AR034735A1 - Sintesis e intermediarios - Google Patents

Sintesis e intermediarios

Info

Publication number
AR034735A1
AR034735A1 ARP020102537A ARP020102537A AR034735A1 AR 034735 A1 AR034735 A1 AR 034735A1 AR P020102537 A ARP020102537 A AR P020102537A AR P020102537 A ARP020102537 A AR P020102537A AR 034735 A1 AR034735 A1 AR 034735A1
Authority
AR
Argentina
Prior art keywords
protecting group
synthesis
intermediaries
hydroxy protecting
hydrogen
Prior art date
Application number
ARP020102537A
Other languages
English (en)
Spanish (es)
Original Assignee
Ciba Sc Holding Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Sc Holding Ag filed Critical Ciba Sc Holding Ag
Publication of AR034735A1 publication Critical patent/AR034735A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/74—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ARP020102537A 2001-07-06 2002-07-05 Sintesis e intermediarios AR034735A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01810670 2001-07-06

Publications (1)

Publication Number Publication Date
AR034735A1 true AR034735A1 (es) 2004-03-17

Family

ID=8184014

Family Applications (3)

Application Number Title Priority Date Filing Date
ARP020102535A AR034733A1 (es) 2001-07-06 2002-07-05 Sintesis e intermediarios
ARP020102536A AR034734A1 (es) 2001-07-06 2002-07-05 Sintesis e intermediarios
ARP020102537A AR034735A1 (es) 2001-07-06 2002-07-05 Sintesis e intermediarios

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ARP020102535A AR034733A1 (es) 2001-07-06 2002-07-05 Sintesis e intermediarios
ARP020102536A AR034734A1 (es) 2001-07-06 2002-07-05 Sintesis e intermediarios

Country Status (17)

Country Link
US (3) US7420078B2 (US07420078-20080902-C00029.png)
EP (2) EP1404639A1 (US07420078-20080902-C00029.png)
JP (1) JP2004533479A (US07420078-20080902-C00029.png)
KR (2) KR20040017277A (US07420078-20080902-C00029.png)
CN (2) CN101880227A (US07420078-20080902-C00029.png)
AR (3) AR034733A1 (US07420078-20080902-C00029.png)
AU (1) AU2002354701B2 (US07420078-20080902-C00029.png)
BR (1) BR0210842A (US07420078-20080902-C00029.png)
CA (1) CA2448917A1 (US07420078-20080902-C00029.png)
CZ (1) CZ2004150A3 (US07420078-20080902-C00029.png)
ES (1) ES2340260T3 (US07420078-20080902-C00029.png)
HR (1) HRPK20040119B3 (US07420078-20080902-C00029.png)
HU (1) HUP0401145A3 (US07420078-20080902-C00029.png)
IL (3) IL159050A0 (US07420078-20080902-C00029.png)
PL (1) PL366392A1 (US07420078-20080902-C00029.png)
PT (1) PT1404642E (US07420078-20080902-C00029.png)
WO (1) WO2003004450A1 (US07420078-20080902-C00029.png)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6101484A (en) 1999-03-31 2000-08-08 Mercata, Inc. Dynamic market equilibrium management system, process and article of manufacture
WO2002057229A1 (en) 2001-01-19 2002-07-25 Biocon India Limited FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN)
EP1404639A1 (en) 2001-07-06 2004-04-07 Ciba SC Holding AG Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino 3,5-dihydroxy heptanoic acid derivatives, and intermediates thereof
DK1417180T3 (da) 2001-07-13 2007-04-10 Astrazeneca Uk Ltd Fremstilling af aminopyrimidinforbindelser
US7361772B2 (en) 2001-08-16 2008-04-22 Biocon Limited Process for the production of atorvastatin calcium
WO2003078379A1 (en) 2002-03-18 2003-09-25 Biocon Limited AMORPHOUS Hmg-CoA REDUCTASE INHIBITORS OF DESIRED PARTICLE SIZE
US7179942B2 (en) 2002-07-05 2007-02-20 Bicon Limited Halo-substituted active methylene compounds
WO2004046105A2 (en) * 2002-11-15 2004-06-03 Teva Pharmaceutical Industries Ltd. Synthesis of 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acids
EP1631533B1 (en) 2003-04-22 2009-03-11 Biocon Limited Novel process for stereoselective reduction of beta-ketoesters
AU2003272080A1 (en) 2003-09-18 2005-04-06 Biocon Limited Novel process for the preparation of tert-butyl 6-cyano-5-hydroxy-3-oxohexanoate
GB0428328D0 (en) 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process
WO2007034909A1 (ja) * 2005-09-22 2007-03-29 Kaneka Corporation （３ｒ，５ｒ）－７－アミノ－３，５－ジヒドロキシヘプタン酸誘導体の製造法
KR20100080432A (ko) * 2008-12-29 2010-07-08 한미약품 주식회사 스타틴 화합물의 신규 제조방법 및 이에 사용되는 벤조티아졸릴 술폰 화합물
SI2616454T1 (sl) * 2010-09-16 2015-08-31 Dsm Sinochem Pharmaceuticals Netherlands B.V. Estri heksanojskih kislin, kot vmesne spojine za pripravo atorvastatina
EP2705075B1 (de) 2011-05-06 2016-12-21 Basf Se Verfahren zur herstellung wasserabsorbierender polymerpartikel
US8420773B2 (en) 2011-05-06 2013-04-16 Basf Se Process for producing water-absorbing polymer particles
CA2857078A1 (en) * 2011-11-28 2013-06-06 Mylan Laboratories Ltd Process for producing chiral statin side chain intermediates employing candida/antarctica lipase b
US10149720B2 (en) 2013-03-08 2018-12-11 Auris Health, Inc. Method, apparatus, and a system for facilitating bending of an instrument in a surgical or medical robotic environment
EP2778229A1 (de) * 2013-03-11 2014-09-17 Sandoz Ag Verfahren zur enantioselektiven Herstellung von 3-Hydroxyglutarsäuremonoestern und deren Verwendung
US10376672B2 (en) 2013-03-15 2019-08-13 Auris Health, Inc. Catheter insertion system and method of fabrication
CA2944989A1 (en) 2013-04-08 2014-10-16 Cytodyn Inc. Felinized antibodies and methods of treating retroviral infections in felines
CN104230879B (zh) * 2014-08-15 2016-08-24 新发药业有限公司 一种2-((4r, 6s)-6-甲酰基-2,2-二取代基-1,3-二氧六环-4-基)乙酸酯制备方法
CN108033899B (zh) * 2017-12-06 2020-04-10 浙江科技学院 一种(r)-6-氰基-5-羟基-3-羰基己酸叔丁酯的制备方法
CN108997324A (zh) * 2018-08-21 2018-12-14 南京欧信医药技术有限公司 瑞舒伐他汀钙中间体的制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4677211A (en) * 1984-06-29 1987-06-30 Sandoz Pharmaceuticals Corp. Preparation of lactones
US4950775A (en) 1985-10-11 1990-08-21 University Of California Antihypercholesterolemic compounds and synthesis thereof
US5003080A (en) 1988-02-22 1991-03-26 Warner-Lambert Company Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis
IT1226726B (it) 1988-07-29 1991-02-05 Zambon Spa Composti attivi come inibitori della biosintesi del colesterolo.
US5196440A (en) * 1988-07-29 1993-03-23 Zambon Group S.P.A. Compounds active as inhibitors of the cholesterol biosynthesis
IT1224795B (it) * 1988-12-01 1990-10-24 Sigma Tau Ind Farmaceuti Uso dell'acetil d-carnitina nel trattamento terapeutico del glaucoma e composizioni farmaceutiche utili in tale trattamento
IT1237792B (it) 1989-12-21 1993-06-17 Zambon Spa Composti attivi come inibitori dell'enzima hmg-coa reduttasi
US5155251A (en) 1991-10-11 1992-10-13 Warner-Lambert Company Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate
JP3652394B2 (ja) * 1995-01-27 2005-05-25 高砂香料工業株式会社 Ｎ−置換−７−アミノ−５−ヒドロキシ−３−オキソヘプタン酸誘導体およびその製造法
JP2003535077A (ja) * 2000-05-26 2003-11-25 チバ スペシャルティ ケミカルズ ホールディング インコーポレーテッド インドール誘導体を製造する方法、および該方法の中間体
EP1404639A1 (en) 2001-07-06 2004-04-07 Ciba SC Holding AG Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino 3,5-dihydroxy heptanoic acid derivatives, and intermediates thereof
IL159719A0 (en) 2001-07-06 2004-06-20 Teva Pharma Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives
SK792004A3 (sk) 2001-07-06 2005-03-04 Teva Pharmaceutical Industries Ltd. Syntéza a medziprodukty derivátov 3,5-dihydroxyheptánovej kyseliny

