JPS55129219A - Slow-releasing preparation - Google Patents

Slow-releasing preparation

Info

Publication number
JPS55129219A
JPS55129219A JP3628279A JP3628279A JPS55129219A JP S55129219 A JPS55129219 A JP S55129219A JP 3628279 A JP3628279 A JP 3628279A JP 3628279 A JP3628279 A JP 3628279A JP S55129219 A JPS55129219 A JP S55129219A
Authority
JP
Japan
Prior art keywords
side effects
slow
coating
thfu
tetrahydrofuryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3628279A
Other languages
Japanese (ja)
Other versions
JPH024575B2 (en
Inventor
Nobuyuki Suzuki
Kazuyuki Ogata
Akira Ikegawa
Kunio Iizuka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Industry Co Ltd filed Critical Asahi Chemical Industry Co Ltd
Priority to JP3628279A priority Critical patent/JPS55129219A/en
Publication of JPS55129219A publication Critical patent/JPS55129219A/en
Publication of JPH024575B2 publication Critical patent/JPH024575B2/ja
Granted legal-status Critical Current

Links

Abstract

PURPOSE: To provide a slow-releasing carcinostatic preparation having improved duration of activity, reduced administration frequency, and suppressed side effects, by coating 1-(2-tetrahydrofuryl)-5-fluorouracil with a specific coating film.
CONSTITUTION: 1-(Tetrahydrofuryl)-5-fluorouracil (THFU) is coated with a pH- insensitive semi-permeable coating film (e.g. a composite containing ethyl cellulose or paraffin). Although THFU has lower side effects than 5-FU, it exhibits considerable side effects by high-dose administration, and loses its activity in a short time. By coating the compound with the above film, the concentration of 5FU in blood is maintained at an effective level for a long time, and accordingly, the administration frequency and dose can be reduced, which results in the reduction of the side effects.
COPYRIGHT: (C)1980,JPO&Japio
JP3628279A 1979-03-29 1979-03-29 Slow-releasing preparation Granted JPS55129219A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3628279A JPS55129219A (en) 1979-03-29 1979-03-29 Slow-releasing preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3628279A JPS55129219A (en) 1979-03-29 1979-03-29 Slow-releasing preparation

Publications (2)

Publication Number Publication Date
JPS55129219A true JPS55129219A (en) 1980-10-06
JPH024575B2 JPH024575B2 (en) 1990-01-29

Family

ID=12465421

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3628279A Granted JPS55129219A (en) 1979-03-29 1979-03-29 Slow-releasing preparation

Country Status (1)

Country Link
JP (1) JPS55129219A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63301816A (en) * 1987-01-29 1988-12-08 Takeda Chem Ind Ltd Core-containing granule and production thereof
JPH03227916A (en) * 1990-02-02 1991-10-08 Ss Pharmaceut Co Ltd Foamable drug preparation composition
JP2005533079A (en) * 2002-06-24 2005-11-04 レ ラボラトワール セルヴィエ Microcapsules for delayed and controlled release of perindopril
JP2007182288A (en) * 2006-01-06 2007-07-19 Mitsubishi Motors Corp Workpiece conveyance facility
CN114767643A (en) * 2022-05-17 2022-07-22 海南海和制药有限公司 Fluorouracil tablet and preparation process thereof

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102621610B (en) * 2012-04-13 2013-11-13 中国科学院光电技术研究所 Manufacture method of high resolution super diffraction focusing structure lens

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2010416A1 (en) * 1970-03-05 1971-09-16 Farbwerke Hoechst AG, vorm Meister Lucius & Bruning, 6000 Frankfurt Orally applicable dosage form with sustained release effect
DE2148391A1 (en) * 1970-09-28 1972-04-06 Controlled Medications Ltd , CaI gary Alberta (Kanada) Medicines with prolonged release of active substances
JPS5362821A (en) * 1976-11-11 1978-06-05 Takeda Chem Ind Ltd Preparation of slow-release drug

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2010416A1 (en) * 1970-03-05 1971-09-16 Farbwerke Hoechst AG, vorm Meister Lucius & Bruning, 6000 Frankfurt Orally applicable dosage form with sustained release effect
DE2148391A1 (en) * 1970-09-28 1972-04-06 Controlled Medications Ltd , CaI gary Alberta (Kanada) Medicines with prolonged release of active substances
JPS5362821A (en) * 1976-11-11 1978-06-05 Takeda Chem Ind Ltd Preparation of slow-release drug

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63301816A (en) * 1987-01-29 1988-12-08 Takeda Chem Ind Ltd Core-containing granule and production thereof
JPH0832625B2 (en) * 1987-01-29 1996-03-29 武田薬品工業株式会社 Nucleated granule and method for producing the same
JPH03227916A (en) * 1990-02-02 1991-10-08 Ss Pharmaceut Co Ltd Foamable drug preparation composition
JP2005533079A (en) * 2002-06-24 2005-11-04 レ ラボラトワール セルヴィエ Microcapsules for delayed and controlled release of perindopril
JP2007182288A (en) * 2006-01-06 2007-07-19 Mitsubishi Motors Corp Workpiece conveyance facility
CN114767643A (en) * 2022-05-17 2022-07-22 海南海和制药有限公司 Fluorouracil tablet and preparation process thereof

Also Published As

Publication number Publication date
JPH024575B2 (en) 1990-01-29

Similar Documents

Publication Publication Date Title
JPS55153715A (en) Prolonged granule of theophylline
JPS5312844A (en) Nn44halogenobenzyllnnmethyl*or nonsubstitutedd*cycloalkylln**phenylurea or thiourea compounds* their preparation and fungicides containing the same as active constituents
HU188768B (en) Fungicides, insecticides and acaricides,as well as process for the preparation of their amino-pyrimidine derivatives active ingredients
HUT52030A (en) Fungicide, insecticide and miticide compositions containing propene-carboxylic acid derivatives as active components and process for producing the active components
GB1534829A (en) Process for incorporating flavourants and/or odorants into cellulosic substrates and products produced thereby
ES475024A1 (en) Solid particles containing calcium peroxide, their preparation and their utilisation for the treatment of water.
EP0171528A3 (en) Controlled release pharmaceutical preparations
NZ218734A (en) Tablets containing coated microspheres which contain ibuprofen (2-(4-isobutyl phenyl)propanoic acid)
ATE16394T1 (en) STABLE SALTS OF S-ADENOSINYLMETHIONINE, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE DERIVATIVES AS THE ACTIVE SUBSTANCE.
JPS55129219A (en) Slow-releasing preparation
ZA773259B (en) Improvements in or relating to methods for reducing the doses of biologically active substances while maintaining the biological effects
JPS5332124A (en) Carcinostatic agent
JPS5767518A (en) Radiosensitizing agent or agent for increasing effect of radiomimetic substance
PT65521B (en) "N-TE TRAHYDROFURFURYL-NOROXYMORPHONE OF THE SOLE ADDITIONAL SALT, MEDICAMENTS CONTAINING THEM AND METHOD OF PREPARING THEM
Nguyen et al. In vitro activity of cotrimoxazole on the intracellular multiplication of Toxoplasma gondii
DE3166825D1 (en) Process for manufacture of a coated acetylsalicylic-acid formulation
JPS55122724A (en) Antidiabetic agent
JPS6459A (en) Ethyl-3-(2-ethyl-2,2-dimethylhydrazinium)-propionate
DE3163972D1 (en) 2-substituted 5-phenoxy-phenyl-phosphinic-acid derivatives with herbicidal activity, process for preparing them, herbicidal compositions containing them and use of these active substances and compositions
JPS5686114A (en) Pharmaceutical composition for suppository
JPS5742623A (en) Antialcoholic adipohepatic agent
DE59205626D1 (en) A RETARD MEDICINE CONTAINING A FLURBIPROFEN AND ITS USE
JPS5545659A (en) Carcinostatic agent
JPS57108013A (en) Antibacterial agent
JPS56118096A (en) Novel elladitannin and its derivative