AR040461A1 - Microcapsulas para la liberacion retardada y controlada de perindopril - Google Patents

Microcapsulas para la liberacion retardada y controlada de perindopril

Info

Publication number
AR040461A1
AR040461A1 AR20030102233A ARP030102233A AR040461A1 AR 040461 A1 AR040461 A1 AR 040461A1 AR 20030102233 A AR20030102233 A AR 20030102233A AR P030102233 A ARP030102233 A AR P030102233A AR 040461 A1 AR040461 A1 AR 040461A1
Authority
AR
Argentina
Prior art keywords
microcapsules
perindopril
delayed
controlled release
pharmaceutically acceptable
Prior art date
Application number
AR20030102233A
Other languages
English (en)
Inventor
De Barochez Bruno Huet
Patrick Wuthrich
Valerie Legrand
Catherine Castan
Remi Meyrueix
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of AR040461A1 publication Critical patent/AR040461A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

Microcápsulas que permiten la liberación retardada y controlada de perindopril, o de una de sus sales farmacéuticamente aceptables, destinadas a una administración por vía oral. Reivindicación 1: Microcápsulas (tanque) para la liberación retardada y controlada de perindopril o de una de sus sales farmacéuticamente aceptables, destinadas a la administración oral, caracterizadas porque esas microcápsulas están: constituidas por micropartículas de perindopril o de una de sus sales farmacéuticamente aceptables, y cada una de ellas está recubierta por al menos una película de recubrimiento, y esta película de recubrimiento está constituida por un material composite que comprende: al menos un polímero hidrófilo A portador de grupos ionizados de ph neutro, al menos un compuesto hidrófobo B, y representan una fracción másica (% de peso con respecto a la masa total de las microcápsulas) inferior o igual a 40, y de diámetro inferior a 1200 micrones. Reivindicación 13: Composición farmacéutica caracterizada porque comprende microcápsulas de acuerdo con una cualquiera de las reivindicaciones 1 a 11.
AR20030102233A 2002-06-24 2003-06-23 Microcapsulas para la liberacion retardada y controlada de perindopril AR040461A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0207778A FR2841140B1 (fr) 2002-06-24 2002-06-24 Microcapsules pour la liberation retardee et controlee du perindopril

Publications (1)

Publication Number Publication Date
AR040461A1 true AR040461A1 (es) 2005-04-06

Family

ID=29719985

Family Applications (1)

Application Number Title Priority Date Filing Date
AR20030102233A AR040461A1 (es) 2002-06-24 2003-06-23 Microcapsulas para la liberacion retardada y controlada de perindopril

Country Status (37)

Country Link
US (1) US20060165808A1 (es)
EP (1) EP1515704B1 (es)
JP (1) JP4723243B2 (es)
KR (1) KR100722082B1 (es)
CN (1) CN100345541C (es)
AP (1) AP2029A (es)
AR (1) AR040461A1 (es)
AT (1) ATE429214T1 (es)
AU (1) AU2003260620B2 (es)
BR (1) BR0312026A (es)
CA (1) CA2491172C (es)
CR (1) CR7648A (es)
CY (1) CY1109154T1 (es)
DE (1) DE60327318D1 (es)
DK (1) DK1515704T3 (es)
EA (1) EA007571B1 (es)
EC (1) ECSP055570A (es)
ES (1) ES2326218T3 (es)
FR (1) FR2841140B1 (es)
GE (1) GEP20074212B (es)
HR (1) HRP20050055B1 (es)
IL (1) IL165896A0 (es)
IS (1) IS2679B (es)
MA (1) MA27262A1 (es)
ME (1) ME00452B (es)
MX (1) MXPA05000086A (es)
NO (1) NO20050163L (es)
NZ (1) NZ537408A (es)
OA (1) OA12875A (es)
PL (1) PL374377A1 (es)
PT (1) PT1515704E (es)
RS (1) RS50914B (es)
SI (1) SI1515704T1 (es)
TN (1) TNSN04259A1 (es)
UA (1) UA81121C2 (es)
WO (1) WO2004000286A1 (es)
ZA (1) ZA200410333B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8101209B2 (en) * 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
BRPI0615607A2 (pt) * 2005-08-30 2011-05-24 Lek Pharmaceuticals composição farmacêutica compreendendo perindopril ou seus sais
FR2891459B1 (fr) * 2005-09-30 2007-12-28 Flamel Technologies Sa Microparticules a liberation modifiee d'au moins un principe actif et forme galenique orale en comprenant
FR2897865B1 (fr) * 2006-02-28 2008-04-18 Servier Lab Forme cristalline beta du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FI125776B2 (fi) 2008-06-27 2023-07-28 Metsaeliitto Osuuskunta Menetelmä puulevyn käsittelemiseksi
CN106983731A (zh) * 2017-04-20 2017-07-28 上药东英（江苏）药业有限公司 一种培哚普利控释片及其制备方法
DE102018123500A1 (de) 2018-09-25 2020-03-26 Man Energy Solutions Se Vorrichtung und Verfahren zur Einstellung der Länge einer Pleuelstange eines Zylinders einer Brennkraftmaschine

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2247186A1 (de) * 1972-09-26 1974-03-28 Bayer Ag Antimykotisches mittel
JPS55129219A (en) * 1979-03-29 1980-10-06 Asahi Chem Ind Co Ltd Slow-releasing preparation
EP1442745A1 (en) * 1993-10-07 2004-08-04 Euro-Celtique Orally administrable opioid formulations having extended duration of effect
DE19724696A1 (de) 1997-06-12 1998-12-24 Hexal Ag Pharmazeutische Zubereitung mit drei Pelletarten
FR2771010B1 (fr) * 1997-11-19 2003-08-15 Adir Utilisation d'une combinaison d'un inhibiteur de l'enzyme de conversion de l'angiotensine et d'un diuretique pour le traitement des desordres microcirculatoires
JPH11171769A (ja) * 1997-12-05 1999-06-29 Nichiko Pharmaceutical Co Ltd ３−イソブチリル−２−イソプロピルピラゾロ〔１，５−ａ〕ピリジンの徐放性製剤及びその製法
GB9910773D0 (en) * 1999-05-11 1999-07-07 West Pharm Serv Drug Res Ltd Novel single unit coated dosage forms that can be used to minimise the effect of food on the absorption of drugs from the gastrointestinal tract
CA2409437A1 (en) * 2000-05-11 2001-11-22 Pharmacia Corporation Aldosterone antagonist composition for release during aldosterone acrophase
IL164222A0 (en) * 2002-04-09 2005-12-18 Flamel Tech Sa Oral pharmaceutical formulation in the form of aqueous suspension for modified release of active principle(s)
CN1189150C (zh) * 2002-11-07 2005-02-16 张凤英 祛斑美白面膜
CN100389300C (zh) * 2004-01-17 2008-05-21 湖北清江水布垭工程建设公司 大坝面板挠度或坝体内部变形监测方法及装置

Also Published As

Publication number Publication date
FR2841140B1 (fr) 2004-10-01
IL165896A0 (en) 2006-01-15
NO20050163L (no) 2005-01-12
AU2003260620B2 (en) 2008-07-31
RS50914B (sr) 2010-08-31
MXPA05000086A (es) 2005-04-08
PT1515704E (pt) 2009-05-20
EA007571B1 (ru) 2006-12-29
EA200500030A1 (ru) 2005-06-30
AU2003260620A1 (en) 2004-01-06
KR100722082B1 (ko) 2007-05-25
ECSP055570A (es) 2006-04-19
US20060165808A1 (en) 2006-07-27
CY1109154T1 (el) 2014-07-02
DE60327318D1 (de) 2009-06-04
JP2005533079A (ja) 2005-11-04
ZA200410333B (en) 2006-07-26
CR7648A (es) 2005-07-18
ME00452B (me) 2011-10-10
CN1665491A (zh) 2005-09-07
JP4723243B2 (ja) 2011-07-13
ATE429214T1 (de) 2009-05-15
AP2029A (en) 2009-08-24
TNSN04259A1 (fr) 2007-03-12
CA2491172A1 (fr) 2003-12-31
HRP20050055B1 (hr) 2013-11-08
IS7634A (is) 2005-01-07
EP1515704B1 (fr) 2009-04-22
DK1515704T3 (da) 2009-07-20
SI1515704T1 (sl) 2009-08-31
MA27262A1 (fr) 2005-03-01
UA81121C2 (en) 2007-12-10
RS112904A (en) 2007-02-05
EP1515704A1 (fr) 2005-03-23
CA2491172C (fr) 2011-02-15
PL374377A1 (en) 2005-10-17
NZ537408A (en) 2006-07-28
ES2326218T3 (es) 2009-10-05
AP2004003193A0 (en) 2004-12-31
OA12875A (en) 2006-09-15
KR20050023337A (ko) 2005-03-09
HRP20050055A2 (en) 2005-02-28
WO2004000286A1 (fr) 2003-12-31
FR2841140A1 (fr) 2003-12-26
CN100345541C (zh) 2007-10-31
BR0312026A (pt) 2005-03-22
IS2679B (is) 2010-09-15
GEP20074212B (en) 2007-10-10

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