AR031612A1 - Imidazoles sustituidos, composiciones farmaceuticas, metodo para su preparacion y el uso de los mismos para preparar un medicamento como agonistas o antagonistas h1 y h3 de histamina - Google Patents
Imidazoles sustituidos, composiciones farmaceuticas, metodo para su preparacion y el uso de los mismos para preparar un medicamento como agonistas o antagonistas h1 y h3 de histaminaInfo
- Publication number
- AR031612A1 AR031612A1 ARP010104400A ARP010104400A AR031612A1 AR 031612 A1 AR031612 A1 AR 031612A1 AR P010104400 A ARP010104400 A AR P010104400A AR P010104400 A ARP010104400 A AR P010104400A AR 031612 A1 AR031612 A1 AR 031612A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- substituted
- lower alkyl
- histamine
- nr3c
- Prior art date
Links
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 title abstract 4
- 229960001340 histamine Drugs 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000000556 agonist Substances 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 2
- 150000002460 imidazoles Chemical class 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 208000027744 congestion Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000009977 dual effect Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000003395 histamine H3 receptor antagonist Substances 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23403800P | 2000-09-20 | 2000-09-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR031612A1 true AR031612A1 (es) | 2003-09-24 |
Family
ID=22879621
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010104400A AR031612A1 (es) | 2000-09-20 | 2001-09-18 | Imidazoles sustituidos, composiciones farmaceuticas, metodo para su preparacion y el uso de los mismos para preparar un medicamento como agonistas o antagonistas h1 y h3 de histamina |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6528522B2 (enExample) |
| EP (1) | EP1318993B1 (enExample) |
| JP (1) | JP2004509869A (enExample) |
| CN (1) | CN1558907A (enExample) |
| AR (1) | AR031612A1 (enExample) |
| AT (1) | ATE405557T1 (enExample) |
| AU (1) | AU2001291040A1 (enExample) |
| CA (1) | CA2422210C (enExample) |
| DE (1) | DE60135471D1 (enExample) |
| ES (1) | ES2311544T3 (enExample) |
| HK (1) | HK1052180A1 (enExample) |
| MX (1) | MXPA03002445A (enExample) |
| MY (1) | MY120281A (enExample) |
| WO (1) | WO2002024657A2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
| RU2015139700A (ru) * | 2013-02-19 | 2017-03-27 | Икан Скул Оф Медсин Эт Маунт Синай | Трициклические гетероциклические соединения в качестве противораковых средств |
| US9675587B2 (en) | 2013-03-14 | 2017-06-13 | Allergan Holdings Unlimited Company | Opioid receptor modulator dosage formulations |
| JP6966425B2 (ja) | 2015-09-09 | 2021-11-17 | アイカーン スクール オブ メディスン アット マウント サイナイIcahn School of Medicine at Mt. Sinai | 抗がん剤としての複素環式の限定された三環系スルホンアミド |
| JP6955485B2 (ja) | 2015-09-09 | 2021-10-27 | アイカーン スクール オブ メディスン アット マウント サイナイＩｃａｈｎ Ｓｃｈｏｏｌ ｏｆ Ｍｅｄｉｃｉｎｅ ａｔ Ｍｔ． Ｓｉｎａｉ | 抗がん剤としての複素環式の限定された三環系スルホンアミド |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2586562B1 (fr) | 1985-09-02 | 1989-03-10 | Inst Nat Sante Rech Med | Composition pharmaceutique contenant de l'a-methylhistamine |
| GB8916947D0 (en) | 1989-07-25 | 1989-09-13 | Smith Kline French Lab | Medicaments |
| EP0448765B1 (de) | 1990-03-30 | 1994-08-17 | HEUMANN PHARMA GMBH & CO | Verwendung von Guanidinderivaten zur Herstellung eines Arzneimittels mit NPY-antagonistischer Wirkung |
| GB9115740D0 (en) | 1991-07-20 | 1991-09-04 | Smithkline Beecham Plc | Medicaments |
| AU662588B2 (en) | 1991-12-18 | 1995-09-07 | Schering Corporation | Imidazolyl-alkyl-piperazine and -diazepine derivatives as histamine H3 agonists/antagonists |
| US5352707A (en) | 1992-03-26 | 1994-10-04 | Harbor Branch Oceanographic Institution, Inc. | Method for treating airway congestion |
| NZ276883A (en) | 1993-11-15 | 1998-08-26 | Schering Corp | 1h-imidazol-4-yl)alkyl]benzene derivatives |
| FR2732017B1 (fr) | 1995-03-21 | 2000-09-22 | Inst Nat Sante Rech Med | Nouveaux derives de l'imidazole antagonistes et/ou agonistes du recepteur h3 de l'histamine, leur preparation et leurs applications therapeutiques |
| PT1019050E (pt) | 1997-06-24 | 2002-09-30 | Novo Nordisk As | Utilizacao de agonisticos e de antagonisticos de somatostatina para o tratamento de doencas associadas ao olho |
| US5869479A (en) | 1997-08-14 | 1999-02-09 | Schering Corporation | Treatment of upper airway allergic responses |
-
2001
- 2001-09-18 WO PCT/US2001/029037 patent/WO2002024657A2/en not_active Ceased
- 2001-09-18 MY MYPI20014363A patent/MY120281A/en unknown
- 2001-09-18 AR ARP010104400A patent/AR031612A1/es unknown
- 2001-09-18 ES ES01971115T patent/ES2311544T3/es not_active Expired - Lifetime
- 2001-09-18 AT AT01971115T patent/ATE405557T1/de not_active IP Right Cessation
- 2001-09-18 US US09/954,863 patent/US6528522B2/en not_active Expired - Fee Related
- 2001-09-18 AU AU2001291040A patent/AU2001291040A1/en not_active Abandoned
- 2001-09-18 HK HK03104437.0A patent/HK1052180A1/zh unknown
- 2001-09-18 EP EP01971115A patent/EP1318993B1/en not_active Expired - Lifetime
- 2001-09-18 CA CA002422210A patent/CA2422210C/en not_active Expired - Fee Related
- 2001-09-18 MX MXPA03002445A patent/MXPA03002445A/es active IP Right Grant
- 2001-09-18 CN CNA018159702A patent/CN1558907A/zh active Pending
- 2001-09-18 DE DE60135471T patent/DE60135471D1/de not_active Expired - Lifetime
- 2001-09-18 JP JP2002529069A patent/JP2004509869A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002024657A3 (en) | 2002-07-11 |
| MXPA03002445A (es) | 2003-06-19 |
| MY120281A (en) | 2005-09-30 |
| EP1318993B1 (en) | 2008-08-20 |
| CA2422210C (en) | 2009-10-27 |
| JP2004509869A (ja) | 2004-04-02 |
| CA2422210A1 (en) | 2002-03-28 |
| US20020082272A1 (en) | 2002-06-27 |
| EP1318993A2 (en) | 2003-06-18 |
| DE60135471D1 (de) | 2008-10-02 |
| CN1558907A (zh) | 2004-12-29 |
| US6528522B2 (en) | 2003-03-04 |
| ATE405557T1 (de) | 2008-09-15 |
| AU2001291040A1 (en) | 2002-04-02 |
| WO2002024657A2 (en) | 2002-03-28 |
| ES2311544T3 (es) | 2009-02-16 |
| HK1052180A1 (zh) | 2003-09-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1513826T3 (da) | Hidtil ukendte indolylpiperidinderivater som kraftige antihistamin- og antiallergimidler | |
| EP3288558B1 (en) | Combinations of inhibitors of irak4 with inhibitors of btk | |
| ECSP045367A (es) | "derivados de bencimidazol utiles como antagonistas de histamina h3" | |
| ME02583B (me) | Jedinjenja pirolidinil uree, pirolidinil tiouree i pirolidinil guanidina kao inhibitori trka kinaze | |
| AR117164A1 (es) | Derivados de amino-triazoloquinazolina 9-sustituidos como antagonistas del receptor de adenosina, composiciones farmacéuticas y su uso para el tratamiento de diversos tipos de cáncer | |
| JP2006524254A5 (enExample) | ||
| ECSP045519A (es) | Nuevos derivados de quinuclidina-amida | |
| YU31303A (sh) | Jedinjenja imidazola sa pripojenim arilom ili heteroarilom kao anti-inflamatorni i analgetički agensi | |
| MXPA04002338A (es) | Derivados de carbazol y su uso como antagonistas receptores del npy5. | |
| MX2007010156A (es) | Derivados de pirido (2,3-d) pirimidina sustituidos, utiles como medicinas para el tratamiento de desordenes autoinmunes. | |
| YU30902A (sh) | Novi ciklopropani kao cgrp antagonisti, lekovi koji sadrže navedena jedinjenja i postupak za njihovu proizvodnju | |
| ECSP056115A (es) | ANTAGONISTAS DEL RECEPTOR A2a DE 2-ALQUINIL- Y 2-ALQUENIL-PIRAZOLO-[4,3-e]-1,2,4-TRIAZOLO-[1,5-c]-PIRIMIDINA ADENOSINA | |
| EA200801909A1 (ru) | Соединения пиридина для лечения заболеваний, опосредованных действием простагландина | |
| BR0111301A (pt) | Cicloexilaminas bicìclicas e seu uso como antagonistas de receptor de nmda | |
| AR037350A1 (es) | Derivados de piperidina, proceso para preparar estos compuestos, composicion farmaceutica, y uso de estos compuestos para la manufactura de un medicamento util para el tratamiento de una enfermedad mediada por ccr5 (tal como artritis reumatoidea) | |
| FR2870541A1 (fr) | Derives de pyrimidines antigonistes du recepteur de la vitronectine | |
| DK1615893T3 (da) | 2-azabicylo3.3.1 nonan-derivater som opioidreceptorantagonister | |
| RU2003131970A (ru) | Производные 4-(фенил-пиперидин-4-илиден-метил)-бензамида и их применение для лечения боли, тревоги или желудочно-кишечных расстройств | |
| MEP19108A (en) | Aminoquinoline derivatives and their use as adenosine a3 ligands | |
| BRPI0414643A (pt) | composto, composições farmacêuticas, e, uso de um composto | |
| ECSP066474A (es) | Arilindenopiridinas y arilindenopirimidinas y su uso como antagonista del receptor adenosina a2a | |
| AR030946A1 (es) | Derivados de imidazoles sustituidos un metodo para su preparacion, composiciones farmaceuticas y el uso de dichos derivados para la manufactura de medicamentos como agonistas o antagonistas duales de h1 y h3 de histamina | |
| DK1497292T3 (da) | Azaindolylpiperidinderivater som antihistamin- og antiallergimidler | |
| ATE384066T1 (de) | Thieno-pyrrole verbindungen als antagonisten der gonadotropin-freisetzenden hormonrezeptoren | |
| FR2801309B1 (fr) | Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |