JPS55129219A - Slow-releasing preparation - Google Patents
Slow-releasing preparationInfo
- Publication number
- JPS55129219A JPS55129219A JP3628279A JP3628279A JPS55129219A JP S55129219 A JPS55129219 A JP S55129219A JP 3628279 A JP3628279 A JP 3628279A JP 3628279 A JP3628279 A JP 3628279A JP S55129219 A JPS55129219 A JP S55129219A
- Authority
- JP
- Japan
- Prior art keywords
- side effects
- slow
- coating
- thfu
- tetrahydrofuryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To provide a slow-releasing carcinostatic preparation having improved duration of activity, reduced administration frequency, and suppressed side effects, by coating 1-(2-tetrahydrofuryl)-5-fluorouracil with a specific coating film.
CONSTITUTION: 1-(Tetrahydrofuryl)-5-fluorouracil (THFU) is coated with a pH- insensitive semi-permeable coating film (e.g. a composite containing ethyl cellulose or paraffin). Although THFU has lower side effects than 5-FU, it exhibits considerable side effects by high-dose administration, and loses its activity in a short time. By coating the compound with the above film, the concentration of 5FU in blood is maintained at an effective level for a long time, and accordingly, the administration frequency and dose can be reduced, which results in the reduction of the side effects.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3628279A JPS55129219A (en) | 1979-03-29 | 1979-03-29 | Slow-releasing preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3628279A JPS55129219A (en) | 1979-03-29 | 1979-03-29 | Slow-releasing preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS55129219A true JPS55129219A (en) | 1980-10-06 |
JPH024575B2 JPH024575B2 (en) | 1990-01-29 |
Family
ID=12465421
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3628279A Granted JPS55129219A (en) | 1979-03-29 | 1979-03-29 | Slow-releasing preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55129219A (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63301816A (en) * | 1987-01-29 | 1988-12-08 | Takeda Chem Ind Ltd | Core-containing granule and production thereof |
JPH03227916A (en) * | 1990-02-02 | 1991-10-08 | Ss Pharmaceut Co Ltd | Foamable drug preparation composition |
JP2005533079A (en) * | 2002-06-24 | 2005-11-04 | レ ラボラトワール セルヴィエ | Microcapsules for delayed and controlled release of perindopril |
JP2007182288A (en) * | 2006-01-06 | 2007-07-19 | Mitsubishi Motors Corp | Workpiece conveyance facility |
CN114767643A (en) * | 2022-05-17 | 2022-07-22 | 海南海和制药有限公司 | Fluorouracil tablet and preparation process thereof |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102621610B (en) * | 2012-04-13 | 2013-11-13 | 中国科学院光电技术研究所 | Manufacture method of high resolution super diffraction focusing structure lens |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2010416A1 (en) * | 1970-03-05 | 1971-09-16 | Farbwerke Hoechst AG, vorm Meister Lucius & Bruning, 6000 Frankfurt | Orally applicable dosage form with sustained release effect |
DE2148391A1 (en) * | 1970-09-28 | 1972-04-06 | Controlled Medications Ltd , CaI gary Alberta (Kanada) | Medicines with prolonged release of active substances |
JPS5362821A (en) * | 1976-11-11 | 1978-06-05 | Takeda Chem Ind Ltd | Preparation of slow-release drug |
-
1979
- 1979-03-29 JP JP3628279A patent/JPS55129219A/en active Granted
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2010416A1 (en) * | 1970-03-05 | 1971-09-16 | Farbwerke Hoechst AG, vorm Meister Lucius & Bruning, 6000 Frankfurt | Orally applicable dosage form with sustained release effect |
DE2148391A1 (en) * | 1970-09-28 | 1972-04-06 | Controlled Medications Ltd , CaI gary Alberta (Kanada) | Medicines with prolonged release of active substances |
