CO6190602A2 - S-nitrosotioles estables procedimiento de sintesis y uso - Google Patents
S-nitrosotioles estables procedimiento de sintesis y usoInfo
- Publication number
- CO6190602A2 CO6190602A2 CO09078487A CO09078487A CO6190602A2 CO 6190602 A2 CO6190602 A2 CO 6190602A2 CO 09078487 A CO09078487 A CO 09078487A CO 09078487 A CO09078487 A CO 09078487A CO 6190602 A2 CO6190602 A2 CO 6190602A2
- Authority
- CO
- Colombia
- Prior art keywords
- group
- alkynyl
- cycloalkyl
- alkenyl
- alkyl
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000000304 alkynyl group Chemical group 0.000 abstract 7
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 7
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000000623 heterocyclic group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/54—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Reproductive Health (AREA)
- Transplantation (AREA)
- Virology (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Gynecology & Obstetrics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
1.- Un compuesto con la fórmula (I)en la que R1 y R3 cada uno se selecciona independientemente del grupo constituido por hidrógeno, alquilo, alquenilo, cicloalquilo y alquinilo; o R1 y R3 juntos forman un anillo de 5 ó 6 miembros que incluye X; R2, R4, R5, R6, R7 y R8 cada uno se selecciona independientemente del grupo constituido por hidrógeno, alquilo, alquenilo, cicloalquilo y alquinilo; R9 se selecciona del grupo constituido por hidrógeno, alquilo, alquenilo, cicloalquilo, alquinilo, arilo y aralquilo; R10 se selecciona del grupo constituido por hidrógeno, alquilo, cicloalquilo, alquenilo, alquinilo, heterociclilo, -C(=O) R11 y -S(=O)2R11, en las que R11 se selecciona del grupo constituido por hidrógeno, alquilo, alquenilo, cicloalquilo, alquinilo, arilo, aralquilo y heterociclilo; Y es un alcoxicarbonilo con la fórmula -C(=O)OR12, en la que R12 se selecciona del grupo constituido por alquilo, alquenilo, cicloalquilo, alquinilo, arilo, aralquilo y heterociclilo; y X se selecciona del grupo constituido por un átomo de oxígeno, un átomo de azufre, y -NR13; en la que R13 se selecciona del grupo constituido por hidrógeno, alquilo, alquenilo, cicloalquilo, alquinilo, arilo, aralquilo y heterociclilo; o diastereoisómeros, enantiómeros, sales o solvatos de los mismos.2.- Compuesto según la reivindicación 1 en el que cada uno de R5, R6, R7 y R8 es hidrógeno.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06380340A EP1939179A1 (en) | 2006-12-28 | 2006-12-28 | Stable S-nitrosothiols, method of synthesis and use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6190602A2 true CO6190602A2 (es) | 2010-08-19 |
Family
ID=38123898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO09078487A CO6190602A2 (es) | 2006-12-28 | 2009-07-28 | S-nitrosotioles estables procedimiento de sintesis y uso |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8012993B2 (es) |
| EP (2) | EP1939179A1 (es) |
| JP (1) | JP2010514732A (es) |
| KR (1) | KR20100090187A (es) |
| CN (1) | CN101600692B (es) |
| AR (1) | AR064542A1 (es) |
| AU (1) | AU2007341284B2 (es) |
| BR (1) | BRPI0720665A2 (es) |
| CA (1) | CA2673988C (es) |
| CL (1) | CL2007003834A1 (es) |
| CO (1) | CO6190602A2 (es) |
| ES (1) | ES2307410B1 (es) |
| IL (1) | IL198940A0 (es) |
| MX (1) | MX2009007042A (es) |
| NO (1) | NO20092773L (es) |
| PA (1) | PA8764701A1 (es) |
| PE (1) | PE20081554A1 (es) |
| RU (1) | RU2009128961A (es) |
| UY (1) | UY30849A1 (es) |
| WO (1) | WO2008080934A1 (es) |
| ZA (1) | ZA200903645B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2601940A1 (en) * | 2011-12-05 | 2013-06-12 | Lacer, S.A. | (4-mercapto-piperidin-4-yl)-aminoacetic acid derivatives, pharmaceutical compositions and uses thereof |
| GB201505347D0 (en) * | 2015-03-27 | 2015-05-13 | Salupont Consulting Ltd | Sterilisation of s-nitrosothiols |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1567561A (en) | 1977-01-18 | 1980-05-14 | Ucb Sa | Amino-spiro(oxa-(orthia)cycloalkane-penam) - carboxylic acids |
| DE69008454T2 (de) | 1989-08-07 | 1994-08-25 | Takeda Chemical Industries Ltd | Nitrolsothiolderivate, ihre Herstellung und Verwendung. |
| EP0676964B1 (en) | 1991-11-14 | 2001-01-24 | Brigham And Women's Hospital | Nitrosylation of enzyme sh groups as a therapeutic modality |
| AU698748B2 (en) | 1993-09-17 | 1998-11-05 | Brigham And Women's Hospital | Use of nitric oxide-adducts to prevent thrombosis on artificial and vascular surfaces |
| AU704173B2 (en) | 1993-11-02 | 1999-04-15 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College, The | Use of nitric oxide releasing compounds as protective agents in ischemia reperfusion injury |
| ES2147162B1 (es) * | 1999-01-27 | 2001-03-16 | Lacer Sa | "s-nitrosotioles como agentes para el tratamiento de disfunciones circulatorias". |
| AR035313A1 (es) | 1999-01-27 | 2004-05-12 | Wyeth Corp | Inhibidores de tace acetilenicos de acido hidroxamico de sulfonamida a base de alfa-aminoacidos, composiciones farmaceuticas y el uso de los mismos para la manufactura de medicamentos. |
| US6225311B1 (en) | 1999-01-27 | 2001-05-01 | American Cyanamid Company | Acetylenic α-amino acid-based sulfonamide hydroxamic acid tace inhibitors |
| US6559387B1 (en) * | 2000-09-01 | 2003-05-06 | Senior Industries, Inc. | Universal ground clamp with S-shaped second strap |
| US20030203915A1 (en) * | 2002-04-05 | 2003-10-30 | Xinqin Fang | Nitric oxide donors, compositions and methods of use related applications |
-
2006
- 2006-12-28 EP EP06380340A patent/EP1939179A1/en not_active Withdrawn
-
2007
- 2007-01-23 ES ES200700182A patent/ES2307410B1/es not_active Expired - Fee Related
- 2007-03-01 US US11/680,815 patent/US8012993B2/en not_active Expired - Fee Related
- 2007-12-27 BR BRPI0720665-8A patent/BRPI0720665A2/pt not_active IP Right Cessation
- 2007-12-27 ZA ZA200903645A patent/ZA200903645B/xx unknown
- 2007-12-27 JP JP2009543470A patent/JP2010514732A/ja active Pending
- 2007-12-27 KR KR1020097015822A patent/KR20100090187A/ko not_active Application Discontinuation
- 2007-12-27 MX MX2009007042A patent/MX2009007042A/es active IP Right Grant
- 2007-12-27 UY UY30849A patent/UY30849A1/es not_active Application Discontinuation
- 2007-12-27 CN CN2007800480933A patent/CN101600692B/zh not_active Expired - Fee Related
- 2007-12-27 RU RU2009128961/04A patent/RU2009128961A/ru not_active Application Discontinuation
- 2007-12-27 WO PCT/EP2007/064565 patent/WO2008080934A1/en active Application Filing
- 2007-12-27 PA PA20078764701A patent/PA8764701A1/es unknown
- 2007-12-27 AU AU2007341284A patent/AU2007341284B2/en not_active Ceased
- 2007-12-27 CL CL200703834A patent/CL2007003834A1/es unknown
- 2007-12-27 CA CA2673988A patent/CA2673988C/en not_active Expired - Fee Related
- 2007-12-27 EP EP07858162A patent/EP2125727B1/en active Active
- 2007-12-27 AR ARP070105910A patent/AR064542A1/es unknown
-
2008
- 2008-01-02 PE PE2008000042A patent/PE20081554A1/es not_active Application Discontinuation
-
2009
- 2009-05-25 IL IL198940A patent/IL198940A0/en unknown
- 2009-07-28 CO CO09078487A patent/CO6190602A2/es not_active Application Discontinuation
- 2009-07-28 NO NO20092773A patent/NO20092773L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP2125727B1 (en) | 2012-11-21 |
| UY30849A1 (es) | 2008-05-31 |
| CN101600692B (zh) | 2012-07-04 |
| CA2673988C (en) | 2012-09-11 |
| US8012993B2 (en) | 2011-09-06 |
| ZA200903645B (en) | 2010-08-25 |
| NO20092773L (no) | 2009-07-28 |
| EP1939179A1 (en) | 2008-07-02 |
| EP2125727A1 (en) | 2009-12-02 |
| ES2307410A1 (es) | 2008-11-16 |
| JP2010514732A (ja) | 2010-05-06 |
| IL198940A0 (en) | 2010-02-17 |
| CA2673988A1 (en) | 2008-07-10 |
| AU2007341284B2 (en) | 2010-12-02 |
| PE20081554A1 (es) | 2008-12-23 |
| CL2007003834A1 (es) | 2008-07-11 |
| PA8764701A1 (es) | 2008-12-18 |
| ES2307410B1 (es) | 2009-08-07 |
| AU2007341284A1 (en) | 2008-07-10 |
| BRPI0720665A2 (pt) | 2014-01-14 |
| US20080161354A1 (en) | 2008-07-03 |
| KR20100090187A (ko) | 2010-08-13 |
| AR064542A1 (es) | 2009-04-08 |
| RU2009128961A (ru) | 2011-02-10 |
| MX2009007042A (es) | 2009-08-25 |
| WO2008080934A1 (en) | 2008-07-10 |
| CN101600692A (zh) | 2009-12-09 |
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