AR049654A1 - Derivados de tetrahidroquinolina como reguladores de proteinas motoras mitoticas - Google Patents
Derivados de tetrahidroquinolina como reguladores de proteinas motoras mitoticasInfo
- Publication number
- AR049654A1 AR049654A1 ARP050102681A ARP050102681A AR049654A1 AR 049654 A1 AR049654 A1 AR 049654A1 AR P050102681 A ARP050102681 A AR P050102681A AR P050102681 A ARP050102681 A AR P050102681A AR 049654 A1 AR049654 A1 AR 049654A1
- Authority
- AR
- Argentina
- Prior art keywords
- nnr2
- naryl
- nheteroaryl
- nxr
- xch
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Los compuestos de la formula (1), en la que: W es CH o N; R1, R2, R3 son, de modo independiente entre sí, H, A, arilo, heteroarilo, Hal, -(CY2)n-SA, -(CY2)n-SCF3, -(CY2)n-SCN, -(CY2)n-CF3, -(CY2)n-OCF3, cicloalquilo, -SCH3, -SCN, -CF3, -OCF3, -OA, - (CY2)n-OH, -(CY2)n-CO2R, -(CY2)n-CN, -(CY2)n-Hal, -(CY2)n-NR2, (CY2)n-OA, (CY2)n-OCOA, -SCF3, (CY2)n-CONR2, -(CY2)n-NHCOA, -(CY2)n-NHSO2A; Y es H, A Hal; A es alquilo o cicloalquilo; Hal es F, Cl, Br o I; R es H o A, en caso de radicales geminales R también son juntos -(CH2)5-, -(CH2)4- o -(CH2)2-NR-(CH2)2; R4, R5 son juntos -X(CH2)2X-, -X(CR2)X-, -XCH(CH2OR)X-, -XCH(CH2OR)CR2X-, -XCR2CH(CH2OR)X-, -XCH(CH2NR2)X-, -XCH(CH2NR2)CR2X-, -XCR2CH(CH2NR2)X-, -OCH2CH2O-, -X(CH2)2X-, -XCHQCR2X, -XCR2CHQX- , -XCR2X-, -XCH(CH2OR)X-, -XCH(CH2OR)CR2X-, -X-C(=X)-X-, -XCH(CH2NR2)X-, -XCH(CH2NR2)CR2X-, -OCH2CH2O-, -X-C(=X)-X-; Q es CH2Hal, CHO, CORa, CH2Ra, CH2OCORa, CH2NCOR1, CH2N(R1)2, CH2OR1, CH2OCON(R1)2, CH2OCOOR1, CH2NHCON(R1)2, CH2NHCOOR1; Ra es un resto seleccionado del grupo de formulas (2), OR, NHR2, NR2OR, NHR2, NR2, NR(CH2)narilo, NR(CH2)nOR, COOR, radical de N-pirrolidona, OCOR, NR(CH2)nNR2, N[(CH2)nNR2]CO(CH2)narilo, N[(CH2)nNHCOOR]COarilo, R1, N[CH2(CH2)nOR]2, NR(CH2)nNCOOR, X(CH2)nX(CH2)nXR, NR(CH2)nX(CH2)nOH, NR(CH2)nO(CH2)nOH, (CH2)nCOOR, O(CO)NR(CH2)OR, O(CO)(CH2)nNR2, NR(CH2)nNR2, N[(CH2)nNR2]CO(CH2)narilo, N[(CH2)nXR]CO(CH2)narilo, N[(CH2)nXR]CO(CH2)nheteroarilo, N[(CH2)nNR2]CO(CH2)nheteroarilo, N[(CH2)nNR2]CO(CH2)nR1, N(R)(CH2)nN(R)COOR, XCOO(CH2)nNR2, OSO2A, OSO2CF3, OSO2Ar, OCONR2, OCH2(CH2)nNR2; Z es CH2, X, CHCONH2, CH(CH2)nNRCOOR, CHNRCOOR, NCO, CH(CH2)nCOOR, NCOOR, CH(CH2)nOH, N(CH2)nOH, CHNH2, CH(CH2)nNR2, CH(CH2)nNR2, C(OH)R, CHNCOR, CH(CH2)narilo, CH(CH2)nheteroarilo, CH(CH2)nR1, N(CH2)nCOOR, CH(CH2)nX(CH2)narilo, CH(CH2)nX(CH2)nheteroarilo, N(CH2)nCONR2, XCONR(CH2)nNR2, N[(CH2)nXCOOR]CO(CH2)narilo, N[(CH2)nXR]CO(CH2)narilo, N[(CH2)nXR]CO(CH2)nXarilo, N[(CH2)nXR]SO2(CH2)narilo, N[(CH2)nNRCOOR]CO(CH2)narilo, N[(CH2)nNR2]CO(CH2)narilo, N[(CH2)nNR2]CO(CH2)nNRarilo, N[(CH2)nNR2]SO2(CH2)narilo, N[(CH2)nXR]CO(CH2)nheteroarilo, N[(CH2)nXR]CO(CH2)nXheteroarilo, N[(CH2)nXR]SO2(CH2)nheteroarilo, N[(CH2)nNRCOOR]CO(CH2)nheteroarilo, N[(CH2)nNR2]CO(CH2)nheteroarilo, N[(CH2)nNR2]CO(CH2)nNRheteroarilo, N[(CH2)nNR2]SO2(CH2)nheteroarilo, O(CH2)nNR2, X(CH2)nNR2, NCO(CH2)nNR2, X es O, S o NR; R6 es arilo o heteroarilo insustituido o mono- o polisustituido con arilo o heteroarilo, que puede estar sustituido con Hal, NO2, CN, A, OR, OCOR, NR2, CF3, OCF3, OCH(CF3)2, Hal, NO2, CN, OR, A, -(CY2)n-OR, -OCOR, -(CY2)n-CO2R, -(CY2)n-CN o -(CY2)n-NR2; R7 es (C=O)-R, (C=O)-NR2, (C=O)-OR, H o A; y n, m son, de modo independiente entre sí, 0, 1, 2, 3, 4, 5, 6 o 7, así como sus derivados, solvatos, tautomeros, sales y estereoisomeros de utilidad farmacéutica, así como sus mezclas en todas las proporciones, pueden ser utilizados, por ejemplo, para el tratamiento de tumores.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102004031656A DE102004031656A1 (de) | 2004-06-30 | 2004-06-30 | Tetrahydrochinoline |
Publications (1)
Publication Number | Publication Date |
---|---|
AR049654A1 true AR049654A1 (es) | 2006-08-23 |
Family
ID=35063029
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP050102681A AR049654A1 (es) | 2004-06-30 | 2005-06-29 | Derivados de tetrahidroquinolina como reguladores de proteinas motoras mitoticas |
Country Status (14)
Country | Link |
---|---|
US (1) | US7915416B2 (es) |
EP (1) | EP1778694A1 (es) |
JP (1) | JP5121450B2 (es) |
KR (1) | KR20070037585A (es) |
CN (1) | CN1976936A (es) |
AR (1) | AR049654A1 (es) |
AU (1) | AU2005259676B2 (es) |
BR (1) | BRPI0512784A (es) |
CA (1) | CA2572350C (es) |
DE (1) | DE102004031656A1 (es) |
MX (1) | MXPA06014293A (es) |
RU (1) | RU2007103300A (es) |
WO (1) | WO2006002726A1 (es) |
ZA (1) | ZA200700819B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102007013854A1 (de) * | 2007-03-20 | 2008-09-25 | Merck Patent Gmbh | Tetrahydrochinoline |
AU2008312401C1 (en) | 2007-10-19 | 2014-07-10 | Merck Sharp & Dohme Llc | Spiro-condensed 1, 3, 4-thiadiazole derivatives for inhibiting KSP kinesin activity |
EP2647638A1 (en) * | 2012-04-02 | 2013-10-09 | Almirall, S.A. | Substituted tricyclic compounds with activity towards ep1 receptors |
CN109666666B (zh) * | 2019-01-21 | 2021-03-05 | 天津科技大学 | 一种基于分子动力学的酶柔性分析提高肝素酶i热稳定性的突变体及其制备方法 |
CN111233761B (zh) * | 2020-03-16 | 2022-01-14 | 大连理工大学 | 一类2-取代四氢喹啉化合物及其衍生物、制备方法和应用 |
WO2022006365A2 (en) * | 2020-07-02 | 2022-01-06 | Purdue Research Foundation | Tetrahydro-3h-pyrazolo quinolone and tetrahydro-3h-pyrrolo[3,2-f]quinoline-containing compounds and uses thereof |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3631050A (en) * | 1968-11-13 | 1971-12-28 | Parke Davis & Co | Hexahydro-9b-methylfuro(3 2-c) quinoline compounds |
DK0451486T3 (da) * | 1990-03-08 | 1995-05-08 | Lepetit Spa | Antibiotikum GE 2270 faktorer B1, B2, C1, C2, D1, D2, E og T |
HUT72495A (en) * | 1992-10-01 | 1996-05-28 | Cold Spring Harbor Lab | Complex combinatorial chemical libraries encoded with tags |
US6503759B1 (en) * | 1992-10-01 | 2003-01-07 | The Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
US5428051A (en) * | 1992-10-13 | 1995-06-27 | University Of North Carolina | Methods of combating pneumocystis carinii pneumonia and compounds useful therefor |
US5602172A (en) * | 1994-05-06 | 1997-02-11 | The University Of North Carolina At Chapel Hill | Methods of inhibiting Pneumocystis carinii pneumonia, Giardia lamblia, and Cryptosporidium and compounds useful therefor |
US5521189A (en) * | 1994-05-06 | 1996-05-28 | The University Of Nc At Ch | Methods of treating pneumocystis carinii pneumonia |
US5643935A (en) * | 1995-06-07 | 1997-07-01 | The University Of North Carolina At Chapel Hill | Method of combatting infectious diseases using dicationic bis-benzimidazoles |
US5723495A (en) * | 1995-11-16 | 1998-03-03 | The University Of North Carolina At Chapel Hill | Benzamidoxime prodrugs as antipneumocystic agents |
US5790244A (en) | 1996-08-23 | 1998-08-04 | Laser Technology, Inc. | Pre-biasing technique for a transistor based avalanche circuit in a laser based distance measurement and ranging instrument |
AU5797098A (en) | 1996-12-18 | 1998-07-15 | Eli Lilly And Company | Combinatorial process for preparing hydrofuroquinoline libraries |
US6180940B1 (en) * | 1998-04-07 | 2001-01-30 | Universite Laval | Light-driven molecular rotational motor |
US6180640B1 (en) | 1998-06-25 | 2001-01-30 | Sepracor, Inc. | Di- and tetra-hydroquinoline-indole antimicrobial agents, uses and compositions related thereto |
AU758563B2 (en) * | 1998-08-20 | 2003-03-27 | University Of North Carolina At Chapel Hill, The | Dicationic dibenzofuran and dibenzothiophene compounds and methods of use thereof |
DE69933890T2 (de) * | 1998-09-17 | 2007-03-15 | University Of North Carolina At Chapel Hill | Antimykotische wirkung von dikationischen molekülen |
PL366584A1 (en) * | 2001-04-30 | 2005-02-07 | Pfizer Products Inc. | Compounds useful as intermediates |
US7250423B2 (en) * | 2001-09-24 | 2007-07-31 | Chao-Jun Li | Methods for synthesizing heterocycles and therapeutic use of the heterocycles for cancers |
WO2005016255A2 (en) | 2003-07-16 | 2005-02-24 | Ligand Pharmaceuticals Incorporated | Substituted tetrahydroquinolines, phenylacetic acids and benzoic acids as hepatocyte nuclear factor 4 (hnf-4 ) modulator compounds |
AU2009291719A1 (en) * | 2008-09-10 | 2010-03-18 | Alcon Research, Ltd | Heterocyclic inhibitors of histamine receptors for the treatment of disease |
-
2004
- 2004-06-30 DE DE102004031656A patent/DE102004031656A1/de not_active Withdrawn
-
2005
- 2005-06-03 KR KR1020067027545A patent/KR20070037585A/ko not_active Application Discontinuation
- 2005-06-03 RU RU2007103300/04A patent/RU2007103300A/ru unknown
- 2005-06-03 BR BRPI0512784-0A patent/BRPI0512784A/pt not_active Application Discontinuation
- 2005-06-03 EP EP05750999A patent/EP1778694A1/de not_active Withdrawn
- 2005-06-03 CN CNA2005800214423A patent/CN1976936A/zh active Pending
- 2005-06-03 MX MXPA06014293A patent/MXPA06014293A/es not_active Application Discontinuation
- 2005-06-03 JP JP2007519634A patent/JP5121450B2/ja not_active Expired - Fee Related
- 2005-06-03 AU AU2005259676A patent/AU2005259676B2/en not_active Ceased
- 2005-06-03 WO PCT/EP2005/005981 patent/WO2006002726A1/de active Application Filing
- 2005-06-03 CA CA2572350A patent/CA2572350C/en not_active Expired - Fee Related
- 2005-06-03 US US11/631,185 patent/US7915416B2/en not_active Expired - Fee Related
- 2005-06-29 AR ARP050102681A patent/AR049654A1/es unknown
-
2007
- 2007-01-29 ZA ZA200700819A patent/ZA200700819B/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2005259676A1 (en) | 2006-01-12 |
DE102004031656A1 (de) | 2006-01-19 |
CN1976936A (zh) | 2007-06-06 |
ZA200700819B (en) | 2008-01-30 |
WO2006002726A1 (de) | 2006-01-12 |
CA2572350A1 (en) | 2006-01-12 |
JP2008505136A (ja) | 2008-02-21 |
KR20070037585A (ko) | 2007-04-05 |
US7915416B2 (en) | 2011-03-29 |
RU2007103300A (ru) | 2008-08-10 |
AU2005259676B2 (en) | 2011-03-10 |
MXPA06014293A (es) | 2007-02-19 |
CA2572350C (en) | 2013-02-19 |
JP5121450B2 (ja) | 2013-01-16 |
BRPI0512784A (pt) | 2008-04-08 |
EP1778694A1 (de) | 2007-05-02 |
US20090030028A1 (en) | 2009-01-29 |
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