Also Published As

Publication number Publication date
JP2004533479A (ja) 2004-11-04
HRPK20040119B3 (en) 2006-07-31
KR20040017277A (ko) 2004-02-26
US20040186313A1 (en) 2004-09-23
HUP0401145A2 (hu) 2004-09-28
PT1404642E (pt) 2010-03-29
HUP0401145A3 (en) 2008-08-28
AU2002354701B2 (en) 2007-11-22
WO2003004450A1 (en) 2003-01-16
CN1610657A (zh) 2005-04-27
US8026383B2 (en) 2011-09-27
IL159050A0 (en) 2004-05-12
CZ2004150A3 (cs) 2004-09-15
US20080312466A1 (en) 2008-12-18
US7420078B2 (en) 2008-09-02
EP2161250A1 (en) 2010-03-10
CA2448917A1 (en) 2003-01-16
CN101880227A (zh) 2010-11-10
KR20040017278A (ko) 2004-02-26
ES2340260T3 (es) 2010-06-01
IL214164A0 (en) 2011-08-31
PL366392A1 (en) 2005-01-24
AR034733A1 (es) 2004-03-17
AR034734A1 (es) 2004-03-17
EP1404639A1 (en) 2004-04-07
HRP20040119A2 (en) 2005-04-30
IL214165A0 (en) 2011-08-31
US20110046411A1 (en) 2011-02-24
BR0210842A (pt) 2004-07-13
US7855302B2 (en) 2010-12-21

Similar Documents

Publication Publication Date Title
AR034735A1 (es) Sintesis e intermediarios
BR0114630A (pt) Secretagogos de hormÈnio do crescimento
BR0010704A (pt) Composições e métodos de anti-náusea
DK1474406T3 (da) Disubstituerede thiazolylcarboxanilider samt deres anvendelse som mikrobicider
UY28103A1 (es) Nuevas imidazo-piridinonas sustituidas, su preparación y su empleo como medicacmentos
AR049646A1 (es) Derivados de sulfamato y sulfamida utiles para el tratamiento de la epilepsia y trastornos relacionados
IL159418A0 (en) Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
TR200401755T4 (tr) Metanesulfonamıdo-benzofuran hazırlama metodu ve bunun sentez ara ürünü olarak kullanım şekli
ATE490253T1 (de) Synthese von 5-substituierten 7-azaindolen und 7- azaindolinen
AR044400A1 (es) Procesos para la preparacion de derivados de pirimidina
MA27501A1 (fr) Derives d'imidazoquinoline en tant que ligands recepteurs de l'adenosine a3
BR0209936A (pt) Composição combinada farmacêutica,e uso de um composto e de um inibidor de cianoguanidina ikk
BR9808486A (pt) Processo para a preparação de um composto
BR0311410A (pt) Composto de piperidina
NO20001781L (no) 3-amino-3-arylpropan-1-og lignende-derivater, deres fremstilling og anvendelse
BR0208812A (pt) Derivados fenil heterociclil éter como inibidores de recaptação de serotonina
BR0209901A (pt) Processos para a sìntese de derivados de 2,3-dihidro-1,4-dioxino-[2,3-f] quinolina
BR0312863A (pt) Derivados de aldeìdo de polietileno glicol
BR9912556A (pt) Triazolpiridinas para o tratamento de distúrbios trombóticos
AR027067A1 (es) Benzoilciclohexanodionas substituidas
BR0317852A (pt) Formulações semelhantes a óleo aspergìveis
MXPA03008248A (es) Agentes colorantes para fibras de queratina que contienen derivados de n-heteroarilmetil-m-fenilendiamina, asi como nuevos derivados de n-heteroarilmetil-m-fenilendiamina.
BRPI0408899A (pt) compostos benzo[1,2,5]tiadiazol
BR0317249A (pt) Método de preparar compostos de aminocianopiridina tricìclica
AR003977A1 (es) Composiciones endoparasiticidas a base de didepsipeptidos, nuevos didepsipeptidos y procedimientos para su produccion.

Legal Events

Date Code Title Description
FA Abandonment or withdrawal