AR039115A1 - 4-aminociclohexanoles sustituidos - Google Patents

4-aminociclohexanoles sustituidos

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Publication number
AR039115A1
AR039115A1 ARP030101014A ARP030101014A AR039115A1 AR 039115 A1 AR039115 A1 AR 039115A1 AR P030101014 A ARP030101014 A AR P030101014A AR P030101014 A ARP030101014 A AR P030101014A AR 039115 A1 AR039115 A1 AR 039115A1
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Argentina
Prior art keywords
substituted
unsubstituted
unsaturated
saturated
heterocyclyl
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ARP030101014A
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English (en)
Inventor
Bernd Sundermann
H Hennies
Englberger Werner Guenter Dr
B-Y Kogel
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Gruenenthal Gmbh
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Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of AR039115A1 publication Critical patent/AR039115A1/es

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Abstract

Reivindicación 1: 4-aminociclohexanoles sustituidos con la fórmula general (1) donde R1 se selecciona entre H, alquilo C1-8 saturado o no saturado, ramificado o no ramificado, sustituido una o más veces o no sustituido; cicloalquilo C3-8, sustituido una o más veces o no sustituido; arilo sustituido una o más veces o no sustituido; heterociclilo, saturado o no saturado, sustituido una o más veces o no sustituido, arilo o cicloalquilo C3-8, enlazado a través de un puente de alquilo, cada uno sustituido una o más veces o no sustituido, o heterociclilo, saturado o no saturado, sustituido una o más veces o no sustituido, enlazado a través de un puente de alquilo C1-3: R2 se selecciona entre H, alquilo C1-8, saturado o no saturado, ramificado o no ramificado, sustituido una o más veces o no sustituido, cicloalquilo C3-8 sustituido una o más veces o no sustituido, arilo, sustituido una o más veces o no sustituido; heterociclilo, saturado o no saturado, sustituido una o más veces o no sustituido, arilo o cicloalquilo C3-8 enlazados a través de un puente de alquilo C1-3, cada uno sustituido una o más veces o no sustituido, o heterociclilo, saturado o no saturado, sustituido una o más veces o no sustituido, enlazado a través de un puente de alquilo C1-3; o bien los grupos R1 y R2 forman juntos un anillo, y representan CH2CH2OCH2CH2, CH2CH2NR5CH2CH2 o (CH2)3-6, donde los grupos alquilo pueden estar sustituidos una o más veces, con R5 seleccionado entre H, alquilo C1-8, saturado o no saturado, ramificado o no ramificado, sustituido una o más veces o no sustituido, cicloalquilo C3-8, sustituido una o más veces o no sustituido; arilo, sustituido una o más veces o no sustituido, heterociclilo, saturado o no saturado, sustituido una o más veces o no sustituido; arilo o cicloalquilo C3-8 enlazados a través de un puente de alquilo C1-3, cada uno sustituido una o más veces, o heterociclilo, saturado o no saturado, sustituido una o más veces o no sustituido, enlazado a través de un puente de alquilo C1-3, R3 se selecciona entre alquilo C1-8, saturado o no saturado, ramificado o no ramificado, sustituido una o más veces o no sustituido; cicloalquilo C3-8, sustituido una o más veces o no sustituido, arilo, sustituido una o más veces o no sustituido, heterociclilo, saturado o no saturado, sustituido una o más veces o no sustituido, arilo o cicloalquilo C3-8 enlazados a través de un puente de alquilo C1-3, cada uno sustituido una o más veces o no sustituido, o heterociclilo, saturado o no saturado, sustituido una o más veces o no sustituido, enlazado a través de un puente de alquilo C1-3; R4 se selecciona entre cicloalquilo C3-8, sustituido una o más veces o no sustituido, arilo sustituido una o más veces o no sustituido; heterociclilo, saturado o no saturado, sustituido una o más veces o no sustituido; -CHR6R7, -CHR6-CH2R7, -CHR6-CH2-CH2R7, -CHR6-CH2-CH2-CH2R7 o -R8-L-R9, donde R6 se selecciona entre H, alquilo C1-8, saturado o no saturado, ramificado o no ramificado, sustituido una o más veces o no sustituido; cicloalquilo C3-8 sustituido una o más veces, o no sustituido; arilo, sustituido una o más veces o no sustituido, heterociclilo, saturado o no saturado, sustituido o no sustituido; o C(O)O-R10, donde R10 se selecciona entre alquilo C1-7, saturado o no saturado, ramificado o no ramificado, sustituido una o más veces o no sustituido; cicloalquilo C3-8, sustituido una o más veces o no sustituido, arilo sustituido una o más veces, o no sustituido; heterociclilo, saturado o no saturado, sustituido una o más veces, o no sustituido, donde R7 se selecciona entre H, cicloalquilo C3-8 sustituido una o más veces o no sustituido, arilo sustituido una o más veces o no sustituido, heterociclilo saturado o no saturado, sustituido una o más veces o no sustituido, con R8 seleccionado entre cicloalquilo C3-8, sustituido una o más veces o no sustituido, arilo sustituido una o más veces o no sustituido; heterociclilo, saturado o no saturado, sustituido una o más veces o no sustituido, con L seleccionado entre -C(O)-NH, -NH-C(O)-, -C(O)-O-, -O-C(O)-, -S- o -S(O)2-, con R9 seleccionado entre H, alquilo C1-8, saturado o no saturado, ramificado o no ramificado, sustituido una o más veces o no sustituido; cicloalquilo C3-8, sustituido una o más veces o no sustituido; arilo, sustituido una o más veces o no sustituido; heterociclilo, saturado o no saturado, sustituido una o más veces o no sustituido, según el caso en forma de sus racematos, sus estereoisómeros puros, en especial enantiómeros o diastereómeros, o en forma de mezcla de estereoisómeros, en especial de enantiómeros o diastereómeros, en cualquier relación de mezcla; en forma pura o en forma de sus ácidos o sus bases, o en forma de sus sales, en especial de las sales fisiológicamente admisibles, o en forma de sus solvatos, en especial de los hidratos, con la condición que cuando los grupos R1 y R2 formas juntos un anillo, R4 no sea CH3 o cuando los grupos R1 y R2 formen juntos un anillo y representen (CH2)5, R4 no sea -CH2-fenilo.
ARP030101014A 2002-03-23 2003-03-24 4-aminociclohexanoles sustituidos AR039115A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10213051A DE10213051B4 (de) 2002-03-23 2002-03-23 Substituierte 4-Aminocyclohexanole

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AR039115A1 true AR039115A1 (es) 2005-02-09

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US (1) US7211694B2 (es)
EP (1) EP1487778B1 (es)
JP (1) JP4663239B2 (es)
AR (1) AR039115A1 (es)
AU (1) AU2003212366A1 (es)
CA (1) CA2480038C (es)
CY (1) CY1113116T1 (es)
DE (1) DE10213051B4 (es)
DK (1) DK1487778T3 (es)
ES (1) ES2387983T3 (es)
PE (1) PE20040162A1 (es)
PL (1) PL217415B1 (es)
PT (1) PT1487778E (es)
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EP1487778B1 (de) 2012-07-11
JP2005526795A (ja) 2005-09-08
CA2480038C (en) 2010-10-12
CA2480038A1 (en) 2003-10-02
US7211694B2 (en) 2007-05-01
CY1113116T1 (el) 2016-04-13
DK1487778T3 (da) 2012-08-06
PE20040162A1 (es) 2004-03-22
ES2387983T3 (es) 2012-10-05
PT1487778E (pt) 2012-07-26
PL217415B1 (pl) 2014-07-31
DE10213051A1 (de) 2003-10-30
DE10213051B4 (de) 2013-03-07
SI1487778T1 (sl) 2012-09-28
US20050187220A1 (en) 2005-08-25
WO2003080557A1 (de) 2003-10-02
AU2003212366A1 (en) 2003-10-08
EP1487778A1 (de) 2004-12-22
JP4663239B2 (ja) 2011-04-06
PL372307A1 (en) 2005-07-11

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