AR040607A1 - Derivados aldehido de polietilenglicol - Google Patents
Derivados aldehido de polietilenglicolInfo
- Publication number
- AR040607A1 AR040607A1 AR20030102609A ARP030102609A AR040607A1 AR 040607 A1 AR040607 A1 AR 040607A1 AR 20030102609 A AR20030102609 A AR 20030102609A AR P030102609 A ARP030102609 A AR P030102609A AR 040607 A1 AR040607 A1 AR 040607A1
- Authority
- AR
- Argentina
- Prior art keywords
- polyethylene glycol
- aldehyde derivatives
- formula
- compounds
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/321—Polymers modified by chemical after-treatment with inorganic compounds
- C08G65/324—Polymers modified by chemical after-treatment with inorganic compounds containing oxygen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
- C08G65/2603—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen
- C08G65/2615—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen the other compounds containing carboxylic acid, ester or anhydride groups
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
- C08G65/2618—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing nitrogen
- C08G65/2621—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing nitrogen containing amine groups
- C08G65/2624—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing nitrogen containing amine groups containing aliphatic amine groups
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
Abstract
Se proporciona compuestos aldehídos de polietilenglicol. Los procesos de elaboración y uso de tales compuestos, así como también se proporcionan los intermediarios químicos. Reivindicación 1: Un compuesto de fórmula R1-(CH2CH2O)n-CH2CH2-X-Y-NH-(CH2)p-CHO en donde R1 es un grupo de cabeza X es O o NH, X es O o NH, Y se selecciona del grupo consistente en la fórmula -(CH)2m-C(O)-, -C(O)-, -(CH2)1-8-C(OH)H-(CH2)1-8, -C(O)-(NH-C(Z)H-C(O))1-5, Z es un cadena lateral de un amoniácido, m es de 1 a 17, n es de 10 a 10,000, y p es 1 a 3.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39819602P | 2002-07-24 | 2002-07-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR040607A1 true AR040607A1 (es) | 2005-04-13 |
Family
ID=31495721
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AR20030102609A AR040607A1 (es) | 2002-07-24 | 2003-07-21 | Derivados aldehido de polietilenglicol |
Country Status (28)
Country | Link |
---|---|
US (2) | US7273909B2 (es) |
EP (1) | EP1539857B1 (es) |
JP (1) | JP4071238B2 (es) |
KR (1) | KR100615753B1 (es) |
CN (1) | CN1671769B (es) |
AR (1) | AR040607A1 (es) |
AT (1) | ATE344289T1 (es) |
AU (1) | AU2003250971B2 (es) |
BR (1) | BR0312863B1 (es) |
CA (1) | CA2493221C (es) |
DE (1) | DE60309482T2 (es) |
DK (1) | DK1539857T3 (es) |
ES (1) | ES2274277T3 (es) |
GT (1) | GT200300154A (es) |
HR (1) | HRP20050026A2 (es) |
IL (1) | IL165920A0 (es) |
JO (1) | JO2400B1 (es) |
MX (1) | MXPA05000799A (es) |
NO (1) | NO336974B1 (es) |
PA (1) | PA8577601A1 (es) |
PE (1) | PE20040703A1 (es) |
PL (1) | PL214871B1 (es) |
PT (1) | PT1539857E (es) |
RU (1) | RU2288212C2 (es) |
TW (1) | TWI276647B (es) |
UY (1) | UY27902A1 (es) |
WO (1) | WO2004013205A1 (es) |
ZA (1) | ZA200410296B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2315526T3 (es) | 2002-09-09 | 2009-04-01 | Nektar Therapeutics Al, Corporation | Metodo para preparar derivados polimericos solubles en agua que llevan un acido carboxilico terminal. |
JP4764630B2 (ja) | 2002-09-09 | 2011-09-07 | ネクター セラピューティックス | 水溶性ポリマーアルカナール |
US20050214250A1 (en) | 2003-11-06 | 2005-09-29 | Harris J M | Method of preparing carboxylic acid functionalized polymers |
US7989554B2 (en) * | 2006-01-10 | 2011-08-02 | Enzon Pharmaceuticals, Inc. | Reacting polyalkylene oxide with base, tertiary alkyl haloacetate, then acid to prepare polyalkylene oxide carboxylic acid |
WO2008051383A2 (en) * | 2006-10-19 | 2008-05-02 | Amgen Inc. | Use of alcohol co-solvents to improve pegylation reaction yields |
WO2008048079A1 (en) * | 2006-10-20 | 2008-04-24 | Postech Academy-Industry Foundation | Long acting formulation of biopharmaceutical |
US8247493B2 (en) * | 2007-10-22 | 2012-08-21 | Postech Academy-Industry Foundation | Long acting formulation of biopharmaceutical |
KR100967833B1 (ko) * | 2008-05-20 | 2010-07-05 | 아이디비켐(주) | 고순도의 폴리에틸렌글리콜 알데하이드 유도체의 제조방법 |
EP2331139B1 (en) * | 2008-09-11 | 2019-04-17 | Nektar Therapeutics | Polymeric alpha-hydroxy aldehyde and ketone reagents and conjugation method |
EP2592103A1 (en) | 2011-11-08 | 2013-05-15 | Adriacell S.p.A. | Polymer aldehyde derivatives |
BR112015032200A2 (pt) * | 2013-06-24 | 2017-11-21 | Hanwha Chemical Corp | conjugado anticorpo-droga com estabilidade melhorada, método de preparação, composição farmacêutica e uso do mesmo |
KR102247701B1 (ko) * | 2016-02-26 | 2021-05-03 | 한미정밀화학주식회사 | 폴리에틸렌글리콜 디알데히드 유도체의 제조방법 |
KR102372857B1 (ko) * | 2016-03-07 | 2022-03-11 | 한미약품 주식회사 | 폴리에틸렌 글리콜 유도체 및 이의 용도 |
JP7377195B2 (ja) * | 2017-09-29 | 2023-11-09 | ハンミ ファーマシューティカル カンパニー リミテッド | リンカーとして非ペプチド性重合体結合脂肪酸誘導体化合物を含むタンパク質結合体及びその製造方法 |
WO2023111213A1 (en) | 2021-12-16 | 2023-06-22 | Rdp Pharma Ag | Cell penetrating polypeptides (cpps) and their use in human therapy |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5252714A (en) * | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
CH690143A5 (de) | 1995-01-27 | 2000-05-15 | Rieter Automotive Int Ag | Lambda/4-Schallabsorber. |
US5672662A (en) | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
US5990237A (en) | 1997-05-21 | 1999-11-23 | Shearwater Polymers, Inc. | Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines |
AU1325400A (en) * | 1998-10-26 | 2000-05-15 | University Of Utah Research Foundation | Method for preparation of polyethylene glycol aldehyde derivatives |
PE20010288A1 (es) | 1999-07-02 | 2001-03-07 | Hoffmann La Roche | Derivados de eritropoyetina |
KR100488351B1 (ko) | 2001-12-11 | 2005-05-11 | 선바이오(주) | 신규한 폴리에틸렌글리콜-프로피온알데히드 유도체 |
WO2003049699A2 (en) | 2001-12-11 | 2003-06-19 | Sun Bio, Inc. | Novel monofunctional polyethylene glycol aldehydes |
-
2003
- 2003-07-16 BR BRPI0312863-6A patent/BR0312863B1/pt not_active IP Right Cessation
- 2003-07-16 WO PCT/EP2003/007734 patent/WO2004013205A1/en active IP Right Grant
- 2003-07-16 ES ES03766194T patent/ES2274277T3/es not_active Expired - Lifetime
- 2003-07-16 AT AT03766194T patent/ATE344289T1/de active
- 2003-07-16 AU AU2003250971A patent/AU2003250971B2/en not_active Ceased
- 2003-07-16 EP EP03766194A patent/EP1539857B1/en not_active Expired - Lifetime
- 2003-07-16 DK DK03766194T patent/DK1539857T3/da active
- 2003-07-16 DE DE60309482T patent/DE60309482T2/de not_active Expired - Lifetime
- 2003-07-16 PL PL375266A patent/PL214871B1/pl unknown
- 2003-07-16 JP JP2004525223A patent/JP4071238B2/ja not_active Expired - Fee Related
- 2003-07-16 KR KR1020057001223A patent/KR100615753B1/ko not_active IP Right Cessation
- 2003-07-16 CN CN038176491A patent/CN1671769B/zh not_active Expired - Fee Related
- 2003-07-16 PT PT03766194T patent/PT1539857E/pt unknown
- 2003-07-16 RU RU2005105568/04A patent/RU2288212C2/ru not_active IP Right Cessation
- 2003-07-16 CA CA002493221A patent/CA2493221C/en not_active Expired - Fee Related
- 2003-07-16 MX MXPA05000799A patent/MXPA05000799A/es active IP Right Grant
- 2003-07-20 JO JO200383A patent/JO2400B1/en active
- 2003-07-21 US US10/623,978 patent/US7273909B2/en not_active Expired - Fee Related
- 2003-07-21 PE PE2003000727A patent/PE20040703A1/es not_active Application Discontinuation
- 2003-07-21 PA PA20038577601A patent/PA8577601A1/es unknown
- 2003-07-21 TW TW092119827A patent/TWI276647B/zh not_active IP Right Cessation
- 2003-07-21 AR AR20030102609A patent/AR040607A1/es not_active Application Discontinuation
- 2003-07-22 UY UY27902A patent/UY27902A1/es not_active Application Discontinuation
- 2003-07-23 GT GT200300154A patent/GT200300154A/es unknown
-
2004
- 2004-12-21 ZA ZA200410296A patent/ZA200410296B/en unknown
- 2004-12-22 IL IL16592004A patent/IL165920A0/xx not_active IP Right Cessation
-
2005
- 2005-01-03 NO NO20050019A patent/NO336974B1/no not_active IP Right Cessation
- 2005-01-11 HR HR20050026A patent/HRP20050026A2/hr not_active Application Discontinuation
-
2007
- 2007-03-14 US US11/724,009 patent/US20070167606A1/en not_active Abandoned
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure | ||
FG | Grant, registration | ||
FD | Application declared void or lapsed, e.g., due to non-payment of fee |