AR030571A1 - Proceso para preparar 2-(-piridin-4-ilamino)-pirido[2,3-d] pirimidinas e intermediarios en su sintesis - Google Patents
Proceso para preparar 2-(-piridin-4-ilamino)-pirido[2,3-d] pirimidinas e intermediarios en su sintesisInfo
- Publication number
- AR030571A1 AR030571A1 ARP010103717A ARP010103717A AR030571A1 AR 030571 A1 AR030571 A1 AR 030571A1 AR P010103717 A ARP010103717 A AR P010103717A AR P010103717 A ARP010103717 A AR P010103717A AR 030571 A1 AR030571 A1 AR 030571A1
- Authority
- AR
- Argentina
- Prior art keywords
- phenyl
- formula
- substituted
- alkyl
- synthesis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Proceso para preparar con alta pureza y rendimiento satisfactorio, 2-(piridin-4-ilamino)-pirido[2,3-d]pirimidina de formula 2 que comprende hacer reaccionar 4-aminopirimidina de formula 3 con 2-(4-imino-4-H-piridin-1-il)-pirido[2,3-d]pirimidina de formula 1 en presencia de una base; donde R' y R'' son hidrogeno, alquilo C1-6, alcoxi C1-6 o fenilo; R2 es (CH2)nPh, donde Ph es fenilo o fenilo sustituido, y n es 0, 1, 2, o 3; heteroaromático, cicloalquilo, alquilo C1-6, y alquenilo C2-6, donde los grupos alquilo y alquenilo pueden ser sustituidos por NR5R6, fenilo, fenilo sustituido, cicloalquilo y donde R5 y R6 son alquilo de C1-6, alquenilo de C2-6, (CH2)nPh como se definio y cicloalquilo, heteroaromático y R5 y R6 junto con el nitrogeno pueden completar un anillo C3-7 y opcionalmente contienen 1, 2 o 3 átomos de nitrogeno, nitrogeno sustituido, oxígeno o azufre y Ar es fenilo y fenilo sustituido o heteroaromático. Compuestos intermediarios en dicha síntesis, de formula 1 y 3 como se definen en la memoria. Los compuestos de formula 2 son agentes anticáncer, comercialmetne viables.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22308400P | 2000-08-04 | 2000-08-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR030571A1 true AR030571A1 (es) | 2003-08-27 |
Family
ID=22834962
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010103717A AR030571A1 (es) | 2000-08-04 | 2001-08-03 | Proceso para preparar 2-(-piridin-4-ilamino)-pirido[2,3-d] pirimidinas e intermediarios en su sintesis |
Country Status (9)
Country | Link |
---|---|
US (1) | US6960662B2 (es) |
EP (1) | EP1307451A2 (es) |
JP (1) | JP2004505974A (es) |
AR (1) | AR030571A1 (es) |
AU (1) | AU2001278908A1 (es) |
BR (1) | BR0112861A (es) |
CA (1) | CA2417937A1 (es) |
MX (1) | MXPA03000289A (es) |
WO (1) | WO2002012237A2 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2311532T3 (es) * | 2000-08-04 | 2009-02-16 | Warner-Lambert Company Llc | 2-(4-pirdil)amino-6-dialcoxifenil-pirido(2.3-d)pirimidin-7-onas. |
ES2248233T3 (es) * | 2000-08-04 | 2006-03-16 | Warner-Lambert Company Llc | Procedimiento de preparacion de 2-(4-piridil)amino-6-dialquiloxifenil-pirido(2,3-d)pirimidin-7-onas. |
US7196090B2 (en) * | 2002-07-25 | 2007-03-27 | Warner-Lambert Company | Kinase inhibitors |
US7098332B2 (en) | 2002-12-20 | 2006-08-29 | Hoffmann-La Roche Inc. | 5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones |
GB0230019D0 (en) * | 2002-12-23 | 2003-01-29 | Syngenta Ltd | Fungicides |
WO2005082903A1 (en) * | 2004-02-18 | 2005-09-09 | Warner-Lambert Company Llc | 2-(pyridin-3-ylamino)-pyrido[2,3-d]pyrimidin-7-ones |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1336904C (en) | 1987-08-26 | 1995-09-05 | Mitsuyuki Takesue | Pyrimidines and their pharmaceutically acceptable salts thereof |
DE4408404A1 (de) | 1994-03-12 | 1995-09-14 | Huels Chemische Werke Ag | Verfahren zur Herstellung von Chlorpyrimidinen |
US5801183A (en) | 1995-01-27 | 1998-09-01 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | Aza and aza (N-oxy) analogs of glycine/NMDA receptor antagonists |
US5620981A (en) | 1995-05-03 | 1997-04-15 | Warner-Lambert Company | Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation |
IL117923A (en) | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
US5945422A (en) * | 1997-02-05 | 1999-08-31 | Warner-Lambert Company | N-oxides of amino containing pyrido 2,3-D! pyrimidines |
RU2221787C9 (ru) | 1998-03-13 | 2020-11-26 | Зингента Партисипейшнс Аг | Производные 3-гидрокси-4-арил-5-оксопиразолина, обладающие гербицидным действием, композиция и способ борьбы с нежелательной растительностью |
NZ505921A (en) | 1998-03-31 | 2003-08-29 | Warner Lambert Co | 1-[5-(2,6-Dimethylpiperidino)pentyl] substituted quinolone serine protease inhibitors and their use for treating thrombin related disorders |
ES2311532T3 (es) * | 2000-08-04 | 2009-02-16 | Warner-Lambert Company Llc | 2-(4-pirdil)amino-6-dialcoxifenil-pirido(2.3-d)pirimidin-7-onas. |
ES2248233T3 (es) * | 2000-08-04 | 2006-03-16 | Warner-Lambert Company Llc | Procedimiento de preparacion de 2-(4-piridil)amino-6-dialquiloxifenil-pirido(2,3-d)pirimidin-7-onas. |
PL220952B1 (pl) * | 2002-01-22 | 2016-01-29 | Warner Lambert Co | 2-(Pirydyn-2-yloamino)pirydo[2,3-d]pirymidyn-7-ony |
-
2001
- 2001-07-12 WO PCT/US2001/022001 patent/WO2002012237A2/en active Application Filing
- 2001-07-12 AU AU2001278908A patent/AU2001278908A1/en not_active Abandoned
- 2001-07-12 CA CA002417937A patent/CA2417937A1/en not_active Abandoned
- 2001-07-12 EP EP01957137A patent/EP1307451A2/en not_active Withdrawn
- 2001-07-12 BR BR0112861-2A patent/BR0112861A/pt not_active IP Right Cessation
- 2001-07-12 US US10/343,805 patent/US6960662B2/en not_active Expired - Fee Related
- 2001-07-12 JP JP2002518212A patent/JP2004505974A/ja active Pending
- 2001-07-12 MX MXPA03000289A patent/MXPA03000289A/es active IP Right Grant
- 2001-08-03 AR ARP010103717A patent/AR030571A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
BR0112861A (pt) | 2003-07-01 |
WO2002012237A3 (en) | 2002-05-10 |
US20030216415A1 (en) | 2003-11-20 |
WO2002012237A2 (en) | 2002-02-14 |
MXPA03000289A (es) | 2003-06-06 |
JP2004505974A (ja) | 2004-02-26 |
AU2001278908A1 (en) | 2002-02-18 |
CA2417937A1 (en) | 2002-02-14 |
EP1307451A2 (en) | 2003-05-07 |
US6960662B2 (en) | 2005-11-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20020406A1 (es) | 7-OXO-PIRIDO[2,3-d]PIRIMIDINAS 2,6-DISUSTITUIDAS COMO INHIBIDORES DE LAS PROTEINAS CINASAS | |
PE20120814A1 (es) | Compuestos y composiciones como inhibidores de la proteina cinasa | |
AR035111A1 (es) | Procedimiento para preparar un compuesto de pirimidinona | |
PE20050774A1 (es) | Pirazolopirimidinas como inhibidores de quinasa ciclina-dependientes | |
AR051995A1 (es) | Derivados de tieno-piridina como intensificadores alostericos de gaba -b | |
PE20060600A1 (es) | Derivados de aminopiridina como inhibidores selectivos de la aurora a quinasa | |
ES2166954T3 (es) | Derivados de 1-fenilpirazol y su uso como agentes parasiticidas. | |
PE20030761A1 (es) | Derivados del 7-amino-benzotiazol | |
DE60113104D1 (de) | 5 phenyl substituierte 2-(cyanoamino)-pyrimidine als fungizide | |
BRPI0414059A (pt) | sìntese seletiva de pirimidinas substituìdas em cf3 | |
PE20020524A1 (es) | 7-oxo-piridopirimidinas como inhibidores de quinasas | |
AR030571A1 (es) | Proceso para preparar 2-(-piridin-4-ilamino)-pirido[2,3-d] pirimidinas e intermediarios en su sintesis | |
DE602006017038D1 (de) | Menthancarbonsäureamidderivate mit kühlenden eigenschaften | |
MY138051A (en) | Compounds and processes | |
AR060962A1 (es) | Proceso de preparacion de derivados de quinazolina e intermediarios de sintesis | |
PE20021058A1 (es) | Indolinonas sustituidas en posicion 6, su preparacion y su utilizacion como medicamentos | |
TW200942546A (en) | A crystalline form of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one | |
FI895956A0 (fi) | Menetelmä terapeuttisesti käyttökelpoisten amidiinien ja guanidiinien valmistamiseksi | |
PE20010300A1 (es) | Preparacion de piperidin-4-onas sustituidas | |
FI932904A (fi) | Foerfarande foer framstaellning av substituerade bensofuranderivat | |
AR043273A1 (es) | Derivados de bifenilo, su uso, un proceso para prepararlos y medicamentos que los contienen. | |
AR031121A1 (es) | Proceso para preparar 2-(piridin-4-ilamino)-pirido[2,3-d]pirimidin-7-ona | |
FI911016A0 (fi) | Menetelmä farmakologisesti aktiivisten substituoitujen -diketonien valmistamiseksi | |
DK0458387T3 (da) | Isochromanderivater | |
ID30435A (id) | Proses-proses untuk menyiapkan perantara-perantara pestisidal |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |