AR031854A1 - FORMAS/HIDRATOS POLIMORFICAS/OS DE DIHIDROCLORURO DE N-[4-(3-CLORO-4-FLUORFENILAMINO)-7-(3-MORFOLIN-4-ILPROPOXI)-QUINAZOLIN-6-IL]-ACRILAMIDA, PROCEDIMIENTOS PARA SU OBTENCION Y SU USO EN LA PREPARACION DE MEDICAMENTOS QUE TIENEN UNA ACCION DE INHIBICIoN IRREVERSIBLE DE TIROSINA QUINASA - Google Patents
FORMAS/HIDRATOS POLIMORFICAS/OS DE DIHIDROCLORURO DE N-[4-(3-CLORO-4-FLUORFENILAMINO)-7-(3-MORFOLIN-4-ILPROPOXI)-QUINAZOLIN-6-IL]-ACRILAMIDA, PROCEDIMIENTOS PARA SU OBTENCION Y SU USO EN LA PREPARACION DE MEDICAMENTOS QUE TIENEN UNA ACCION DE INHIBICIoN IRREVERSIBLE DE TIROSINA QUINASAInfo
- Publication number
- AR031854A1 AR031854A1 ARP010103135A ARP010103135A AR031854A1 AR 031854 A1 AR031854 A1 AR 031854A1 AR P010103135 A ARP010103135 A AR P010103135A AR P010103135 A ARP010103135 A AR P010103135A AR 031854 A1 AR031854 A1 AR 031854A1
- Authority
- AR
- Argentina
- Prior art keywords
- obtaining
- preparation
- quinazolin
- medicines
- water
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Se describen formas/hidratos polimorficas/os de dihidrocloruro de N-[4-(3-cloro-4-fluorfenilamino)-7-(3-morfolin-4-ilpropoxi)-quinazolin-6-il]-acrilamida, procedimientos para su preparacion y su uso en la obtencion de medicamentos que presentan una accion de inhibicion irreversible de tirosina quinasa. Se han preparado e identificado cuatro formas/hidratos polimorficas/os de dihidrocloruro de N-[4-(3-cloro-4-fluorfenilamino)-7-(3-morfolin-4-ilpropoxi)-quinazolin-6-il]-acrilamida de la siguiente formula (1): Concretamente la forma A con alrededor de 3 moles de agua, la forma B como compuesto polimorfico de la forma A, igualmente con alrededor de 3 moles de agua, la formar H con alrededor de 7 moles de agua y la forma M con alrededor de 1 mol de agua. Las diferentes formas del compuesto (1) son adecuadas de la misma manera que el propio compuesto (1) para utilizarse como inhibidores irreversibles de tirosina quinasa y, de este modo, se pueden emplear en la preparacion de medicamentos para el tratamiento de cáncer, arteriosclerosis, restenosis, endometriosis y psoriasis. Procedimiento para su preparacion y su uso en la obtencion de medicamentos que presentan una accion de inhibicion irreversible de tirosina quinasa.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10031971A DE10031971A1 (de) | 2000-06-30 | 2000-06-30 | Polymorphe Formen/Hydrate von N-[4-(3-Chlor-4-fluor-phenylamino)-7-(3-morpholin-4-yl-propoxy)-chinazolin-6-yl]-acrylamid Dihydrochlorid, Verfahren zu ihrer Herstellung sowie die Verwendung derselben zur Herstellung von Medikamenten mit irreversibler Tyrosinkinasehemmwirkung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR031854A1 true AR031854A1 (es) | 2003-10-08 |
Family
ID=7647397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010103135A AR031854A1 (es) | 2000-06-30 | 2001-06-29 | FORMAS/HIDRATOS POLIMORFICAS/OS DE DIHIDROCLORURO DE N-[4-(3-CLORO-4-FLUORFENILAMINO)-7-(3-MORFOLIN-4-ILPROPOXI)-QUINAZOLIN-6-IL]-ACRILAMIDA, PROCEDIMIENTOS PARA SU OBTENCION Y SU USO EN LA PREPARACION DE MEDICAMENTOS QUE TIENEN UNA ACCION DE INHIBICIoN IRREVERSIBLE DE TIROSINA QUINASA |
Country Status (39)
| Country | Link |
|---|---|
| US (1) | US20040034022A1 (es) |
| EP (1) | EP1299363A1 (es) |
| JP (1) | JP2004501902A (es) |
| KR (1) | KR20030014403A (es) |
| CN (1) | CN1438994A (es) |
| AP (1) | AP2002002694A0 (es) |
| AR (1) | AR031854A1 (es) |
| AU (1) | AU2001283861A1 (es) |
| BG (1) | BG107352A (es) |
| BR (1) | BR0112082A (es) |
| CA (1) | CA2412535A1 (es) |
| CZ (1) | CZ20024037A3 (es) |
| DE (1) | DE10031971A1 (es) |
| DZ (1) | DZ3342A1 (es) |
| EA (1) | EA005294B1 (es) |
| EC (1) | ECSP024413A (es) |
| EE (1) | EE200200714A (es) |
| GT (1) | GT200100124A (es) |
| HN (1) | HN2001000134A (es) |
| HR (1) | HRP20021019A2 (es) |
| HU (1) | HUP0300900A3 (es) |
| IL (1) | IL152419A0 (es) |
| IS (1) | IS6596A (es) |
| MA (1) | MA26924A1 (es) |
| MX (1) | MXPA03000101A (es) |
| NO (1) | NO20026193L (es) |
| NZ (1) | NZ522001A (es) |
| OA (1) | OA12301A (es) |
| PA (1) | PA8520801A1 (es) |
| PE (1) | PE20020116A1 (es) |
| PL (1) | PL365127A1 (es) |
| SK (1) | SK17642002A3 (es) |
| SV (1) | SV2002000517A (es) |
| TN (1) | TNSN01090A1 (es) |
| UA (1) | UA73588C2 (es) |
| UY (1) | UY26803A1 (es) |
| WO (1) | WO2002000630A1 (es) |
| YU (1) | YU99802A (es) |
| ZA (1) | ZA200209717B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1746999E (pt) * | 2004-05-06 | 2012-01-11 | Warner Lambert Co | 4-fenilamino-quinazolin-6-il-amidas |
| DE102006000122A1 (de) * | 2006-03-17 | 2007-09-20 | Aug. Winkhaus Gmbh & Co. Kg | Schlüssel für einen Schließzylinder und Schließzylinder für einen solchen Schlüssel |
| CN108430990B (zh) * | 2015-12-25 | 2020-08-25 | 山东轩竹医药科技有限公司 | 喹唑啉衍生物的晶体及其制备方法 |
| EP3395810B1 (en) * | 2015-12-25 | 2020-02-12 | Xuanzhu Pharma Co., Ltd. | Crystals of quinazoline derivative and preparation method therefor |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2249446C (en) * | 1996-04-12 | 2008-06-17 | Warner-Lambert Company | Irreversible inhibitors of tyrosine kinases |
| NZ512189A (en) * | 1998-11-19 | 2003-10-31 | Warner Lambert Co | N-[4-(3-chloro-4-fluoro-phenylamino)-7-(3-morpholin-4- yl-propoxy)-quinazolin-6-yl]-acrylamide useful as an irreversible inhibitor of tyrosine kinases |
-
2000
- 2000-06-30 DE DE10031971A patent/DE10031971A1/de not_active Withdrawn
-
2001
- 2001-06-15 EA EA200300094A patent/EA005294B1/ru not_active IP Right Cessation
- 2001-06-15 PL PL01365127A patent/PL365127A1/xx not_active Application Discontinuation
- 2001-06-15 UA UA2003010793A patent/UA73588C2/uk unknown
- 2001-06-15 HU HU0300900A patent/HUP0300900A3/hu unknown
- 2001-06-15 IL IL15241901A patent/IL152419A0/xx unknown
- 2001-06-15 CN CN01811998A patent/CN1438994A/zh active Pending
- 2001-06-15 OA OA1200200394A patent/OA12301A/fr unknown
- 2001-06-15 AU AU2001283861A patent/AU2001283861A1/en not_active Abandoned
- 2001-06-15 WO PCT/EP2001/006733 patent/WO2002000630A1/en active IP Right Grant
- 2001-06-15 SK SK1764-2002A patent/SK17642002A3/sk unknown
- 2001-06-15 US US10/312,173 patent/US20040034022A1/en not_active Abandoned
- 2001-06-15 JP JP2002505378A patent/JP2004501902A/ja not_active Withdrawn
- 2001-06-15 DZ DZ013342A patent/DZ3342A1/fr active
- 2001-06-15 YU YU99802A patent/YU99802A/sh unknown
- 2001-06-15 BR BR0112082-4A patent/BR0112082A/pt not_active IP Right Cessation
- 2001-06-15 EE EEP200200714A patent/EE200200714A/xx unknown
- 2001-06-15 AP APAP/P/2002/002694A patent/AP2002002694A0/en unknown
- 2001-06-15 NZ NZ522001A patent/NZ522001A/en unknown
- 2001-06-15 CZ CZ20024037A patent/CZ20024037A3/cs unknown
- 2001-06-15 EP EP01962739A patent/EP1299363A1/en not_active Withdrawn
- 2001-06-15 CA CA002412535A patent/CA2412535A1/en not_active Abandoned
- 2001-06-15 MX MXPA03000101A patent/MXPA03000101A/es unknown
- 2001-06-15 KR KR1020027017829A patent/KR20030014403A/ko not_active Application Discontinuation
- 2001-06-15 TN TNTNSN01090A patent/TNSN01090A1/fr unknown
- 2001-06-21 PA PA20018520801A patent/PA8520801A1/es unknown
- 2001-06-25 GT GT200100124A patent/GT200100124A/es unknown
- 2001-06-26 PE PE2001000623A patent/PE20020116A1/es not_active Application Discontinuation
- 2001-06-26 HN HN2001000134A patent/HN2001000134A/es unknown
- 2001-06-27 UY UY26803A patent/UY26803A1/es not_active Application Discontinuation
- 2001-06-29 SV SV2001000517A patent/SV2002000517A/es not_active Application Discontinuation
- 2001-06-29 AR ARP010103135A patent/AR031854A1/es unknown
-
2002
- 2002-10-28 IS IS6596A patent/IS6596A/is unknown
- 2002-11-29 ZA ZA200209717A patent/ZA200209717B/en unknown
- 2002-12-04 BG BG107352A patent/BG107352A/bg unknown
- 2002-12-19 HR HR20021019A patent/HRP20021019A2/xx not_active Application Discontinuation
- 2002-12-23 NO NO20026193A patent/NO20026193L/no not_active Application Discontinuation
- 2002-12-30 MA MA26984A patent/MA26924A1/fr unknown
- 2002-12-30 EC EC2002004413A patent/ECSP024413A/es unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |