HK1049006A1 - 芴衍生物 - Google Patents

芴衍生物 Download PDF

Info

Publication number
HK1049006A1
HK1049006A1 HK03101305.5A HK03101305A HK1049006A1 HK 1049006 A1 HK1049006 A1 HK 1049006A1 HK 03101305 A HK03101305 A HK 03101305A HK 1049006 A1 HK1049006 A1 HK 1049006A1
Authority
HK
Hong Kong
Prior art keywords
formula
substituted
compounds
atoms
acid
Prior art date
Application number
HK03101305.5A
Other languages
English (en)
Chinese (zh)
Inventor
Stahle Wolfgang
Goodman Simon
Original Assignee
默克专利股份公司
默克專利股份公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 默克专利股份公司, 默克專利股份公司 filed Critical 默克专利股份公司
Publication of HK1049006A1 publication Critical patent/HK1049006A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/48—Nitrogen atoms not forming part of a nitro radical with acyclic hydrocarbon or substituted acyclic hydrocarbon radicals, attached to said nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK03101305.5A 1999-08-07 2000-07-26 芴衍生物 HK1049006A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19937394.9 1999-08-07
DE19937394A DE19937394A1 (de) 1999-08-07 1999-08-07 Fluorenderivate
PCT/EP2000/007153 WO2001010841A2 (de) 1999-08-07 2000-07-26 Fluorenderivate als integrin inhibitoren

Publications (1)

Publication Number Publication Date
HK1049006A1 true HK1049006A1 (zh) 2003-04-25

Family

ID=7917613

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03101305.5A HK1049006A1 (zh) 1999-08-07 2000-07-26 芴衍生物

Country Status (18)

Country Link
EP (1) EP1208088A2 (cs)
JP (1) JP2003506439A (cs)
KR (1) KR20020012631A (cs)
CN (1) CN1368962A (cs)
AR (1) AR025042A1 (cs)
AU (1) AU6828600A (cs)
BR (1) BR0013083A (cs)
CA (1) CA2380981A1 (cs)
CZ (1) CZ2002298A3 (cs)
DE (1) DE19937394A1 (cs)
HK (1) HK1049006A1 (cs)
HU (1) HUP0202464A3 (cs)
MX (1) MXPA02001297A (cs)
NO (1) NO20020592L (cs)
PL (1) PL353054A1 (cs)
SK (1) SK1402002A3 (cs)
WO (1) WO2001010841A2 (cs)
ZA (1) ZA200201873B (cs)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101102808B1 (ko) * 2010-04-13 2012-01-05 윤태삼 라이저 인장 장치
US8574899B2 (en) 2010-12-22 2013-11-05 Vladimir B Serikov Methods for augmentation collection of placental hematopoietic stem cells and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04506350A (ja) * 1989-06-22 1992-11-05 ノバ　ファーマスーティカル　コーポレイション 炎症の処置用の医薬組成物及び炎症の処置方法
IL113196A0 (en) * 1994-03-31 1995-06-29 Bristol Myers Squibb Co Imidazole derivatives and pharmaceutical compositions containing the same
EP0889877B1 (en) * 1996-03-29 2001-08-29 G.D. Searle & Co. META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS
DE19654483A1 (de) * 1996-06-28 1998-01-02 Merck Patent Gmbh Phenylalanin-Derivate
CA2214931A1 (en) * 1996-09-26 1998-03-26 Henry Uhlman Bryant Tetrahydrobenzo-a-fluorene compounds and method of use

Also Published As

Publication number Publication date
SK1402002A3 (en) 2002-06-04
EP1208088A2 (de) 2002-05-29
ZA200201873B (en) 2003-08-27
CZ2002298A3 (cs) 2002-04-17
JP2003506439A (ja) 2003-02-18
AR025042A1 (es) 2002-11-06
NO20020592D0 (no) 2002-02-06
BR0013083A (pt) 2002-04-23
PL353054A1 (en) 2003-10-06
AU6828600A (en) 2001-03-05
KR20020012631A (ko) 2002-02-16
CN1368962A (zh) 2002-09-11
WO2001010841A3 (de) 2001-09-07
HUP0202464A3 (en) 2003-02-28
CA2380981A1 (en) 2001-02-15
MXPA02001297A (es) 2004-07-16
DE19937394A1 (de) 2001-02-08
WO2001010841A2 (de) 2001-02-15
HUP0202464A2 (hu) 2002-12-28
NO20020592L (no) 2002-04-04

Similar Documents

Publication Publication Date Title
US6559144B2 (en) Bicyclic amino acids
KR20000022190A (ko) 인테그린 저해제로서의 페닐알라닌 유도체
KR20000071030A (ko) 이환 아미노산
US6849646B1 (en) Chromenone and chromanone derivatives as integrin inhibitors
US6645991B1 (en) αvβ3 integrin inhibitors
US7371854B2 (en) Method for the production of bicyclic aromatic amino acids and intermediate products thereof
HK1049006A1 (zh) 芴衍生物
US6521646B1 (en) Dibenzoazulene derivatives for treating thrombosis, osteoporosis, arteriosclerosis
JP2003507458A (ja) 新規なインテグリンαｖβ３阻害剤
US20030187289A1 (en) Biphenyl derivatives and the use thereof as integrin inhibitors
MXPA01004272A (en) Chromenone and chromanone derivatives as integrin inhibitors