AR048932A1 - Derivados de piridoindolona substituidos en -6, su preparacion y composiciones farmaceuticas - Google Patents
Derivados de piridoindolona substituidos en -6, su preparacion y composiciones farmaceuticasInfo
- Publication number
- AR048932A1 AR048932A1 ARP050101576A ARP050101576A AR048932A1 AR 048932 A1 AR048932 A1 AR 048932A1 AR P050101576 A ARP050101576 A AR P050101576A AR P050101576 A ARP050101576 A AR P050101576A AR 048932 A1 AR048932 A1 AR 048932A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- hydrogen atom
- alkyl group
- alkyl
- mnr9r10
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 15
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 12
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004981 cycloalkylmethyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Abstract
Procedimientos de preparacion y composiciones farmacéuticas que los contienen. Compuesto que responde a la formula (1), en la cual: R1 representa un átomo de hidrogeno; un grupo alquilo C1-4; un grupo -(CH2)mOH; un grupo -(CH2)mCN; un grupo - (CH2)mNR9R10; R2 representa un átomo de hidrogeno o un grupo alquilo C1-4; R3 representa un fenilo sustituido por R6; R7, R8; R4 representa: Un grupo de formula -C(R11)=N-O-R12; un grupo heterocíclico elegido entre un grupo de formulas (2); R5 representa un átomo de hidrogeno o un grupo alquilo C1-4; R6, R7 y R8 representan, cada uno independientemente entre sí, un átomo de hidrogeno; un átomo de halogeno; un grupo alquilo C1-4; un grupo alcoxi C1-4; un hidroxi; un ciano; un grupo - (CH2)nNR9R10; un grupo -O-(CH2)mNR9R10; R9 y R10 representan cada uno, independientemente entre sí, un átomo de hidrogeno o un grupo alquilo C1-4; o bien R9 y R10 junto con el átomo de nitrogeno al cual están unidos, constituyen un radical heterocíclico elegido entre pirrolidin-1-ilo, piperidin-1-ilo, morfolin-4-ilo o piperazin-1-ilo no sustituido o sustituido en posicion -4- por un alquilo C1-4; R11 representa un átomo de hidrogeno o un grupo alquilo C1-4; R12 representa un átomo de hidrogeno; un grupo alquilo C1-4; un grupo -(CH2)m-CO-R16; R13 representa un átomo de hidrogeno; un grupo alquilo C1-4; un fenilo; un grupo -NR17R19; un grupo de formula (3); R14 representa un átomo de hidrogeno; un grupo alquilo C1-4; un grupo - NR17R18; R15 representa un átomo de hidrogeno; un grupo alquilo C1-4; un grupo -NR19R20; un grupo -COO-alquiloC1-4; R16 representa un hidroxi; un alcoxi C1-4; un grupo -NR9R10; R17 y R18 representan, cada uno independientemente, un átomo de hidrogeno o un grupo alquilo C1-4; R18 puede, además, representar un grupo -COR21; un grupo -SO2R22; R19 y R20 representan cada uno independientemente, un átomo de hidrogeno o un grupo alquilo C1-4; R20 puede, además representar un grupo cicloalquilo C3-6, un grupo cicloalquilmetilo C3-6, un grupo -(CH2)mNR9R10; R21 representa un grupo alquilo C1-4; un grupo cicloalquilo C3-6; un grupo -(CH2)mNR9R10; R22 representa un grupo alquilo C1-4; m es 1, 2 o 3; n es 0, 1, 2, o 3; en estado de base o de sal de adicion con un ácido, así como en estado de hidrato o de solvato.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0404251A FR2869316B1 (fr) | 2004-04-21 | 2004-04-21 | Derives de pyridoindolone substitues en -6, leur preparation et leur application en therapeutique. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR048932A1 true AR048932A1 (es) | 2006-06-14 |
Family
ID=34945552
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050101576A AR048932A1 (es) | 2004-04-21 | 2005-04-21 | Derivados de piridoindolona substituidos en -6, su preparacion y composiciones farmaceuticas |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US7812165B2 (es) |
| EP (1) | EP1742947B1 (es) |
| JP (1) | JP4809830B2 (es) |
| KR (1) | KR20070002094A (es) |
| CN (1) | CN100537568C (es) |
| AR (1) | AR048932A1 (es) |
| AT (1) | ATE405565T1 (es) |
| AU (1) | AU2005240816A1 (es) |
| BR (1) | BRPI0510060A (es) |
| CA (1) | CA2562561A1 (es) |
| CR (1) | CR8677A (es) |
| DE (1) | DE602005009166D1 (es) |
| DK (1) | DK1742947T3 (es) |
| EC (1) | ECSP066918A (es) |
| ES (1) | ES2313371T3 (es) |
| FR (1) | FR2869316B1 (es) |
| HK (1) | HK1106223A1 (es) |
| IL (1) | IL178444A0 (es) |
| MA (1) | MA28546B1 (es) |
| MX (1) | MXPA06012127A (es) |
| MY (1) | MY137599A (es) |
| NO (1) | NO20065323L (es) |
| PL (1) | PL1742947T3 (es) |
| PT (1) | PT1742947E (es) |
| RU (1) | RU2364595C2 (es) |
| TN (1) | TNSN06337A1 (es) |
| TW (1) | TW200538114A (es) |
| UA (1) | UA85709C2 (es) |
| UY (1) | UY28864A1 (es) |
| WO (1) | WO2005108398A1 (es) |
| ZA (1) | ZA200608646B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2823975B1 (fr) | 2001-04-27 | 2003-05-30 | Sanofi Synthelabo | Nouvelle utilisation de pyridoindolone |
| FR2846329B1 (fr) | 2002-10-23 | 2004-12-03 | Sanofi Synthelabo | Derives de pyridoindolone substitues en -3 par un phenyle, leur preparation et leur application en therapeutique |
| US7456193B2 (en) | 2002-10-23 | 2008-11-25 | Sanofi-Aventis | Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics |
| FR2892416B1 (fr) * | 2005-10-20 | 2008-06-27 | Sanofi Aventis Sa | Derives de 6-heteroarylpyridoindolone, leur preparation et leur application en therapeutique |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1268772A (en) | 1968-03-15 | 1972-03-29 | Glaxo Lab Ltd | NOVEL alpha-CARBOLINE DERIVATIVES, THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME |
| US4263304A (en) * | 1978-06-05 | 1981-04-21 | Sumitomo Chemical Company, Limited | 7 H-indolo[2,3-c]isoquinolines |
| SU833971A1 (ru) | 1979-07-10 | 1981-05-30 | Ленинградский Химико-Фармацевтическийинститут | Способ получени 3-фенил-2-оксо- - КАРбОлиНОВ |
| FR2595701B1 (fr) * | 1986-03-17 | 1988-07-01 | Sanofi Sa | Derives du pyrido-indole, leur application a titre de medicaments et les compositions les renfermant |
| JPH10501686A (ja) | 1994-04-13 | 1998-02-17 | ザ ロックフェラー ユニヴァーシティ | 神経系の細胞へのｄｎａのａａｖ仲介送達 |
| DE19502753A1 (de) * | 1995-01-23 | 1996-07-25 | Schering Ag | Neue 9H-Pyrido[3,4-b]indol-Derivate |
| FR2765582B1 (fr) | 1997-07-03 | 1999-08-06 | Synthelabo | Derives de 3-alkyl-1,9-dihydro-2h-pyrido[2,3-b]indol-2-one leur preparation et leur application en therapeutique |
| FR2765581B1 (fr) * | 1997-07-03 | 1999-08-06 | Synthelabo | Derives de 3-aryl-1,9-dihydro-2h-pyrido[2,3-b]indol-2-one, leur preparation et leur application en therapeutique |
| CA2326319A1 (en) | 1998-04-02 | 1999-10-14 | Neurogen Corporation | Aminoalkyl substituted 5,6,7,8-tetrahydro-9h pyrimidino[2,3-b]indole and 5,6,7,8-tetrahydro-9h-pyrimidino[4,5-b]indole derivatives: crf1 specific ligands |
| IT1313592B1 (it) | 1999-08-03 | 2002-09-09 | Novuspharma Spa | Derivati di 1h-pirido 3,4-b indol-1-one. |
| US20020156016A1 (en) | 2001-03-30 | 2002-10-24 | Gerald Minuk | Control of cell growth by altering cell membrane potentials |
| FR2823975B1 (fr) * | 2001-04-27 | 2003-05-30 | Sanofi Synthelabo | Nouvelle utilisation de pyridoindolone |
| FR2846330B1 (fr) | 2002-10-23 | 2004-12-03 | Sanofi Synthelabo | Derives de pyridoindolone substitues en -3 par groupe heterocyclique, leur preparation et leur application en therapeutique |
| US7456193B2 (en) * | 2002-10-23 | 2008-11-25 | Sanofi-Aventis | Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics |
| FR2846329B1 (fr) * | 2002-10-23 | 2004-12-03 | Sanofi Synthelabo | Derives de pyridoindolone substitues en -3 par un phenyle, leur preparation et leur application en therapeutique |
| FR2892416B1 (fr) * | 2005-10-20 | 2008-06-27 | Sanofi Aventis Sa | Derives de 6-heteroarylpyridoindolone, leur preparation et leur application en therapeutique |
-
2004
- 2004-04-21 FR FR0404251A patent/FR2869316B1/fr not_active Expired - Fee Related
-
2005
- 2005-04-20 MX MXPA06012127A patent/MXPA06012127A/es active IP Right Grant
- 2005-04-20 WO PCT/FR2005/000971 patent/WO2005108398A1/fr active IP Right Grant
- 2005-04-20 CA CA002562561A patent/CA2562561A1/fr not_active Abandoned
- 2005-04-20 UA UAA200612183A patent/UA85709C2/ru unknown
- 2005-04-20 TW TW094112639A patent/TW200538114A/zh unknown
- 2005-04-20 AT AT05759933T patent/ATE405565T1/de not_active IP Right Cessation
- 2005-04-20 KR KR1020067024310A patent/KR20070002094A/ko not_active Application Discontinuation
- 2005-04-20 PL PL05759933T patent/PL1742947T3/pl unknown
- 2005-04-20 RU RU2006140998/04A patent/RU2364595C2/ru not_active IP Right Cessation
- 2005-04-20 MY MYPI20051746A patent/MY137599A/en unknown
- 2005-04-20 ZA ZA200608646A patent/ZA200608646B/en unknown
- 2005-04-20 PT PT05759933T patent/PT1742947E/pt unknown
- 2005-04-20 AU AU2005240816A patent/AU2005240816A1/en not_active Abandoned
- 2005-04-20 BR BRPI0510060-7A patent/BRPI0510060A/pt not_active IP Right Cessation
- 2005-04-20 DE DE602005009166T patent/DE602005009166D1/de active Active
- 2005-04-20 JP JP2007508935A patent/JP4809830B2/ja not_active Expired - Fee Related
- 2005-04-20 EP EP05759933A patent/EP1742947B1/fr active Active
- 2005-04-20 DK DK05759933T patent/DK1742947T3/da active
- 2005-04-20 ES ES05759933T patent/ES2313371T3/es active Active
- 2005-04-20 CN CNB2005800163258A patent/CN100537568C/zh not_active Expired - Fee Related
- 2005-04-21 AR ARP050101576A patent/AR048932A1/es unknown
- 2005-04-21 UY UY28864A patent/UY28864A1/es not_active Application Discontinuation
-
2006
- 2006-10-04 IL IL178444A patent/IL178444A0/en unknown
- 2006-10-09 CR CR8677A patent/CR8677A/es not_active Application Discontinuation
- 2006-10-11 EC EC2006006918A patent/ECSP066918A/es unknown
- 2006-10-18 TN TNP2006000337A patent/TNSN06337A1/en unknown
- 2006-10-18 US US11/582,769 patent/US7812165B2/en not_active Expired - Fee Related
- 2006-10-20 MA MA29404A patent/MA28546B1/fr unknown
- 2006-11-20 NO NO20065323A patent/NO20065323L/no not_active Application Discontinuation
-
2007
- 2007-10-22 HK HK07111367.5A patent/HK1106223A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR044874A1 (es) | Derivados de 4- cianopirazol-3 - carboxamida, su preparacion y su aplicacion en terapeutica | |
| NO20065184L (no) | 1-amino-ftalazinderivater, deres fremstilling og terapeutiske anvendelse derav | |
| AR046711A1 (es) | 5-7-diaminopirazolo[4,3d]pirimidinas como inhibidores de la pde-5,composiciones farmaceuticas que las contienen y usos en el tratamiento de hipertensiones | |
| AR047817A1 (es) | Derivados de aril- y heteroarilpiperidincarboxilatos, su preparacion y su aplicacion en terapeutica | |
| AR037731A1 (es) | Uso de ureas de benzotiazoles | |
| ECSP099395A (es) | Nuevos derivados de los ácidos amino-nicotínico y amino-isonicotínico | |
| AR051092A1 (es) | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa | |
| ECSP066695A (es) | Derivados de n-(1,5-difenil-1h-pirazol-3-il) sulfonamida con afinidad por los receptores cb1 | |
| PE20050896A1 (es) | Intermediarios de quinolina como inhibidores de tirosina quinasas de receptores y la sintesis de los mismos | |
| AR070992A1 (es) | Derivados de 2-aril-6-fenil-inidazo[1,2a]piridinas, su preparacion, composiciones farmaceuticas y su uso en enfermedades que implican los receptores nucleares nurr-1 | |
| CO5611126A2 (es) | Derivados de indolinona utiles como inhibidores de la proteina cinasa | |
| AR034203A1 (es) | Derivados de 1-aril- o 1-alquilsulfonilbenzazol como ligandos de 5-hidroxitriptamina-6, un metodo para su preparacion, composicion farmaceutica y el uso de los mismos para la fabricacion de un medicamento | |
| AR084913A1 (es) | Derivados de aril-benzocicloalquil-amida | |
| AR062499A1 (es) | Derivados de n-fenil pirazol y piridil pirazoles, composiciones farmaceuticas que los contienen y usos como agentes antiagregantes plaquetarios y antitromboticos. | |
| AR044906A1 (es) | Derivados de difenilpiridina, su preparacion y su aplicacion en terapeutica | |
| CO6321168A2 (es) | Nuevos derivados de 2-amidotiadiazol | |
| AR039988A1 (es) | Derivados de benzoxazina como moduladores de 5-ht6 y usos de los mismos | |
| AR050283A1 (es) | Derivados de n-(1h-indolil)-1h-indol-2-carboxamidas, su preparacion y su aplicacion en terapeuticas. | |
| AR069814A1 (es) | Derivados de 4 amino-pirimidina, proceso de preparacion y composiciones farmaceuticas que los contienen | |
| EA201100368A1 (ru) | Амидные соединения, полезные в терапии | |
| NO20076680L (no) | Utvalgte CGRP-antagonister, metoder for fremstilling av disse og deres anvendelse som medikamenter | |
| AR070485A1 (es) | Compuestos derivados de azetidinas, su preparacion y su aplicacion en terapeutica | |
| AR069813A1 (es) | Derivados de 2- amino-pirimidina, una composicion farmaceutica, un metodo de preparacion del compuesto y uso del mismo para preparar un medicamento | |
| AR040247A1 (es) | Derivados de piperazinilacilpiperidina substituidos, su preparacion, composicion farmaceutica y medicamento que lo comprenden | |
| AR040570A1 (es) | Deriados de acilaminotiazol, su preparacion y su aplicacion en terapeutica |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |