AR030571A1 - Proceso para preparar 2-(-piridin-4-ilamino)-pirido[2,3-d] pirimidinas e intermediarios en su sintesis - Google Patents

Proceso para preparar 2-(-piridin-4-ilamino)-pirido[2,3-d] pirimidinas e intermediarios en su sintesis

Info

Publication number
AR030571A1
AR030571A1 ARP010103717A ARP010103717A AR030571A1 AR 030571 A1 AR030571 A1 AR 030571A1 AR P010103717 A ARP010103717 A AR P010103717A AR P010103717 A ARP010103717 A AR P010103717A AR 030571 A1 AR030571 A1 AR 030571A1
Authority
AR
Argentina
Prior art keywords
phenyl
formula
substituted
alkyl
synthesis
Prior art date
Application number
ARP010103717A
Other languages
English (en)
Inventor
Vladimir Genukh Beylin
Richard Jungkyu Lee
Mark Eugene Marlatt
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of AR030571A1 publication Critical patent/AR030571A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Proceso para preparar con alta pureza y rendimiento satisfactorio, 2-(piridin-4-ilamino)-pirido[2,3-d]pirimidina de formula 2 que comprende hacer reaccionar 4-aminopirimidina de formula 3 con 2-(4-imino-4-H-piridin-1-il)-pirido[2,3-d]pirimidina de formula 1 en presencia de una base; donde R' y R'' son hidrogeno, alquilo C1-6, alcoxi C1-6 o fenilo; R2 es (CH2)nPh, donde Ph es fenilo o fenilo sustituido, y n es 0, 1, 2, o 3; heteroaromático, cicloalquilo, alquilo C1-6, y alquenilo C2-6, donde los grupos alquilo y alquenilo pueden ser sustituidos por NR5R6, fenilo, fenilo sustituido, cicloalquilo y donde R5 y R6 son alquilo de C1-6, alquenilo de C2-6, (CH2)nPh como se definio y cicloalquilo, heteroaromático y R5 y R6 junto con el nitrogeno pueden completar un anillo C3-7 y opcionalmente contienen 1, 2 o 3 átomos de nitrogeno, nitrogeno sustituido, oxígeno o azufre y Ar es fenilo y fenilo sustituido o heteroaromático. Compuestos intermediarios en dicha síntesis, de formula 1 y 3 como se definen en la memoria. Los compuestos de formula 2 son agentes anticáncer, comercialmetne viables.
ARP010103717A 2000-08-04 2001-08-03 Proceso para preparar 2-(-piridin-4-ilamino)-pirido[2,3-d] pirimidinas e intermediarios en su sintesis AR030571A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22308400P 2000-08-04 2000-08-04

Publications (1)

Publication Number Publication Date
AR030571A1 true AR030571A1 (es) 2003-08-27

Family

ID=22834962

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010103717A AR030571A1 (es) 2000-08-04 2001-08-03 Proceso para preparar 2-(-piridin-4-ilamino)-pirido[2,3-d] pirimidinas e intermediarios en su sintesis

Country Status (9)

Country Link
US (1) US6960662B2 (es)
EP (1) EP1307451A2 (es)
JP (1) JP2004505974A (es)
AR (1) AR030571A1 (es)
AU (1) AU2001278908A1 (es)
BR (1) BR0112861A (es)
CA (1) CA2417937A1 (es)
MX (1) MXPA03000289A (es)
WO (1) WO2002012237A2 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2311532T3 (es) * 2000-08-04 2009-02-16 Warner-Lambert Company Llc 2-(4-pirdil)amino-6-dialcoxifenil-pirido(2.3-d)pirimidin-7-onas.
ES2248233T3 (es) * 2000-08-04 2006-03-16 Warner-Lambert Company Llc Procedimiento de preparacion de 2-(4-piridil)amino-6-dialquiloxifenil-pirido(2,3-d)pirimidin-7-onas.
US7196090B2 (en) * 2002-07-25 2007-03-27 Warner-Lambert Company Kinase inhibitors
US7098332B2 (en) 2002-12-20 2006-08-29 Hoffmann-La Roche Inc. 5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones
GB0230019D0 (en) * 2002-12-23 2003-01-29 Syngenta Ltd Fungicides
WO2005082903A1 (en) * 2004-02-18 2005-09-09 Warner-Lambert Company Llc 2-(pyridin-3-ylamino)-pyrido[2,3-d]pyrimidin-7-ones

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1336904C (en) 1987-08-26 1995-09-05 Mitsuyuki Takesue Pyrimidines and their pharmaceutically acceptable salts thereof
DE4408404A1 (de) 1994-03-12 1995-09-14 Huels Chemische Werke Ag Verfahren zur Herstellung von Chlorpyrimidinen
US5801183A (en) 1995-01-27 1998-09-01 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Aza and aza (N-oxy) analogs of glycine/NMDA receptor antagonists
US5620981A (en) 1995-05-03 1997-04-15 Warner-Lambert Company Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation
IL117923A (en) 1995-05-03 2000-06-01 Warner Lambert Co Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds
US5945422A (en) * 1997-02-05 1999-08-31 Warner-Lambert Company N-oxides of amino containing pyrido 2,3-D! pyrimidines
RU2221787C9 (ru) 1998-03-13 2020-11-26 Зингента Партисипейшнс Аг Производные 3-гидрокси-4-арил-5-оксопиразолина, обладающие гербицидным действием, композиция и способ борьбы с нежелательной растительностью
NZ505921A (en) 1998-03-31 2003-08-29 Warner Lambert Co 1-[5-(2,6-Dimethylpiperidino)pentyl] substituted quinolone serine protease inhibitors and their use for treating thrombin related disorders
ES2311532T3 (es) * 2000-08-04 2009-02-16 Warner-Lambert Company Llc 2-(4-pirdil)amino-6-dialcoxifenil-pirido(2.3-d)pirimidin-7-onas.
ES2248233T3 (es) * 2000-08-04 2006-03-16 Warner-Lambert Company Llc Procedimiento de preparacion de 2-(4-piridil)amino-6-dialquiloxifenil-pirido(2,3-d)pirimidin-7-onas.
PL220952B1 (pl) * 2002-01-22 2016-01-29 Warner Lambert Co 2-(Pirydyn-2-yloamino)pirydo[2,3-d]pirymidyn-7-ony

Also Published As

Publication number Publication date
BR0112861A (pt) 2003-07-01
WO2002012237A3 (en) 2002-05-10
US20030216415A1 (en) 2003-11-20
WO2002012237A2 (en) 2002-02-14
MXPA03000289A (es) 2003-06-06
JP2004505974A (ja) 2004-02-26
AU2001278908A1 (en) 2002-02-18
CA2417937A1 (en) 2002-02-14
EP1307451A2 (en) 2003-05-07
US6960662B2 (en) 2005-11-01

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