AR025042A1 - Derivados del fluoreno, sus enantiomeros y diastereomeros, un procedimiento para su preparacion, un medicamento a base de estos derivados, laspreparaciones farmaceuticas que los contienen y el empleo de los mismos para preparar un medicamento - Google Patents
Derivados del fluoreno, sus enantiomeros y diastereomeros, un procedimiento para su preparacion, un medicamento a base de estos derivados, laspreparaciones farmaceuticas que los contienen y el empleo de los mismos para preparar un medicamentoInfo
- Publication number
- AR025042A1 AR025042A1 ARP000104035A ARP000104035A AR025042A1 AR 025042 A1 AR025042 A1 AR 025042A1 AR P000104035 A ARP000104035 A AR P000104035A AR P000104035 A ARP000104035 A AR P000104035A AR 025042 A1 AR025042 A1 AR 025042A1
- Authority
- AR
- Argentina
- Prior art keywords
- atoms
- derivatives
- trisubstituted
- mono
- hal
- Prior art date
Links
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- NIHNNTQXNPWCJQ-UHFFFAOYSA-N fluorene Chemical class C1=CC=C2CC3=CC=CC=C3C2=C1 NIHNNTQXNPWCJQ-UHFFFAOYSA-N 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 125000004429 atom Chemical group 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 101100516568 Caenorhabditis elegans nhr-7 gene Proteins 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000003983 fluorenyl group Chemical class C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 abstract 1
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 238000007327 hydrogenolysis reaction Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 238000003797 solvolysis reaction Methods 0.000 abstract 1
- 230000001131 transforming effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/48—Nitrogen atoms not forming part of a nitro radical with acyclic hydrocarbon or substituted acyclic hydrocarbon radicals, attached to said nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19937394A DE19937394A1 (de) | 1999-08-07 | 1999-08-07 | Fluorenderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR025042A1 true AR025042A1 (es) | 2002-11-06 |
Family
ID=7917613
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000104035A AR025042A1 (es) | 1999-08-07 | 2000-08-04 | Derivados del fluoreno, sus enantiomeros y diastereomeros, un procedimiento para su preparacion, un medicamento a base de estos derivados, laspreparaciones farmaceuticas que los contienen y el empleo de los mismos para preparar un medicamento |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP1208088A2 (cs) |
| JP (1) | JP2003506439A (cs) |
| KR (1) | KR20020012631A (cs) |
| CN (1) | CN1368962A (cs) |
| AR (1) | AR025042A1 (cs) |
| AU (1) | AU6828600A (cs) |
| BR (1) | BR0013083A (cs) |
| CA (1) | CA2380981A1 (cs) |
| CZ (1) | CZ2002298A3 (cs) |
| DE (1) | DE19937394A1 (cs) |
| HK (1) | HK1049006A1 (cs) |
| HU (1) | HUP0202464A3 (cs) |
| MX (1) | MXPA02001297A (cs) |
| NO (1) | NO20020592L (cs) |
| PL (1) | PL353054A1 (cs) |
| SK (1) | SK1402002A3 (cs) |
| WO (1) | WO2001010841A2 (cs) |
| ZA (1) | ZA200201873B (cs) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101102808B1 (ko) * | 2010-04-13 | 2012-01-05 | 윤태삼 | 라이저 인장 장치 |
| US8574899B2 (en) | 2010-12-22 | 2013-11-05 | Vladimir B Serikov | Methods for augmentation collection of placental hematopoietic stem cells and uses thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04506350A (ja) * | 1989-06-22 | 1992-11-05 | ノバ ファーマスーティカル コーポレイション | 炎症の処置用の医薬組成物及び炎症の処置方法 |
| IL113196A0 (en) * | 1994-03-31 | 1995-06-29 | Bristol Myers Squibb Co | Imidazole derivatives and pharmaceutical compositions containing the same |
| EP0889877B1 (en) * | 1996-03-29 | 2001-08-29 | G.D. Searle & Co. | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS |
| DE19654483A1 (de) * | 1996-06-28 | 1998-01-02 | Merck Patent Gmbh | Phenylalanin-Derivate |
| CA2214931A1 (en) * | 1996-09-26 | 1998-03-26 | Henry Uhlman Bryant | Tetrahydrobenzo-a-fluorene compounds and method of use |
-
1999
- 1999-08-07 DE DE19937394A patent/DE19937394A1/de not_active Withdrawn
-
2000
- 2000-07-26 EP EP00956284A patent/EP1208088A2/de not_active Withdrawn
- 2000-07-26 AU AU68286/00A patent/AU6828600A/en not_active Abandoned
- 2000-07-26 KR KR1020027000660A patent/KR20020012631A/ko not_active Withdrawn
- 2000-07-26 MX MXPA02001297A patent/MXPA02001297A/es not_active Application Discontinuation
- 2000-07-26 BR BR0013083-4A patent/BR0013083A/pt not_active Application Discontinuation
- 2000-07-26 CN CN00811476A patent/CN1368962A/zh active Pending
- 2000-07-26 SK SK140-2002A patent/SK1402002A3/sk unknown
- 2000-07-26 HU HU0202464A patent/HUP0202464A3/hu unknown
- 2000-07-26 PL PL00353054A patent/PL353054A1/xx unknown
- 2000-07-26 CA CA002380981A patent/CA2380981A1/en not_active Abandoned
- 2000-07-26 JP JP2001515308A patent/JP2003506439A/ja active Pending
- 2000-07-26 WO PCT/EP2000/007153 patent/WO2001010841A2/de not_active Ceased
- 2000-07-26 CZ CZ2002298A patent/CZ2002298A3/cs unknown
- 2000-07-26 HK HK03101305.5A patent/HK1049006A1/zh unknown
- 2000-08-04 AR ARP000104035A patent/AR025042A1/es unknown
-
2002
- 2002-02-06 NO NO20020592A patent/NO20020592L/no not_active Application Discontinuation
- 2002-03-06 ZA ZA200201873A patent/ZA200201873B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SK1402002A3 (en) | 2002-06-04 |
| EP1208088A2 (de) | 2002-05-29 |
| ZA200201873B (en) | 2003-08-27 |
| CZ2002298A3 (cs) | 2002-04-17 |
| JP2003506439A (ja) | 2003-02-18 |
| NO20020592D0 (no) | 2002-02-06 |
| BR0013083A (pt) | 2002-04-23 |
| PL353054A1 (en) | 2003-10-06 |
| AU6828600A (en) | 2001-03-05 |
| KR20020012631A (ko) | 2002-02-16 |
| CN1368962A (zh) | 2002-09-11 |
| WO2001010841A3 (de) | 2001-09-07 |
| HUP0202464A3 (en) | 2003-02-28 |
| CA2380981A1 (en) | 2001-02-15 |
| MXPA02001297A (es) | 2004-07-16 |
| DE19937394A1 (de) | 2001-02-08 |
| WO2001010841A2 (de) | 2001-02-15 |
| HK1049006A1 (zh) | 2003-04-25 |
| HUP0202464A2 (hu) | 2002-12-28 |
| NO20020592L (no) | 2002-04-04 |
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