AR030291A1 - Diazepinoindoles para el tratamiento de una enfermedad de obstruccion pulmonar cronica - Google Patents

Diazepinoindoles para el tratamiento de una enfermedad de obstruccion pulmonar cronica

Info

Publication number
AR030291A1
AR030291A1 ARP010102725A ARP010102725A AR030291A1 AR 030291 A1 AR030291 A1 AR 030291A1 AR P010102725 A ARP010102725 A AR P010102725A AR P010102725 A ARP010102725 A AR P010102725A AR 030291 A1 AR030291 A1 AR 030291A1
Authority
AR
Argentina
Prior art keywords
amino
diazepinoindoles
treatment
chronic pulmonary
diazepino
Prior art date
Application number
ARP010102725A
Other languages
English (en)
Inventor
Annette Doherty
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of AR030291A1 publication Critical patent/AR030291A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Uso para tratamiento de enfermedades de obstruccion pulmonar cronica (EOPC) de diazepinoindoles de formula (1) donde A es arilo o heteroarilo con nitrogeno, sustituido opcionalmente con uno a tres grupos seleccionados entre halogeno, alquilo, haloalquilo o alcoxi inferiores y otros como se define en la memoria y B es OH o amino sustituidos como ser ûOR1, NR2R3. ûNR2R3 y otros como se define en la memoria, las formas racémicas e isomeros de configuracion determinada por carbono 3 del anillo de diazepinoindol-4-ona, y derivados farmacéuticamente aceptables de los mismos. Dichos diazepinoindoles poseen una configuracion absoluta de acuerdo con la regla Cahn-Ingold-Prelog, considerando átomo de carbono asimétrico en posicion alfa relativa al carbonilo del anillo de diazepina. Comprende (3R)-4-amino-N-(9amino-4-oxo-1-fenil-3,4,6,7-tetrahidro-[1,4]diazepino[6,7,1-hi]indol-3-il)benzamida y (3R)N-(9-amino-4-oxo-1-fenil-3,4,6,7-tetrahidro-[1,4]diazepino[6,7,1-hi]indol-3-il)-nicotinamida.
ARP010102725A 2000-06-09 2001-06-07 Diazepinoindoles para el tratamiento de una enfermedad de obstruccion pulmonar cronica AR030291A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00401646A EP1161949A1 (en) 2000-06-09 2000-06-09 Use od diazepinoindoles for the treatment of chronic obstructive pulmonary disease

Publications (1)

Publication Number Publication Date
AR030291A1 true AR030291A1 (es) 2003-08-20

Family

ID=8173724

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010102725A AR030291A1 (es) 2000-06-09 2001-06-07 Diazepinoindoles para el tratamiento de una enfermedad de obstruccion pulmonar cronica

Country Status (19)

Country Link
US (1) US6544983B2 (es)
EP (1) EP1161949A1 (es)
JP (1) JP2002138090A (es)
KR (1) KR20010111457A (es)
CN (1) CN1345725A (es)
AR (1) AR030291A1 (es)
AU (1) AU5181301A (es)
BR (1) BR0102289A (es)
CA (1) CA2347337A1 (es)
CZ (1) CZ20011999A3 (es)
EA (1) EA200100515A3 (es)
HU (1) HUP0102388A3 (es)
IL (1) IL143636A0 (es)
MX (1) MXPA01005726A (es)
NO (1) NO20012831L (es)
NZ (1) NZ512222A (es)
PL (1) PL347922A1 (es)
SK (1) SK7832001A3 (es)
ZA (1) ZA200104616B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090274676A1 (en) * 2003-07-31 2009-11-05 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a pde-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050085430A1 (en) * 2003-07-31 2005-04-21 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a PDE-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050026883A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a PDE-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050187278A1 (en) * 2003-08-28 2005-08-25 Pharmacia Corporation Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors
ES2378374T3 (es) * 2003-11-20 2012-04-11 Astellas Pharma Inc. Inhibidores de la PDE 4 para el tratamiento de la cistitis intersticial
DE102004002557A1 (de) * 2004-01-17 2005-08-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von substituierten Pyrimido(5,4-d)pyrimidinen zur Behandlung von Atemwegserkrankungen
KR20090045233A (ko) 2006-07-10 2009-05-07 파이온 유케이 리미티드 속효형 벤조디아제핀 염 및 이의 중합체 형태
CA2711865A1 (en) 2008-01-11 2009-07-16 Astellas Pharma Inc. A pathological animal model simultaneously developing testicular pain or discomfort behaviors and urinary frequency
EP2450039A1 (en) 2010-11-08 2012-05-09 PAION UK Ltd. Dosing regimen for sedation with CNS 7056 (Remimazolam)
CN104968348B (zh) * 2012-05-22 2018-04-17 Paion英国有限公司 包含短效苯二氮杂*类化合物的组合物
AR094963A1 (es) 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2652352A1 (fr) 1989-09-28 1991-03-29 Jouveinal Sa Benzodiazepines, leur procede et intermediaires de preparation et leurs applications en therapeutique.
FR2725719B1 (fr) 1994-10-14 1996-12-06 Jouveinal Inst Rech Diazepino-indoles inhibiteurs de phosphodiesterases iv
FR2746800B1 (fr) * 1996-03-29 1998-06-05 Jouveinal Inst Rech Diazepino-indoles inhibiteurs de phosphodiesterases 4
FR2762841B1 (fr) 1997-04-30 1999-07-02 Jouveinal Inst Rech Diazepino-indolones inhibitrices de phosphodiesterases iv

Also Published As

Publication number Publication date
NO20012831D0 (no) 2001-06-08
EA200100515A3 (ru) 2002-06-27
CA2347337A1 (en) 2001-12-09
US6544983B2 (en) 2003-04-08
IL143636A0 (en) 2002-04-21
CN1345725A (zh) 2002-04-24
PL347922A1 (en) 2001-12-17
EA200100515A2 (ru) 2001-12-24
BR0102289A (pt) 2002-03-12
CZ20011999A3 (cs) 2002-04-17
AU5181301A (en) 2001-12-13
KR20010111457A (ko) 2001-12-19
HUP0102388A2 (hu) 2002-04-29
ZA200104616B (en) 2002-10-30
NZ512222A (en) 2002-10-25
MXPA01005726A (es) 2003-08-20
HU0102388D0 (en) 2001-08-28
SK7832001A3 (en) 2002-05-09
HUP0102388A3 (en) 2004-11-29
US20020010175A1 (en) 2002-01-24
NO20012831L (no) 2001-12-10
JP2002138090A (ja) 2002-05-14
EP1161949A1 (en) 2001-12-12

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