PA8577601A1 - Derivados aldehido de polietilenglicol - Google Patents

Derivados aldehido de polietilenglicol

Info

Publication number
PA8577601A1
PA8577601A1 PA20038577601A PA8577601A PA8577601A1 PA 8577601 A1 PA8577601 A1 PA 8577601A1 PA 20038577601 A PA20038577601 A PA 20038577601A PA 8577601 A PA8577601 A PA 8577601A PA 8577601 A1 PA8577601 A1 PA 8577601A1
Authority
PA
Panama
Prior art keywords
polyethylene glycol
aldehyde derivatives
compounds
aldehyde
derivatives
Prior art date
Application number
PA20038577601A
Other languages
English (en)
Inventor
Chee-Youb Won
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PA8577601A1 publication Critical patent/PA8577601A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/321—Polymers modified by chemical after-treatment with inorganic compounds
    • C08G65/324—Polymers modified by chemical after-treatment with inorganic compounds containing oxygen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
    • C08G65/2603—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen
    • C08G65/2615—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen the other compounds containing carboxylic acid, ester or anhydride groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
    • C08G65/2618—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing nitrogen
    • C08G65/2621—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing nitrogen containing amine groups
    • C08G65/2624—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing nitrogen containing amine groups containing aliphatic amine groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Polyethers (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

SE PROPORCIONAN COMPUESTOS ALDEHIDOS DE POLIETILENGLICOL. LOS PROCESOS DE ELABORACION Y USO DE TALES COMPUESTOS, ASI COMO TAMBIEN SE PROPORCIONAN LOS INTERMEDIARIOS QUIMICOS.
PA20038577601A 2002-07-24 2003-07-21 Derivados aldehido de polietilenglicol PA8577601A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39819602P 2002-07-24 2002-07-24

Publications (1)

Publication Number Publication Date
PA8577601A1 true PA8577601A1 (es) 2004-02-07

Family

ID=31495721

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20038577601A PA8577601A1 (es) 2002-07-24 2003-07-21 Derivados aldehido de polietilenglicol

Country Status (28)

Country Link
US (2) US7273909B2 (es)
EP (1) EP1539857B1 (es)
JP (1) JP4071238B2 (es)
KR (1) KR100615753B1 (es)
CN (1) CN1671769B (es)
AR (1) AR040607A1 (es)
AT (1) ATE344289T1 (es)
AU (1) AU2003250971B2 (es)
BR (1) BR0312863B1 (es)
CA (1) CA2493221C (es)
DE (1) DE60309482T2 (es)
DK (1) DK1539857T3 (es)
ES (1) ES2274277T3 (es)
GT (1) GT200300154A (es)
HR (1) HRP20050026A2 (es)
IL (1) IL165920A0 (es)
JO (1) JO2400B1 (es)
MX (1) MXPA05000799A (es)
NO (1) NO336974B1 (es)
PA (1) PA8577601A1 (es)
PE (1) PE20040703A1 (es)
PL (1) PL214871B1 (es)
PT (1) PT1539857E (es)
RU (1) RU2288212C2 (es)
TW (1) TWI276647B (es)
UY (1) UY27902A1 (es)
WO (1) WO2004013205A1 (es)
ZA (1) ZA200410296B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4959133B2 (ja) 2002-09-09 2012-06-20 ネクター セラピューティックス 末端カルボン酸またはそのエステルを有する水溶性ポリマー誘導体の調製方法
KR100974843B1 (ko) 2002-09-09 2010-08-11 넥타르 테라퓨틱스 수용성 중합체 알카날
US20050214250A1 (en) 2003-11-06 2005-09-29 Harris J M Method of preparing carboxylic acid functionalized polymers
US7989554B2 (en) * 2006-01-10 2011-08-02 Enzon Pharmaceuticals, Inc. Reacting polyalkylene oxide with base, tertiary alkyl haloacetate, then acid to prepare polyalkylene oxide carboxylic acid
WO2008051383A2 (en) * 2006-10-19 2008-05-02 Amgen Inc. Use of alcohol co-solvents to improve pegylation reaction yields
WO2008048079A1 (en) * 2006-10-20 2008-04-24 Postech Academy-Industry Foundation Long acting formulation of biopharmaceutical
US8247493B2 (en) * 2007-10-22 2012-08-21 Postech Academy-Industry Foundation Long acting formulation of biopharmaceutical
KR100967833B1 (ko) * 2008-05-20 2010-07-05 아이디비켐(주) 고순도의 폴리에틸렌글리콜 알데하이드 유도체의 제조방법
US8492503B2 (en) * 2008-09-11 2013-07-23 Nektar Therapeutics Polymeric alpha-hydroxy aldehyde and ketone reagents and conjugation method
EP2592103A1 (en) 2011-11-08 2013-05-15 Adriacell S.p.A. Polymer aldehyde derivatives
AU2014299561B2 (en) * 2013-06-24 2017-06-08 Ablbio Antibody-drug conjugate having improved stability and use thereof
KR102247701B1 (ko) 2016-02-26 2021-05-03 한미정밀화학주식회사 폴리에틸렌글리콜 디알데히드 유도체의 제조방법
JP6937773B2 (ja) * 2016-03-07 2021-09-22 ハンミ ファーマシューティカル カンパニー リミテッド ポリエチレングリコール誘導体及びその用途
CN111164128A (zh) * 2017-09-29 2020-05-15 韩美药品株式会社 包含作为接头的非肽基聚合物偶联的脂肪酸衍生物化合物的蛋白复合物及其制备方法
WO2023111213A1 (en) 2021-12-16 2023-06-22 Rdp Pharma Ag Cell penetrating polypeptides (cpps) and their use in human therapy

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5252714A (en) * 1990-11-28 1993-10-12 The University Of Alabama In Huntsville Preparation and use of polyethylene glycol propionaldehyde
CH690143A5 (de) * 1995-01-27 2000-05-15 Rieter Automotive Int Ag Lambda/4-Schallabsorber.
US5672662A (en) * 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
US5990237A (en) * 1997-05-21 1999-11-23 Shearwater Polymers, Inc. Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines
US6465694B1 (en) * 1998-10-26 2002-10-15 University Of Utah Research Foundation Method for preparation of polyethylene glycol aldehyde derivatives
PE20010288A1 (es) * 1999-07-02 2001-03-07 Hoffmann La Roche Derivados de eritropoyetina
AU2002357806A1 (en) 2001-12-11 2003-06-23 Sun Bio, Inc. Novel monofunctional polyethylene glycol aldehydes
KR100488351B1 (ko) * 2001-12-11 2005-05-11 선바이오(주) 신규한 폴리에틸렌글리콜-프로피온알데히드 유도체

Also Published As

Publication number Publication date
RU2005105568A (ru) 2005-10-20
AR040607A1 (es) 2005-04-13
BR0312863A (pt) 2005-06-14
CN1671769B (zh) 2010-05-12
PL214871B1 (pl) 2013-09-30
CA2493221C (en) 2008-11-18
NO20050019L (no) 2005-02-23
NO336974B1 (no) 2015-12-07
ZA200410296B (en) 2006-07-26
TWI276647B (en) 2007-03-21
CN1671769A (zh) 2005-09-21
EP1539857B1 (en) 2006-11-02
KR100615753B1 (ko) 2006-08-25
IL165920A0 (en) 2006-01-15
GT200300154A (es) 2004-03-15
KR20050025974A (ko) 2005-03-14
DE60309482T2 (de) 2007-06-28
PE20040703A1 (es) 2004-10-14
TW200416241A (en) 2004-09-01
RU2288212C2 (ru) 2006-11-27
BR0312863B1 (pt) 2013-02-05
JP4071238B2 (ja) 2008-04-02
WO2004013205A1 (en) 2004-02-12
EP1539857A1 (en) 2005-06-15
PL375266A1 (en) 2005-11-28
ATE344289T1 (de) 2006-11-15
JP2005533913A (ja) 2005-11-10
US7273909B2 (en) 2007-09-25
MXPA05000799A (es) 2005-04-19
CA2493221A1 (en) 2004-02-12
US20070167606A1 (en) 2007-07-19
DE60309482D1 (de) 2006-12-14
UY27902A1 (es) 2003-12-31
AU2003250971A1 (en) 2004-02-23
AU2003250971B2 (en) 2008-04-03
HRP20050026A2 (en) 2006-02-28
PT1539857E (pt) 2007-01-31
DK1539857T3 (da) 2007-03-12
JO2400B1 (en) 2007-06-17
US20040019157A1 (en) 2004-01-29
ES2274277T3 (es) 2007-05-16

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