AR044043A1 - Fenacilo 2-hidroxi-3-diaminoalcanos - Google Patents
Fenacilo 2-hidroxi-3-diaminoalcanosInfo
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- AR044043A1 AR044043A1 ARP040101346A ARP040101346A AR044043A1 AR 044043 A1 AR044043 A1 AR 044043A1 AR P040101346 A ARP040101346 A AR P040101346A AR P040101346 A ARP040101346 A AR P040101346A AR 044043 A1 AR044043 A1 AR 044043A1
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07D213/40—Acylated substituent nitrogen atom
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- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/40—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
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- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D215/42—Nitrogen atoms attached in position 4
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- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
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- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
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- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
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- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
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Abstract
La presente se refiere a fenacilo 2-hidroxi-3-diaminoalcanos. Estos compuestos incluyen inhibidores de la enzima b-secretasa que son útiles para el tratamiento del mal de Alzheimer y otras enfermedades similares, caracterizadas por la deposición de un péptido Ab en un mamífero. También son útiles en composiciones farmacéuticas y métodos de tratamiento para reducir la formación de un péptido Ab. También se describe el método de preparación de dichos compuestos. Reivindicación 1: Un compuesto de la fórmula (1) o una sal farmacéuticamente aceptable del mismo, en donde Z es [C(R4)(R4')]m-B; m es 1-3; en donde R4 y R4' son, de modo independiente en cada aparición, H, alquilo C1-6, (CH2)0-3(cicloalquilo C3-7), -(CH2)0-3OH, F, CF3, -OCF3, -O- fenilo, alcoxi C1-6, cicloalcoxi C3-7, arilo o heteroarilo, o en donde R4 y R4´ se toman juntos con el C al que están unidos para formar un anillo carbocíclico de 3-7 miembros en donde 1 a 3 C del anillo están opcionalmente sustituidos con O, -N(H, alquilo C1-6 o fenilo) o -S(O)0-2; en donde B es arilo, heteroarilo o heterociclilo, en donde dichos grupos están opcionalmente sustituidos con 1 o 2 grupos RB, en donde RB en cada aparición está seleccionado, de modo independiente, de halógeno, - OH, -OCF3, -O-fenilo, -CN, -NR100R101, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, alcoxi C1-6, (CH2)0-3(cicloalquilo C3-7), en donde los grupos alquilo, alquenilo, alquinilo, alcoxi, cicloalquilo están opcionalmente sustituidos con 1 o 2 sustituyentes seleccionados de modo independiente del grupo integrado por alquilo C1-4, alcoxi C1-4, halógeno, -OH, -CN o -NR100R101; en donde R100 y R101 son en cada aparición, de modo independiente, H, alquilo C1-6 o fenilo; X es -(C=O)- o -(SO2)- ; R1 es alquilo C1-10 opcionalmente sustituido con 1, 2 o 3 grupos seleccionados de modo independiente de halógeno, -OH, =O, -SH, -CN, -CF3, -OCF3, -cicloalquilo C3-7, -alcoxi C1-4, amino, mono- dialquilamino, arilo, heteroarilo, heterocicloalquilo en donde cada grupo arilo está opcionalmente sustituido con 1, 2, o 3 grupos R50; en donde R50 está seleccionado de halógeno, OH, SH, CN, CO-(alquilo C1-4), -NR7R8, -S(O)0-2-(alquilo C1-4), alquilo