AR031612A1 - Imidazoles sustituidos, composiciones farmaceuticas, metodo para su preparacion y el uso de los mismos para preparar un medicamento como agonistas o antagonistas h1 y h3 de histamina - Google Patents

Imidazoles sustituidos, composiciones farmaceuticas, metodo para su preparacion y el uso de los mismos para preparar un medicamento como agonistas o antagonistas h1 y h3 de histamina

Info

Publication number
AR031612A1
AR031612A1 ARP010104400A ARP010104400A AR031612A1 AR 031612 A1 AR031612 A1 AR 031612A1 AR P010104400 A ARP010104400 A AR P010104400A AR P010104400 A ARP010104400 A AR P010104400A AR 031612 A1 AR031612 A1 AR 031612A1
Authority
AR
Argentina
Prior art keywords
group
substituted
lower alkyl
histamine
nr3c
Prior art date
Application number
ARP010104400A
Other languages
English (en)
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of AR031612A1 publication Critical patent/AR031612A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Imidazol sustituido que comprende un compuesto, que incluye enantiomeros, estereoisomeros y tautomeros de los mismos, o sales o solvatos farmacéuticamente aceptables de dicho compuesto, donde dicho compuesto tiene la estructura general que se muestra en la formula (1) en la cual G está seleccionado del grupo que consiste en -(CH2)v-NR3-, -(CH2)v-O-, -(CH2)v-S(O)z-, -(CH2)v-NR3-, -C(NR4)-NR3-, -(CH2)v-O-C(O)NR3-, -(CH2)v-NR3C(O)NR3-, -(CH2)v-NR3C(O)O-, -(CH2)v-NR3C(O)-, -(CH2)vC(O)NR3-; M es un grupo alquilo C1-6 ramificado o no ramificado, o un grupo alquenilo C2-6 ramificado o no ramificado ; X e Y están independientemente seleccionados del grupo que consiste en N, CH, o N-oxido; R1 y R2 pueden ser cada uno el numero 1-4 y están independientemente seleccionados del grupo que consiste en H, halogeno, alquilo inferior, alcoxi inferior, polihalo alcoxi inferior, OH, CF3, NH2, NHC(O)alquilo, CN o NO2; R3 está independientemente seleccionado del grupo que consiste en H, alquilo inferior, fenilo sustituido o no sustituido, bencilo sustituido o no sustituido, o un grupo que tiene la formula (2); R4 está seleccionado del grupo que consiste en H, CN, CO2R5; R5 está seleccionado del grupo que consiste en alquilo inferior y bencilo sustituido o no sustituido; R6 está seleccionado del grupo que consiste en H o alquilo inferior; q es 2-5; v es 0-6; y z es 0, 1 o 2; que tiene actividad antagonista del receptor H3 o actividad antagonista del receptor dual H1 y H3 de histamina. En otra realizacion, se describen composiciones farmacéuticas que comprenden dichos imidazoles así como también métodos para su preparacion y usos de dichos compuestos para preparar un medicamento para tratar alergia, congestion, enfermedades inflamatorias y enfermedades relacionadas con SNC y otros.
ARP010104400A 2000-09-20 2001-09-18 Imidazoles sustituidos, composiciones farmaceuticas, metodo para su preparacion y el uso de los mismos para preparar un medicamento como agonistas o antagonistas h1 y h3 de histamina AR031612A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23403800P 2000-09-20 2000-09-20

Publications (1)

Publication Number Publication Date
AR031612A1 true AR031612A1 (es) 2003-09-24

Family

ID=22879621

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010104400A AR031612A1 (es) 2000-09-20 2001-09-18 Imidazoles sustituidos, composiciones farmaceuticas, metodo para su preparacion y el uso de los mismos para preparar un medicamento como agonistas o antagonistas h1 y h3 de histamina

Country Status (14)

Country Link
US (1) US6528522B2 (es)
EP (1) EP1318993B1 (es)
JP (1) JP2004509869A (es)
CN (1) CN1558907A (es)
AR (1) AR031612A1 (es)
AT (1) ATE405557T1 (es)
AU (1) AU2001291040A1 (es)
CA (1) CA2422210C (es)
DE (1) DE60135471D1 (es)
ES (1) ES2311544T3 (es)
HK (1) HK1052180A1 (es)
MX (1) MXPA03002445A (es)
MY (1) MY120281A (es)
WO (1) WO2002024657A2 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds
WO2014130534A1 (en) * 2013-02-19 2014-08-28 Icahn School Of Medicine At Mount Sinai Tricyclic heterocycles as anticancer agents
US9675587B2 (en) 2013-03-14 2017-06-13 Allergan Holdings Unlimited Company Opioid receptor modulator dosage formulations
JP6966425B2 (ja) 2015-09-09 2021-11-17 アイカーン スクール オブ メディスン アット マウント サイナイIcahn School of Medicine at Mt. Sinai 抗がん剤としての複素環式の限定された三環系スルホンアミド
JP6955485B2 (ja) 2015-09-09 2021-10-27 アイカーン スクール オブ メディスン アット マウント サイナイＩｃａｈｎ Ｓｃｈｏｏｌ ｏｆ Ｍｅｄｉｃｉｎｅ ａｔ Ｍｔ． Ｓｉｎａｉ 抗がん剤としての複素環式の限定された三環系スルホンアミド

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2586562B1 (fr) 1985-09-02 1989-03-10 Inst Nat Sante Rech Med Composition pharmaceutique contenant de l'a-methylhistamine
GB8916947D0 (en) 1989-07-25 1989-09-13 Smith Kline French Lab Medicaments
ATE109979T1 (de) 1990-03-30 1994-09-15 Heumann Pharma Gmbh & Co Verwendung von guanidinderivaten zur herstellung eines arzneimittels mit npy-antagonistischer wirkung.
GB9115740D0 (en) 1991-07-20 1991-09-04 Smithkline Beecham Plc Medicaments
WO1993012093A1 (en) 1991-12-18 1993-06-24 Schering Corporation Imidazolyl-alkyl-piperazine and -diazepine derivatives as histamine h3 agonists/antagonists
US5352707A (en) 1992-03-26 1994-10-04 Harbor Branch Oceanographic Institution, Inc. Method for treating airway congestion
ATE234290T1 (de) 1993-11-15 2003-03-15 Schering Corp Phenylalkyl-imidazole als h3-rezeptor- antagonisten
FR2732017B1 (fr) * 1995-03-21 2000-09-22 Inst Nat Sante Rech Med Nouveaux derives de l'imidazole antagonistes et/ou agonistes du recepteur h3 de l'histamine, leur preparation et leurs applications therapeutiques
ATE214604T1 (de) 1997-06-24 2002-04-15 Novo Nordisk As Verwendung von somatostatin agonisten und antagonisten zur behandlung von augenkrankheiten
US5869479A (en) 1997-08-14 1999-02-09 Schering Corporation Treatment of upper airway allergic responses

Also Published As

Publication number Publication date
DE60135471D1 (de) 2008-10-02
US20020082272A1 (en) 2002-06-27
AU2001291040A1 (en) 2002-04-02
JP2004509869A (ja) 2004-04-02
MY120281A (en) 2005-09-30
CA2422210A1 (en) 2002-03-28
CN1558907A (zh) 2004-12-29
HK1052180A1 (zh) 2003-09-05
WO2002024657A2 (en) 2002-03-28
WO2002024657A3 (en) 2002-07-11
EP1318993B1 (en) 2008-08-20
US6528522B2 (en) 2003-03-04
ATE405557T1 (de) 2008-09-15
EP1318993A2 (en) 2003-06-18
ES2311544T3 (es) 2009-02-16
CA2422210C (en) 2009-10-27
MXPA03002445A (es) 2003-06-19

Similar Documents

Publication Publication Date Title
DK1513826T3 (da) Hidtil ukendte indolylpiperidinderivater som kraftige antihistamin- og antiallergimidler
ECSP045367A (es) "derivados de bencimidazol utiles como antagonistas de histamina h3"
RU2001124816A (ru) Производные хиназолина в качестве ингибиторов ангиогенеза
MX2007010156A (es) Derivados de pirido (2,3-d) pirimidina sustituidos, utiles como medicinas para el tratamiento de desordenes autoinmunes.
ECSP056115A (es) ANTAGONISTAS DEL RECEPTOR A2a DE 2-ALQUINIL- Y 2-ALQUENIL-PIRAZOLO-[4,3-e]-1,2,4-TRIAZOLO-[1,5-c]-PIRIMIDINA ADENOSINA
BRPI0519398A2 (pt) compostos de piridina para o tratamento de doenÇas mediadas por prostaglandina
MY130803A (en) New quinuclidine amide derivatives
EA200601160A1 (ru) 2,6-бисгетероарил-4-аминопиримидины в качестве антагонистов аденозиновых рецепторов
RU2018101897A (ru) Бициклическое гетероциклическое амидное производное
NO20060702L (no) Aminokinolinderivater og deres anvendelse som adenosin A3 ligander
UY28906A1 (es) Derivados de pirimidina que son antagonistas del receptor vitronectina
YU30902A (sh) Novi ciklopropani kao cgrp antagonisti, lekovi koji sadrže navedena jedinjenja i postupak za njihovu proizvodnju
IL142893A0 (en) Fused polyclic heterocyclic compounds and pharmaceutical compositions containing the same
RU2008127260A (ru) Производные хиназолинона в качестве антагонистов ваниллоидов
TW200606153A (en) Process for producing pyridine derivatives of Nk-1 receptor antagonist
AR031612A1 (es) Imidazoles sustituidos, composiciones farmaceuticas, metodo para su preparacion y el uso de los mismos para preparar un medicamento como agonistas o antagonistas h1 y h3 de histamina
DK0733051T3 (da) Bicykliske, heterocykliske forbindelser som neurokinin A-antagonister
TR199801218T2 (xx) Takikinin antagonistleri olarak N-asil-2-ikameli-4-(Benzimidazolil-ya da imidazopiridinil-ikameli art�klar)-piperidinler.
HRP20120257T1 (hr) Antagonisti receptora 5-ht7
RU2003131970A (ru) Производные 4-(фенил-пиперидин-4-илиден-метил)-бензамида и их применение для лечения боли, тревоги или желудочно-кишечных расстройств
BR0111301A (pt) Cicloexilaminas bicìclicas e seu uso como antagonistas de receptor de nmda
AR037350A1 (es) Derivados de piperidina, proceso para preparar estos compuestos, composicion farmaceutica, y uso de estos compuestos para la manufactura de un medicamento util para el tratamiento de una enfermedad mediada por ccr5 (tal como artritis reumatoidea)
AR032894A1 (es) Compuestos imidazoles sustituidos, composicion farmaceutica, metodo para su preparacion y el uso de los mismos para la manufactura de medicamentos como agonistas o antagonistas de h1 y h3 de histamina.
RU2003131971A (ru) Производные 4-(фенил-пиперидин-4-илиден-метил)-бензамида и их применение для лечения боли, тревоги или желудочно-кишечных расстройств
AR030946A1 (es) Derivados de imidazoles sustituidos un metodo para su preparacion, composiciones farmaceuticas y el uso de dichos derivados para la manufactura de medicamentos como agonistas o antagonistas duales de h1 y h3 de histamina

Legal Events

Date Code Title Description
FB Suspension of granting procedure