AR034221A1 - Derivados de acido galico, un proceso para su preparacion, composicion farmaceutica, reactivos, sistema de reactivos, uso de dichos compuestos reactivos para preparar un ensayo in vitro de la coagulacion endogena, su utilizacion en la exploracion de la coagulacion endogena, y un metodo para medir el - Google Patents
Derivados de acido galico, un proceso para su preparacion, composicion farmaceutica, reactivos, sistema de reactivos, uso de dichos compuestos reactivos para preparar un ensayo in vitro de la coagulacion endogena, su utilizacion en la exploracion de la coagulacion endogena, y un metodo para medir elInfo
- Publication number
- AR034221A1 AR034221A1 ARP020101046A ARP020101046A AR034221A1 AR 034221 A1 AR034221 A1 AR 034221A1 AR P020101046 A ARP020101046 A AR P020101046A AR P020101046 A ARP020101046 A AR P020101046A AR 034221 A1 AR034221 A1 AR 034221A1
- Authority
- AR
- Argentina
- Prior art keywords
- coagulation
- reagents
- exploration
- derivatives
- prepare
- Prior art date
Links
- 239000003153 chemical reaction reagent Substances 0.000 title abstract 6
- 230000015271 coagulation Effects 0.000 title abstract 6
- 238000005345 coagulation Methods 0.000 title abstract 6
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- 238000000338 in vitro Methods 0.000 title 1
- PGOHTUIFYSHAQG-LJSDBVFPSA-N (2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]hexanoic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O PGOHTUIFYSHAQG-LJSDBVFPSA-N 0.000 abstract 1
- 102000002262 Thromboplastin Human genes 0.000 abstract 1
- 108010000499 Thromboplastin Proteins 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical class OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 abstract 1
- 238000000099 in vitro assay Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/50—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/82—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
- C07C69/88—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with esterified carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
- C08G73/02—Polyamines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Polymers & Plastics (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Polyethers (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Fats And Perfumes (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Derivados del ácido gálico, que comprende un compuesto de la fórmula (1), en la cual: A es seleccionado de entre el grupo consistente en las fórmulas (2), (3) ó (4); M+ representa un catión, siendo q igual a 1 ó 2, y siendo p tal que p x q = 2; R representa un compuesto de fórmula (5) ó (6), siendo m igual a 2, 3, 4 ó 5, y siendo n un número entero entre 1 y 170; o -AA1-AA2-.......-AAr-, siendo AA un aminoácido natural o exótico, y siendo r un número entero entre 1 y 10, con la condición que el compuesto no es un compuesto de fórmula (7) cuando m es 2, 3 ó 4; un proceso para su preparación, composición farmacéutica, reactivos, sistema de reactivos, uso de dichos compuestos reactivos para preparar un ensayo in vitro de la coagulación endógena, su utilización en la exploración de la coagulación endógena y un método para medir el tiempo de la tromboplastina parcial activada.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0103979A FR2822462B1 (fr) | 2001-03-23 | 2001-03-23 | Composes activateurs de la coagulation endogene utilisation pour l'exploration de la coagulation endogene |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR034221A1 true AR034221A1 (es) | 2004-02-04 |
Family
ID=8861494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020101046A AR034221A1 (es) | 2001-03-23 | 2002-03-22 | Derivados de acido galico, un proceso para su preparacion, composicion farmaceutica, reactivos, sistema de reactivos, uso de dichos compuestos reactivos para preparar un ensayo in vitro de la coagulacion endogena, su utilizacion en la exploracion de la coagulacion endogena, y un metodo para medir el |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7208266B2 (es) |
| EP (1) | EP1280758A1 (es) |
| JP (1) | JP4563648B2 (es) |
| KR (1) | KR20030005359A (es) |
| CN (1) | CN100432046C (es) |
| AR (1) | AR034221A1 (es) |
| BR (1) | BR0204494A (es) |
| CA (1) | CA2407779A1 (es) |
| FR (1) | FR2822462B1 (es) |
| HK (1) | HK1054737A1 (es) |
| HU (1) | HUP0302136A3 (es) |
| MX (1) | MXPA02011565A (es) |
| PL (1) | PL357449A1 (es) |
| RU (1) | RU2002131457A (es) |
| WO (1) | WO2002076921A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA05007165A (es) * | 2002-12-31 | 2005-09-21 | Nektar Therapeutics Al Corp | Reactivos polimericos que comprnden una cetona o un grupo funcional relacionado. |
| DE102007062323A1 (de) * | 2007-12-21 | 2009-06-25 | Siemens Healthcare Diagnostics Products Gmbh | Langzeitstabiles Thromboplastin-Reagenz |
| JP6577778B2 (ja) * | 2015-07-30 | 2019-09-18 | シスメックス株式会社 | 凝固時間の測定方法およびその装置、凝固時間測定用試薬ならびに試薬キット |
| CN105424945B (zh) * | 2015-11-20 | 2018-05-18 | 重庆贝羿生物科技有限公司 | 一种凝血激活检测试剂及其制备方法与用途 |
| KR101651605B1 (ko) * | 2015-12-10 | 2016-08-26 | 대봉엘에스 주식회사 | 신규 페놀산류 유도체 화합물, 및 이의 용도 |
| CN108344875B (zh) * | 2017-01-22 | 2021-11-02 | 上海长岛生物技术有限公司 | 提高活化部分凝血活酶时间试剂对肝素敏感性的方法及用途 |
| EP3859327A4 (en) * | 2018-09-25 | 2022-09-07 | Sekisui Medical Co., Ltd. | METHOD OF MEASUREMENT OF BLOOD COAGING TIME |
| CN110824154A (zh) * | 2019-10-15 | 2020-02-21 | 常熟常江生物技术有限公司 | 用于血栓弹力图仪的激活剂 |
| CN113679039B (zh) * | 2021-05-12 | 2023-05-09 | 浙江大学 | 一种没食子酸聚乙二醇酯蛋白载体增效剂及其制备方法与应用 |
| CN116496186A (zh) * | 2023-05-04 | 2023-07-28 | 浙江海洋大学 | 一类水溶性没食子酸衍生物、制备方法及其在水产品抗氧化处理中的应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1565823A (en) * | 1976-11-11 | 1980-04-23 | Pilkington Brothers Ltd | Coating of glass fibres |
| JPS60199850A (ja) * | 1984-03-26 | 1985-10-09 | Eisai Co Ltd | 新規な没食子酸誘導体 |
| DE3544338A1 (de) * | 1985-12-14 | 1987-06-19 | Hoechst Ag | Peptid-derivate mit inhibitorischer wirkung auf hydroxylierende enzyme, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung |
| CA1313997C (en) * | 1986-04-11 | 1993-03-02 | Hideo Anraku | Accelerator of the activity of hydrolase |
| US4994192A (en) * | 1990-01-16 | 1991-02-19 | Eastman Kodak Company | Amine polymers as coagulator accelerators in blood phase separation |
| US4979471A (en) * | 1990-04-09 | 1990-12-25 | Larry Hartshorn | Animal confinement chute |
| JPH05506309A (ja) * | 1990-04-17 | 1993-09-16 | アナリティカル・コントロール・システムズ・インコーポレーテッド | 凝固アッセイおよび試薬 |
-
2001
- 2001-03-23 FR FR0103979A patent/FR2822462B1/fr not_active Expired - Fee Related
-
2002
- 2002-03-22 KR KR1020027015528A patent/KR20030005359A/ko not_active Ceased
- 2002-03-22 HK HK03105405.5A patent/HK1054737A1/zh unknown
- 2002-03-22 BR BR0204494-3A patent/BR0204494A/pt not_active IP Right Cessation
- 2002-03-22 HU HU0302136A patent/HUP0302136A3/hu unknown
- 2002-03-22 AR ARP020101046A patent/AR034221A1/es not_active Application Discontinuation
- 2002-03-22 CN CNB028007956A patent/CN100432046C/zh not_active Expired - Fee Related
- 2002-03-22 PL PL02357449A patent/PL357449A1/xx unknown
- 2002-03-22 CA CA002407779A patent/CA2407779A1/fr not_active Abandoned
- 2002-03-22 WO PCT/FR2002/001020 patent/WO2002076921A1/fr not_active Ceased
- 2002-03-22 EP EP02722368A patent/EP1280758A1/fr not_active Withdrawn
- 2002-03-22 RU RU2002131457/04A patent/RU2002131457A/ru not_active Application Discontinuation
- 2002-03-22 MX MXPA02011565A patent/MXPA02011565A/es unknown
- 2002-03-22 JP JP2002576184A patent/JP4563648B2/ja not_active Expired - Fee Related
- 2002-11-22 US US10/302,649 patent/US7208266B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004519507A (ja) | 2004-07-02 |
| RU2002131457A (ru) | 2004-04-10 |
| FR2822462A1 (fr) | 2002-09-27 |
| HK1054737A1 (zh) | 2003-12-12 |
| MXPA02011565A (es) | 2004-09-06 |
| CA2407779A1 (fr) | 2002-10-03 |
| CN100432046C (zh) | 2008-11-12 |
| US7208266B2 (en) | 2007-04-24 |
| BR0204494A (pt) | 2003-04-08 |
| KR20030005359A (ko) | 2003-01-17 |
| JP4563648B2 (ja) | 2010-10-13 |
| EP1280758A1 (fr) | 2003-02-05 |
| CN1460098A (zh) | 2003-12-03 |
| FR2822462B1 (fr) | 2005-07-15 |
| HUP0302136A2 (hu) | 2003-09-29 |
| HUP0302136A3 (en) | 2005-12-28 |
| US20030157582A1 (en) | 2003-08-21 |
| WO2002076921A1 (fr) | 2002-10-03 |
| PL357449A1 (en) | 2004-07-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |