AR041954A1 - Un proceso para preparar acetato de risperidona y compuestos intermediarios para dicho proceso - Google Patents

Un proceso para preparar acetato de risperidona y compuestos intermediarios para dicho proceso

Info

Publication number
AR041954A1
AR041954A1 ARP030104179A ARP030104179A AR041954A1 AR 041954 A1 AR041954 A1 AR 041954A1 AR P030104179 A ARP030104179 A AR P030104179A AR P030104179 A ARP030104179 A AR P030104179A AR 041954 A1 AR041954 A1 AR 041954A1
Authority
AR
Argentina
Prior art keywords
intermediate compounds
oxime
isomers
acetate
prepare
Prior art date
Application number
ARP030104179A
Other languages
English (en)
Inventor
Pavel Slanina
Jiri Barti
Original Assignee
Synthon Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthon Bv filed Critical Synthon Bv
Publication of AR041954A1 publication Critical patent/AR041954A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

El proceso de formación de risperidona es mejorado mediante el uso de un compuesto intermedio (o varios compuesto intermedios) que es(son) una oxima de grupo fórmula (1) enriquecida en isómeros Z. La(s) oxima(s) puede(n) ser enriquecida(s) isoméricamente mediante una variedad de técnicas, incluyendo el uso de una nueva sal de ácido acético de la(s) misma(s), que provee, Inter. alia, la resolución de los isómeros, y/o mediante conversión térmica.
ARP030104179A 2002-11-13 2003-11-13 Un proceso para preparar acetato de risperidona y compuestos intermediarios para dicho proceso AR041954A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US42572702P 2002-11-13 2002-11-13

Publications (1)

Publication Number Publication Date
AR041954A1 true AR041954A1 (es) 2005-06-01

Family

ID=32313043

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030104179A AR041954A1 (es) 2002-11-13 2003-11-13 Un proceso para preparar acetato de risperidona y compuestos intermediarios para dicho proceso

Country Status (9)

Country Link
US (2) US7405298B2 (es)
EP (1) EP1560814A1 (es)
CN (1) CN100390146C (es)
AR (1) AR041954A1 (es)
AU (1) AU2003288017A1 (es)
HR (1) HRP20050424A2 (es)
NO (1) NO20052859L (es)
WO (1) WO2004043923A1 (es)
ZA (1) ZA200503698B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA200603113B (en) * 2003-09-26 2007-08-29 Jubilant Organosys Ltd Process for the preparation of risperidone
WO2009077551A1 (en) * 2007-12-18 2009-06-25 Janssen Pharmaceutica Nv Process for preparing risperidone
US8772345B2 (en) 2011-08-03 2014-07-08 Southwest Research Institute Oximes for treatment of peripheral and central nervous system exposure to acetyl cholinesterase inhibitors
US8653108B1 (en) 2011-08-03 2014-02-18 Southwest Research Institute Oximes for treatment of peripheral and central nervous system exposure to acetyl cholinesterase inhibitors
US9162983B2 (en) 2013-05-22 2015-10-20 Southwest Research Institute Reactivators of organophosphorous inhibited acetylcholinesterase
CN104557918A (zh) * 2014-12-12 2015-04-29 瑞阳制药有限公司 苯并异恶唑类抗精神病药利培酮的制备方法
CN107422055A (zh) * 2017-07-27 2017-12-01 天津药物研究院药业有限责任公司 一种利培酮原料或制剂中杂质的检测方法
CN108445101B (zh) * 2018-03-16 2021-01-01 安徽新世纪药业有限公司 一种利培酮口服溶液有关物质的检测方法
CN109438443A (zh) * 2018-12-24 2019-03-08 浙江工业大学上虞研究院有限公司 利培酮的制备方法
CN111777601B (zh) * 2020-05-23 2021-07-16 白银京宇新药业有限公司 一种6-氟-3-(4-哌啶基)-1，2苯并异噁唑盐酸盐的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3946022A (en) * 1974-03-04 1976-03-23 Richardson-Merrell Inc. Piperidine derivatives
US4335127A (en) 1979-01-08 1982-06-15 Janssen Pharmaceutica, N.V. Piperidinylalkyl quinazoline compounds, composition and method of use
US4342870A (en) 1980-03-28 1982-08-03 Janssen Pharmaceutica N.V. Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives
US4408054A (en) * 1981-11-12 1983-10-04 Hoechst-Roussel Pharmaceuticals Inc. Oximes of 4-benzoyl-piperidines
US4804663A (en) 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
CA2000786C (en) 1988-11-07 1999-01-26 Cornelus G. M. Janssen 3-piperidinyl-1,2-benzisoxazoles
GB9008850D0 (en) 1990-04-19 1990-06-13 Janssen Pharmaceutica Nv Novel 2,9-disubstituted-4h-pyridol(1,2-a)pyrimidin-4-ones
ES2050069B1 (es) * 1992-07-10 1994-12-16 Vita Invest Sa Procedimiento para la obtencion de 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-il)piperidino)etil)-2-metil-6,7,8,9-tetrahidro-4h-pirido(1,2-a) pirimidin-4-ona.
ES2074966B1 (es) 1994-02-11 1996-06-16 Vita Invest Sa Procedimiento para la obtencion de 3-(2-(4-(6-fluoro-benzo(d)isoxazol-3-il)piperidin-1-il)-etil)-2-metil-6,7,8,9-tetrahidro-4h-pirido-(1,2-a)pirimidin-4-ona.
WO2001085731A1 (en) 2000-05-05 2001-11-15 Rpg Life Sciences Limited A PROCESS FOR THE PREPARATION OF ANTI-PSCHOTIC 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2,-a]pyrimidin-4-one
WO2002012200A1 (en) 2000-08-08 2002-02-14 Teva Pharmaceutical Industries Ltd. Preparation of risperidone
ES2310410T3 (es) 2000-08-14 2009-01-01 Teva Pharmaceutical Industries Ltd. Preparacion de risperidona.
HU227118B1 (en) 2001-11-13 2010-07-28 Egis Gyogyszergyar Nyilvanosan Process for the preparation of 3-{2-[4-(6-fluoro-1,2-benzizoxazol-3-yl)-1-piperidinyl]-ethyl}-6,7,8,9-tetrahydro-2-methyl-4h-pyrido[1,2-a]pyrimidin-4-one
CA2551346A1 (en) * 2003-12-31 2005-07-21 Warner-Lambert Company Llc N-substituted piperidine and piperazine derivatives

Also Published As

Publication number Publication date
NO20052859L (no) 2005-08-05
AU2003288017A1 (en) 2004-06-03
NO20052859D0 (no) 2005-06-13
EP1560814A1 (en) 2005-08-10
CN1720228A (zh) 2006-01-11
CN100390146C (zh) 2008-05-28
US20080262227A1 (en) 2008-10-23
HRP20050424A2 (en) 2006-08-31
US7405298B2 (en) 2008-07-29
ZA200503698B (en) 2006-08-30
WO2004043923A1 (en) 2004-05-27
US20040097523A1 (en) 2004-05-20

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