AR047850A1 - Derivados de amida de acido carboxilico. obtencion y composiciones farmaceuticas que los contienen. - Google Patents

Derivados de amida de acido carboxilico. obtencion y composiciones farmaceuticas que los contienen.

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Publication number
AR047850A1
AR047850A1 ARP040104655A ARP040104655A AR047850A1 AR 047850 A1 AR047850 A1 AR 047850A1 AR P040104655 A ARP040104655 A AR P040104655A AR P040104655 A ARP040104655 A AR P040104655A AR 047850 A1 AR047850 A1 AR 047850A1
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Argentina
Prior art keywords
mono
atoms
hal
con
unsubstituted
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ARP040104655A
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English (en)
Inventor
Bertram Cezanne
Dorsch Chem Dieter
Werner Mederski
Christos Tsaklakidis
Johannes Gleitz
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Merck Patent Gmbh
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Publication of AR047850A1 publication Critical patent/AR047850A1/es

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Abstract

Los nuevos compuestos de la formula (1) en donde: D es un carbociclo o heterociclo aromático mono o bicíclico insustituido o mono o polisustituido con Hal, A, OR2, N(R2)2, NO2, CN, COOR2, CON(R2)2 o -C:::CH con 0 a 4 átomos de N, O y/o S, X es NR3 u O; Y es O, S, NH, N-CN o N-NO2; R1 es H, Ar, Het, cicloalquilo o A, que puede estar mono, di o trisustituido con OR2, SR2, S(O)mR2, SO2N(R2)2,SO3R2, S(=O)(=NR2)R2, NR2SO2R2, OSO2R2, OSO2N(R2)2, N(R2)2, CN, COOR2, CON(R2)2, Ar, Het o cicloalquilo; E es CH o N; Z está ausente o es un grupo (CH2)q insustituido o monosustituido con el O del carbonilo (=O), en donde uno o dos grupos CH2 pueden estar reemplazados por átomos de N, O y/o S y/o por un grupo -CH=CH-, Z' está ausente o es un grupo (CH2)q' insustituido o monosustituido con el O del carbonilo (=O), en donde uno o dos grupos CH2 pueden estar reemplazados por átomos de N, O y/o S y/o por un grupo -CH:::CH-, Q está ausente, es O, NR2, C=O, SO2 o C(R2)n; R2 es H, A, -[C(R3)2]n-Ar', -[C(R3)2]nHet', -[C(R3)2]n-cicloalquilo, -[C(R3)2]n-N(R3)2 o -[C(R3)2]n-OR3; R3 es H o A; R4, R4' cada uno, de modo independiente entre sí, está ausente, son A, OH u OA; R4 y R4' también son juntos metileno o etileno, T es un carbociclo o heterociclo mono o bicíclico saturado, insaturado o aromático con 0 a 4 átomos de N, O y/o S, que puede estar mono, di o trisustituido con =O, =S, =NH, =NR3, =NOR3, =NCOR3, =NCOOR3, =NOCOR3, R3, Hal, A, -[C(R3)2]n-Ar, -[C(R3)2]n-Het, -[C(R3)2]n- cicloalquilo, OR3, N(R3)2, NO2, CN, COOR3, CON(R3)2, NR3COA, NR3CON(R3)2, NR3SO2A, COR3, SO2NR2 y/o S(O)nA; A es alquilo no ramificado o ramificado con 1-10 átomos de C, en donde uno o dos grupos CH2 pueden estar reemplazados por átomos de O o S y/o por grupos -CH=CH- y/o también 1-7 átomos de H pueden estar reemplazados por F; Ar es fenilo, naftilo o bifenilo insustituido o mono, di o trisustituido con Hal, A, OR2, N(R2)2, NO2, CN, COOR2, CON(R2)2, NR2COA, NR2SO2A, COR2, SO2N(R2)2, -[C(R3)2]n- COOR2, -O-[C(R3)2]o-COOR2, SO3H o S(O)nA; Ar' es fenilo insustituido o mono, di o trisustituido con Hal, A, OR3, N(R3)2, NO2, CN, COOR3, CON(R3)2, NR3COA, NR3CON(R3)2, NR3SO2A, COR3, SO2N(R3)2, S(O)nA, -[C(R3)2]n-COOR3 u -O-[C(R3)2]o-COOR3; Het es un heterociclo mono o bicíclico saturado, insaturado o aromático con 1 a 4 átomos de N, O y/o S, que puede estar insustituido o mono, di o trisustituido con el O del carbonilo (=O), =S, =N(R2)2, Hal, A, -[C(R3)2]n-Ar, -[C(R3)2]n-Het', -[C(R3)2]n- cicloalquilo, -[C(R3)2]n-OR2, -[C(R3)2]n-N(R3)2, NO2, CN, -[C(R3)2]n-COOR2, -[C(R3)2]n-CON(R2)2, -[C(R3)2]n-NR2COA, NR2CON(R2)2, -[C(R3)2]n-NR2SO2A, COR2, SO2N(R2)2 y/o S(O)nA; Het' es un heterociclo mono o bicíclico saturado, insaturado o aromático con 1 a 4 átomos de N, O y/o S, que puede estar insustituido o mono o disustituido con el O del carbonilo, =S, =N(R3)2, Hal, A, OR3, N(R3)2, NO2, CN, COOR3, CON(R3)2, NR3COA, NR3CON(R3)2, NR3SO2A, COR3, SO2N(R3)2 y/o S(O)nA; Hal es F, Cl, Br o I; m es 1 o 2; n es 0, 1 o 2; o es 1, 2 o 3; p es 1, 2, 3, 4 o 5; q, q' son cada uno, de modo independiente entre sí, 0, 1, 2, 3 o 4, en donde al menos uno de los grupos Z o Z' está ausente, y 0<q + q <6, así como sus derivados, solvatos, sales y estereoisomeros de utilidad farmacéutica, incluyendo sus mezclas en todas las proporciones. Son inhibidores del factor de coagulacion Xa y se pueden emplear para la profilaxis y/o la terapia de enfermedades tromboembolicas y para el tratamiento de tumores. Obtencion y composiciones farmacéuticas.
ARP040104655A 2003-12-15 2004-12-15 Derivados de amida de acido carboxilico. obtencion y composiciones farmaceuticas que los contienen. AR047850A1 (es)

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CA2550012A1 (en) * 2003-12-17 2005-06-30 Takeda Pharmaceutical Company Limited Urea derivative, process for producing the same and use
WO2006063113A2 (en) * 2004-12-07 2006-06-15 Portola Pharmaceuticals, Inc. Ureas as factor xa inhibitors
US7601844B2 (en) * 2006-01-27 2009-10-13 Bristol-Myers Squibb Company Piperidinyl derivatives as modulators of chemokine receptor activity
TWI433838B (zh) * 2008-06-25 2014-04-11 必治妥美雅史谷比公司 作為趨化因子受體活性調節劑之六氫吡啶衍生物
US8642622B2 (en) 2010-06-16 2014-02-04 Bristol-Myers Squibb Company Piperidinyl compound as a modulator of chemokine receptor activity
AU2011336973A1 (en) 2010-12-03 2013-07-11 Allergan, Inc. Pharmaceutical compositions comprising 3,4- dihydroisoquinolin-2(1 H)-yl-3-phenylurea derivatives having formyl peptide receptor like-1 (FPRL-1) agonist or antagonist activity
FR2985256B1 (fr) * 2011-12-30 2016-03-04 Pitty Marc Henry Derives piperazinyles pour le traitement de cancers
WO2019097318A1 (en) 2017-11-17 2019-05-23 Cellix Bio Private Limited Compositions and methods for the treatment of eye disorders
WO2022221686A1 (en) * 2021-04-15 2022-10-20 Pardes Biosciences, Inc. Inhibitors of cysteine proteases and methods of use thereof

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JPH0655758B2 (ja) * 1984-08-24 1994-07-27 味の素株式会社 アミノ酸誘導体
US5346907A (en) * 1988-04-05 1994-09-13 Abbott Laboratories Amino acid analog CCK antagonists
US5721251A (en) * 1993-12-10 1998-02-24 Merck & Co., Inc. Piperidine, pyrrolidine and hexahydro-1H-azepines promote release of growth hormone
IL115420A0 (en) * 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
JPH09227523A (ja) * 1996-02-26 1997-09-02 Toubishi Yakuhin Kogyo Kk セリンから誘導される抗ｃｃｋ活性化合物
US5847148A (en) * 1997-04-10 1998-12-08 Pharmacia & Upjohn Company Thiadiazole derivatives useful for the treatment of diseases related to connective tissue degradation
DE10063008A1 (de) * 2000-12-16 2002-06-20 Merck Patent Gmbh Carbonsäureamidderivate
AU2002322585A1 (en) * 2001-07-20 2003-03-03 Adipogenix, Inc. Fat accumulation-modulating compounds
IL162851A0 (en) * 2001-12-04 2005-11-20 Actelion Pharmaceuticals Ltd 4-(Piperidyl-and pyrrolidyl-alkyl-ureido)-quinolines as urotensin ii receptor antagonists
US7115609B2 (en) * 2001-12-12 2006-10-03 Eli Lilly And Company Alanyl-piperidine heterocyclic derivatives useful against cardiovascular diseases
EP1499591A1 (de) * 2002-04-27 2005-01-26 MERCK PATENT GmbH Carbonsäureamide als inhibitoren des koagulationsfaktors xa
US7220862B2 (en) * 2002-06-05 2007-05-22 Bristol-Myers Squibb Company Calcitonin gene related peptide receptor antagonists
DE10302500A1 (de) * 2003-01-23 2004-07-29 Merck Patent Gmbh Carbonsäureamidderivate
US6846836B2 (en) * 2003-04-18 2005-01-25 Bristol-Myers Squibb Company N-substituted phenylurea inhibitors of mitochondrial F1F0 ATP hydrolase
KR20070014108A (ko) * 2003-09-26 2007-01-31 액테리온 파마슈티칼 리미티드 피리딘 유도체 및 이의 우로텐신 ⅱ 길항제로서의 용도

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