AR038405A1 - Gen de streptomyces avermitilis que rige la relacion de avermectinas b2:b1 - Google Patents

Gen de streptomyces avermitilis que rige la relacion de avermectinas b2:b1

Info

Publication number
AR038405A1
AR038405A1 ARP030100408A ARP030100408A AR038405A1 AR 038405 A1 AR038405 A1 AR 038405A1 AR P030100408 A ARP030100408 A AR P030100408A AR P030100408 A ARP030100408 A AR P030100408A AR 038405 A1 AR038405 A1 AR 038405A1
Authority
AR
Argentina
Prior art keywords
avermitilis
avec
avermectins
class
ratio
Prior art date
Application number
ARP030100408A
Other languages
English (en)
Spanish (es)
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AR038405A1 publication Critical patent/AR038405A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detergent Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ARP030100408A 2002-02-12 2003-02-10 Gen de streptomyces avermitilis que rige la relacion de avermectinas b2:b1 AR038405A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US35622202P 2002-02-12 2002-02-12

Publications (1)

Publication Number Publication Date
AR038405A1 true AR038405A1 (es) 2005-01-12

Family

ID=27734621

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030100408A AR038405A1 (es) 2002-02-12 2003-02-10 Gen de streptomyces avermitilis que rige la relacion de avermectinas b2:b1

Country Status (25)

Country Link
US (2) US7388085B2 (https=)
EP (2) EP2050815B1 (https=)
JP (1) JP2005517406A (https=)
KR (1) KR100718378B1 (https=)
CN (2) CN102392028B (https=)
AR (1) AR038405A1 (https=)
AT (2) ATE530645T1 (https=)
AU (1) AU2003245052B2 (https=)
BR (1) BRPI0307620B8 (https=)
CA (1) CA2475214C (https=)
CY (2) CY1110454T1 (https=)
DE (1) DE60326824D1 (https=)
DK (2) DK2050815T3 (https=)
ES (2) ES2373629T3 (https=)
IL (3) IL162866A0 (https=)
ME (1) ME00472B (https=)
MX (1) MXPA04007777A (https=)
PL (1) PL211693B1 (https=)
PT (2) PT2050815E (https=)
RS (1) RS50813B (https=)
RU (1) RU2293117C2 (https=)
SI (2) SI2050815T1 (https=)
TW (1) TWI341330B (https=)
WO (1) WO2003068955A2 (https=)
ZA (1) ZA200405345B (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL162866A0 (en) 2002-02-12 2005-11-20 Pfizer Prod Inc Streptomyces a vermitilis gene directing the ratioof b2:b1 avermectins
CN102241750B (zh) * 2010-05-14 2014-05-28 中国科学院微生物研究所 一种生产阿维菌素的基因工程方法及其专用菌株
CN102093997B (zh) * 2010-12-01 2013-03-13 中国科学院上海有机化学研究所 一种改造除虫链霉菌产生多拉菌素的方法
CN109576196B (zh) * 2019-01-25 2022-01-04 北大方正集团有限公司 一种生产多拉菌素的发酵培养基及多拉菌素的生产方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE434277B (sv) 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4429042A (en) 1978-09-08 1984-01-31 Merck & Co., Inc. Strain of Streptomyces for producing antiparasitic compounds
IN167980B (https=) 1987-01-23 1991-01-19 Pfizer
US5252474A (en) 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
SI9420059A (en) * 1993-10-05 1997-02-28 Pfizer Process and antiparasitic intermediates for doramectin
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
KR20040099389A (ko) * 1998-02-13 2004-11-26 화이자 프로덕츠 인코포레이티드 스트렙토마이세스 하이그로스코피쿠스 유전자
US6248579B1 (en) 1998-02-13 2001-06-19 Pfizer Inc Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins
RU2156301C2 (ru) * 1998-06-09 2000-09-20 Мосин Владимир Александрович Штамм актиномицета streptomyces avermitilis ссм 4697 - продуцент авермектинов
US6197591B1 (en) 1998-09-14 2001-03-06 Pfizer Inc. Streptomyces avermitilis regulatory genes for increased avermectin production
HK1046710B (zh) * 1999-08-12 2005-05-13 Zoetis Services Llc 介导除虫菌素b2：b1比例的除虫链霉菌基因
BR0013551A (pt) 1999-08-13 2003-06-17 Vertex Pharma Inibidores de cinases n-terminal cjun (jnk) e outras cinases de proteìnas
IL162866A0 (en) * 2002-02-12 2005-11-20 Pfizer Prod Inc Streptomyces a vermitilis gene directing the ratioof b2:b1 avermectins

Also Published As

Publication number Publication date
ZA200405345B (en) 2005-06-14
CY1112491T1 (el) 2015-12-09
ES2321827T3 (es) 2009-06-12
IL162866A0 (en) 2005-11-20
CA2475214C (en) 2012-07-31
BRPI0307620B8 (pt) 2016-09-13
US20090017508A1 (en) 2009-01-15
PL211693B1 (pl) 2012-06-29
EP2050815A1 (en) 2009-04-22
DK2050815T3 (da) 2011-12-12
ME00472B (me) 2011-10-10
RS50813B (sr) 2010-08-31
ATE530645T1 (de) 2011-11-15
BR0307620A (pt) 2004-12-07
DK1476539T3 (da) 2009-05-11
CN102392028A (zh) 2012-03-28
HK1168383A1 (en) 2012-12-28
CY1110454T1 (el) 2015-04-29
EP1476539A2 (en) 2004-11-17
PT1476539E (pt) 2009-04-09
IL192371A0 (en) 2008-12-29
IL162866A (en) 2009-11-18
EP2050815B1 (en) 2011-10-26
WO2003068955A2 (en) 2003-08-21
ES2373629T3 (es) 2012-02-07
EP1476539B1 (en) 2009-03-25
RU2293117C2 (ru) 2007-02-10
PL371320A1 (en) 2005-06-13
CN1630712B (zh) 2011-09-28
WO2003068955A3 (en) 2003-11-13
TWI341330B (en) 2011-05-01
CA2475214A1 (en) 2003-08-21
AU2003245052A1 (en) 2003-09-04
DE60326824D1 (de) 2009-05-07
RU2004124521A (ru) 2005-04-10
CN102392028B (zh) 2013-08-14
SI1476539T1 (sl) 2009-06-30
KR100718378B1 (ko) 2007-05-14
CN1630712A (zh) 2005-06-22
SI2050815T1 (sl) 2012-01-31
ATE426659T1 (de) 2009-04-15
PT2050815E (pt) 2012-01-02
US20030166165A1 (en) 2003-09-04
KR20040081199A (ko) 2004-09-20
US8008078B2 (en) 2011-08-30
US7388085B2 (en) 2008-06-17
TW200303918A (en) 2003-09-16
AU2003245052B2 (en) 2008-07-31
MXPA04007777A (es) 2004-10-15
HK1074644A1 (en) 2005-11-18
BRPI0307620B1 (pt) 2015-08-11
IL192371A (en) 2010-11-30
JP2005517406A (ja) 2005-06-16
RS70004A (sr) 2006-10-27

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