AR038479A1 - Compuestos hidrosolubles de platino con porfirina con alta selectividad tumoral y su uso para preparar medicamentos para el tratamiento de enfermedades tumorales benignas y malignas - Google Patents
Compuestos hidrosolubles de platino con porfirina con alta selectividad tumoral y su uso para preparar medicamentos para el tratamiento de enfermedades tumorales benignas y malignasInfo
- Publication number
- AR038479A1 AR038479A1 ARP030100329A ARP030100329A AR038479A1 AR 038479 A1 AR038479 A1 AR 038479A1 AR P030100329 A ARP030100329 A AR P030100329A AR P030100329 A ARP030100329 A AR P030100329A AR 038479 A1 AR038479 A1 AR 038479A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- cycloalkyl
- hetarylalkyl
- aralkyl
- aryl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 206010028980 Neoplasm Diseases 0.000 title abstract 4
- 229940079593 drug Drugs 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 150000004032 porphyrins Chemical class 0.000 title abstract 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 title 2
- 229910052697 platinum Inorganic materials 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 17
- -1 hetarylalkyl Chemical group 0.000 abstract 14
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 12
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 10
- 125000003118 aryl group Chemical group 0.000 abstract 10
- 125000001072 heteroaryl group Chemical group 0.000 abstract 10
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 150000003057 platinum Chemical class 0.000 abstract 3
- UJKPHYRXOLRVJJ-MLSVHJFASA-N CC(O)C1=C(C)/C2=C/C3=N/C(=C\C4=C(CCC(O)=O)C(C)=C(N4)/C=C4\N=C(\C=C\1/N\2)C(C)=C4C(C)O)/C(CCC(O)=O)=C3C Chemical compound CC(O)C1=C(C)/C2=C/C3=N/C(=C\C4=C(CCC(O)=O)C(C)=C(N4)/C=C4\N=C(\C=C\1/N\2)C(C)=C4C(C)O)/C(CCC(O)=O)=C3C UJKPHYRXOLRVJJ-MLSVHJFASA-N 0.000 abstract 2
- 229960003569 hematoporphyrin Drugs 0.000 abstract 2
- 238000002483 medication Methods 0.000 abstract 2
- NPRDEIDCAUHOJU-UHFFFAOYSA-N [Pt].N1C(C=C2N=C(C=C3NC(=C4)C=C3)C=C2)=CC=C1C=C1C=CC4=N1 Chemical class [Pt].N1C(C=C2N=C(C=C3NC(=C4)C=C3)C=C2)=CC=C1C=C1C=CC4=N1 NPRDEIDCAUHOJU-UHFFFAOYSA-N 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000002428 photodynamic therapy Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Polyethers (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Compuestos hidrosolubles de platino con porfirina de los derivados de tipo platino con tetraarilporfirina o de los derivados de tipo platino con hematoporfirina con alta selectividad tumoral y el uso de los mismos para preparar medicamentos para el tratamiento de tumores (enfermedades tumorales benignas y malignas). Medicamentos que comprenden el compuesto. En particular, los compuestos son apropiados para la terapia fotodinámica antitumoral. Reivindicación 1: Derivados de platino con porfirina de los (a) derivados de tipo platino con tetraarilporfirina de acuerdo con la fórmula (1): en donde: R es un compuesto de fórmula (2); n = 1-20; X es O, S, NH, N-alquilo; R2/R3 son H, alquilo, arilo, aralquilo, hetarilo, hetarilalquilo, cicloalquilo; R4 es H, alquilo, arilo, aralquilo, hetarilo, hetarilalquilo, cicloalquilo; R5 es H, alquilo, O-alquilo, S-alquilo, halógeno, nitro, ciano, amino, amino sustituido; R6 es H, alquilo, O-alquilo, S-alquilo, halógeno, nitro, ciano, amino, amino sustituido; y de acuerdo con la fórmula (3); en donde R es un compuesto de fórmula (4); n = 1-20; X es O, S, NH, N-alquilo; R1/R2/R3/R4 son H, alquilo, arilo, aralquilo, hetarilo, hetarilalquilo, cicloalquilo; o R2-Z-R3, Z es (CH2)n, n = 0-6; R1/R4 es H, -(CH2)n-COOR8, n = 0-6; R5 es H, alquilo, arilo, aralquilo, hetarilo, hetarilalquilo, cicloalquilo; R6 es H, alquilo, O-alquilo, S-alquilo, halógeno, nitro, ciano, amino, amino sustituido; R7 es H, alquilo, O-alquilo, S-alquilo, halógeno, nitro, ciano, amino, amino sustituido; R8 es H, alquilo; y (b) derivados de tipo platino con hematoporfirina de acuerdo con la fórmula (5); R2/R3 es H, alquilo, arilo, aralquilo, hetarilo, hetarilalquilo, cicloalquilo; R4 es H, alquilo, cicloalquilo; R5 es H, alquilo, cicloalquilo; R6 es H, alquilo, arilo, aralquilo, hetarilo, hetarilalquilo, cicloalquilo; y de acuerdo con la fórmula (6); R1/R2/R3/R4 son H, alquilo, arilo, aralquilo, hetarilo, hetarilalquilo, cicloalquilo o R2-Z-R4, con Z es (CH2)n, n = 0-6; o R1/R3 es H, -(CH2)n-COOR6, n = 0-6; R4/R5 son H, alquilo, arilo, aralquilo, hetarilo, hetarilalquilo, cicloalquilo; R6 son H, alquilo, arilo, aralquilo, hetarilo, hetarilalquilo, cicloalquilo; R7 son H, alquilo, arilo, aralquilo, hetarilo, hetarilalquilo, cicloalquilo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35358502P | 2002-02-01 | 2002-02-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR038479A1 true AR038479A1 (es) | 2005-01-19 |
Family
ID=27663224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030100329A AR038479A1 (es) | 2002-02-01 | 2003-02-03 | Compuestos hidrosolubles de platino con porfirina con alta selectividad tumoral y su uso para preparar medicamentos para el tratamiento de enfermedades tumorales benignas y malignas |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7087214B2 (es) |
| EP (1) | EP1470139A2 (es) |
| JP (1) | JP2005522429A (es) |
| KR (1) | KR20040083098A (es) |
| CN (1) | CN1303090C (es) |
| AR (1) | AR038479A1 (es) |
| BR (1) | BR0307400A (es) |
| CA (1) | CA2418410A1 (es) |
| HK (1) | HK1078585A1 (es) |
| HR (1) | HRP20040788A2 (es) |
| MX (1) | MXPA04007443A (es) |
| NO (1) | NO20043650L (es) |
| NZ (1) | NZ534541A (es) |
| PL (1) | PL373346A1 (es) |
| RU (1) | RU2004126637A (es) |
| TW (1) | TWI233929B (es) |
| UA (1) | UA78007C2 (es) |
| WO (1) | WO2003064424A2 (es) |
| ZA (1) | ZA200405925B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6995260B2 (en) * | 2004-05-20 | 2006-02-07 | Brookhaven Science Associates, Llc | Carboranylporphyrins and uses thereof |
| US8287839B2 (en) * | 2006-12-04 | 2012-10-16 | Brookhaven Science Associates, Llc | Carboranylporphyrins and uses thereof |
| EP1950217A1 (en) * | 2007-01-26 | 2008-07-30 | Université de Neuchâtel | Organometallic compounds for the treatment of cancer |
| US8444953B2 (en) * | 2007-03-22 | 2013-05-21 | Brookhaven Science Associates, Llc | Symmetric and asymmetric halogen-containing metallocarboranylporphyrins and uses thereof |
| US20080279781A1 (en) * | 2007-05-10 | 2008-11-13 | Brookhaven Science Associates, Llc | Glycosylated Carboranylporphyrins and Uses Thereof |
| JP5823413B2 (ja) * | 2010-01-22 | 2015-11-25 | カウンシル オブ サイエンティフィック アンド インダストリアル リサーチ | 新規なポルフィリン誘導体の製造方法、ならびにｐｄｔ剤および蛍光プローブとしてのそれらの使用 |
| CN102408452B (zh) * | 2011-12-13 | 2014-09-03 | 中山大学 | 四吡啶基卟啉桥联十字形四核铂配合物及其制备方法和抗肿瘤活性 |