C1-6, alquenilo C2-6, alquinilo C2-6, alcoxi C1-6 y cicloalquilo C3-8; en donde los grupos alquilo, alquenilo, alquinilo, alcoxi y cicloalquilo están opcionalmente sustituidos con 1 o 2 sustituyentes seleccionados de modo independiente del grupo integrado por alquilo C1-4, halógeno, OH, -NR5R6, CN, haloalcoxi C1-4, NR7R8 y alcoxi C1-4; en donde R5 y R6 son, de modo independiente, H o alquilo C1-6; o en donde R5 y R6 y el N al que están unidos forman un anillo heterocicloalquilo de 5 o 6 miembros; y en donde R7 y R8 están seleccionados de modo independiente del grupo integrado por H, -alquilo C1-4 opcionalmente sustituido con 1, 2, o 3 grupos seleccionados de modo independiente del grupo integrado por -OH, -NH2, y halógeno; -cicloalquilo C3-6, -(alquil C1-4)-O-(alquilo C1-4); -alquenilo C2-4; y -alquinilo C2-4; en donde cada heteroarilo está opcionalmente sustituido con 1 o 2 grupos R50; en donde cada grupo heterocicloalquilo está opcionalmente sustituido con 1 o 2 grupos que son, de modo independiente , R50 u =O; R2 y R3 están seleccionados, de modo independiente, de -H; -F, -alquilo C1-6 opcionalmente sustituido con un sustituyentes seleccionado del grupo integrado por -F, -OH, -CºN, -CF3, alcoxi C1-3 y -NR5R6; -(CH2)0-2-R17; -(CH2)0-2-R18; -alquenilo C2-6 o alquinilo C2- 6, en donde cada uno está opcionalmente sustituido con un sustituyente independiente seleccionado del grupo integrado por -F, -OH, -CºN, -CF3, y alcoxi C1-3; -(CH2)0-2-cicloalquilo C3-7, opcionalmente sustituido un sustituyente independiente seleccionado del grupo integrado por -F, -OH, -CºN, -CF3, alcoxi C1-3 y -NR5R6; o R2 y R3 y el C al que están unidos forman un carbociclo de 3 a 7 átomos de C, en donde un átomo de C está opcionalmente reemplazado por un grupo seleccionado de -O-, - S-, -SO2- o -NR7; en donde R17 en cada aparición es un grupo arilo seleccionado de fenilo, 1-naftilo, 2-naftilo, indanilo, indenilo, dihidronaftilo y tetralinilo, en donde dichos grupos arilo están opcionalmente sustituidos con uno o dos grupos que son, de modo independiente, -alquilo C1-3; -alcoxi C1-4; CF3; o -alquenilo C2-6 o -alquinilo C2-6, cada uno de los cuales está opcionalmente sustituidos con un sustituyente seleccionado del grupo integrado por F, OH, alcoxi C1-3; o -halógeno; -OH, - CºN; -cicloalquilo C3-7; -CO-(alquilo C1-4); -SO2-(alquilo C1-4); en donde R18 es un grupo heteroarilo seleccionado de piridinilo, pirimidinilo, quinolinilo, indolilo, piridazinilo, pirazinilo, isoquinolilo, quinazolinilo, quinoxalinilo, ftalazinilo, imidazolilo, isoxazolilo, oxazolilo, tiazolilo, furanilo, tienilo, pirrolilo, oxadiazolilo o tiadiazolilo, en donde cada uno de dichos grupos heteroarilo está opcionalmente sustituido con uno o dos grupos que son, de modo independiente, -alquilo C1-6 opcionalmente sustituido con un sustituyente seleccionado del grupo integrado por OH, CºN, CF3, alcoxi C1-3, y -NR5R6; R15 está seleccionado del grupo integrado por H, alquilo C1-6, alcoxi C1-6, alcoxi C1-6 alquilo C1-6, hidroxialquilo C1-6, haloalquilo C1-6, cada uno de los cuales está insustituido o sustituido con 1, 2, 3 o 4 grupos seleccionados de modo independiente de halógeno, alquilo C1-6, hidroxi, alcoxi C1-6, NH2 y -R26-R27; en donde R26 está seleccionado del grupo integrado por un enlace, -C(O)-, -SO2-, -CO2-, -C(O)NR5-, y NR5C(O)-, en donde R27 está seleccionado del grupo integrado por alquilo C1-6, alcoxi C1-6, arilalquilo C1-6, heterocicloalquilo y heteroarilo, en donde cada uno de los anteriores está insustituido o sustituido con 1, 2, 3, 4 o 5 grupos que son, de modo independiente, alquilo C1-4, alcoxi C1-4, halógeno, haloalquilo, hidroxialquilo, -NR5R6, -C(O)NR5R6; Rc está seleccionado del grupo integrado por -(CH2)0-3-cicloalquilo (C3-8) en donde el cicloalquilo está opcionalmente sustituido con 1, 2, o 3 grupos seleccionados de modo independiente del grupo integrado por -R205, -CO2-(alquilo C1-4) y arilo, en donde el arilo está opcionalmente sustituido con 1 o 2 grupos R200 seleccionados de modo independiente; -(CR245R250)0-4-arilo; -(CR245R250)0-4-heteroarilo; -(CR245R250)0-4-heterocicloalquilo; -(CR245R250)0-4-aril-heteroarilo; -(CR245R250)0-4-aril-heterocicloalquilo; -(CR245R250)0-4-aril-arilo; -(CR245R250)0-4- heteroaril-arilo; -(CR245R250)0-4-heteroaril-heterocicloalquilo; -(CR245R250)0-4-heteroaril-heteroarilo;-(CR245R250)0-4-heterocicloalquil-heteroarilo; -(CR245R250)0-4-heterocicloalquil-heterocicloalquilo; -(CR245R250)0-4-heterocicloalquil-arilo; un anillo monocíclico o bicíclico de 5, 6, 7, 8, 9, o 10 C condensados a 1 o 2 grupos arilo, heteroarilo o heterocicloalquilo, en donde 1, 2 o 3 C del anillo monocíclico o bicíclico están opcionalmente reemplazados con-NH, -N(CO)0-1R215,-N(CO)0-1-R220, -O o -S(=O)0-2, y en donde el anillo monocíclico o bicíclico está opcionalmente sustituido con 1, 2 o 3 grupos que son, de modo independiente, -R205, -R245, -R250 u =O; -alquenilo C2-6 opcionalmente sustituidos con 1, 2 o 3 grupos R205; -alquinilo C2-6 opcionalmente sustituido con 1, 2 o 3 grupos R205; en donde cada grupo arilo unido directa o indirectamente al grupo -(CR245R250)0-4 está opcionalmente sustituido con 1, 2, 3 o 4 grupos R200; en donde cada grupo heteroarilo unido directa o indirectamente al grupo -(CR245R250)0-4 está opcionalmente sustituido con 1, 2, 3 o 4 R200; en donde cada heterocicloalquilo unido directa o indirectamente al grupo -(CR245R250)0-4 está opcionalmente sustituido con 1, 2, 3 o 4 R210; en donde R200 en cada aparición está seleccionado, de modo independiente, del grupo integrado por -alquilo C1-6 opcionalmente sustituido con 1, 2 o 3 grupos R205; -OH; -NO2; -halógeno; -CºN; -(CH2)0-4-CO-NR220R225; -(CH2)0-4-CO-(C1-8 alquilo); -(CH2)0-4-CO-(C2-8 alquenilo), -(CH2)0-4-CO-(C2-8 alquinilo); -(CH2)0-4-CO-(cicloalquilo C3-7); -(CH2)0-4-(CO)0-1-arilo; -(CH2)0-4-(CO)0-1-heteroarilo; -(CH2)0-4-(CO)0-1-heterocicloalquilo; -(CH2)0-4-CO2R215;-(CH2)0-4-SO2-NR220R225; -(CH2)0-4-S(O)0-2-(alquilo C1-8), - (CH2)0-4-S(O)0-2-(cicloalquilo C3-7); -(CH2)0-4-N(H o R215)-CO2R215; -(CH2)0-4-N(H o R215)-SO2-R220; -(CH2)0-4-N(H o R215)-CO-N(R215)2; -(CH2)0-4-N(-H o R215)-CO-R220; -(CH2)0-4-NR220R225; -(CH2)0-4-O-CO-(alquilo C1-6); -(CH2)0-4-O-(R215); -(CH2)0-4- S-(R215); -(CH2)0-4-O-(alquilo C1-6 opcionalmente sustituido con 1, 2, 3 o 5 -F); alquenilo C2-6 opcionalmente sustituido con 1 o 2 grupos R205; alquinilo C2-6 opcionalmente sustituido con 1 o 2 grupos R205, y -(CH2)0-4-cicloalquilo C3-7; en donde cada grupo arilo incluido dentro de R200 está opcionalmente sustituido con 1, 2 o 3 grupos que son, de modo independiente, R205, R210 o alquilo C1-6 sustituido con 1, 2 o 3 grupos que son, de modo independiente, R205 o R210; en donde cada grupo heterocicloalquilo incluido dentro de R200 está opcionalmente sustituido con 1, 2 o 3 grupos que son de modo independiente R210; en donde cada grupo heteroarilo incluido dentro de R200 está opcionalmente sustituido con 1, 2 o 3 grupos que son, de modo independiente, R205, R210 o alquilo C1-6 sustituido con 1, 2 o 3 grupos que son, de modo independiente, R205 o R210; en donde R205 en cada aparición está seleccionado de modo independiente, del grupo integrado por alquilo C1-6, alquenilo C2-6, alquinilo C2-6, haloalcoxi C1-6, -(CH2)0-3(cicloalquilo C3-7), halógeno, -(CH2)0-6-OH, -O-fenilo, -SH, -(CH2)0-6-CºN, -(CH2)0-6-C(=O)NR235R240, CF3, alcoxi C1-6 y NR235R240, en donde R210 en cada aparición está seleccionado, de modo independiente, del grupo integrado por alquilo C1-6 opcionalmente sustituido con 1, 2 o 3 grupos R205; alquenilo C2-6 opcionalmente sustituido con 1, 2 o 3 grupos R205; alquinilo C2-6 opcionalmente sustituido con 1, 2, o 3 grupos R205; halógeno, alcoxi C1-6, haloalcoxi C1-6, NR220R225; -OH, -CºN, cicloalquilo C3-7 opcionalmente sustituido con 1, 2 o 3 grupos R205
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AR044043A1 true AR044043A1 (es) | 2005-08-24 |
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ARP040101346A AR044043A1 (es) | 2003-04-21 | 2004-04-21 | Fenacilo 2-hidroxi-3-diaminoalcanos |
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US (2) | US20050054690A1 (es) |
EP (1) | EP1615915A1 (es) |
JP (1) | JP2006524258A (es) |
AR (1) | AR044043A1 (es) |
BR (1) | BRPI0409627A (es) |
CA (1) | CA2522805A1 (es) |
CL (1) | CL2004000848A1 (es) |
MX (1) | MXPA05011203A (es) |
PA (1) | PA8601001A1 (es) |
PE (1) | PE20050420A1 (es) |
TW (1) | TW200505418A (es) |
UY (1) | UY28279A1 (es) |
WO (1) | WO2004094413A1 (es) |
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WO2005087752A2 (en) * | 2004-03-09 | 2005-09-22 | Elan Pharmaceuticals, Inc. | Substituted hydroxyethylamine aspartyl protease inhibitors |
EP1734961A2 (en) * | 2004-03-09 | 2006-12-27 | Elan Pharmaceuticals, Inc. | Methods of treatment of amyloidosis using bi-cyclic aspartyl protease inhibitors |
AU2005265354A1 (en) * | 2004-07-09 | 2006-01-26 | Elan Pharmaceuticals, Inc. | Oxime derivative hydroxyethylamine aspartyl-protease inhibitors |
US7385085B2 (en) | 2004-07-09 | 2008-06-10 | Elan Pharmaceuticals, Inc. | Oxime derivative substituted hydroxyethylamine aspartyl protease inhibitors |
WO2006085216A1 (en) * | 2005-02-14 | 2006-08-17 | Pfizer Products Inc. | Substituted hydroxyethylamines |
WO2007047305A1 (en) | 2005-10-12 | 2007-04-26 | Elan Pharmaceuticals, Inc. | Methods of treating amyloidosis using cyclopropyl derivative aspartyl protease inhibitors |
US7745484B2 (en) | 2005-11-21 | 2010-06-29 | Amgen Inc. | Beta-secretase modulators and methods of use |
JP5274258B2 (ja) * | 2005-11-21 | 2013-08-28 | アムジエン・インコーポレーテツド | β−セクレターゼ調節物質及び使用方法 |
US7838676B2 (en) * | 2005-11-21 | 2010-11-23 | Amgen Inc. | Beta-secretase modulators and methods of use |
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US8163909B2 (en) | 2007-05-25 | 2012-04-24 | Amgen Inc. | Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use |
US8173810B2 (en) | 2007-05-25 | 2012-05-08 | Amgen Inc. | Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use |
US7803809B2 (en) | 2008-11-12 | 2010-09-28 | Amgen Inc. | Substituted pyrano [2,3-b] pyridinamine compounds as beta-secretase modulators and methods of use |
CA2736130C (en) * | 2008-09-11 | 2014-01-14 | Amgen Inc. | Spiro-tetracyclic ring compounds as beta-secretase modulators and methods of use |
WO2011063233A1 (en) | 2009-11-23 | 2011-05-26 | Amgen Inc. | Amino heteroaryl compounds as beta-secretase modulators and methods of use |
WO2011063272A1 (en) | 2009-11-23 | 2011-05-26 | Amgen Inc. | Amino heteroaryl compounds as beta-secretase modulators and methods of use |
EP2526092B1 (en) | 2010-01-19 | 2014-08-06 | Amgen Inc. | Amino heteroaryl compounds as beta-secretase modulators and methods of use |
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US8497264B2 (en) | 2010-03-15 | 2013-07-30 | Amgen Inc. | Amino-oxazines and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use |
US9346827B2 (en) | 2011-02-07 | 2016-05-24 | Amgen Inc. | 5-amino-oxazepine and 5-amino-thiazepane compounds as beta secretase antagonists and methods of use |
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WO2013044092A1 (en) | 2011-09-21 | 2013-03-28 | Amgen Inc. | Amino-oxazines and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use |
US9725469B2 (en) | 2012-11-15 | 2017-08-08 | Amgen, Inc. | Amino-oxazine and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use |
CN115215848B (zh) * | 2021-04-20 | 2024-04-19 | 中国药科大学 | 蛋白激酶抑制剂及其衍生物、制备方法、药物组合物和应用 |
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CA2450557A1 (en) * | 2001-06-11 | 2002-12-19 | Michel Maillard | Substituted aminoalcohols useful in treatment of alzheimer's disease |
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BR0211119A (pt) * | 2001-07-11 | 2005-12-13 | Elan Pharm Inc | Composto, método de tratar um paciente que tenha, ou de prevenir um paciente de pegar, uma doença ou condição, uso de um composto, e, método para fabricar um composto |
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JP2005520791A (ja) * | 2001-11-08 | 2005-07-14 | イーラン ファーマスーティカルズ、インコーポレイテッド | N,n’−置換−1,3−ジアミノ−2−ヒドロキシプロパン誘導体 |
UY27967A1 (es) * | 2002-09-10 | 2004-05-31 | Pfizer | Acetil 2-hindroxi-1,3-diaminoalcanos |
JP2006524255A (ja) * | 2003-04-21 | 2006-10-26 | イーラン ファーマスーティカルズ、インコーポレイテッド | ベンズアミド2−ヒドロキシ−3−ジアミノアルカン |
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-
2004
- 2004-04-21 PE PE2004000393A patent/PE20050420A1/es not_active Application Discontinuation
- 2004-04-21 TW TW093111149A patent/TW200505418A/zh unknown
- 2004-04-21 BR BRPI0409627-4A patent/BRPI0409627A/pt not_active IP Right Cessation
- 2004-04-21 CL CL200400848A patent/CL2004000848A1/es unknown
- 2004-04-21 WO PCT/US2004/012384 patent/WO2004094413A1/en active Application Filing
- 2004-04-21 UY UY28279A patent/UY28279A1/es not_active Application Discontinuation
- 2004-04-21 AR ARP040101346A patent/AR044043A1/es unknown
- 2004-04-21 JP JP2006513208A patent/JP2006524258A/ja active Pending
- 2004-04-21 CA CA002522805A patent/CA2522805A1/en not_active Abandoned
- 2004-04-21 MX MXPA05011203A patent/MXPA05011203A/es active IP Right Grant
- 2004-04-21 US US10/828,582 patent/US20050054690A1/en not_active Abandoned
- 2004-04-21 EP EP04760106A patent/EP1615915A1/en not_active Withdrawn
- 2004-04-21 PA PA20048601001A patent/PA8601001A1/es unknown
-
2007
- 2007-11-21 US US11/943,961 patent/US20080207696A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CL2004000848A1 (es) | 2005-01-28 |
US20050054690A1 (en) | 2005-03-10 |
MXPA05011203A (es) | 2005-12-15 |
UY28279A1 (es) | 2004-11-30 |
JP2006524258A (ja) | 2006-10-26 |
WO2004094413A1 (en) | 2004-11-04 |
US20080207696A1 (en) | 2008-08-28 |
PA8601001A1 (es) | 2005-02-04 |
EP1615915A1 (en) | 2006-01-18 |
TW200505418A (en) | 2005-02-16 |
BRPI0409627A (pt) | 2006-04-25 |
CA2522805A1 (en) | 2004-11-04 |
PE20050420A1 (es) | 2005-06-13 |
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