BRPI0508985A - derivado de trombina, dna, e, composição farmacêutica - Google Patents

derivado de trombina, dna, e, composição farmacêutica

Info

Publication number
BRPI0508985A
BRPI0508985A BRPI0508985-9A BRPI0508985A BRPI0508985A BR PI0508985 A BRPI0508985 A BR PI0508985A BR PI0508985 A BRPI0508985 A BR PI0508985A BR PI0508985 A BRPI0508985 A BR PI0508985A
Authority
BR
Brazil
Prior art keywords
thrombin
dna
pharmaceutical composition
derivative
thrombin derivative
Prior art date
Application number
BRPI0508985-9A
Other languages
English (en)
Inventor
Kazuya Hosokawa
Kosuke Kashima
Original Assignee
Chisso Corp
Fujimori Kogyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chisso Corp, Fujimori Kogyo Co filed Critical Chisso Corp
Priority claimed from PCT/JP2005/005170 external-priority patent/WO2005089070A1/ja
Publication of BRPI0508985A publication Critical patent/BRPI0508985A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

DERIVADO DE TROMBINA, DNA, E, COMPOSIçãO FARMACêUTICA Pretende-se fornecer um derivado de trombina, compreendendo as cadeias A e B, em que a cadeia B tem uma seqüência de aminoácido derivada da seqüência de aminoácido da cadeia de trombina B, pela substituição, em um ou mais aminoácidos centrais ativos, selecionados dentre serina na posição-205, glicina na posição-203, ácido aspártico na posição-99 e histidina na posição-43 e (1) no caso de reagir com um substrato de trombina a 37 C por 3 horas em um tampão de tris cloridreto 50 mM (pH7,4), contendo NaC1 0,1 M, a relação do substrato de trombina, decomposto pelo derivado de trombina, sendo 10% ou menos; e (2) sustentar a estrutura do sítio externo I.
BRPI0508985-9A 2004-03-19 2005-03-22 derivado de trombina, dna, e, composição farmacêutica BRPI0508985A (pt)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2004080950 2004-03-19
JP2004170346 2004-06-08
JP2004217834 2004-07-26
JP2004315631 2004-10-29
JP2005029360 2005-02-04
PCT/JP2005/005170 WO2005089070A1 (ja) 2004-03-19 2005-03-22 トロンビン誘導体、およびそれを含有する医薬組成物

Publications (1)

Publication Number Publication Date
BRPI0508985A true BRPI0508985A (pt) 2007-08-28

Family

ID=34994126

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0508985-9A BRPI0508985A (pt) 2004-03-19 2005-03-22 derivado de trombina, dna, e, composição farmacêutica

Country Status (8)

Country Link
US (1) US20070282095A1 (pt)
EP (1) EP1734116A4 (pt)
JP (1) JP4848270B2 (pt)
KR (1) KR20060133031A (pt)
CN (1) CN1934252B (pt)
AU (1) AU2005222763B2 (pt)
BR (1) BRPI0508985A (pt)
CA (1) CA2560247A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007320353A1 (en) * 2006-11-15 2008-05-22 Fujimori Kogyo Co., Ltd. Thrombin mutant
KR20140130725A (ko) * 2007-09-21 2014-11-11 아이진 주식회사 트롬빈 유래 펩타이드를 포함하는 망막증 또는 녹내장 치료용 조성물
AU2009320153B2 (en) 2008-10-27 2016-07-14 Trustees Of Tufts College Nucleic acids encoding peptides for treating wounds, anti-angiogenic compounds, and uses thereof
GB0916576D0 (en) * 2009-09-22 2009-10-28 Malmsten Nils M Polypeptides and uses thereof
US20130309753A1 (en) * 2012-05-16 2013-11-21 Saint Louis University Recombinant auto-activating protease precursors
US11958911B2 (en) 2017-02-10 2024-04-16 Shanghai Benemae Pharmaceutical Anti-coagulation factor XI antibody
KR20180117529A (ko) * 2017-04-19 2018-10-29 주식회사 프로티나 단백질-단백질 상호작용 분석에 의한 약물 반응성 예측 방법
CN116217674A (zh) * 2023-02-07 2023-06-06 湖南中晟全肽生化有限公司 一种抗菌/抗炎多肽及其用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0728210B1 (en) * 1993-11-12 2005-04-13 Gilead Sciences, Inc. Thrombin mutants
CN1281624C (zh) * 2001-03-19 2006-10-25 藤森工业株式会社 凝血酶衍生物及其制造方法

Also Published As

Publication number Publication date
WO2005089070A2 (ja) 2005-09-29
WO2005089070A3 (ja) 2006-01-05
EP1734116A2 (en) 2006-12-20
CN1934252A (zh) 2007-03-21
JPWO2005089070A1 (ja) 2008-01-31
CA2560247A1 (en) 2005-09-29
AU2005222763B2 (en) 2011-04-28
JP4848270B2 (ja) 2011-12-28
CN1934252B (zh) 2011-02-23
KR20060133031A (ko) 2006-12-22
US20070282095A1 (en) 2007-12-06
AU2005222763A1 (en) 2005-09-29
EP1734116A4 (en) 2007-09-05

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Legal Events

Date Code Title Description
B25G Requested change of headquarter approved

Owner name: CHISSO CORPORATION (JP) , FUJIMORI KOGYO CO., LTD.

Free format text: ENDERECO DO 2O DEPOSITANTES ALTERADO CONFORME PET. NO 020100105844/RJ, DE 11/11/2010.

B25G Requested change of headquarter approved

Owner name: FUJIMORI KOGYO CO., LTD. (JP) , CHISSO CORPORATION

Free format text: ENDERECO DO 1O DEPOSITANTE ALTERADO CONFORME SOLICITADO NA PETICAO NO 020110072440/RJ DE 08/07/2011.

B25A Requested transfer of rights approved

Owner name: FUJIMORI KOGYO CO., LTD. (JP) , JNC CORPORATION (J

Free format text: TRANSFERIDO DE: CHISSO CORPORATION

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2204 DE 02/04/2013.