| RU2682674C2 (ru) | 2013-03-15 | 2019-03-20 | Шерри Энн МАКФАРЛЭНД | Координационные комплексы на основе металлов в качестве фотодинамических соединений и их применение |
| WO2019217606A1 (en) * | 2018-05-09 | 2019-11-14 | Virginia Commonwealth University | Near-ir activatable fluorescent small molecules with dual modes of cytotoxicity |
| CN109251206B (zh) * | 2018-09-21 | 2022-02-08 | 上海大学 | 水溶性铂-卟啉配合物及其制备方法 |
| CN110028513B (zh) * | 2019-04-30 | 2020-12-11 | 北京太阳升高科医药研究股份有限公司 | 卟啉衍生物及声敏剂 |
| CN110590852B (zh) * | 2019-08-29 | 2022-12-09 | 合肥学院 | 一种具有抗肿瘤活性的铂配合物及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0615545B2 (ja) * | 1984-10-01 | 1994-03-02 | 東洋薄荷工業株式会社 | 金属フェオホーバイド誘導体および金属ポルフィリン誘導体 |
| ZA86704B (en) | 1985-02-23 | 1986-10-29 | Asta Werke Ag Chem Fab | Tumor retarding(1-benzyl-ethylenediamine9-platin(ii)-complexes |
| EP0220686B1 (en) * | 1985-10-23 | 1992-12-30 | Nihon Medi-Physics Co., Ltd. | Porphyrin derivatives, and their production and use |
| DE19824653A1 (de) | 1998-02-25 | 1999-08-26 | Schering Ag | Nekrose-affine Verbindungen und ihre Verwendung zur Herstellung von Präparaten zur Pharmakotherapie |
-
2003
- 2003-01-27 US US10/353,788 patent/US7087214B2/en not_active Expired - Fee Related
- 2003-01-29 BR BR0307400-5A patent/BR0307400A/pt not_active IP Right Cessation
- 2003-01-29 JP JP2003564047A patent/JP2005522429A/ja not_active Withdrawn
- 2003-01-29 RU RU2004126637/04A patent/RU2004126637A/ru not_active Application Discontinuation
- 2003-01-29 WO PCT/EP2003/000874 patent/WO2003064424A2/en not_active Application Discontinuation
- 2003-01-29 PL PL03373346A patent/PL373346A1/xx unknown
- 2003-01-29 CN CNB038045524A patent/CN1303090C/zh not_active Expired - Fee Related
- 2003-01-29 UA UA20040806544A patent/UA78007C2/uk unknown
- 2003-01-29 KR KR10-2004-7011734A patent/KR20040083098A/ko not_active Application Discontinuation
- 2003-01-29 NZ NZ534541A patent/NZ534541A/en unknown
- 2003-01-29 EP EP03734604A patent/EP1470139A2/en not_active Withdrawn
- 2003-02-03 AR ARP030100329A patent/AR038479A1/es unknown
- 2003-02-03 CA CA002418410A patent/CA2418410A1/en not_active Abandoned
- 2003-02-06 TW TW092102414A patent/TWI233929B/zh not_active IP Right Cessation
-
2004
- 2004-07-26 ZA ZA200405925A patent/ZA200405925B/en unknown
- 2004-07-30 MX MXPA04007443A patent/MXPA04007443A/es unknown
- 2004-08-30 HR HRP20040788 patent/HRP20040788A2/hr not_active Application Discontinuation
- 2004-08-31 NO NO20043650A patent/NO20043650L/no not_active Application Discontinuation
-
2005
- 2005-11-18 HK HK05110413A patent/HK1078585A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1639178A (zh) | 2005-07-13 |
| NO20043650L (no) | 2004-10-29 |
| TWI233929B (en) | 2005-06-11 |
| US7087214B2 (en) | 2006-08-08 |
| PL373346A1 (en) | 2005-08-22 |
| WO2003064424A2 (en) | 2003-08-07 |
| MXPA04007443A (es) | 2004-10-11 |
| HK1078585A1 (en) | 2006-03-17 |
| JP2005522429A (ja) | 2005-07-28 |
| BR0307400A (pt) | 2004-12-21 |
| NZ534541A (en) | 2005-10-28 |
| KR20040083098A (ko) | 2004-09-30 |
| US20040023942A1 (en) | 2004-02-05 |
| CA2418410A1 (en) | 2003-08-01 |
| EP1470139A2 (en) | 2004-10-27 |
| RU2004126637A (ru) | 2006-02-10 |
| TW200305571A (en) | 2003-11-01 |
| UA78007C2 (en) | 2007-02-15 |
| ZA200405925B (en) | 2004-09-07 |
| WO2003064424A3 (en) | 2004-01-15 |
| CN1303090C (zh) | 2007-03-07 |
| HRP20040788A2 (en) | 2004-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |