PA8520801A1 - Formas/hidratos polimorficas/os de dihidrocloruro de n-4-(3-cloro-4-fluorfenilamino)-7-(3-morfolin-4-ilpropoxi)-quinazolin-6-il - acrilamida, procedimientos para su obtencion y su uso en la preparacion de medicamentos que tienen una accion de inhibic - Google Patents

Formas/hidratos polimorficas/os de dihidrocloruro de n-4-(3-cloro-4-fluorfenilamino)-7-(3-morfolin-4-ilpropoxi)-quinazolin-6-il - acrilamida, procedimientos para su obtencion y su uso en la preparacion de medicamentos que tienen una accion de inhibic

Info

Publication number
PA8520801A1
PA8520801A1 PA20018520801A PA8520801A PA8520801A1 PA 8520801 A1 PA8520801 A1 PA 8520801A1 PA 20018520801 A PA20018520801 A PA 20018520801A PA 8520801 A PA8520801 A PA 8520801A PA 8520801 A1 PA8520801 A1 PA 8520801A1
Authority
PA
Panama
Prior art keywords
ilpropoxi
morfolin
quinazolin
medicines
acrylamide
Prior art date
Application number
PA20018520801A
Other languages
English (en)
Inventor
Hubert Barth
Klaus Steiner
Simon Schneider
Dietmar Huls
Andreas Muhlenfeld
Manfred Westermayer
Original Assignee
Goedecke Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Goedecke Gmbh filed Critical Goedecke Gmbh
Publication of PA8520801A1 publication Critical patent/PA8520801A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

SE DESCRIBEN FORMAS/HIDRATOS POLIMORFICAS/OS DE DIHIDROCLORURO DE N-[4-(3-CLORO-4-FLUORFENILAMINO)-7-(3-MORFOLIN-4-ILPROPOXI)-QUINAZOLIN-6-iL]- ACRILAMIDA, PROCEDIMIENTOS PARA SU PREPARACION Y SU USO EN LA OBTENCION DE MEDICAMENTOS QUE PRESENTAN UNA ACCION DE INHIBICION IRREVERSIBLE DE TIROSINA QUINASA.
PA20018520801A 2000-06-30 2001-06-21 Formas/hidratos polimorficas/os de dihidrocloruro de n-4-(3-cloro-4-fluorfenilamino)-7-(3-morfolin-4-ilpropoxi)-quinazolin-6-il - acrilamida, procedimientos para su obtencion y su uso en la preparacion de medicamentos que tienen una accion de inhibic PA8520801A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10031971A DE10031971A1 (de) 2000-06-30 2000-06-30 Polymorphe Formen/Hydrate von N-[4-(3-Chlor-4-fluor-phenylamino)-7-(3-morpholin-4-yl-propoxy)-chinazolin-6-yl]-acrylamid Dihydrochlorid, Verfahren zu ihrer Herstellung sowie die Verwendung derselben zur Herstellung von Medikamenten mit irreversibler Tyrosinkinasehemmwirkung

Publications (1)

Publication Number Publication Date
PA8520801A1 true PA8520801A1 (es) 2003-06-30

Family

ID=7647397

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20018520801A PA8520801A1 (es) 2000-06-30 2001-06-21 Formas/hidratos polimorficas/os de dihidrocloruro de n-4-(3-cloro-4-fluorfenilamino)-7-(3-morfolin-4-ilpropoxi)-quinazolin-6-il - acrilamida, procedimientos para su obtencion y su uso en la preparacion de medicamentos que tienen una accion de inhibic

Country Status (39)

Country Link
US (1) US20040034022A1 (es)
EP (1) EP1299363A1 (es)
JP (1) JP2004501902A (es)
KR (1) KR20030014403A (es)
CN (1) CN1438994A (es)
AP (1) AP2002002694A0 (es)
AR (1) AR031854A1 (es)
AU (1) AU2001283861A1 (es)
BG (1) BG107352A (es)
BR (1) BR0112082A (es)
CA (1) CA2412535A1 (es)
CZ (1) CZ20024037A3 (es)
DE (1) DE10031971A1 (es)
DZ (1) DZ3342A1 (es)
EA (1) EA005294B1 (es)
EC (1) ECSP024413A (es)
EE (1) EE200200714A (es)
GT (1) GT200100124A (es)
HN (1) HN2001000134A (es)
HR (1) HRP20021019A2 (es)
HU (1) HUP0300900A3 (es)
IL (1) IL152419A0 (es)
IS (1) IS6596A (es)
MA (1) MA26924A1 (es)
MX (1) MXPA03000101A (es)
NO (1) NO20026193L (es)
NZ (1) NZ522001A (es)
OA (1) OA12301A (es)
PA (1) PA8520801A1 (es)
PE (1) PE20020116A1 (es)
PL (1) PL365127A1 (es)
SK (1) SK17642002A3 (es)
SV (1) SV2002000517A (es)
TN (1) TNSN01090A1 (es)
UA (1) UA73588C2 (es)
UY (1) UY26803A1 (es)
WO (1) WO2002000630A1 (es)
YU (1) YU99802A (es)
ZA (1) ZA200209717B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005239878B9 (en) * 2004-05-06 2010-01-07 Warner-Lambert Company Llc 4-phenylamino-quinazolin-6-yl-amides
DE102006000122A1 (de) * 2006-03-17 2007-09-20 Aug. Winkhaus Gmbh & Co. Kg Schlüssel für einen Schließzylinder und Schließzylinder für einen solchen Schlüssel
JP6674027B2 (ja) * 2015-12-25 2020-04-01 シュアンチュー ファーマ カンパニー，リミティド キナゾリン誘導体の結晶及びその調製方法
JP6717947B2 (ja) * 2015-12-25 2020-07-08 シュアンチュー ファーマ カンパニー，リミティド キナゾリン誘導体の結晶及びその調製方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL190489B1 (pl) * 1996-04-12 2005-12-30 Warner Lambert Co Nieodwracalne inhibitory kinaz tyrozyny, kompozycja farmaceutyczna je zawierająca i ich zastosowanie
EE200100271A (et) * 1998-11-19 2002-10-15 Warner-Lambert Company N-[4-(3-kloro-4-fluorofenüülamino)-7-(3-morfoliin-4-üülpropoksü)kinasoliin-6-üül]ak rüülamiid kui türosiinkinaaside pöördumatu inhibiitor

Also Published As

Publication number Publication date
TNSN01090A1 (fr) 2005-11-10
NO20026193D0 (no) 2002-12-23
IL152419A0 (en) 2003-05-29
US20040034022A1 (en) 2004-02-19
AR031854A1 (es) 2003-10-08
AU2001283861A1 (en) 2002-01-08
HRP20021019A2 (en) 2004-02-29
NO20026193L (no) 2003-01-27
DZ3342A1 (fr) 2002-01-03
PL365127A1 (en) 2004-12-27
CN1438994A (zh) 2003-08-27
CA2412535A1 (en) 2002-01-03
PE20020116A1 (es) 2002-02-27
BG107352A (bg) 2003-07-31
HUP0300900A3 (en) 2004-01-28
UA73588C2 (en) 2005-08-15
UY26803A1 (es) 2002-01-31
GT200100124A (es) 2002-06-27
KR20030014403A (ko) 2003-02-17
EP1299363A1 (en) 2003-04-09
WO2002000630A1 (en) 2002-01-03
AP2002002694A0 (en) 2002-12-31
BR0112082A (pt) 2003-05-06
HUP0300900A2 (hu) 2003-10-28
CZ20024037A3 (cs) 2004-01-14
IS6596A (is) 2002-10-28
OA12301A (en) 2003-11-10
YU99802A (sh) 2005-11-28
HN2001000134A (es) 2001-09-11
DE10031971A1 (de) 2002-01-10
JP2004501902A (ja) 2004-01-22
SV2002000517A (es) 2002-07-03
EE200200714A (et) 2004-08-16
MA26924A1 (fr) 2004-12-20
NZ522001A (en) 2004-07-30
MXPA03000101A (es) 2004-09-13
SK17642002A3 (sk) 2004-05-04
ZA200209717B (en) 2003-12-01
ECSP024413A (es) 2003-03-31
EA005294B1 (ru) 2004-12-30
EA200300094A1 (ru) 2003-04-24

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