JPS5362821A (en) * | 1976-11-11 | 1978-06-05 | Takeda Chem Ind Ltd | Preparation of slow-release drug |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63301816A (en) * | 1987-01-29 | 1988-12-08 | Takeda Chem Ind Ltd | Core-containing granule and production thereof |
JPH0832625B2 (en) * | 1987-01-29 | 1996-03-29 | 武田薬品工業株式会社 | Nucleated granule and method for producing the same |
JPH03227916A (en) * | 1990-02-02 | 1991-10-08 | Ss Pharmaceut Co Ltd | Foamable drug preparation composition |
JP2005533079A (en) * | 2002-06-24 | 2005-11-04 | レ ラボラトワール セルヴィエ | Microcapsules for delayed and controlled release of perindopril |
JP2007182288A (en) * | 2006-01-06 | 2007-07-19 | Mitsubishi Motors Corp | Workpiece conveyance facility |
CN114767643A (en) * | 2022-05-17 | 2022-07-22 | 海南海和制药有限公司 | Fluorouracil tablet and preparation process thereof |
Also Published As
Publication number | Publication date |
---|---|
JPH024575B2 (en) | 1990-01-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS55153715A (en) | Prolonged granule of theophylline | |
JPS5312844A (en) | Nn44halogenobenzyllnnmethyl*or nonsubstitutedd*cycloalkylln**phenylurea or thiourea compounds* their preparation and fungicides containing the same as active constituents | |
HU188768B (en) | Fungicides, insecticides and acaricides,as well as process for the preparation of their amino-pyrimidine derivatives active ingredients | |
HUT52030A (en) | Fungicide, insecticide and miticide compositions containing propene-carboxylic acid derivatives as active components and process for producing the active components | |
GB1534829A (en) | Process for incorporating flavourants and/or odorants into cellulosic substrates and products produced thereby | |
ES475024A1 (en) | Solid particles containing calcium peroxide, their preparation and their utilisation for the treatment of water. | |
EP0171528A3 (en) | Controlled release pharmaceutical preparations | |
NZ218734A (en) | Tablets containing coated microspheres which contain ibuprofen (2-(4-isobutyl phenyl)propanoic acid) | |
ATE16394T1 (en) | STABLE SALTS OF S-ADENOSINYLMETHIONINE, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE DERIVATIVES AS THE ACTIVE SUBSTANCE. | |
JPS55129219A (en) | Slow-releasing preparation | |
ZA773259B (en) | Improvements in or relating to methods for reducing the doses of biologically active substances while maintaining the biological effects | |
JPS5332124A (en) | Carcinostatic agent | |
JPS5767518A (en) | Radiosensitizing agent or agent for increasing effect of radiomimetic substance | |
PT65521B (en) | "N-TE TRAHYDROFURFURYL-NOROXYMORPHONE OF THE SOLE ADDITIONAL SALT, MEDICAMENTS CONTAINING THEM AND METHOD OF PREPARING THEM | |
Nguyen et al. | In vitro activity of cotrimoxazole on the intracellular multiplication of Toxoplasma gondii | |
DE3166825D1 (en) | Process for manufacture of a coated acetylsalicylic-acid formulation | |
JPS55122724A (en) | Antidiabetic agent | |
JPS6459A (en) | Ethyl-3-(2-ethyl-2,2-dimethylhydrazinium)-propionate | |
DE3163972D1 (en) | 2-substituted 5-phenoxy-phenyl-phosphinic-acid derivatives with herbicidal activity, process for preparing them, herbicidal compositions containing them and use of these active substances and compositions | |
JPS5686114A (en) | Pharmaceutical composition for suppository | |
JPS5742623A (en) | Antialcoholic adipohepatic agent | |
DE59205626D1 (en) | A RETARD MEDICINE CONTAINING A FLURBIPROFEN AND ITS USE | |
JPS5545659A (en) | Carcinostatic agent | |
JPS57108013A (en) | Antibacterial agent | |
JPS56118096A (en) | Novel elladitannin and its derivative |