AR044304A1 - Compuesto de macrolido de 14 y 15 miembros sustituido en la posicion 4'', procedimiento para la preparacion del mismo, su uso para la fabricacion de un medicamento y composicion farmaceutica que lo comprende - Google Patents
Compuesto de macrolido de 14 y 15 miembros sustituido en la posicion 4'', procedimiento para la preparacion del mismo, su uso para la fabricacion de un medicamento y composicion farmaceutica que lo comprendeInfo
- Publication number
- AR044304A1 AR044304A1 ARP040101609A ARP040101609A AR044304A1 AR 044304 A1 AR044304 A1 AR 044304A1 AR P040101609 A ARP040101609 A AR P040101609A AR P040101609 A ARP040101609 A AR P040101609A AR 044304 A1 AR044304 A1 AR 044304A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- optionally substituted
- alkoxy
- independently
- halogen
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 18
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 8
- 229910052736 halogen Inorganic materials 0.000 abstract 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 6
- 150000002367 halogens Chemical class 0.000 abstract 5
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 4
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 4
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 4
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 3
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 abstract 2
- 101001043818 Mus musculus Interleukin-31 receptor subunit alpha Proteins 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 238000011282 treatment Methods 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000003120 macrolide antibiotic agent Substances 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- LYGJENNIWJXYER-UHFFFAOYSA-N nitromethane Chemical compound C[N+]([O-])=O LYGJENNIWJXYER-UHFFFAOYSA-N 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
- 125000004001 thioalkyl group Chemical group 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0310962A GB0310962D0 (en) | 2003-05-13 | 2003-05-13 | Novel compounds |
| GB0407391A GB0407391D0 (en) | 2004-03-31 | 2004-03-31 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR044304A1 true AR044304A1 (es) | 2005-09-07 |
Family
ID=33454579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040101609A AR044304A1 (es) | 2003-05-13 | 2004-05-11 | Compuesto de macrolido de 14 y 15 miembros sustituido en la posicion 4'', procedimiento para la preparacion del mismo, su uso para la fabricacion de un medicamento y composicion farmaceutica que lo comprende |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20070293472A1 (enExample) |
| EP (1) | EP1628989B1 (enExample) |
| JP (1) | JP2006528667A (enExample) |
| AR (1) | AR044304A1 (enExample) |
| AT (1) | ATE348837T1 (enExample) |
| CA (1) | CA2525455A1 (enExample) |
| CL (1) | CL2004001012A1 (enExample) |
| DE (1) | DE602004003809T2 (enExample) |
| DK (1) | DK1628989T3 (enExample) |
| ES (1) | ES2278319T3 (enExample) |
| HR (1) | HRP20070094T3 (enExample) |
| PL (1) | PL1628989T3 (enExample) |
| PT (1) | PT1628989E (enExample) |
| SI (1) | SI1628989T1 (enExample) |
| WO (1) | WO2004101587A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7601695B2 (en) | 2003-03-10 | 2009-10-13 | Optimer Pharmaceuticals, Inc. | Antibacterial agents |
| AU2005240849B2 (en) * | 2004-05-06 | 2008-10-23 | Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. | Ester linked macrolides useful for the treatment of microbial infections |
| GB0424961D0 (en) * | 2004-11-11 | 2004-12-15 | Glaxo Group Ltd | Novel compounds |
| WO2007054295A1 (en) * | 2005-11-09 | 2007-05-18 | Glaxo Group Limited | New 4*-substituted erythromycin derivative |
| GB0424958D0 (en) * | 2004-11-11 | 2004-12-15 | Glaxo Group Ltd | Novel compounds |
| JP2008540503A (ja) | 2005-05-10 | 2008-11-20 | グラクソスミスクライン・イストラジヴァッキ・センタル・ザグレブ・ドルズバ・ゼー・オメイェノ・オドゴヴォルノスティオ | 細菌感染症の処置に有用なエーテル結合マクロライド |
| WO2007054296A1 (en) * | 2005-11-09 | 2007-05-18 | Glaxo Group Limited | Macrolones |
| AU2008316830B2 (en) | 2007-10-25 | 2016-03-17 | Cempra Pharmaceuticals, Inc. | Process for the preparation of macrolide antibacterial agents |
| CN107854477A (zh) | 2008-10-24 | 2018-03-30 | 森普拉制药公司 | 使用含三唑的大环内酯治疗抗性疾病的方法 |
