AR035530A1 - Composiciones farmaceuticas topicas estabilizadas de brivudina y uso de pigmentos de oxido metalico como fotoestabilizadores - Google Patents
Composiciones farmaceuticas topicas estabilizadas de brivudina y uso de pigmentos de oxido metalico como fotoestabilizadoresInfo
- Publication number
- AR035530A1 AR035530A1 ARP020100151A ARP020100151A AR035530A1 AR 035530 A1 AR035530 A1 AR 035530A1 AR P020100151 A ARP020100151 A AR P020100151A AR P020100151 A ARP020100151 A AR P020100151A AR 035530 A1 AR035530 A1 AR 035530A1
- Authority
- AR
- Argentina
- Prior art keywords
- brivudine
- pigments
- iron oxide
- oxide
- stabilized
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Inorganic Chemistry (AREA)
- Communicable Diseases (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Composiciones tópicas de brivudina estabilizadas frente a la fotodegradación por medio de pigmentos del tipo de óxido metálicos. La composición farmacéutica tópica estabilizada contiene brivudina, ((E)-5-(2-bromovinil)-2'-desoxiuridina),como sustancia activa y uno o más pigmentos de tipo de óxido metálico en una concentración de entre 10% y 50% p/p, preferentemente entre 15% y 35% p/p, junto con excipientes aceptables para el uso farmacéutico. El contenido de brivudina varía usualmente entre 0,3% y 0,8% p/p. Ejemplos de óxidos metálicos adecuados son dióxido de titanio, óxido de hierro y óxido de zinc. Los pigmentos preferidos son dióxido de titanio y óxido de hierro amarillo. El dióxido de titanio tiene color blanco, mientras que el óxido de hierro amarillo conduce a una crema de color amarillo. El óxido de hierro puede usarse exitosamente como agente colorante para las cremas blancas que contienen titanio. Tales pigmentos pueden usarse solos o en combinación. Las composiciones farmacéuticas se presentan en la forma de cremas, lápiz labial, lipogel, hidrogel, emulsión de agua/aceite. Uso de pigmentos de óxido metálico como fotoestabilizador en formulaciones tópicas de brivudina.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01100968 | 2001-01-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR035530A1 true AR035530A1 (es) | 2004-06-02 |
Family
ID=8176229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020100151A AR035530A1 (es) | 2001-01-17 | 2002-01-16 | Composiciones farmaceuticas topicas estabilizadas de brivudina y uso de pigmentos de oxido metalico como fotoestabilizadores |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US20040087602A1 (es) |
| EP (1) | EP1365772A2 (es) |
| JP (1) | JP2004519460A (es) |
| KR (1) | KR20030070109A (es) |
| CN (1) | CN1236777C (es) |
| AR (1) | AR035530A1 (es) |
| AU (1) | AU2002244642B2 (es) |
| BG (1) | BG107988A (es) |
| BR (1) | BR0206478A (es) |
| CA (1) | CA2434743A1 (es) |
| CZ (1) | CZ20031912A3 (es) |
| EE (1) | EE200300322A (es) |
| HR (1) | HRP20030559A2 (es) |
| HU (1) | HUP0302741A3 (es) |
| IL (1) | IL156933A0 (es) |
| MA (1) | MA26266A1 (es) |
| MX (1) | MXPA03006307A (es) |
| MY (1) | MY136633A (es) |
| NO (1) | NO20033206L (es) |
| PE (1) | PE20020818A1 (es) |
| PL (1) | PL365741A1 (es) |
| RU (1) | RU2280453C2 (es) |
| SK (1) | SK8992003A3 (es) |
| TN (1) | TNSN03036A1 (es) |
| UA (1) | UA80673C2 (es) |
| WO (1) | WO2002056913A2 (es) |
| YU (1) | YU57103A (es) |
| ZA (1) | ZA200305437B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005046769A1 (de) * | 2005-09-29 | 2007-04-05 | Berlin-Chemie Ag | Lichtstabile, brivudinhaltige pharmazeutische Formulierung zur Behandlung von Augenherpes (Herpes Ophthalmicus) |
| FR2936706B1 (fr) * | 2008-10-08 | 2010-12-17 | Oreal | Composition cosmetique contenant un derive de dibenzoylmethane et un compose dithiolane ; procede de photostabilisation du derive de dibenzoylmethane |
| JP5591128B2 (ja) * | 2009-01-29 | 2014-09-17 | 大日本住友製薬株式会社 | 内核を有する口腔内崩壊錠 |
| EP3272346A4 (en) * | 2015-03-19 | 2018-08-01 | Daiichi Sankyo Company, Limited | Solid preparation containing colorant |
| CN104988791A (zh) * | 2015-06-25 | 2015-10-21 | 广东义晟实业有限公司 | 一种抗病毒添加剂及添加该添加剂的胶水和uv漆 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0072137A1 (en) * | 1981-08-01 | 1983-02-16 | Beecham Group Plc | Antiviral deoxyuridine compounds |
| HU196038B (en) * | 1987-08-07 | 1988-09-28 | Mta Koezponti Kemiai Kutato In | Process for producing antiherpetic pharmaceutics for external use, containing 5-isopropyl-2'-beta-deoxy-uridine |
| DE4122337A1 (de) * | 1991-07-05 | 1993-01-14 | Cedona Pharm Bv | Pharmazeutische zubereitung |
| FR2737118B1 (fr) * | 1995-07-28 | 1997-09-05 | Oreal | Composition dermatologique ou pharmaceutique, procede de preparation et utilisation |
| GB9521454D0 (en) * | 1995-10-19 | 1995-12-20 | Kappa Pharmaceuticals Ltd | Compositions for the treatment of conditions caused by herpes virus |
| US6558710B1 (en) * | 1999-06-14 | 2003-05-06 | Helen Rebecca Godfrey | Topical zinc compositions and methods of use |
| DE10162593A1 (de) * | 2001-12-19 | 2003-07-03 | Menarini Ricerche Spa | Stabilisierte topische Brivudin-Formulierungen |
-
2001
- 2001-12-24 MY MYPI20015863A patent/MY136633A/en unknown
-
2002
- 2002-01-10 WO PCT/EP2002/000163 patent/WO2002056913A2/en not_active Application Discontinuation
- 2002-01-10 AU AU2002244642A patent/AU2002244642B2/en not_active Ceased
- 2002-01-10 BR BR0206478-2A patent/BR0206478A/pt not_active IP Right Cessation
- 2002-01-10 CN CNB028037448A patent/CN1236777C/zh not_active Expired - Fee Related
- 2002-01-10 SK SK899-2003A patent/SK8992003A3/sk not_active Application Discontinuation
- 2002-01-10 RU RU2003121639/15A patent/RU2280453C2/ru not_active IP Right Cessation
- 2002-01-10 CZ CZ20031912A patent/CZ20031912A3/cs unknown
- 2002-01-10 PL PL02365741A patent/PL365741A1/xx not_active Application Discontinuation
- 2002-01-10 EE EEP200300322A patent/EE200300322A/xx unknown
- 2002-01-10 CA CA002434743A patent/CA2434743A1/en not_active Abandoned
- 2002-01-10 IL IL15693302A patent/IL156933A0/xx unknown
- 2002-01-10 HU HU0302741A patent/HUP0302741A3/hu unknown
- 2002-01-10 KR KR10-2003-7009444A patent/KR20030070109A/ko not_active Application Discontinuation
- 2002-01-10 YU YU57103A patent/YU57103A/sh unknown
- 2002-01-10 EP EP02712810A patent/EP1365772A2/en not_active Withdrawn
- 2002-01-10 JP JP2002557420A patent/JP2004519460A/ja active Pending
- 2002-01-10 MX MXPA03006307A patent/MXPA03006307A/es not_active Application Discontinuation
- 2002-01-10 US US10/466,305 patent/US20040087602A1/en not_active Abandoned
- 2002-01-16 AR ARP020100151A patent/AR035530A1/es not_active Application Discontinuation
- 2002-01-16 PE PE2002000027A patent/PE20020818A1/es not_active Application Discontinuation
- 2002-10-01 UA UA2003076388A patent/UA80673C2/uk unknown
-
2003
- 2003-06-30 MA MA27219A patent/MA26266A1/fr unknown
- 2003-07-08 TN TNPCT/EP2002/000163A patent/TNSN03036A1/fr unknown
- 2003-07-10 BG BG107988A patent/BG107988A/bg unknown
- 2003-07-10 HR HR20030559A patent/HRP20030559A2/hr not_active Application Discontinuation
- 2003-07-15 ZA ZA200305437A patent/ZA200305437B/xx unknown
- 2003-07-15 NO NO20033206A patent/NO20033206L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PL365741A1 (en) | 2005-01-10 |
| NO20033206D0 (no) | 2003-07-15 |
| UA80673C2 (en) | 2007-10-25 |
| CN1236777C (zh) | 2006-01-18 |
| TNSN03036A1 (en) | 2005-04-08 |
| MY136633A (en) | 2008-11-28 |
| KR20030070109A (ko) | 2003-08-27 |
| CN1486185A (zh) | 2004-03-31 |
| AU2002244642B2 (en) | 2005-12-15 |
| HRP20030559A2 (en) | 2005-06-30 |
| YU57103A (sh) | 2006-08-17 |
| MA26266A1 (fr) | 2004-09-01 |
| WO2002056913A3 (en) | 2002-11-07 |
| CZ20031912A3 (cs) | 2004-01-14 |
| PE20020818A1 (es) | 2002-10-21 |
| CA2434743A1 (en) | 2002-07-25 |
| SK8992003A3 (en) | 2003-11-04 |
| US20040087602A1 (en) | 2004-05-06 |
| BR0206478A (pt) | 2003-12-30 |
| HUP0302741A3 (en) | 2007-06-28 |
| JP2004519460A (ja) | 2004-07-02 |
| EE200300322A (et) | 2003-10-15 |
| RU2280453C2 (ru) | 2006-07-27 |
| WO2002056913A2 (en) | 2002-07-25 |
| IL156933A0 (en) | 2004-02-08 |
| HUP0302741A2 (hu) | 2003-11-28 |
| ZA200305437B (en) | 2004-07-15 |
| EP1365772A2 (en) | 2003-12-03 |
| NO20033206L (no) | 2003-07-15 |
| MXPA03006307A (es) | 2003-09-16 |
| RU2003121639A (ru) | 2005-02-10 |
| BG107988A (bg) | 2004-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal | ||
| FA | Abandonment or withdrawal |