CA (1) | CA2557303A1 (es) |
DE (1) | DE102004009933A1 (es) |
WO (1) | WO2005085220A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007106391A1 (en) * | 2006-03-10 | 2007-09-20 | Lymphosign Inc. | Compounds for modulating cell proliferation, compositions and methods related thereto |
WO2010073011A2 (en) * | 2008-12-23 | 2010-07-01 | Betagenon Ab | Compounds useful as medicaments |
WO2022031736A1 (en) | 2020-08-04 | 2022-02-10 | Nura Bio, Inc. | Substituted pyridine derivatives as sarm1 inhibitors |
US11945796B2 (en) | 2020-09-16 | 2024-04-02 | Nura Bio, Inc. | Substituted pyridine derivatives as SARM1 inhibitors |
US11629136B1 (en) | 2021-07-28 | 2023-04-18 | Nura Bio, Inc. | Substituted pyridine derivatives as SARM1 inhibitors |
EP4282862A1 (en) * | 2022-05-25 | 2023-11-29 | Irbm S.P.A. | Flavivirus inhibitors |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DD241740A1 (de) * | 1985-10-15 | 1986-12-24 | Univ Rostock | Verfahren zur herstellung von substituierten 2-ureido-1,3,4-thiadiazolen |
WO1999020617A1 (en) * | 1997-10-21 | 1999-04-29 | Active Biotech Ab | Antiinflammatory thiadiazolyl ureas which act as lfa-1 and mac-1 inhibitors |
US20030236287A1 (en) * | 2002-05-03 | 2003-12-25 | Piotrowski David W. | Positive allosteric modulators of the nicotinic acetylcholine receptor |
DE60335099D1 (de) * | 2002-05-06 | 2011-01-05 | Vertex Pharma | Thiadiazole oder oxadiazole und ihre verwendung als jak proteinkinaseinhibitoren |
GB0308511D0 (en) * | 2003-04-14 | 2003-05-21 | Astex Technology Ltd | Pharmaceutical compounds |
-
2004
- 2004-02-26 DE DE102004009933A patent/DE102004009933A1/de not_active Withdrawn
-
2005
- 2005-01-31 CA CA002557303A patent/CA2557303A1/en not_active Abandoned
- 2005-01-31 EP EP05701263A patent/EP1720846A1/de not_active Withdrawn
- 2005-01-31 JP JP2007500082A patent/JP2007523922A/ja active Pending
- 2005-01-31 US US10/590,729 patent/US20070191353A1/en not_active Abandoned
- 2005-01-31 WO PCT/EP2005/000908 patent/WO2005085220A1/de not_active Application Discontinuation
- 2005-01-31 AU AU2005219499A patent/AU2005219499A1/en not_active Abandoned
- 2005-02-25 AR ARP050100704A patent/AR049773A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
AU2005219499A1 (en) | 2005-09-15 |
JP2007523922A (ja) | 2007-08-23 |
DE102004009933A1 (de) | 2005-09-15 |
WO2005085220A1 (de) | 2005-09-15 |
CA2557303A1 (en) | 2005-09-15 |
US20070191353A1 (en) | 2007-08-16 |
EP1720846A1 (de) | 2006-11-15 |
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