| US9937194B1 (en) | 2009-06-12 | 2018-04-10 | Cempra Pharmaceuticals, Inc. | Compounds and methods for treating inflammatory diseases |
| US9480679B2 (en) | 2009-09-10 | 2016-11-01 | Cempra Pharmaceuticals, Inc. | Methods for treating malaria, tuberculosis and MAC diseases |
| BR112012029586A2 (pt) * | 2010-05-20 | 2016-08-02 | Cempra Pharmaceuticals Inc | processos para preparar macrolídeos e cetolídeos e intermediários dos mesmos |
| KR20130120458A (ko) | 2010-09-10 | 2013-11-04 | 셈프라 파마슈티컬스, 인크. | 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드 |
| WO2013148891A1 (en) | 2012-03-27 | 2013-10-03 | Cempra Pharmaceuticals, Inc. | Parenteral formulations for administering macrolide antibiotics |
| WO2014152326A1 (en) | 2013-03-14 | 2014-09-25 | Cempra Pharmaceuticals, Inc. | Methods for treating respiratory diseases and formulations therefor |
| AU2014233240B2 (en) | 2013-03-15 | 2018-08-09 | Cempra Pharmaceuticals, Inc. | Convergent processes for preparing macrolide antibacterial agents |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4180654A (en) * | 1978-01-03 | 1979-12-25 | Pfizer Inc. | 4"-Deoxy-4"-acylamido derivatives of oleandomycin, erythromycin and erythromycin carbonate |
| US4512982A (en) * | 1984-04-13 | 1985-04-23 | Pfizer Inc. | 9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method |
| US4686207A (en) * | 1985-11-12 | 1987-08-11 | Abbott Laboratories | Erythromycin A 11,12-carbonates and method of use |
| IL93936A (en) * | 1989-03-28 | 1994-06-24 | Abbott Lab | History of 9-dioxo-21,9-epoxy - erythromycin, method of preparation History of 11-oxo and 11-hydroxy, and pharmaceutical preparations containing them |
| WO1996034007A1 (es) * | 1995-04-27 | 1996-10-31 | Laboratorios Aranda, S.A. De C.V. | Derivados de quinolonilcarboxieritromicina y composiciones farmaceuticas que los contienen |
| DE69723848T2 (de) * | 1996-05-07 | 2004-07-01 | Abbott Laboratories, Abbott Park | 3-descladinose-2,3-anhydroerythromycin-derivate |
| EP0895999A1 (en) * | 1997-08-06 | 1999-02-10 | Pfizer Products Inc. | C-4" substituted macrolide antibiotics |
| GB0025688D0 (en) * | 2000-10-19 | 2000-12-06 | Glaxo Group Ltd | Macrolides |
| JP4311203B2 (ja) * | 2001-08-08 | 2009-08-12 | 大正製薬株式会社 | １１ａ−アザライド化合物及びその製造方法 |
| GB0127349D0 (en) * | 2001-11-14 | 2002-01-02 | Glaxo Group Ltd | Macrolides |
| GB0225384D0 (en) * | 2002-10-31 | 2002-12-11 | Glaxo Group Ltd | Novel compounds |
-
2004
- 2004-05-11 EP EP04732108A patent/EP1628989B1/en not_active Expired - Lifetime
- 2004-05-11 US US10/556,708 patent/US20070293472A1/en not_active Abandoned
- 2004-05-11 WO PCT/EP2004/005083 patent/WO2004101587A1/en not_active Ceased
- 2004-05-11 DE DE602004003809T patent/DE602004003809T2/de not_active Expired - Fee Related
- 2004-05-11 CA CA002525455A patent/CA2525455A1/en not_active Abandoned
- 2004-05-11 AR ARP040101609A patent/AR044304A1/es not_active Application Discontinuation
- 2004-05-11 PT PT04732108T patent/PT1628989E/pt unknown
- 2004-05-11 PL PL04732108T patent/PL1628989T3/pl unknown
- 2004-05-11 ES ES04732108T patent/ES2278319T3/es not_active Expired - Lifetime
- 2004-05-11 DK DK04732108T patent/DK1628989T3/da active
- 2004-05-11 AT AT04732108T patent/ATE348837T1/de not_active IP Right Cessation
- 2004-05-11 SI SI200430216T patent/SI1628989T1/sl unknown
- 2004-05-11 HR HR20070094T patent/HRP20070094T3/xx unknown
- 2004-05-11 JP JP2006529795A patent/JP2006528667A/ja active Pending
- 2004-05-11 CL CL200401012A patent/CL2004001012A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL1628989T3 (pl) | 2007-05-31 |
| ES2278319T3 (es) | 2007-08-01 |
| PT1628989E (pt) | 2007-03-30 |
| DE602004003809D1 (de) | 2007-02-01 |
| ATE348837T1 (de) | 2007-01-15 |
| EP1628989A1 (en) | 2006-03-01 |
| HRP20070094T3 (hr) | 2008-05-31 |
| US20070293472A1 (en) | 2007-12-20 |
| EP1628989B1 (en) | 2006-12-20 |
| WO2004101587A1 (en) | 2004-11-25 |
| SI1628989T1 (sl) | 2007-06-30 |
| CA2525455A1 (en) | 2004-11-25 |
| DK1628989T3 (da) | 2007-10-08 |
| DE602004003809T2 (de) | 2007-10-11 |
| CL2004001012A1 (es) | 2005-03-18 |
| JP2006528667A (ja) | 2006-12-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |